El presente proyecto es un edificio mixto bajo el concepto “in between” (espacios intermedios), cuya principal tipología es una residencia universitaria, complementaria a esta surgen usos complementarios como el comercio, las oficinas co- working y las salas de usos múltiples. Se ubica, estratégicamente, en el distrito de Pueblo Libre, cerca de equipamiento necesario y complementario a estas tipologías. Con la elaboración de este proyecto, se busca cubrir el 3.05% de la demanda actual existente por parte de estudiantes de provincia o del extranjero, quienes por falta de edificios como este, tienen la necesidad de hospedarse en ambientes no aptos arquitectónicamente a sus necesidades. El objetivo de la residencia universitaria es alojar a los estudiantes y brindarles espacios de ocio y descanso cuya calidad arquitectónica permita que los estudiantes se desenvuelvan en el aspecto personal, académico, social y cultural. Por otro lado, es preciso mencionar que las oficinas co- working, el comercio y las salas de uso múltiple son espacios complementarios a esta residencia que se incluyen en el proyecto con la finalidad de hacer que este sea más atractivo a los inversionistas y, por ende, más rentable. / The present project is a mixed building under the concept “in between” (intermediate spaces), the main typology of which is a university residence, complementary to which arise complementary uses such as commerce, co-working offices and multipurpose rooms. It is strategically located in the Pueblo Libre district, close to the necessary and complementary equipment for these typologies. With the elaboration of this project, the aim is to cover 3.05% of the current demand from students from the province or from abroad, who due to a lack of buildings like this, have the need to stay in environments that are not architecturally suitable for their needs. The objective of the university residence is to accommodate the students and provide them with leisure and rest spaces whose architectural quality allows the students to function personally, academically, socially and culturally. On the other hand, it is necessary to mention that co-working offices, shops and multipurpose rooms are complementary spaces to this residence, which are included in the project in order to make it more attractive to investors and, therefore, hence, more profitable. / Trabajo de investigación

This Master’s Thesis introducing active preload control of machine tool head supported by a company TOSHULIN, a.s. It presents a way of creating models from rigid body models to flexible bodies and finally to multi-body systems with control loop. The goal of this thesis is create active preload control using a piezo-stack system for simplified linear model of ma-chine tool head.

Les interactions protéine-protéine (IPP) jouent un rôle essentiel dans le vivant. Mon travail de thèse s’est concentré sur développement de méthodes bio-informatiques pour la prédiction et la modélisation structurale des IPP. Mon objectif était d'améliorer le pouvoir prédictif des méthodes permettant de prédire les structures d’assemblages macromoléculaires (docking) et d'aborder les problèmes rencontrés par les biologistes sur des cas réels d’interactions.Pour obtenir des modèles de protéines isolées de meilleure qualité, j’ai tout d’abord développé le serveur HHalign-Kbest basé sur des algorithmes d’alignements sous-optimaux. Ensuite, dans le domaine du « docking », j’ai élaboré le serveur InterEvDock qui prend en compte les informations de coévolution entre protéines. Les validations en aveugle montrent que ce serveur atteint de meilleures performances que d’autres serveurs de référence lorsque l’information évolutive est disponible.Afin de tester plus à fond nos méthodes, nous avons participé au concours CAPRI - un concours international pour la prédiction des interactions protéiques. Sur les sessions couvrant la période 2013-2016, notre groupe s’est classé 1er. Enfin, j'ai développé un jeu de données d’apprentissage et de test, PPI4DOCK. Il contient un très grand nombre de cibles de complexes (plus de 1000) et permettra d'améliorer les méthodes de docking à partir des structures expérimentales ou de modèles.En termes d'applications, je me investis dans différents projets collaboratifs, qui touchent des domaines aussi variés que, la recherche de partenaires pour le chaperon d’histone Asf1; la prédiction des modes d’interaction entre CENP-F et Nup133 dans le contexte de la mitose et de Exo70 et Abi dans celui de la régulation de la mobilité cellulaire; la simulation des modes de liaison entre le complexe Ku et ses partenaires peptidiques, dans les voies de réparation de l'ADN. / Protein-protein interactions (PPIs) play essential roles in life. My PhD work aimed at developing advanced bioinformatics methods in the field of PPI prediction at the structural scale. My goal was to improve the predictive power of methods which model the structures of macromolecular assemblies (docking) and to tackle real-life problems faced by biologists.First, I developed HHalign-Kbest server using algorithms for the search of suboptimal solutions to gain better-quality models. Second, in the field of protein docking, I built InterEvDock server which can take co-evolutionary information into account. It yields better performance than other state-of-the-art servers. In order to further test our methods, we participated in CAPRI – an international challenge for prediction of protein interactions. Over years 2013-2016, our group ranked 1st at the 6th CAPRI evaluation meeting. At last, I developed a realistic benchmark dataset PPI4DOCK, largest dataset so far, in order to improve docking methods for the scientific community.In terms of applications, I was involved in a variety of collaborative projects with different labs. As representative examples, I searched for binding partners of the histone chaperone Asf1; I studied the CENP-F/Nup133 interaction in the context of mitosis and the Exo70/Abi interaction related to cell mobility regulation; I also simulated the binding modes of multiple peptides, partners of Ku complex involved in DNA repair pathway.

Les Environnements Virtuels Immersifs (EVI) peuvent être utilisés pour amener des utilisateurs, répartis géographiquement ou co-localisés, à partager un même monde virtuel pour collaborer. Si l’on compare aux situations distantes, les utilisateurs d’une immersion co-localisée collaborent aussi dans le monde virtuel, mais a contrario, partagent physiquement un même espace de travail. Cette co-localisation facilite le travail collaboratif en permettant des communications directes et des interactions sans médiation informatique entre les utilisateurs.Avec le développement de l'affichage multi-utilisateur et de la technologie de tracking, les dispositifs immersifs classiques basés sur la rétroprojection (ex. CAVE) peuvent offrir maintenant l'immersion pour plusieurs utilisateurs co-localisés en affichant différentes vues stéréoscopiques sans distorsion visuelle pour chacun d’eux. Dans ce contexte, la coexistence de l'information du monde virtuel et réel, en particulier lorsque les utilisateurs ne partagent pas un référentiel spatial commun, offre aux utilisateurs une nouvelle expérience perceptive et cognitive. Dans cette thèse nous nous sommes intéressés à la façon dont les utilisateurs se perçoivent et communiquent entre eux pour atteindre un contexte commun pour la collaboration, et aux moyens permettant d’élargir des scénarios collaboratifs déjà pris en charge dans ce type de dispositifs, basés sur des techniques de contrôle plus flexible des points de vue des utilisateurs. Cette thèse de doctorat traite donc principalement des problèmes perceptifs et de cohabitation que nous avons identifiés dans l’objectif d’assurer la sécurité et l’efficacité des collaborations co-localisées dans les environnements virtuels immersifs. Tout d'abord, nous avons mené une étude de cas pour examiner comment les conflits perceptifs modifieraient la communication entre les utilisateurs et leur performance. Deuxièmement, nous avons conçu et évalué des paradigmes de navigation appropriés pour permettre la navigation virtuelle individuelle tout en résolvant les problèmes de la cohabitation dans un espace de travail partagé physiquement limité. Enfin, sur la base des résultats de ces travaux, nous avons proposé un modèle dynamique générique qui intègre des contraintes de l'espace de travail physique et aussi ceux du monde virtuel pour gérer la collaboration co-localisée dans les systèmes immersifs multi-utilisateurs. / Immersive virtual environment can be used to bring both geographically distributed and co-located users to the same virtual place for collaboration. Compared to remote situations, co-located users collaborate in the same virtual world on top of a shared physical workspace. This collocation allows direct user communication and interaction without computer mediation which facilitates collaborative work. With the development of multi-user display and tracking technology, classical projection-based immersive setups (e.g. CAVE) can now support group immersion for co-located users by offering individual stereoscopic views without visual distortion. In this context, the coexistence of information from the virtual and real world, especially when users do not share a common spatial reference frame, provides users with a new kind of perceptual and cognitive experience. We are interested in how users perceive and communicate with each other to achieve a shared context for collaboration, and how we can broaden supported collaborative scenarios with more flexible viewpoint control.This PhD thesis mainly addresses perceptual and cohabitation issues that we identified in the aim of supporting safe and efficient co-located collaboration in immersive virtual environment. First, we conducted a case study to examine how perceptual conflicts would alter user communication and task performance. Second, we concentrated on the design and evaluation of appropriate navigation paradigms to allow individual virtual navigation while solving cohabitation problems in a shared limited physical workspace. At last, based on the results of previous studies, we designed a generic dynamic navigation model which integrates constrains from the physical workspace and also the virtual world to enable co-located collaboration in multi-user immersive systems.

Title: Study of new catalytic materials for proton exchange membrane fuel cells Author: Petr Homola Department: Department of Surface and Plasma Science Supervisor: Prof. RNDr. Vladimír Matolín, DrSc. Abstract: Submitted thesis deals with study of thin layers based on platinum and cerium oxides in order to use them in fuel cells with polymer membrane (PEM- FC). A set of samples with different amount of platinum was prepared by means of magnetron sputtering. Samples were investigated by X - ray Photoelectron Spectroscopy (XPS) and results were confronted with sputtering parameters. It was found out that chemical state of platinum is related to its amount in thin layer. The less platinum was contained in thin layer, the less amount of Pt0 state was observed and amounts of Pt2+ and Pt4+ states increased. Furthermore the temperature stability of prepared layers in the interval from room temperature to 250 ◦ C was studied by means of XPS. The adsorption of carbon monoxide was measured by infrared absorption spectroscopy (IRAS). Increasing degree of adsorption on sample probably related to platinum reduction with increased tem- perature was observed. Measurements of other samples were devaluated by strong contamination with nickel carbonyls. Keywords: PEMFC, cerium oxide, magnetron sputtering, XPS, CO adsorption

Title: Study of CeOX / Rh inverse catalyst Author: Bc. Miroslav Kettner Department: Department of Surface and Plasma Science Supervisor: doc. RNDr. Václav Nehasil, Dr., Department of Surface and Plasma Science Abstract: Inverse catalysts of cerium oxide deposited on polycrystalline and monocrystalline (111) rhodium substrates were studied by means of surface science experimental methods. Growth characteristics of cerium oxide were investigated in dependence on deposition conditions and different thickness determination methods were compared. Acording to oxidizing or reducing exposition conditions changes in degree of oxidation of CeOX were observed. Further spectra analysis showed additional Ce-Rh alloy formation. Adsorption positions CO on-top and CO hollow on Rh (111) surface were differentiated by spectra fitting procedures. Oxygen absorption and reverse desorption in CeOX was confirmed. Performed experiments indicate that this process occurs through oxide-metal interface. CO oxidation reaction mechanisms at room temperature were proposed. Cerium oxide presence is necessary for reaction occurrence. Significant influence of deposited CeOX on proposed CO oxidation reaction mechanisms was proved by this way. Keywords: Rhodium, cerium oxide, alloy, inverse catalyst, CO oxidation.

Title: High pressure CO and methanol oxidation study over nanopowder Rare Earth Oxides and platinum thin film catalysts Author: Mgr. Andrii Rednyk Department: Department of Surface and Plasma Science Supervisor: Prof. RNDr. Vladimír Matolín, DrSc. matolin@mbox.troja.mff.cuni.cz Abstract: This doctoral thesis focuses on reactivity study of nanopowder rare earth oxides (REOs) and platinum based thin film catalysts using microreactor with high pressure reaction cell. REOs nanoparticles were prepared by new approach based on sol-gel chemistry. Magnetron sputtering technique was used for preparation of thin film samples. In the first part of the thesis CO oxidation on REOs and on Pt, PtOx thin films were performed. Among prepared REOs catalyst better activity exhibited alumina stabilized ceria, due to higher surface area. Both Pt and PtOx deposited on silicon substrate exhibited similar activity. When carbon (G-foil or C interlayer) is used as support, activity of Pt thin film decreases while PtOx preserves high activity. In the second part of the thesis steam reforming of methanol (SRM) and partial oxidation of methanol (POM) were performed on Pt thin films. It was shown that PtOx thin film exhibited superior activity compared to other samples with the same thickness. It is due to the reduction of platinum...

Title: Study of cerium oxide-metal intraction with gases - carbon monoxide oxidation and methanol decomposition Author: Tatiana Kolářová Department: Department of Surface and Plasma Science Supervisor: Doc. RNDr. Václav Nehasil, Dr., Department of Surface and Plasma Science Abstract: Dissertation thesis is focused on the study of two catalytic systems on the basis of cerium oxide-metal. The systems were characterized by various methods of surface analysis. The first part of the work concerns influence of the preparation parameters on the character of gold nanoparticles deposited onto the sputtered cerium oxide layers from a solution. Catalytic activity of prepared Au/CeOx/(C)/Si systems, containing particles with the mean sizes of 4- 10 nm, was tested toward CO oxidation at atmospheric pressure. The results show that with increasing amount of gold present on the samples, also the productivity of CO2 during the reactions grows. The work is further focused on the preparation of an inverse model CeOx/Pt(111) system. On this system, adsorption of methanol at low temeperatures and its decomposition during a heating was studied. It is apparent from presented results that the decomposition of methanol on the inverse CeOx/Pt(111) systems behaves in a different way than on a clean platinum sample or a thick...

Co-design workshops (CDW) kan förbättra idégenereringen i designprocessen. CDW grundar sig i att människor ska arbeta tillsammans i realtid men vid forskning om stigmatiserade ämnen kan det vara svårt att genomföra den öga mot öga på grund av stigman. Tidigare forskning visar en större komplexitet med att forska om stigmatiserade ämnen inom human-computer interaction (HCI). Det finns en stor risk för att stigmatisera deltagarna ytterligare eftersom forskningen ofta involverar att designa tillsammans. Syftet med studien är att få kunskap om hur designers kan stöttas vid genomförandet av CDW om stigmatiserade ämnen för att inte stigmatisera deltagarna ytterligare, samt att främja inkludering av människor som upplever stigma i co-design vid design av digitala produkter och tjänster som berör dem. En designorienterad studie har genomförts där designförslag har tagits fram baserat på litteratur. Designförslagen har inkorporerats i en artefakt som i denna studie är en process i form av en CDW som också användes för att utvärdera och testa upplevelsen av CDW med stigmatiserade ämnen. Resultatet av studien är fyra designförslag kopplat till social sårbarhet, känslomässiga reaktioner, initiativtagande och skillnader i kunskap. Dessa kan användas vid genomförandet av CDW om stigmatiserade ämnen för att inte skapa obehag hos deltagarna eller stigmatisera ytterligare. / Co-design workshops (CDW) can improve the production of ideas in the design process. CDW is based on people working together in real time, but when researching stigmatized subjects, it can be difficult to carry out the research eye to eye due to the stigma. Previous research shows a greater complexity in researching stigmatized subjects in human-computer interaction (HCI). There is a great risk of further stigmatizing the participants because the research often involves designing together. The purpose of the study was to gain knowledge about how designers can be supported in the implementation of CDW on stigmatized subjects to prevent further stigmatizing participants, and to encourage the inclusion of people who experience stigma in co-design when designing digital products and services that affect them. A design-oriented study has been carried out where design suggestions have been developed based on literature. The design suggestions have been incorporated into an artifact which in this study is a process in the form of a CDW, which was also used to evaluate and test the experience of CDW with stigmatized subjects. The result of the study are four design suggestions connected to social vulnerability, emotional reactions, initiative and differences in knowledge. These can be used in the implementation of the CDW about stigmatized subjects to not create discomfort among the participants or further stigmatize.

Bakgrund: Developmental Coordination Disorder (DCD) är en motorisk koordinationsstörning som uppstår i tidig ålder. Det är vanligt att barn med diagnosen DCD undviker fysisk aktivitet, lek och även svårt att klara kraven inom skolidrotten. Interventioner med task-oriented approach har varit den behandling som främst rekommenderas för barn med DCD. De senaste åren har nyare interventioner inom task-oriented approach utvecklats och blivit allt mer populära. Syfte: Syftet med denna litteraturstudie har varit att undersöka evidensläget för behandlingsmetoder med task-oriented approach för barn med DCD och sammanställa dessa metoders effekter på balans, koordination och/eller fysisk aktivitet.  Metod: Arbetet utfördes som en narrativ litteraturstudie och en systematisk sökning efter relevanta studier genomfördes i databaserna PubMed, PEDro, Cochrane samt Cinahl. Studierna kvalitetsgranskades med PEDros granskningsmall och bedömning av evidensstyrka genomfördes med GRADEstud. Resultat: Nio studier med task-oriented approach inkluderades i studien. Artiklarnas kvalitet varierade mellan god, moderat och låg. Det sammanvägda resultatets evidensstyrka gällande effekt på balans och koordination med task-oriented approach graderades som mycket låg vid jämförelse med kontrollgrupp eller process-oriented approach och som låg vid jämförelse med annan task-oriented approach. Studiernas låga kvalitet, brist på poweranalyser samt heterogeniteten mellan interventionerna bedömdes vara orsaken till resultatet av evidensgraderingen. Konklusion: De inkluderade studierna har genomgående varit små och av varierande kvalitet. Mer forskning av hög kvalitet behövs för att kunna säkerställa en högre tillförlitlighet på effekten av task-oriented approach för barn med DCD. / Background: Developmental Coordination Disorder (DCD) is a motor coordination disorder that occurs at an early age. It is common for children with DCD to avoid physical activity due to their motor problems and they have difficulty meeting the demands of school sports. Interventions with a task-oriented approach have mainly been what is recommended for children with DCD. In recent years, newer interventions that fall into the task-oriented approach have become increasingly popular. Aim: The aim of this study was to investigate the scientific evidence of treatment methods with task-oriented approach for children with DCD and to summarize  the effects of these methods on balance, coordination and physical activity. Method: For this narrative literature study the search for relevant studies was conducted in the medical databases PubMed, PEDro, Cochrane and Cinahl. The quality was assessed with the PEDro scale and the reliability of the evidence was evaluated with GRADEstud.  Result: Nine studies were included in the study. The quality of the studies varied between good, moderate and low. The reliability of the results to the effect on balance and coordination was graded as very low and low. This was due to the low quality, lack of power analysis and heterogeneity in the interventions with task-oriented approach. Summary: The included studies are generally small and of varying quality. More high-quality research is needed to ensure a higher reliability of the effect of task-oriented approach for children with DCD.