Philosophiae Doctor - PhD / Childbirth is a multifaceted experience that is usually influenced by several factors that could result in an unsatisfactory or satisfactory childbirth experience. These factors include quality of support during labour of which Continuous Labour Support (CLS) is a part; it has been identified as a positive contributor to maternal health. Although CLS has been recommended by the World Health Organization (WHO), lack of a framework has also been an impediment to its implementation in Nigerian hospitals. The purpose of this study is to develop a culturally congruent Continuous Labour Support framework for women in Nigeria. The study adopted a concurrent mixed method design to gain information from various dimensions for the study. The study populations included pregnant women, nurse-midwives and health policy-makers in Ondo state, Nigeria, who were selected through simple random sampling using computer-generated tables for the quantitative strand of the study. For the qualitative strand, participants were selected using a purposeful sampling method. The study was conducted in two phases. Phase 1 focused on the assessment of the perceptions, attitudes and preferences of all groups of participants. Collected quantitative data was analysed using descriptive and inferential statistics through the use of the Statistical Package for Social Science (SPSS) Version 21. Qualitative data was analysed using Tesch's Method of Content Analysis. Findings the study shows that the pregnant women had positive perceptions and attitudes towards CLS from a familiar, close and trusted person, in public health facilities. Findings from the midwives revealed that pregnant women's family members are not usually involved in women's care during labour in public health facilities. However, nurse-midwives expressed satisfaction with the few occasional/discretional occasions on which the practice had been implemented, and the majority showed positive perceptions and attitudes to the introduction of CLS from a person of the woman's choice, in public health facilities. Findings from interviews with the policy-makers affirmed family support system during labour as a cultural expectation and a traditional practice at home but alien to the hospital. The policy-makers also expressed a positive standpoint on the introduction of CLS by persons of the woman’s choice from her social network, in the public hospital. Phase 2 of the study involved the development of the culturally congruent Continuous Labour Support framework for women in south-west Nigeria. The framework was developed using the Model Development Approach by Walker and Avant (2005, 2011). Findings from processes with all stakeholders in Phase 1 of the study were synthesised with literature review, using concept identification and classification. The concepts in this study were identified, described and developed through synthesis of data from questionnaire, the focus group and individual interviews of all stakeholders. Concept classification, description and validation was achieved through the six vantage points of surveying activity listed by Dickoff et al, (1968) in consultation the selected expert reviewers in maternal and child care. The developed framework was followed by a detailed description, and validation of the framework was done through consensus agreement with four experts.

La versatilité de LiNbO3 est bien connue dans le domaine de l’électronique acoustique (filtres SAW), de l’optique non linéaire et de l’optique électronique. Alors que les applications de LiNbO3 congruent sont répandues dans le domaine de l’électronique acoustique et de l’optique où les puissances ne sont pas très élevées, le seuil de dommage optique étant relativement bas, les applications sont limitées dans le domaine des fortes puissances lumineuses. Le seuil de dommage optique de LiNbO3 stœchiométrique est plus haut et rend nécessaire l’utilisation d’une méthode de croissance plus difficile (flux). Les difficultés de la méthode de croissance par flux justifie la recherche en vue de développer des méthodes alternatives ou d’améliorer les méthodes élaborées. Dans ma thèse j’ai présenté des solvants alternatifs á la croissance de monocristaux de LiNbO3 à partir du système ternaire K2O-Li2O-Nb2O5. J’ai prouvé qu’il est possible de faire croître des cristaux stœchiométriques par la méthode HTTSSG à partir des systèmes ternaires X2O-Li2O-Nb2O5 (X = Rb, Cs). Les diagrammes de phase tracés et précisés au cours de ce travail sont importants et donnent la possibilité de composer le flux à partir duquel il est possible d’obtenir le cristal de son choix. Comme pour les matériaux typiquement non stœchiométrique, les paramètres physiques de LiNbO3 sont très sensibles aux moindres variations de la composition (± 0.01 mol%). La détermination précise de la composition est donc très importante. Dans ma thèse, j’ai élaboré une nouvelle méthode de haute précision basée sur le rapport des deux principaux pics vibrationnels OH- dans l’infrarouge. Cette méthode a une précision qui satisfait les exigences de qualification des cristaux de LiNbO3 / The versatility of the application of LiNbO3 is well-known in the practical fields of acousto-electronics and non-linear optics and electro-optics. The optical damage threshold of stoichiometric LiNbO3 is higher so it is more suitable for electo-optical and non-linear optical applications than the congruent crystal which can be grown easier. The growth difficulties justify the development of alternative preparation methods or the improvement of the existing methods. This emphasizes the importance of the growth of stoichiometric LiNbO3 by the HTTSSG method not only from the K2O - Li2O - Nb2O5 ternary system but from the X2O - Li2O - Nb2O5 (X = Rb, Cs) systems as well. Using the presented phase diagrams the composition of the solution in equilibrium with a custom-tailored crystal composition can be determined. Most of the physical parameters of LiNbO3 are composition dependent. Even a small change of the composition (± 0.01 mol%) causes large differences in the properties so the determination of the Li2O content of the crystal with the highest possible accuracy is very important. The accuracy of the composition determination – described in detail in my thesis – based on the intensity ratio of the two characteristic bands in the OH- vibrational spectra of the near stoichiometric LiNbO3 satisfies the requirements imposed by the applications

<p>As amorphous solid dispersions (ASDs) are more widely employed as a formulation strategy for poorly water-soluble drugs, there is a pressing need to increase the drug loading in these formulations. The drug loading is typically kept low to obtain the desired drug release rate, but often results in large or even multiple dosage units, which is undesirable from a patient compliance perspective. We have identified the cause of this conundrum to be the drug loading dependent dissolution mechanism of ASDs. At low drug loadings, the dissolution rate of ASDs is polymer-controlled, while at high drug loadings, the dissolution rate is drug-controlled and considerably slower. This phenomenon is most pronounced for ASDs with hydrophilic polymers, such as poly (vinylpyrrolidone-co-vinyl acetate) (PVPVA) and the change in dissolution mechanism from being polymer-controlled to drug-controlled has been attributed to water-induced amorphous-amorphous phase separation (AAPS) in higher drug loading ASD matrices of hydrophilic polymers. The drug loading limit for this switch has been found to be dependent on drug properties as well as drug-polymer interactions. Interestingly, drug-polymer hydrogen bonding interaction has been found to be detrimental and decrease the drug loading limit for polymer-controlled release while drug log P did not have any impact on this limit. Variable dissolution temperature studies indicated a detrimental impact on the polymer-controlled drug loading limit when the drug-rich phase (of phase separated ASD matrix) exists in a glassy state. ASDs with relatively hydrophobic polymers, such as hypromellose acetate succinate (HPMCAS), have been found to be polymer-controlled up to higher drug loadings. The mechanistic understanding obtained in this body of work can thus be adopted to develop strategies enabling ASD formulations with optimized performance and improved drug loading.</p>

No description available.

Un nombre naturel n est dit congruent si il est l’aire d’un triangle rectangle dont tous les cotés sont de longueur rationnelle. Le problème des nombres congruents consiste à déterminer quels nombres sont congruents. Cette question, connue depuis plus de 1000 ans, est toujours ouverte. Elle est liée à la théorie des courbes elliptiques, car le naturel n est congruent si et seulement si la courbe elliptique y²=x³-n²x possède un point rationnel d’ordre infini. Ce lien entre les nombres congruents et les courbes elliptiques permet d’accéder à des techniques venant de la géométrie algébrique. Une de ces méthodes est le concept des matrices de Monsky qui peuvent être utilisées pour calculer la taille du groupe de 2-Selmer de la courbe elliptique y²=x³-n²x. On peut utiliser ces matrices afin de trouver de nouvelles familles infinies de nombres non-congruents. Cette relation introduit aussi des généralisations possibles au problème des nombres congruents. Par exemple, nous pouvons considérer le problème des nombres θ-congruent qui étudie des triangles avec un avec un angle fixé de taille θ au lieu de seulement des triangles rectangles. Ce problème est aussi lié aux courbes elliptiques et le concept des matrices de Monsky peut être étendu à ce cas. En fait, les matrices de Monsky peuvent être généralisées à n’importe quelle courbe elliptique qui possède une forme de Legendre sur les rationnels. Le but de ce mémoire est de construire une telle généralisation puis de l’appliquer à des problèmes de géométrie arithmétique afin de reprouver efficacement de vieux résultats ainsi que d’en trouver de nouveaux. / A positive integer n is said to be congruent if it is the area of a right triangle whose sides are all of rational length. The task of finding which integers are congruent is an old and famous yet still open question in arithmetic geometry called the congruent number problem. It is linked to the theory of elliptic curves as the integer n is congruent if and only if the elliptic curve y²=x³-n²x has a rational point of infinite order. The link between congruent numbers and elliptic curves enables the application of techniques from algebraic geometry to study the problem. One of these methods is the concept of Monsky matrices that can be used to calculate the size of the 2-Selmer group of the elliptic curve y²=x³-n²x. One can use these matrices in order to find new infinite families of non-congruent numbers. The connection to elliptic curves also introduces generalizations to the congruent number problem. For example, one may consider the θ-congruent number problem which studies triangles with a fixed angle of θ instead of only right triangles. This problem is also related to elliptic curves and the concept of Monsky matrices can be generalized to it. In fact, Monsky matrices can be generalized to any elliptic curve that has a Legendre form over the rationals. The goal of this thesis is to construct such a generalization and then to apply it to relevant problems in arithmetic geometry to efficiently reprove old results and find new ones.

This research project aims to: - Examine how my musical identity as Music-maker can be fused with those of contributing improvising musicians, throughout the collaborative process. - Form creative methodologies/strategies to sufficiently accommodate the improvisatory approaches of others around my own work. - Develop appropriate communication methods, including original notational systems; and explore ways in which technology can be harnessed, to help fulfil the above objectives. This research intends to explore the extent to which improvisation may be incorporated into compositions, by means of practical experiment and investigation. The written commentary will accompany a portfolio of audio recordings and scores. Key works demonstrating various approaches and techniques employed will be examined in detail. An appendix disc of supplementary audio recordings and videos will also be provided to show piecedevelopment and the evolution of my music-making practice. My point of origin straddles that of a professional guitarist experienced in an array of improvised music(s), including: rock, jazz, fusion and contemporary improvisation, and that of a composer interested in collaborative projects which take advantage of the eclectic experience and skill sets of the musicians taking part.

For the purpose of the study we varied the outcome of a sequence of ambiguous behaviors performed by an imaginary individual during World War II. Compared to a control condition where no outcome was presented, this person either ended up saving Jews (heroic behavior) or denouncing Jews to the Gestapo (cowardly behavior). After one week, behavioral antecedents that were consistent with the outcome were likely to be recalled and communicated. Results suggest a tendency  towards forming extreme impressions of the target, depending on the outcome. These extreme impressions in turn guide the recall and evaluations of predictability, and also impact on communication about these episodes and thereby on the formation of collective memory. / Para el estudio se varió el resultado final de una secuencia ambigua de conductas realizadas por una persona ficticia durante la Segunda Guerra Mundial. Después de la secuencia ambigua de acciones, en una condición control no se producía ninguna consecuencia, en otra condición de heroísmo la persona salvaba la vida de Judíos y en otra condición de cobardía los denunciaba a la Gestapo. Los antecedentes congruentes con la conducta final se recordaron y comunicaron más una semana después. Esto sugiere una tendencia a inferir juicios extremos a partir de la conducta final del personaje, que a su vez influyen en el recuerdo en relación al nivel de previsibilidad de la conducta del personaje, e influyen en la comunicación sobre el hecho y la memoria colectiva.

Climate change is no longer imminent but eminent. To combat climate change, effective, efficient and smart energy use is imperative. Thermal energy storage (TES) with phase change materials (PCMs) is one attractive choice to realize this. Besides suitable phase change temperatures and enthalpies, the PCMs should also be robust, non-toxic, environmental-friendly and cost-effective. Cost-effective PCMs can be realized in bulk blends. Blends however do not have robust phase change unless chosen articulately. This thesis links bulk blends and robust, cost-effective PCMs via the systematic design of blends as PCMs involving phase equilibrium evaluations. The key fundamental phase equilibrium knowledge vital to accurately select robust PCMs within blends is established here. A congruent melting composition is the most PCM-ideal among blends. Eutectics are nearly ideal if supercooling is absent. Any incongruent melting composition, including peritectics, are unsuitable as PCMs. A comprehensive state-of-the-art evaluation of the phase equilibrium-based PCM design exposed the underinvestigated categories: congruent melting compositions, metal alloys, polyols and fats. Here the methods and conditions essential for a comprehensive and transparent phase equilibrium assessment for designing PCMs in blends are specified. The phase diagrams of the systems erythritol-xylitol and dodecane-tridecane with PCM potential are comprehensively evaluated. The erythritol-xylitol system contains a eutectic in a partially isomorphous system unlike in a non-isomorphous system as previous literature proposed. The dodecane-tridecane system forms a probable congruent minimum-melting solid solution, but not a maximum-melting liquidus or a eutectic as was previously proposed. The sustainability aspects of a PCM-based TES system are also investigated. Erythritol becomes cost-effective if produced using glycerol from bio-diesel production. Olive oil is cost-effective and has potential PCM compositions for cold storage. A critical need exists in the standardization of methods and transparent results reporting of the phase equilibrium investigations in the PCM-context. This can be achieved e.g. through international TES collaboration platforms. / Energi är en integrerad del av samhället men energiprocesser leder till miljöbelastning, och klimatförändringar. Därför är effektiv energianvändning, ökad energieffektivitet och smart energihantering nödvändigt. Värmeenergilagring (TES) är ett attraktivt val för att bemöta detta behov, där ett lagringsalternativ med hög densitet är s.k. fasomvandlingsmaterial (PCM). Ett exempel på ett billigt, vanligt förekommande PCM är systemet vatten-is, vilket har använts av människor i tusentals år. För att tillgodose de många värme- och kylbehov som idag uppstår inom ett brett temperaturintervall, är det viktigt med innovativ design av PCM. Förutom lämplig fasförändringstemperaturer, entalpi och andra termofysikaliska egenskaper, bör PCM också ha robust fasändring, vara miljövänlig och kostnadseffektiv. För att förverkliga storskaliga TES system med PCM, är måste kostnadseffektivitet och robust funktion under många cykler bland de viktigaste utmaningarna. Kostnadseffektiva PCM kan bäst erhållas från naturliga eller industriella material i bulkskala, vilket i huvudsak leder till materialblandningar, snarare än rena ämnen. Blandningar uppvisar dock komplexa fasförändringsförlopp, underkylning och/eller inkongruent smältprocess som leder till fasseparation. Denna doktorsavhandling ger ny kunskap som möjliggör att bulkblandningar kan bli kostnadseffektiva och robusta PCM-material, med hjälp av den systematiskutvärdering av fasjämvikt och fasdiagram. Arbetet visar att detta kräver förståelse av relevanta grundläggande fasjämviktsteorier, omfattande termiska och fysikalisk-kemiska karakteriseringar, och allmänt tillämpliga teoretiska utvärderingar. Denna avhandling specificerar befintlig fasjämviktsteori för PCM-sammanhang, men sikte på att kunna välja robusta PCM blandningar med specifika egenskaper, beroende på tillämpning. Analysen visar att blandningar med en sammansättning som leder till kongruent smältande, där faser i jämvikt har samma sammansättning, är ideala bland PCM-blandningar. Kongruent smältande fasta faser som utgör föreningar eller fasta lösningar av ingående komponenter är därför ideala. Eutektiska blandningar är nästan lika bra som PCM, så länge underkylning inte förekommer. Därmed finns en stor potential för att finna och karakterisera PCM-ideala blandningar som bildar kongruent smältande föreningar eller fasta lösningar. Därigenom kan blandningar med en skarp, reversibel fasändring och utan fasseparation erhållas – egenskaper som liknar rena materialens fasändringsprocess. Vidare kan man, via fasdiagram, påvisa de blandningar som är inkongruent smältande, inklusive peritektiska blandningar, som är direkt olämpliga som PCM. Denna avhandling ger grundläggande kunskap som är en förutsättning för att designa PCM i blandningar. Genom en omfattande state-of-the-art utvärdering av fas-jämviktsbaserad PCM-design lyfter arbetet de PCM-idealiska blandningarna som hittills inte fått någon uppmärksamhet, såsom kongruenta smältande blandningar, och materialkategorierna metallegeringar, polyoler och fetter. Resultatet av arbetet visar dessutom att vissa PCM-material som ibland föreslås är direkt olämpliga då fasdiagram undersöks, bl a pga underkylning och även peritektiska system med fasseparation och degradering av kapaciteten (t ex Glauber-salt och natriumacetat-trihydrat). Denna avhandling specificerar och upprättar grundläggande teori samt tekniker, tillvägagångssätt och förhållanden som är nödvändiga för en omfattande och genomsynlig fasjämviktsbedömning, för utformning av PCM från blandningar för energilagering. Med detta som bas har följande fasdiagramtagits fram fullständigt: för erytritol-xylitol och för dodekan-tridekan, med PCM-potential för låg temperaturuppvärmning (60-120 °C) respektive frysning (-10 °C till -20 °C) utvärderas fullständigt. Erytritol-xylitol systemet har funnits vara eutektiskt i ett delvis isomorft system, snarare än ett icke-isomorft system vilket har föreslagits tidigare litteratur. Dodekan-tridekan systemet bildar ett system med kongruent smältande fast lösning (idealisk som en PCM) vid en minimumtemperatur, till skillnad från tidigare litteratur som föreslagt en maximumtemperatur, eller ett eutektiskt system. Teoretisk modellering av fasjämvikt har också genomförts för att komplettera det experimentella fasdiagrammet för systemet erytritol-xylitol. Efter granskning av de metoder som använts tidigare i PCM-litteraturen har här valts ett generiskt tillvägagångssätt (CALPHAD-metoden). Denna generiska metod kan bedöma vilken typ av material och fasändring som helst, till skillnad från en tidigare använda metoder som är specifika för materialtyper eller kemiska egenskaper. Denna teoretiska studie bekräftar termodynamiskt solvus, solidus, eutektisk punkt och erytritol-xylitol fasdiagrammet i sin helhet. Vad gäller hållbarhetsaspekter med PCM-baserad TES, lyfter denna avhandling fokus på förnybara och kostnadseffektiva material (t.ex. polyoler och fetter) som PCM. Som exempel har här undersökts erytritol och olivolja, med förnybart ursprung. Erytritol skulle kunna bli ett kostnadseffektivt PCM (163 USD/kWh), om det produceras av glycerol vilket är en biprodukt från biodiesel/bioetanolframställning. Olivolja är ännu ett kostnadseffektivt material (144 USD/kWh), och som här har påvisats innehålla potentiella PCM sammansättningar med lämpliga fasändringsegenskaper för kylatillämpningar. En övergripande slutsats från denna avhandling är att det finns ett behov av att standardisera tekniker, metoder och transparent resultatrapportering när det gäller undersökningar av fasjämvikt och fasdiagram i PCM-sammanhang. Internationella samarbetsplattformar för TES är en väg att koordinera arbetet. / <p>QC 20170830</p>

It is a widely held view that humans have control over their food choices and consumption. However, research also suggests that eating behavior is often triggered by contextual cues and guided by automaticities and habits. Interestingly, the dichotomy between automatic and controlled processing has recently been challenged, suggesting that they may be intertwined. In a large female sample (n = 567), we investigated the hypothesis that task-based and self-reported measures of automatic and controlled processing would interact and impact self-reported eating behavior. Results analyzed via structural equation modeling suggest that automatic, but not controlled processing, during a modified flanker task, including a context-specific proportion congruent (CSPC) manipulation, was inversely associated with self-reported self-control. The influence of self-control on unhealthy eating behavior (i.e., uncontrolled and emotional eating, heightened consumption of fat and sugar) was only indirect via habitual behavior, which itself had a strong direct impact. Unhealthy eating was further associated with real-life outcomes (e.g., body mass index (BMI)). Our findings suggest that eating behavior may indeed be guided primarily by automaticities and habits, whereas self-control might facilitate this association. Having self-control over eating might therefore be most effective by avoiding contextual cues eliciting undesired automatic behavior and establishing habits that serve long-term goals.

This thesis deals with the subjectively perceived problematical relationship between the employees of a day care centre (who are either professional caregivers or teachers) and clients or pupils with severe multiple disabilities. Examining this relationship and other selected problematical situations took place as part of short-term group work project using psychotherapeutic techniques. The group work facilitated a change in the relationship of the day care centre's employees with the clients. The research was conducted with a small group of probands from the Zahrada Integration Centre and from the Zahrádka Elementary School in Prague 3. The following professional methods have been used in the preparation of this thesis: an analysis of the relevant scientific literature, group work with a small group of probands using some elements of psychotherapy, a questionnaire survey, an analysis of records concerning the progression of problematical situations and data analysis of case studies. The findings of this thesis are that group sessions comprising elements of psychotherapy represented a supportive factor in regard to the perception of the problematical relationships of individual probands with their clients. Changes that occurred in these relationships were recorded either in the individual plans of social...