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Coronary artery bypass grafting (CABG) is the most common cardiac surgical operation performed in western countries, and is also increasingly being performed in developing countries. However the long-term results of CABG using the saphenous vein graft have not been satisfactory. Surgeons have therefore been seeking a better conduit. The radial artery (RA) is a potentially suitable alternative conduit and has to date provided good early results. This thesis investigates the utility of the RA as a coronary artery bypass graft from a number of perspectives. It demonstrates the safety of RA harvesting by examining hand collateral circulation using anatomical dissection, physical examination using the modified Allen test, measuring digital blood pressure, and examining the flow velocity in the digital artery using Doppler ultrasound. Anatomical examinations revealed consistent continuity between the RA and ulnar artery in the hand through either superficial or deep palmar arches. The modified Allen test was found to be useful as a screening test compared with the Doppler dynamic test and digital blood pressure index. A histological comparison was made between pre-existing intimal disease in the RA compared with that in the standard conduit the internal thoracic artery (ITA). The RA showed a higher prevalence and degree of intimal disease than ITA. Risk factors for intimal hyperplasia in the RA were age, diabetes, smoking and peripheral vascular disease. The only predictor for medial calcification was age. (For complete abstract open document)

Abstract The identification of risk factors for major adverse events after coronary artery bypass surgery is of main importance as it allows outcome prediction, facilitates preoperative patient selection and improves the quality of care. In the present clinical studies we have evaluated the impact of preoperative angiographic severity of a coronary artery disease and preoperative C-reactive protein (CRP) on the immediate outcome after coronary artery bypass surgery. We have reviewed the results of off-pump (OPCAB) versus conventional on-pump coronary artery bypass surgery (CCAB) in high risk patients. We have evaluated the impact of postoperative pulmonary artery blood temperature on the immediate outcome as well. In addition, we have investigated the incidence, timing and outcome of an atrial fibrillation (AF) related stroke after surgery. The multivariate analysis showed that among 2233 patients, the overall coronary angiographic score was predictive of postoperative death (p = 0.03; OR 1.027, 95% CI: 1.003–1.052) and of a low cardiac output syndrome (p = 0.04; OR 1.172, 95% CI: 1.010–1.218). The poor status of the proximal segment of the left circumflex coronary artery, the diagonal branches and the left obtuse marginal artery were most closely associated with adverse postoperative outcome. Patients (114/764) with a preoperative serum concentration of CRP ≥ 1.0 mg/dL had a higher risk of overall postoperative death (5.3% vs. 1.1%, p = 0.001), cardiac death (4.4% vs. 0.8%, p = 0.002), a low cardiac output syndrome (8.8% vs. 3.7%, p = 0.01). Among 179 high risk patients with an additive EuroSCORE6, the 30-day postoperative death and stroke rates were 7.5% and 6.0% in the OPCAB group, and 5.4% (p = 0.75) and 8.0% (p = 0.77) in the CCAB group, respectively. No significant differences were observed in other major outcome end-points between these non-randomised groups either. High pulmonary artery blood temperature on admission to the ICU among 1639 patients was significantly associated with an increased risk of overall postoperative death (p = 0.002), cardiac death (p = 0.03), and a low cardiac output syndrome (p < 0.0001), and was significantly correlated with prolonged length of the ICU stay (r = 0.095; p < 0.0001), and postoperative bleeding (ρ = –0.091; p = 0.001). Among 2,630 patients who underwent coronary artery bypass grafting (CABG), 52 (2.0%) experienced a postoperative stroke. Twelve out of these 52 patients (23.1%) died postoperatively. The ischemic cerebral event occurred after a mean of 3.7 days (0–33). In 19 patients (36.5%), atrial fibrillation preceded the occurrence of neurological complication. The angiographic severity of the coronary artery disease and the preoperative serum concentration of CRP predict postoperative outcome after a CABG operation. OPCAB can be performed safely in high-risk patients with results as satisfactory as those achieved with CCAB. CABG patients with a high pulmonary artery blood temperature on admission to the ICU seem to have a higher risk of postoperative adverse events. Atrial fibrillation occurring after coronary artery bypass grafting is a major determinant of a postoperative stroke.

The purpose of this study was to compare patients who underwent on- vs. off-pump coronary artery bypass surgery managed with a fast-track protocol. Between September 2012 and December 2018, n = 3505 coronary artery bypass surgeries were managed with a fast-track protocol in our specialized post-anesthesia care unit. Propensity score matching was applied and resulted in two equal groups of n = 926. There was no significant difference in ventilation time (on-pump 75 (55–120) min vs. off-pump 80 (55–120) min, p = 0.973). We found no statistically significant difference in primary fast-track failure in on-pump (8.2% (76)) vs. off-pump (6% (56)) groups (p = 0.702). The secondary fast-track failure rate was comparable (on-pump 12.9% (110) vs. off-pump 12.3% (107), p = 0.702). There were no significant differences between groups in regard to the post-anesthesia care unit, the intermediate care unit, and the hospital length of stay. Postoperative outcome and complications were also comparable, except for a statistically significant difference in PACU postoperative blood loss in on-pump (234 mL) vs. off-pump (323 mL, p < 0.0001) and red blood cell transfusion (11%) and (5%, p < 0.001), respectively. Our results suggest that on- and off-pump coronary artery bypass surgery in fast-track settings are comparable in terms of ventilation time, fast-track failure rate, and postoperative complications rate.

<p> Meta-analysis is a statistical method to summarize the overall evidence of effects on intervention by systematically combining outcomes from available studies in the literature which are homogeneous in research methodology and research interest. The objective of this project is to evaluate the treatment effects of preoperative aspirin on bleeding and other cardiovascular outcomes from 11 randomized control trials (RCT) and 19 observational (non-RCT) studies. Both Bayesian meta-analysis and classical (frequentist) meta-analysis were applied to continuous and binary outcomes, and the results were compared.</p> <p> The robustness of the Bayesian approach is assessed by examining the performances of different likelihood functions and priors. We also discuss strategies on dealing with zero-event studies for binary outcomes, and the implementation of multiple imputation (MI) technique to missing data for continuous outcomes.</p> <p> Most results of primary analysis agree between the Bayesian and classical approaches. We suggest that the final conclusion of a meta-analysis should be based on the comparison of the results from both Bayesian and classical approaches.</p> / Thesis / Master of Science (MSc)

Coronary artery bypass surgery (CABS) is highly stressful for couples, since comorbid anxiety and depression are most commonly reported and hence most researched pre- and postoperative emotional states. Thus, patients' psychological well-being may contribute more to the level of disability than their physical impairment. Despite this extremely stressful process, psychological preparation is ironically often neglected in CABS couples. The primary aim of the study was to examine the feasibility of hypnotherapeutic ego strengthening (HES) to enhance the ability of CABS couples' to cope with psychological distress associated with hospitalisation and surgery. Secondary aims were to determine the contribution of HES in reducing anxiety and depression, as well as enhancing and maintaining ego strength, quality of life and dispositional optimism in CABS patients and spouses. An overview of coronary heart disease (CHD), risk factors involved, psychological aspects concomitant to CABS (specifically anxiety and depression) and a conceptualisation of HES according to the relevant literature, preceded the empirical study. The experimental design consisted of a two-group, pre-post-follow-up assessment design. A sample of fifty married, male patients admitted to Unitas Hospital in Pretoria with a first, uncomplicated CABS was randomly assigned, together with their spouses, to an experimental- (n = 25) and control group (n = 25). Informed consent was obtained for all project participants. Thus, both groups consisted of twenty-five patients and spouses. To test the hypotheses, experimental patients and spouses were required to participate in the HES intervention. Respondents completed the Beck Depression Inventory (BDI-II) (Beck, Steer, & Brown, 1995). Profile of Mood States (POMS) (McNair, Lorr & Doppleman, 1992), Epstein and O'Brien Ego Strength Scale (1982), Quality of Life Inventory (QOLI) (Frisch, 1994) as well as the Life Orientation Test (LOT) (Scheier & Carver, 1985). Test administration of couples occurred preoperatively, on the day of discharge, and at six-week follow-up. Before commencing the intervention, group comparability was confirmed by means of the t-test for independent groups. At programme completion the significance of differences within and between groups was determined by means of t-tests. Statistically significant p-values were subjected to Cohen's d statistic to determine the practical significance of the findings. A confidence interval of 99% determined the values of the differences between the postoperative and follow-up findings. Results confirmed that the HES intervention significantly reduced postoperative anxiety and depression levels in experimental CABS patients and spouses, which was maintained at follow-up. No change was observed among control group patients and spouses. Moreover, the HES intervention significantly improved and maintained postoperative ego strength, quality of life and dispositional optimism in experimental CABS couples. The overall outcome of the control patients and spouses revealed a decreasing trend with regard to dispositional optimism and quality of life. Qualitative responses largely confirmed quantitative indications of reduced comorbidity and enhanced psychological well-being among experimental participants. Despite design limitations, the results confirmed that HES enhanced CABS couples' inner resources and attenuated concomitant negative mood states. Thus, it was concluded that HES played a meaningful role in the preparation and care of CABS couples by reducing comorbidity and improving their psychological well-being. Finally, recommendations for further studies were made. / Thesis (Ph.D. (Psychology))--North-West University, Potchefstroom Campus, 2004.

Coronary artery bypass surgery (CABS) is highly stressful for couples, since comorbid anxiety and depression are most commonly reported and hence most researched pre- and postoperative emotional states. Thus, patients' psychological well-being may contribute more to the level of disability than their physical impairment. Despite this extremely stressful process, psychological preparation is ironically often neglected in CABS couples. The primary aim of the study was to examine the feasibility of hypnotherapeutic ego strengthening (HES) to enhance the ability of CABS couples' to cope with psychological distress associated with hospitalisation and surgery. Secondary aims were to determine the contribution of HES in reducing anxiety and depression, as well as enhancing and maintaining ego strength, quality of life and dispositional optimism in CABS patients and spouses. An overview of coronary heart disease (CHD), risk factors involved, psychological aspects concomitant to CABS (specifically anxiety and depression) and a conceptualisation of HES according to the relevant literature, preceded the empirical study. The experimental design consisted of a two-group, pre-post-follow-up assessment design. A sample of fifty married, male patients admitted to Unitas Hospital in Pretoria with a first, uncomplicated CABS was randomly assigned, together with their spouses, to an experimental- (n = 25) and control group (n = 25). Informed consent was obtained for all project participants. Thus, both groups consisted of twenty-five patients and spouses. To test the hypotheses, experimental patients and spouses were required to participate in the HES intervention. Respondents completed the Beck Depression Inventory (BDI-II) (Beck, Steer, & Brown, 1995). Profile of Mood States (POMS) (McNair, Lorr & Doppleman, 1992), Epstein and O'Brien Ego Strength Scale (1982), Quality of Life Inventory (QOLI) (Frisch, 1994) as well as the Life Orientation Test (LOT) (Scheier & Carver, 1985). Test administration of couples occurred preoperatively, on the day of discharge, and at six-week follow-up. Before commencing the intervention, group comparability was confirmed by means of the t-test for independent groups. At programme completion the significance of differences within and between groups was determined by means of t-tests. Statistically significant p-values were subjected to Cohen's d statistic to determine the practical significance of the findings. A confidence interval of 99% determined the values of the differences between the postoperative and follow-up findings. Results confirmed that the HES intervention significantly reduced postoperative anxiety and depression levels in experimental CABS patients and spouses, which was maintained at follow-up. No change was observed among control group patients and spouses. Moreover, the HES intervention significantly improved and maintained postoperative ego strength, quality of life and dispositional optimism in experimental CABS couples. The overall outcome of the control patients and spouses revealed a decreasing trend with regard to dispositional optimism and quality of life. Qualitative responses largely confirmed quantitative indications of reduced comorbidity and enhanced psychological well-being among experimental participants. Despite design limitations, the results confirmed that HES enhanced CABS couples' inner resources and attenuated concomitant negative mood states. Thus, it was concluded that HES played a meaningful role in the preparation and care of CABS couples by reducing comorbidity and improving their psychological well-being. Finally, recommendations for further studies were made. / Thesis (Ph.D. (Psychology))--North-West University, Potchefstroom Campus, 2004.

Hjärt- och kärlsjukdomar är den största dödsorsaken i världen. En av behandlingarna som kan ges vid detta är koronar bypass operation. Väntan inför denna operation kan upplevas oviss och skapa oro hos patienten. Syftet med litteraturstudien var att undersöka patientens upplevelse i väntan på koronar bypass operation. Metod: Studien genomfördes som en allmän strukturerad litteraturstudie med induktiv ansats där sex kvalitativa, en kvantitativ samt en artikel med mixad metod erhölls. Data bearbetades genom en innehållsanalys. Resultat: Resultatet visade att patienter upplever såväl emotionell som somatisk påfrestning i väntan på koronar bypass operation. De mest framträdande upplevelserna var att patienterna upplevde ängslan och oro, ovisshet, rädsla och fysiska restriktioner. Dessa upplevelser mynnade ut till två teman den emotionella väntan och den somatiska väntan. Konklusion: I väntan på koronar bypass operation var de mest framträdande upplevelserna ovisshet samt ängslan och oro. För att reducera ovissheten, ängslan och oron var det av största vikt att sjuksköterskan arbetade personcentrerat. En sjuksköterskeledd intervention samt möjlighet att prata med tidigare koronar bypass operation patienter visade en signifikant reducering av den emotionella påfrestningen. En ökad förståelse för patienters upplevelse i väntan på koronar bypass operation är av stor vikt för att möjliggöra personcentrerad omvårdnad. / Cardiovascular disease is the leading cause of death in the world. One of the treatments for this is to undergo a coronary artery bypass graft. The waiting time before surgery causes uncertainty and worry in some patients. The aim was to examine patients’ experience while waiting for coronary artery bypass. The Method used was a general structured literature study with an inductive approach, where sixarticles with a qualitative approach, one quantitative and one with mixed method were found. The data was processed through a content analysis. The Result showed that patients experience both emotional and somatic stress while waiting for coronary artery bypass surgery. The most dominant experiences and emotions that patients felt were anxiety, uncertainty, fear, and physical restrictions. These experiences and emotions resulted in two themes Emotional waiting and Somatic waiting. TheConclusion showed to reduce uncertainty and anxiety it was of the utmost importance that the nurse applied person-centered care. A nurse-led intervention as well as the opportunity to talk with former coronary artery bypass patients showed a significant reduction in emotional strain. An increased understanding of patient´s experience while waiting for coronary artery bypass is of great importance to enable person-centered care.

Varje år genomgår omkring 800 000 personer en kranskärlsoperation i världen. En kranskärlsoperation är omfattade och påverkar patienten fysiskt, psykiskt och psykosocialt, vilket i sin tur kan komma att påverka livskvaliteten efter operationen. Livskvalitet är subjektivt och kan upplevas olika beroende på personen i fråga. Eftersom livskvaliteten kan förändras efter en kranskärlsoperation är det viktigt att sjuksköterskan har kunskap och förståelse om vilka faktorer som kan vara betydande för den postoperativa livskvaliteten. Syftet med studien var att belysa faktorer som kan påverka patientens livskvalitet efter en genomgången kranskärlsoperation. Metoden för detta arbete var en litteraturöversikt med en systematisk sökstrategi i databaserna PubMed och CINAHL. Sökningarna som genomförts resulterade i 15 kvantitativa artiklar som analyserades med hjälp av en integrerad analys. Resultatet består av fyra kategorier som belyser faktorer som påverkar livskvaliteten. De kategorier som utgjorde resultatet var fysiska faktorer, psykiska faktorer, biologiska faktorer samt psykosociala faktorer. De mest framstående faktorerna som sågs påverka livskvaliteten var fysiska begränsningar, oro och ångest, social isolering samt komplikationer. Vidare framkom det att faktorer som ålder och kön påverkade hur deltagarna skattade sin livskvalitet. Slutsatsen från denna litteraturöversikt var att livskvaliteten kan komma att påverkas av flera olika faktorer efter en kranskärlsoperation. Resultatet kan vara användbart för sjuksköterskor som arbetar med patienter som ska eller har genomgått en kranskärlsoperation för att kunna ge information om hur livskvaliteten kan påverkas av olika faktorer. Genom att informera patienten om detta kan en trygghet och medvetenhet skapas vilket kan främja hälsan och därmed livskvaliteten. För att få en ytterligare förståelse för hur personer på ett subjektivt sätt ser på livskvalitet behövs mer kvalitativ forskning. / Every year about 800 000 people around the world undergo coronary artery bypass surgery. A coronary artery bypass is an extensive surgery and affects the patient both physically, mentally and psychosocially, which in turn may affect the quality of life after the surgery. Quality of life is subjective and can be experienced differently depending on the person. Since quality of life can change by a coronary artery bypass surgery, it is important that the nurse has knowledge and an understanding of the factors that may be significant for the postoperative quality of life. The aim of this study was to illustrate factors which can affect the quality of life of patients who undergo a coronary artery bypass surgery. The method of this study was a literature review with a systematic search strategy in the databases PubMed and CINAHL. The searches made resulted in 15 quantitative articles that were analyzed using an integrated analysis. The result consists of four categories that illustrate factors which can affect the quality of life. The categories in the result were physical factors, mental factors, biological factors and psychosocial factors. The main factors identified affecting the quality of life were physical limitations, worries and anxiety, social isolation and complications. Furthermore, it emerged that factors such as age and gender also affected how the participant rated their quality of life. The conclusion of this literature review shows that quality of life can be affected by several different factors after coronary artery bypass surgery. The results of this study can be useful for nurses who work with patients who are planning or have undergone coronary artery bypass surgery, by providing adequate information on how quality of life can be affected. By informing patients about these factors which can impact on quality of life, security and awareness can be created, which can help promote health. To gain further understanding of how patients in a subjective way experience quality of life, more qualitative research is needed.

O enxerto de artéria torácica interna tem demonstrado capacidade de remodelamento devido a interação com o leito arterial coronariano. O objetivo deste estudo foi analisar a influência dos fatores clínicos e angiográficos no remodelamento dos enxertos, definido como variação no calibre vascular. Casuística e métodos: No período entre 1983 e 1999, 356 pacientes realizaram cirurgia de revascularização do miocárdio utilizando a artéria torácica interna esquerda para o ramo interventricular anterior e a artéria torácica interna direita para um ramo da circunflexa. Trinta e dois pacientes foram submetidos a cineangiocoronariografia pós-operatória, a qual foi posteriormente analisada com o aplicativo CASS II®. Este estudo observacional apresentou acompanhamento médio de 42 meses(6-204 meses). As variáveis angiográficas analisadas foram os diâmetros proximal e distal dos enxertos arteriais (variável dependente), área coronariana, pontuação de fluxo TIMI, diâmetro de estenose proximal, fluxo dominante distal e ramos patentes. Fatores de risco cardiovascular também foram incluídos. Resultados: O modelo de regressão linear múltiplo demonstrou um R2ajustado=0,69 (p=0,0001) para o modelo a direita e R2ajustado=0,46 (p=0,002) para a esquerda. Os enxertos apresentaram diâmetros proximal e distal de 2,67mm ±0,085 e 2,232mm ±0,085 à esquerda; 2,458mm ±0,088 e 2,010mm ± 0,091 (média±EP) à direita, respectivamente (p>0,05). Nenhuma variável clínica obteve correlação significante estatisticamente. A área coronariana apresentou coeficiente de beta=0,42 (0,14-0,6/IC-95%) e diâmetro de estenose proximal de 0,55 (0,40-0,65/IC-95%) para o remodelamento do lado direito. A área coronariana demonstrou coeficiente de beta=0,54 (0,3- 0,68/IC-95%) para o remodelamento do lado esquerdo. Conclusões: A artéria torácica interna não demonstrou diferença de calibre em relação a lateralidade (esquerda vs direita). O diâmetro de estenose proximal da artéria coronária revascularizada demonstrou correlação positiva com o remodelamento dos enxertos do lado direito. A área da artéria coronária revascularizada foi a única variável de influência para o remodelamento bilateral dos enxertos / Internal thoracic artery grafts has demonstrated capacity for remodeling due to interaction with the coronary artery bed. The goal was to analysis the influence of clinical and angiographic factors in this remodeling as defined as grafts caliber variation. Methods: In a period from 1983 to 1999, 356 patients underwent to coronary artery bypass surgery using the left internal thoracic artery anastomosed to interventricular anterior branch and the right internal thoracic artery to circumflex branches. Thirty two patients were submitted to postoperative coronary angiography which was further analysed by CASS II® software. The mean follow-up of this observational study was 42 months(6- 204 months). Angiographic variables analyzed was proximal and distal diameters of arterial grafts(dependent variable), coronary area, TIMI flow grade, proximal stenosis diameter, dominant distal flow and patent branches. Cardiovascular risk factors were included indeed. Results: The multiple regression model demonstrated R2adjusted=0.69 (p=0.0001) for right side and R2adjusted=0.46 (p=0.002) for left side. The grafts presented proximal and distal diameters of 2.67mm ±0.085 and 2.232mm ±0.085 from left side; 2.458mm ±0.088 and 2.010mm ±0.091 (mean±SE) from right side respectively (p > 0,05). None of the clinical variables had statistical significant correlation. The coronary area presented as a beta coefficient=0.42 (0.14-0.6/CI-95%) and proximal stenosis diameter of 0.55 (0.40-0.65/CI-95%) for right side remodeling. The coronary area shown a beta coefficient=0.54 (0.3- 0.68/CI-95%) for left side remodeling. Conclusions: The internal thoracic artery did not demonstrate difference in caliber about its laterality (left vs right). The proximal stenosis degree of the bypassed coronary artery demonstrated positive correlation with remodeling for the right side grafts. Bilateral grafts remodeling was only explained by positive correlation with the bypassed coronary area