Yes / BACKGROUND: Provision of care and support for people with dementia and family carers is complex, given variation in how dementia manifests, progresses and affects people, co-morbidities associated with ageing, as well as individual preferences, needs, and circumstances. The traditional service-led approach, where individual needs are assessed against current service provision, has been recognised as unfit to meet such complexity. As a result, people with dementia and family members often fail to receive adequate support, with needs remaining unmet. Current research lacks a conceptual framework for explaining variation in satisfaction of care needs. This work develops a conceptual framework mapped onto the care delivery process to explain variations in whether, when and why care needs of people with dementia are met and to expose individual-, service-, system-level factors that enable or hinder needs satisfaction. METHODS: Data collected through 24 in-depth interviews and two focus groups (10 participants) with people with dementia and family carers living in the North East of England (UK) were analysed thematically to develop a typology of care needs. The need most frequently reported for people with dementia (i.e. for support to go out and about) was analysed using themes stemming from the conceptual framework which combined candidacy and discrepancy theories. RESULTS: The operationalisation of the framework showed that satisfaction of the need to go out was first determined at the point of service access, affected by issues about navigation, adjudication, permeability, users' resistance to offers, users' appearance, and systems-level operating conditions, and, subsequently, at the point of service use, when factors related to service structure and care process determined (dis)satisfaction with service and, hence, further contributed to met or unmet need. CONCLUSION: The conceptual framework pinpoints causes of variations in satisfaction of care needs which can be addressed when designing interventions and service improvements. / We gratefully acknowledge financial support from the Health Foundation (grant number 1274233).

This thesis addresses corporate approaches to CSR stakeholder engagement in the pharmaceutical industry in the UK and Germany. Its objective is to undertake mainly exploratory qualitative research to investigate how the selected sample manages CSR. The data was primarily accessed and collected from senior executives within major pharmaceutical companies. Multiple research methods were employed to gather rich new empirical evidence which focuses on the CSR practices and perceptions of CSR managers in both countries. To examine how this 'sensitive' sector responds to what could be termed the 'CSR Challenge', a critical realist perspective and six codes were chosen to map the practices and to compare similarities and differences between the two countries. This research contributes to the academic literature in this field by filling significant gaps in an area which was previously under-investigated. Ultimately, the findings are employed to examine a prespecified framework which was originally developed by the author based on secondary data in separate research. Overall, the results inform, re-examine, and improve this recently published framework. The updated explanatory framework which results from the research is the main conceptual contribution of the thesis. It serves as a management tool which includes the contextual factors which influence decision-makers' practices and perceptions portrayed as a set of inter-related management steps. This new conceptualisation is designed to be of practical use for decision-makers when managing their stakeholder engagement activities. As a result, this research is essentially applied and normative in nature. In addition, this work presents an original contribution to the literature in its field which should be of interest to academics.

ABSTRACT In this Masters Research Report, I argue that different conceptual frameworks play a central role in influencing whether and why independent funders in South Africa choose to engage in either social justice philanthropy or traditional philanthropy. Based on documentary analysis and in-depth interviews with a sample population of independent funders and experts in the philanthropic field in South Africa, this research first puts forward a different understanding of social justice philanthropy, from a South African perspective. Based on this understanding, the research then reflects that the way in which independent funders conceptualise and operationalize the reasons why they do the work they do and their roles in relation to other development role players are the central elements that influence the nature and scope of the funding approaches, priorities and strategies that they adopt.

This paper explores the past, present, and future of Africa's regional integration trajectory. It examines both the “old” and “new theories” of regional integration and compares and different viewpoints in existing literature to illuminate different schools of thought on regional integration with an Africa-centric approach at the centre. The paper argues that Africa's unique set of background conditions necessiates the development of a more relevant theoretical and conceptual framework and attempts to do so. Finally and arguably most importantly, this paper offers policy recommendations and pathways to regional integration through regional value chains that can improve regional production networks and looks at how the establishment of the AfCFTA promotes this process.

This thesis addresses corporate approaches to CSR stakeholder engagement in the pharmaceutical industry in the UK and Germany. Its objective is to undertake mainly exploratory qualitative research to investigate how the selected sample manages CSR. The data was primarily accessed and collected from senior executives within major pharmaceutical companies. Multiple research methods were employed to gather rich new empirical evidence which focuses on the CSR practices and perceptions of CSR managers in both countries. To examine how this ¿sensitive¿ sector responds to what could be termed the ¿CSR Challenge¿, a critical realist perspective and six codes were chosen to map the practices and to compare similarities and differences between the two countries. This research contributes to the academic literature in this field by filling significant gaps in an area which was previously under-investigated. Ultimately, the findings are employed to examine a prespecified framework which was originally developed by the author based on secondary data in separate research. Overall, the results inform, re-examine, and improve this recently published framework. The updated explanatory framework which results from the research is the main conceptual contribution of the thesis. It serves as a management tool which includes the contextual factors which influence decision-makers¿ practices and perceptions portrayed as a set of inter-related management steps. This new conceptualisation is designed to be of practical use for decision-makers when managing their stakeholder engagement activities. As a result, this research is essentially applied and normative in nature. In addition, this work presents an original contribution to the literature in its field which should be of interest to academics.

ABSTRACT Leadership consultants bring specialized knowledge into their clients' organizations. Advisor leadership consultants (ALC) trained as psychotherapists apply concepts from human behavior theories as advisors to business leaders. They also bring service-oriented professional norms and values of objectivity, neutrality, and lack of self-interest. Their business clients in the market sector operate according to norms and values of pragmatism, financial self-interest, and advocacy. In order to establish credibility in the organizational field of business clients, leadership consultants must negotiate between these different value systems. This study is a grounded theory inquiry using narrative analysis tools to study how ALCs navigate across the boundaries of psychotherapy practice and consultation in the corporate setting. How do they describe their practice choices as well as the principles and theoretical framework underlying those choices? In-depth interviews were conducted with a convenience sample of 10 leadership consultants credentialed and experienced as psychotherapists. A snowball method of participant recruitment from my social and professional network yielded a group of 10 ALCs aged 50 to 86. Each of these ALCs entered their careers with a predisposition for business from their families. They each experienced significant loss in early life and followed divergent educational and career pathways. They have built their leadership consulting practices accepting business practices to gain access to clients while incorporating important relationship principles. As institutional entrepreneurs, they managed conflict with values in both the service and the marketplace sectors through innovative therapy, consulting and business practices.

Although replication is considered an indispensable part of the scientific method in software engineering, few replication studies are published each year. The rate of replication, however, is not surprising given that replication theory in software engineering is immature. Not only are replication taxonomies varied and difficult to reconcile, but opinions on the role of replication contradict. In general, we have no clear sense of how to build knowledge via replication, particularly given the practical realities of our research field. Consequently, most replications in software engineering yield little useful information. In particular, the vast majority of external replications (i.e., replications performed by researchers unaffiliated with the original study) not only fail to reproduce the original results, but defy explanation. The net effect is that, as a research field, we consistently fail to produce usable (i.e., transferable) knowledge, and thus, our research results have little if any impact on industry. In this dissertation, we dissect the problem of replication into four primary concerns: 1) rate and explicitness of replication; 2) theoretical foundations of replication; 3) tractability of methods for context analysis; and 4) effectiveness of inter-study communication. We address each of the four concerns via a two-part research strategy involving both a theoretical and a practical component. The theoretical component consists of a grounded theory study in which we integrate and then apply external replication theory to problems of replication in empirical software engineering. The theoretical component makes three key contributions to the literature: first, it clarifies the role of replication with respect to the overall process of science; second, it presents a flexible framework for reconciling disparate replication terminology; and third, it informs a broad range of practical replication concerns. The practical component involves a series of replication studies, through which we explore a variety of replication concepts and empirical methods, ultimately culminating in the development of a tractable method for context analysis (TCA). TCA enables the quantitative evaluation of context variables in greater detail, with greater statistical power, and via considerably smaller datasets than previously possible. As we show (via a complex, real-world example), the method ultimately enables the empirically and statistically-grounded reconciliation and generalization of otherwise contradictory results across dissimilar replications—which problem has previously remained unsolved in software engineering.

Comme à l’approche d’un tsunami, l’incidence grandissante des allergies affecte maintenant plus de 30% de la population des pays développés. Étant la cause de nombreuses morbidités et un risque significatif de mortalité, les allergies nécessitent des dépenses exorbitantes au système de santé et constituent une des plus importantes sources d’invalidité. Cette thèse a pour but de contribuer à faciliter la prise de décision éclairée dans le développement de politiques en santé en lien avec cette maladie immunitaire chronique en utilisant des principes d’éthique comme outils pour guider le développement de politiques en santé. Le premier chapitre démontre le présent déficit d’analyses des enjeux éthiques en allergologie et démontre de quelle façon les réflexions en éthique peuvent guider le développement de politiques et l’élaboration de stratégies appliquées aux allergies. Les chapitres qui suivront présentent des applications spécifiques des principes d’éthiques ciblant des contextes précis comme des méthodes qui fournissent des outils de réflexion et des cadres théoriques qui peuvent être appliqués par les décideurs pour guider des interventions en santé concernant les allergies et les conditions de co-morbidité reliées. Le second chapitre présente un cadre théorique pour l’évaluation et la priorisation d’interventions en santé publique par la diminution des allergènes présents dans l’environnement basées sur des théories de justice sociale. Les critères entourant les politiques d’évaluation se concentrent sur les enjeux éthiques référant aux populations vulnérables, sur une distribution plus égale des bénéfices pour la santé, et sur le devoir d’éviter la stigmatisation. Le troisième chapitre offre aux administrateurs et au personnel infirmier du réseau scolaire un cadre décisionnel pour guider le développement de politiques efficaces et éthiquement justifiables concernant les allergies alimentaires pour les écoles. Dans ce contexte, les principes de base d’éthique en santé publique et en bioéthique - par exemple, l’empowerment des populations vulnérables dans la prise en charge de leur santé et la protection de la confidentialité du dossier médical - servent d’outils pour évaluer les politiques. Le dernier chapitre emploie les principes de base de recherche en éthique comme méthode pour développer un argumentaire en faveur de la réforme des réglementations entourant la production de médicaments immunothérapeutiques. La nécessité éthique d’éviter les risques de méfait à l’endroit du sujet humain dans la recherche permettra de servir de guide pour structurer de futures politiques en santé publique en égard à la production d’immunothérapeutiques à l’échelle mondiale. / Like a slowly rising wave approaching shore, the growing incidence of allergic disease now afflicts over 30% of the population in the developed world. Being the cause of severe morbidities and a significant risk of mortality, allergy requires huge resource expenditures in health care and is a leading cause of disability. This thesis aims to contribute to ameliorating decision-making capacities in health policy development for this chronic immune disease by employing principles of ethics as tools to help structure policy initiatives. The first chapter will demonstrate the current deficiency of ethical analysis in allergology and show how ethical assessments could have utility in guiding policy developments and treatment strategies for allergy. The subsequent chapters present a focused application of ethical principles within specific contexts as a means to provide reflective tools and theoretical frameworks that could be used by decision-makers to guide health interventions for allergy and co-morbid conditions. The second chapter presents a conceptual framework for evaluating and prioritizing public health interventions in minimizing environmental allergens based on theories of social justice. Policy assessment criteria centre on justice issues pertaining to vulnerable populations, the fair distribution of health benefits, and the imperative to avoid stigma. The third chapter provides school administrators with a framework to guide the development of efficacious and ethically sound food allergy policies for schools. In this context, core principles in public health ethics and bioethics – examples being the empowerment of vulnerable populations in controlling their health and protecting confidentiality of medical information – serve as tools for policy assessments. The final chapter employs core principles from research ethics as a method to argue for regulatory reforms in the production of allergenimmunotherapeutic drugs. The ethical imperative to avoid risks of harm to human subjects in research will serve as a guide to structure future health policies in the global production of immuno-therapeutics.

Comme à l’approche d’un tsunami, l’incidence grandissante des allergies affecte maintenant plus de 30% de la population des pays développés. Étant la cause de nombreuses morbidités et un risque significatif de mortalité, les allergies nécessitent des dépenses exorbitantes au système de santé et constituent une des plus importantes sources d’invalidité. Cette thèse a pour but de contribuer à faciliter la prise de décision éclairée dans le développement de politiques en santé en lien avec cette maladie immunitaire chronique en utilisant des principes d’éthique comme outils pour guider le développement de politiques en santé. Le premier chapitre démontre le présent déficit d’analyses des enjeux éthiques en allergologie et démontre de quelle façon les réflexions en éthique peuvent guider le développement de politiques et l’élaboration de stratégies appliquées aux allergies. Les chapitres qui suivront présentent des applications spécifiques des principes d’éthiques ciblant des contextes précis comme des méthodes qui fournissent des outils de réflexion et des cadres théoriques qui peuvent être appliqués par les décideurs pour guider des interventions en santé concernant les allergies et les conditions de co-morbidité reliées. Le second chapitre présente un cadre théorique pour l’évaluation et la priorisation d’interventions en santé publique par la diminution des allergènes présents dans l’environnement basées sur des théories de justice sociale. Les critères entourant les politiques d’évaluation se concentrent sur les enjeux éthiques référant aux populations vulnérables, sur une distribution plus égale des bénéfices pour la santé, et sur le devoir d’éviter la stigmatisation. Le troisième chapitre offre aux administrateurs et au personnel infirmier du réseau scolaire un cadre décisionnel pour guider le développement de politiques efficaces et éthiquement justifiables concernant les allergies alimentaires pour les écoles. Dans ce contexte, les principes de base d’éthique en santé publique et en bioéthique - par exemple, l’empowerment des populations vulnérables dans la prise en charge de leur santé et la protection de la confidentialité du dossier médical - servent d’outils pour évaluer les politiques. Le dernier chapitre emploie les principes de base de recherche en éthique comme méthode pour développer un argumentaire en faveur de la réforme des réglementations entourant la production de médicaments immunothérapeutiques. La nécessité éthique d’éviter les risques de méfait à l’endroit du sujet humain dans la recherche permettra de servir de guide pour structurer de futures politiques en santé publique en égard à la production d’immunothérapeutiques à l’échelle mondiale. / Like a slowly rising wave approaching shore, the growing incidence of allergic disease now afflicts over 30% of the population in the developed world. Being the cause of severe morbidities and a significant risk of mortality, allergy requires huge resource expenditures in health care and is a leading cause of disability. This thesis aims to contribute to ameliorating decision-making capacities in health policy development for this chronic immune disease by employing principles of ethics as tools to help structure policy initiatives. The first chapter will demonstrate the current deficiency of ethical analysis in allergology and show how ethical assessments could have utility in guiding policy developments and treatment strategies for allergy. The subsequent chapters present a focused application of ethical principles within specific contexts as a means to provide reflective tools and theoretical frameworks that could be used by decision-makers to guide health interventions for allergy and co-morbid conditions. The second chapter presents a conceptual framework for evaluating and prioritizing public health interventions in minimizing environmental allergens based on theories of social justice. Policy assessment criteria centre on justice issues pertaining to vulnerable populations, the fair distribution of health benefits, and the imperative to avoid stigma. The third chapter provides school administrators with a framework to guide the development of efficacious and ethically sound food allergy policies for schools. In this context, core principles in public health ethics and bioethics – examples being the empowerment of vulnerable populations in controlling their health and protecting confidentiality of medical information – serve as tools for policy assessments. The final chapter employs core principles from research ethics as a method to argue for regulatory reforms in the production of allergenimmunotherapeutic drugs. The ethical imperative to avoid risks of harm to human subjects in research will serve as a guide to structure future health policies in the global production of immuno-therapeutics.

Isaiah Berlin maintains that there are two distinct forms of freedom or liberty: negative and positive. Berlin’s principal claim is that negative liberty does not require that the self be somehow separate from the empirical world (causally aloof, or an originator of causal chains). My principal claim is that to be an agent is to be committed to a separation of self in this sense, thus that the self for its very being requires to possess a species of positive liberty. This conception proceeds in part from Immanuel Kant’s claim that there is a separation between spontaneity and receptivity. Commitment to this assertion allows there to be an understood distinction between the self as a spontaneous self-active agent that makes choices, and the self as a mere reactionary brute that does what it does by biological imperatives. In this thesis, I defend the view that negative liberty is subsumed under positive liberty: you cannot have the former without the latter. I am therefore taking a rationalist stance towards Berlin’s thinking. My methodology is to bring into consideration two perspectives upon the underlying normative principles within the space of reason. The first is of Kant’s understanding of the principle of responsibility and the activity of spontaneity; the second is John McDowell’s understanding of that principle and activity. The key claim of this thesis is that Berlin misunderstands what it is to be a chooser. To be a chooser is to be raised under the idea that one is an efficient cause; human children are brought up being held responsible for their reasons for acting. This principle allows mere animal being to be raised into the space of reason, where we live out a second nature in terms of reason. Using their conclusions I further investigate Berlin’s understanding of conceptual frameworks, taking particular interest in historic ‘universal’ conceptions that shape human lives. He too finds that that we are choosers is necessary for what it is to be human. I take his conclusion, and suggest that if he had had a clear understanding of the space of reason, the historic claim that we have choice would find a more solid footing in the principle of that space, in that we are responsible for our actions. I conclude that the upshot of understanding the ‘I’ as an originating efficient cause is that we treat ourselves as free from a universal determinism that Berlin himself disparages; and that the cost to Berlin is that all choice is necessarily the activity of a higher choosing self. It is part of a Liberal society’s valuing, by their societal commitment to, the ideology of raising our children to understand themselves as choosers, that we have choice at all. This is irrespective of whether that which fetters choice is internal or external to the agent, or of whether having self-conscious itself requires such a cultural emergence of second nature.