Kath. Univ., Diss--Eichstätt, 2006.

Thesis (M.Sc.)--Memorial University of Newfoundland, Faculty of Medicine, 1999. / Typescript. Bibliography: leaves 82-110.

Submitted by Johnny Rodrigues (johnnyrodrigues@ufcg.edu.br) on 2018-04-05T19:05:37Z No. of bitstreams: 1 IMARALLY VITOR DE SOUZA RIBEIRO NASCIMENTO - DISSERTAÇÃO PPG-CEMat 2014..pdf: 2760797 bytes, checksum: 7ecba4dc55afbb264d93e04510c69d66 (MD5) / Made available in DSpace on 2018-04-05T19:05:37Z (GMT). No. of bitstreams: 1 IMARALLY VITOR DE SOUZA RIBEIRO NASCIMENTO - DISSERTAÇÃO PPG-CEMat 2014..pdf: 2760797 bytes, checksum: 7ecba4dc55afbb264d93e04510c69d66 (MD5) Previous issue date: 2014-08-29 / Capes / Os sistemas de liberação controlada de fármacos oferecem inúmeras vantagens quando comparados a outros de dosagem convencional tendo os polissacarídeos biodegradáveis ganhando bastante aceitação no desenvolvimento desses sistemas. A quitosana é um exemplo de polissacarídeo biodegradáveis, cuja taxa de liberação pode ser modulada a partir da reticulação iônica com o Tripolifosfato de sódio (TPP). A piperina é um dos principais constituintes da pimenta negra, possuindo diversas ações farmacológicas que podem causar a morte de células cancerígenas e quando conjugada com a quitosana apresenta melhor biodisponibilidade e ação mais rápida. Sendo assim, esse trabalho objetivou desenvolver e avaliar comparativamente membranas poliméricas de quitosana e quitosana reticulada pelo TPP para uso em sistema de liberação controlada de piperina, com a finalidade de obter uma via alternativa para a administração desse fármaco. A piperina foi adicionada sob agitação constante à solução de quitosana e as membranas foram obtidas pelo método de evaporação do solvente. As membranas desenvolvidas foram caracterizadas pelas técnicas de Espectroscopia na Região do Infravermelho com Transformada de Fourier (FTIR), Difração de Raios X (DRX), Microscopia Ótica (MO), Microscopia Eletrônica de Varredura (MEV), Espectroscopia por Energia Dispersiva de Raios X (EDS), Análise Termogravimétrica (TG), Análise de Calorimetria Exploratória Diferencia (DSC), Eficiência de Carregamento (EC) através da Cromatografia Liquida de Ultra Eficiência (CLUE), Avaliação da Viabilidade Celular dos Macrófagos (MTT). Observou-se na análise por FTIR bandas características da quitosana, do agente reticulante e da piperina, como também bandas que caracterizam uma interação entre a quitosana e a piperina. A técnica de DRX demonstrou alteração no caráter semicristalino da quitosana com a presença da piperina e do tripolifosfato. Foi possível perceber, através das técnicas de MO e MEV, alteração na morfologia da membrana contendo piperina quando comparada a de quitosana pura, com a presença de partículas fibrilares. As análises de TG e DSC evidenciaram que quando a piperina foi adicionada à quitosana esta proporcionou uma maior estabilidade térmica ao sistema. O ensaio eficiência de carregamento evidenciou que a extração do o fármaco foi eficaz e que a reticulação influenciou na extração deste. As membranas desenvolvidas apresentaram potencial citotóxico para as células de câncer mamário humano MCF 7. Nas condições desenvolvidas nesta pesquisa o sistema indicado como referência para ensaios de liberação e novos ensaios biológicos é o sistema MQPR. Diante do exposto o sistema desenvolvido apresenta-se como promissor para a obtenção de um sistema para liberação controlada de fármacos. / Controlled drug delivery systems offer many advantages when compared to other conventional dosage methods with biodegradable polysaccharides gaining enough acceptance in the development of these systems. Chitosan is an example of a biodegradable polysaccharide, whose rate of release can be modulated from the ionic crosslinking with sodium tripolyphosphate (TPP). Piperine is one of the major constituent of black pepper, having many pharmacological actions that can cause the death of cancer cells and when combined with chitosan has better bioavailability and faster action. Therefore, this study aimed to develop and comparatively evaluate polymer membranes of chitosan and crosslinked chitosan by TPP to be used in a controlled release system of piperine, in order to obtain an alternative route for the administration of this drug system. Piperine was added under constant stirring to the solution of chitosan and membranes were obtained by the solvent evaporation method. The developed membranes were characterized by the techniques of Infrared Spectroscopy in the Region Fourier Transform (FTIR), X-ray Diffraction (XRD), Optical Microscopy (OM), scanning electron microscopy (SEM), Energy Dispersive Spectroscopy X-Ray (EDS), Thermogravimetric Analysis (TGA), Scanning Calorimetry Analysis of Difference (DSC), Efficiency Charge (EC) by liquid Chromatography Ultra Efficiency (HPLC), Assessment of Cell Viability of Macrophages (MTT). It was observed by FTIR analysis, bands characteristic of chitosan, the crosslinking agent and piperine, as well as bands characterizing an interaction between chitosan and piperine. The XRD technique showed change in semi-crystalline nature of chitosan in the presence of piperine and tripolyphosphate. It was possible to see, through the techniques of OM and SEM, changes in the morphology of the membrane containing piperine compared to pure chitosan, with the presence of fibrillar particles. TG analysis showed that, when piperine was added to the chitosan it provided a smaller weight loss of the system, showing the interaction between chitosan and piperine. DSC analysis showed that addition of piperine into chitosan provided greater stability to the system. The charging efficiency test showed that the drug can be entrapped by 57% in the uncrosslinked membranes and crosslinking influenced the extraction of drug. The developed membranes showed cytotoxic potential for human breast cancer cells MCF 7. Under the developed conditions in this research, MQPR system was shown as a reference for drug delivery testing and new biological tests. Given the above, the developed system is presented as promising for obtaining a system for controlled release of drugs.

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Bakgrund: Patientkontrollerad smärtlindring och patientkontrollerad sedering (PCA/PCS) är kliniskt sett säkra metoder för att leverera smärtlindring eller sedering till patienter utan direkt åtgärd från sjuksköterskor. Metoderna anses av sjuksköterskor vara metoder som stärker patienters autonomi, men riskerar att distansera sjuksköterskor från patienter. För att skapa ett bredare perspektiv på metoderna undersöks i detta arbete patienters upplevelser av PCA/PCS. Syfte; Syftet är att beskriva patienters upplevelse i samband med användning av patientkontrollerad smärtlindring och sedering (PCA/PCS). Metod: Integrativ litteraturöversikt baserad på 19 artiklar. Resultat: Två teman med tre respektive två subteman framkom från analysen. Det första temat var Möjligheter med PCA/PCS beskrivet av subteman Att ha färre biverkningar, Att ha ökad autonomi och Att vara bekväm med administreringsmetoden av läkemedel. Det andra temat var Utmaningar med PCA/PCS, beskrivet av subteman Att inte få individuella behov bemötta och Att känna minskad trygghet. Slutsats: Patienters upplevelser av PCA/PCS har varit generellt positiva, med goda möjligheter att öka tillfredställelsen med den vård som erbjuds. Resultatet visar att metoderna är användbara för att stärka patienters upplevelse av autonomi. Vidare påvisas att utmaningar som metoderna innebär kan motverkas av välinformerade patienter. / Background: Patient-controlled analgesia and patient-controlled sedation (PCA/PCS) are clinically safe methods for sedation and pain management for patients without direct intervention from nurses. The methods are viewed by nurses to be a way to strengthen patients' autonomy but poses a risk of distancing patients from nurses. To broaden the perspective on these methods, this paper studies patients' experiences of PCA/PCS. Aim: The aim of this paper is to describe the patients’ experience in relation with the use of patient-controlled analgesia and sedation (PCA/PCS). Method: Integrative review based on 19 articles. Result: Two themes emerged from the analysis. The first theme was Possibilities of PCA/PCS, described by the three subthemes To have fewer side effects, To have strengthened autonomy and To be comfortable the method of drug administration. The second theme was Challenges of PCS/PCS described by the two subthemes To not have individual needs met and To feel unsafe. Conclusion: Patients' experiences of PCA/PCS have been generally positive, with strong possibilities of increasing patients satisfaction with provided care. The result shows that the methods are useful for strengthening patients' autonomy. Additionally, eventual challenges that may occur while using these methods may be alleviated with well-informed patients.

Aerosol particle deposition rates on surfaces inside a clean room are predicted by a model developed to account for particle convection, diffusion and sedimentation. External forces acting on the particle also influence the rate of deposition. Both electrical charge build up on product surfaces and temperature gradients in the air near the product surface are known to effect the rate of deposition. A description of an electrostatic and thermophoretic force on the particle is thus included in the model. The equations governing the particle deposition process and the approach used in obtaining a solution to these equations are both described. A finite element numerical solution is detailed, followed by a description of the electrostatic force models. Finally, predictions of the model are presented with a comparison to data experimentally obtained by other researchers.

Separation anxiety is highly prevalent among intellectually and visually impaired individuals, yet little research has been done into its treatment in this population. Due to delayed cognitive skills, these individuals struggle to develop the abstract concept of person permanence, which is necessary to diminish separation anxiety. The first aim of this study was to investigate whether using technology alone or including caregivers was the most beneficial approach to developing person permanence using technology-assisted therapy. The caregivers received training in advance in an attachment-based protocol about securing attachment relationships with the participant. It was hypothesised that the inclusion of attachment figures in technology-assisted therapy would enhance the acquisition of the person permanence concept. The second aim of this study was to determine whether technology-assisted therapy in tandem with the participation of caregivers consequently decreased separation anxiety and challenging behaviour in an adult with intellectual and visual impairment. It was hypothesised that the subject’s anxiety and challenging behaviour levels would significantly decrease due to the intervention. The final aim was to determine how the caregivers and the participant experienced this intervention. It was hypothesised that they would regard it as a positive experience. This single-subject design used a pre-experimental quantitative approach. It was based on the familiar ABAB design and comprised six phases. Phase A served as baseline, giving the participants time to become acquainted with the technology. Phase B consisted of automated responses to the participant’s messages. In phase C caregivers directed the active reply. The daily messages were discussed when the participant and caregiver reunited, incorporating the attachment-based protocol. Phase B and C were repeated. Phase D followed after the devices were handed in. The technology was a specially adapted touch iPhone with an application comprising coloured emoticons. When the participant was physically separated from the caregiver, he could send happy, sad, angry or scared emoticons, or request help. The caregiver, who had a similar device, responded by sending a pre-determined response such as acknowledging the participant’s “I am angry” message with a “You are angry” message. Due to the association between anxiety and challenging behaviour in this population, standardised instruments were used to measure changes in these behaviours. Repeated measure ANOVA and a non-parametric Friedman test were used to analyse the data, specifically comparing phase B and C. Overall, the results showed that behaviour did significantly change over the course of the intervention. The frequency of the various iPhone messages sent by the participant was recorded daily. ANOVA contracts results demonstrated significantly fewer anxious and angry messages sent during the C phases compared with the B phases. The professional caregivers recorded the frequency and intensity of anxiety and challenging behaviours. The ANOVA contrast results showed a significantly lower frequency and intensity of these behaviours in the C phases compared with the B phases. A questionnaire was developed to evaluate the social validity of the intervention. The independent samples t-test demonstrated a significant difference between the mean scores rated by the caregivers at the beginning and the end of the invention. The participant and caregivers were positive about the intervention. Although the results cannot be generalised, it can be concluded that the inclusion of caregivers in technology-assisted therapy can serve as an invaluable aid to developing the person permanence concept. The findings also indicate that the anxiety and challenging behaviour levels shown by the adult with ID and visual impairment decreased due to technology-assisted therapy applied by caregivers, while responses to the social validity of the intervention were positive. / MSc (Research Psychology), North-West University, Potchefstroom Campus, 2015

Separation anxiety is highly prevalent among intellectually and visually impaired individuals, yet little research has been done into its treatment in this population. Due to delayed cognitive skills, these individuals struggle to develop the abstract concept of person permanence, which is necessary to diminish separation anxiety. The first aim of this study was to investigate whether using technology alone or including caregivers was the most beneficial approach to developing person permanence using technology-assisted therapy. The caregivers received training in advance in an attachment-based protocol about securing attachment relationships with the participant. It was hypothesised that the inclusion of attachment figures in technology-assisted therapy would enhance the acquisition of the person permanence concept. The second aim of this study was to determine whether technology-assisted therapy in tandem with the participation of caregivers consequently decreased separation anxiety and challenging behaviour in an adult with intellectual and visual impairment. It was hypothesised that the subject’s anxiety and challenging behaviour levels would significantly decrease due to the intervention. The final aim was to determine how the caregivers and the participant experienced this intervention. It was hypothesised that they would regard it as a positive experience. This single-subject design used a pre-experimental quantitative approach. It was based on the familiar ABAB design and comprised six phases. Phase A served as baseline, giving the participants time to become acquainted with the technology. Phase B consisted of automated responses to the participant’s messages. In phase C caregivers directed the active reply. The daily messages were discussed when the participant and caregiver reunited, incorporating the attachment-based protocol. Phase B and C were repeated. Phase D followed after the devices were handed in. The technology was a specially adapted touch iPhone with an application comprising coloured emoticons. When the participant was physically separated from the caregiver, he could send happy, sad, angry or scared emoticons, or request help. The caregiver, who had a similar device, responded by sending a pre-determined response such as acknowledging the participant’s “I am angry” message with a “You are angry” message. Due to the association between anxiety and challenging behaviour in this population, standardised instruments were used to measure changes in these behaviours. Repeated measure ANOVA and a non-parametric Friedman test were used to analyse the data, specifically comparing phase B and C. Overall, the results showed that behaviour did significantly change over the course of the intervention. The frequency of the various iPhone messages sent by the participant was recorded daily. ANOVA contracts results demonstrated significantly fewer anxious and angry messages sent during the C phases compared with the B phases. The professional caregivers recorded the frequency and intensity of anxiety and challenging behaviours. The ANOVA contrast results showed a significantly lower frequency and intensity of these behaviours in the C phases compared with the B phases. A questionnaire was developed to evaluate the social validity of the intervention. The independent samples t-test demonstrated a significant difference between the mean scores rated by the caregivers at the beginning and the end of the invention. The participant and caregivers were positive about the intervention. Although the results cannot be generalised, it can be concluded that the inclusion of caregivers in technology-assisted therapy can serve as an invaluable aid to developing the person permanence concept. The findings also indicate that the anxiety and challenging behaviour levels shown by the adult with ID and visual impairment decreased due to technology-assisted therapy applied by caregivers, while responses to the social validity of the intervention were positive. / MSc (Research Psychology), North-West University, Potchefstroom Campus, 2015