L’objectif de cette thèse sur articles était d’identifier des facteurs de risque environnementaux (FRE) associés à la survenue et au maintien des troubles psychotiques non-affectifs, dans un contexte français. Nous nous sommes appuyé sur les modèles socio-développemental-cognitif de Howes et Murray, et de la sensibilisation. Nos résultats ont montré l’implication d’un FRE populationnel, la fragilité économique, et de plusieurs aspects d’un FRE individuel, les traumatismes infantiles, dans l’accroissement du risque de développer ou de survenue d’un trouble psychotique. Concernant l’évolution de la maladie : nous avons identifié les expériences traumatiques infantiles et la consommation de cannabis comme étant deux facteurs modificateurs du cours évolutif de la maladie. Nous avons enfin cherché à montrer les apports de la théorie de la dissociation structurelle de la personnalité, pour intégrer les résultats issus de nos deux modèles initiaux dans un cadre bio-psycho-social. Nos travaux indiquent que des FRE populationnels et individuels sont associés à la survenue et au maintien des troubles psychotiques. Ils ouvrent la voie à de nouvelles stratégies thérapeutiques. / This article thesis aimed to identify environmental risk factors (ERF) that are associated with the onset and the prognosis of non-affective psychotic disorders, in a French context. We based our work on Howes and Murray’s sociodevelopmental-cognitive model, and the sensitization model. Our results showed that one area-level environmental risk factor, namely the economic deprivation, and several aspects of childhood traumas, an individual ERF, are associated with an increased risk to develop psychotic disorders. Furthermore, we identified childhood traumas and cannabis consumption as modifier factors for these disorders. Finally, we sought to link our previous results, the two original models, and conceptual inputs from the theory of structural dissociation of personality in a coherent, clinically useful, and biopsychosocial framework. Our results suggest that both arealevel and individual environmental risk factors are involved in the onset and poor prognosis of psychotic disorders. They open perspectives for new therapeutic strategies.

To understand the glass electrode needs knowledge from more than one level. The construction ofthe glass electrode is one part, an other is the composition and structure of glass. The Nernstequation have an important role, but also the sources of errors in the analysis and the calibration ofthe glass electrode. Focus for this article is how the glass electrode really works and how Gibbs freeenergy made the potential dependent of the concentration of H+and gives the logarithm to thefunction. Nikolskii's ion exchange theory starts to explain the question about how the potentialcreates and Baucke's dissociation mechanism made it more explicit. The big different in theequations from the both theories respectively is the meaning of the constants, but for practical useof the glass electrode in analysis it is not important when the value of the constant is given bycalibration. This is not an excuse for that fact that the dissociation mechanism is more completethan the ion exchange theory in the understanding of the glass electrode. / För att förstå hur glaselektroden fungerar krävs kunskap från mer än ett plan. Glaselektrodenskonstruktion är en del, glasets kemiska struktur en annan. Nernst ekvationen spelar en viktig roll,men även felkällorna i de analyser som görs med glaselektrod, (vanligtvis pH-mätning), samtkalibreringen av glaselektroden. I den här uppsatsen ligger fokus på hur glaselektroden faktisktfungerar och hur Gibbs fria energi gör potentialen beroende av koncentrationen vätejoner och tillförlogaritmen i funktionen för glaselektroden. Nikolskii's ion exchange theory påbörjar förklaringen avpotentialens uppkomst och Baucke's dissociation mechanism gör den tydligare. Skillnaden mellanrespektive teori och dess matematiska funktion är konstantens innebörd och betydelse, men för denpraktiska användningen av glaselektroden till analyser är detta av mindre vikt då konstantens värdefås genom kalibrering. Detta är dock ingen ursäkt för det faktum att the dissociation mechanism geren mer fullständig förklaring och ökad förståelse för hur glaselektroden fungerar än the ionexchange theory.

Because of the inability to deal with traumatic and stressful situations it often happens that a person dissociates. These people then 'move out of the situation', so to speak. The dissociated person can be spiritually, emotionally and physically handicapped for life. In the long term it often results in depression, feelings of guilt, relationship problems, social maladjustment, as well as addiction to medication. Pastoral counselling to this person (as part of a multidisciplinary approach) often results in a decline of the symptoms and a normalisation of the person's situation. From the basis-theoretical research it became clear that throughout history God is present in a very prominent way in the life of the individual. Right from the very beginning at conception, until old age, He is intensely involved. God created man in His image but through sin this image was distorted. Because of His love for man, however, He fulfilled His promise of restoration and healing in and through Jesus Christ. It appears that knowledge regarding the phenomenon of dissociation dates back to as early as 400 BC. Research since the early 1990's onwards resulted in numerous publications, articles and books being written on the topic of dissociation. In thls study, emphasis was placed on a number of such relevant contributions. The specific characteristics of the dissociated person, practical guidelines for counselling hirnlher as proposed by psychology, as well as pastoral psychologists were discussed. It became evident that contributions and research in the field from a psychological perspective seem to be much more advanced compared to what has been done by theologians to date. For this reason it is imperative that pastoral counsellors become more acquainted with the theme of dissociation. With regard to methodology, the eclectic approach proved to be the best option. This will enable the pastoral counsellor in hidher guidance of the dissociated person to draw on the wealth and variety of contributions and perspectives fiom both the psychological and the theological domains. As a result of and flowing forth from the basis-theoretical and meta-theoretical perspectives, practice-theoretical guidelines were formulated according to which pastoral guidance can be provided to the dissociated person. Special emphasis was placed on a multidisciplinary approach where full recognition was given to the possible contributions by psychologists, psychiatrists, medical doctors and others. As part of the preparation for counselling the dissociated person, attention was given to the importance of prayer support. With regard to the counselling process itself, the following five phases appeared to be of significance: introductory prayers, consultation and discussion, prayer as part of the therapeutic process, the development of life skills, and spiritual growth after the therapeutic process. Because of the cultic and ritual abuse that some victims have been exposed to, it is possible that apart from fragmented sub-personalities, demonic influences may also be present. It is thus of extreme importance to distinguish between these two areas, and the counsellor must be well equipped with the necessary knowledge and experience to handle this complicated issue. From this study it became evident that there is a special need for pastoral guidance of the dissociated person by counsellors who are well acquainted with the complexities of this field. Scientific knowledge, together with a pastoral focus as well as total dependence upon the therapeutic power of the Holy Spirit, is indeed a 'winning recipe'. / Thesis (M.A. (Pastoral))--North-West University, Potchefstroom Campus, 2006.

No description available.

Because of the inability to deal with traumatic and stressful situations it often happens that a person dissociates. These people then 'move out of the situation', so to speak. The dissociated person can be spiritually, emotionally and physically handicapped for life. In the long term it often results in depression, feelings of guilt, relationship problems, social maladjustment, as well as addiction to medication. Pastoral counselling to this person (as part of a multidisciplinary approach) often results in a decline of the symptoms and a normalisation of the person's situation. From the basis-theoretical research it became clear that throughout history God is present in a very prominent way in the life of the individual. Right from the very beginning at conception, until old age, He is intensely involved. God created man in His image but through sin this image was distorted. Because of His love for man, however, He fulfilled His promise of restoration and healing in and through Jesus Christ. It appears that knowledge regarding the phenomenon of dissociation dates back to as early as 400 BC. Research since the early 1990's onwards resulted in numerous publications, articles and books being written on the topic of dissociation. In thls study, emphasis was placed on a number of such relevant contributions. The specific characteristics of the dissociated person, practical guidelines for counselling hirnlher as proposed by psychology, as well as pastoral psychologists were discussed. It became evident that contributions and research in the field from a psychological perspective seem to be much more advanced compared to what has been done by theologians to date. For this reason it is imperative that pastoral counsellors become more acquainted with the theme of dissociation. With regard to methodology, the eclectic approach proved to be the best option. This will enable the pastoral counsellor in hidher guidance of the dissociated person to draw on the wealth and variety of contributions and perspectives fiom both the psychological and the theological domains. As a result of and flowing forth from the basis-theoretical and meta-theoretical perspectives, practice-theoretical guidelines were formulated according to which pastoral guidance can be provided to the dissociated person. Special emphasis was placed on a multidisciplinary approach where full recognition was given to the possible contributions by psychologists, psychiatrists, medical doctors and others. As part of the preparation for counselling the dissociated person, attention was given to the importance of prayer support. With regard to the counselling process itself, the following five phases appeared to be of significance: introductory prayers, consultation and discussion, prayer as part of the therapeutic process, the development of life skills, and spiritual growth after the therapeutic process. Because of the cultic and ritual abuse that some victims have been exposed to, it is possible that apart from fragmented sub-personalities, demonic influences may also be present. It is thus of extreme importance to distinguish between these two areas, and the counsellor must be well equipped with the necessary knowledge and experience to handle this complicated issue. From this study it became evident that there is a special need for pastoral guidance of the dissociated person by counsellors who are well acquainted with the complexities of this field. Scientific knowledge, together with a pastoral focus as well as total dependence upon the therapeutic power of the Holy Spirit, is indeed a 'winning recipe'. / Thesis (M.A. (Pastoral))--North-West University, Potchefstroom Campus, 2006.

Les travaux décrits dans cette thèse portent sur la synthèse ainsi que l’étude physico-chimique et photo-chimique de plusieurs séries de nitroxydes et d’alcoxyamines photosensibles fonctionnalisées par des chromophores de type benzophénone, fluorènone, anthraquinone, phényle, naphtyle et anthracényle. En particulier, nous avons focalisé notre effort sur l’introduction de ces chromophores sur un nitroxyde dérivé d’un noyau isoindoline connu pour sa stabilité photo-chimique. L’étude de la photo-dissociation des alcoxyamines préparées a ensuite été conduite par résonance paramagnétique électronique. Les résultats obtenus mettent en évidence deux nouvelles classes d’alcoxyamines photosensibles qui présentent une efficacité remarquable de photo-dissociation homolytique pour donner les radicaux nitroxyle et alkyle correspondant sous UV et irradiation de lumière visible. En effet, les alcoxyamines de type naphtyle et anthraquinone ont donné des rendements de dissociation homolytique quantitatifs sous irradiation UV et visible, et ce, quel que soit le fragment alkyle libéré (i.e. styryle, méthacrylyle, acrylyle). De plus, nous avons également montré que les nitroxydes portant les chromophores naphtyle et anthraquinone présentent une stabilité photochimique élevée. Ainsi, l’analyse de ces résultats suggère que les alcoxyamines dérivées de ces deux nitroxydes présentent toutes les caractéristiques requises pour être des candidats performants en photopolymérisation radicalaire contrôlée en présence de nitroxydes. / The work reported herein details the synthesis, as well as the photophysical and photochemical analysis, of novel unsubstituted benzophenone-, methoxy substituted benzophenone-, pyrrolidine substituted benzophenone-, fluorenone-, anthraquinone-, phenyl-, naphthyl- and anthracenyl-based photosensitive alkoxyamines for potential application in nitroxide-mediated photopolymerization.The high photochemical stability of the isoindoline class of nitroxide was exploited within the structural design. Fusion of the isoindoline motif into the examined chromophores facilitated efficient energy transfer between chromophore and alkoxyamine motifs, whilst exerting minimal influence on the photophysical properties of the investigated chromophores. Photochemical investigation of the examined alkoxyamines highlighted two new classes of photosensitive alkoxyamines which displayed highly desirable photo-dissociation efficiencies to afford nitroxide and alkyl radicals under UV and visible light irradiation. Specifically, styrenic, methacrylic and acrylic naphthyl-based alkoxyamines, as well as, styrenic and methacrylic anthraquinone-based alkoxyamines demonstrated near quantitative yields of photo-dissociation under UV and visible light irradiation respectively. The high yields of photo-dissociation obtained for the naphthyl- and anthraquinone-based systems, as well as the high photochemical stability of their corresponding nitroxides, indicate these new classes of photosensitive alkoxyamines are highly relevant candidates for further investigation within a photopolymerization context.

Les systèmes moléculaires sous irradiation sont présents dans le monde vivant et la matière inerte. D’un point de vue macroscopique, ils sont constitués d’un très grand nombre de molécules mais l’action d’un rayonnement agit à travers les électrons localisés sur une molécule, créant ainsi, localement et sur des échelles de temps courts, une situation manifestement très éloignée de l’équilibre thermodynamique. Etudier les nanosystèmes moléculaires sous irradiation permet d’accéder à la manière dont l’énergie déposée dans une molécule va être redistribuée dans le système, via les interactions entre molécules. Les distributions de vitesses d’une molécule évaporée mesurées pour les nanogouttes de méthanol protonées présentent un comportement bimodal avec, comme observé pour l’eau, l’évaporation de molécules avec des vitesses nettement supérieures à celles attendues après redistribution complète de l’énergie. De plus, une réaction dans l’agrégat, conduisant à la formation du diméthyléther protoné avec élimination d’une molécule d’eau, a été observée. La possibilité d’étudier la compétition suite à l’irradiation entre l’évaporation moléculaire et une réaction d’élimination pourra contribuer à contraindre les hypothèses quant à la formation de molécules prébiotiques en conditions interstellaires.Les résultats sur les nanogouttes mixtes eau-méthanol ont été comparés à ceux obtenus avec celles dopées en pyridine et celles d’eau pure. L’analyse de la partie basse vitesse des distributions de vitesses des molécules d’eau évaporées montrent que l’évaporation intervient avant la redistribution complète de l’énergie dans l’ensemble de l’agrégat. Il apparaît qu’il y a moins d’énergie disponible pour l’évaporation d’une molécule d’eau quand l’excitation initiale est déposée sur le méthanol protoné ou sur l’ion pyrimidium. Ainsi, à la différence de l’ion hydronium qui est parfaitement solvaté, les impuretés favorisent la croissance de ces petits agrégats d’eau dont la présence dans l’atmosphère facilite les premières étapes de la formation des aérosols / Molecular systems under irradiation are present in the living as well as in inert matter. From a macroscopic point of view, the matter is made up of a very large number of molecules but the action of radiation acts through the electrons located on a molecule and thus, creating locally and on short time scales a situation clearly far from the thermodynamic equilibrium. Studying molecular nanosystems under irradiation provides access to understanding of how the energy deposited in a molecule will be redistributed into the system through interactions between surrounding molecules.The velocity distributions of evaporated molecules measured for irradiated protonated methanol nanodroplets have a bimodal behaviour, as observed for water, including evaporation of molecules with much higher velocities than expected after complete redistribution of energy. In addition, a reaction in the cluster leading to the formation of protonated dimethyl-ether with elimination of a water molecule was observed. The possibility of studying the competition between molecular evaporation and an elimination reaction following irradiation of a nanodroplet will contribute to constrain the hypothesis on the formation of prebiotic molecules under interstellar conditions. The results for the water-methanol mixed nanodroplets were compared with those obtained with pyridine doped water nanodroplets and protonated water nanodroplets. Analysis of the low velocity part of the velocity distributions of the evaporated water molecules shows that evaporation occurs before the complete redistribution of energy in the cluster. It appears that there is less energy available for evaporation of a water molecule when the initial excitation is located on the protonated methanol ion or on the pyrimidium. Thus, unlike the hydronium ion which is fully solvated, impurities promote the growth of these small water clusters, whose presence in the atmosphere facilitates the early stages of aerosol formation

No description available.

Cette thèse a pour objet principal la notion de dissociation élémentielle associée à la spatialisation, principalement en musique instrumentale. Elle inclut quatre compositions accompagnées des partitions et des enregistrements de même qu’un texte écrit comprenant les analyses des quatre œuvres présentées. Dans le chapitre I, le texte expose d’abord la notion de dissociation élémentielle, explique que celle-ci naît de l’autonomie des éléments musicaux les uns par rapport aux autres et traite de l’influence exercée sur ma démarche par le compositeur Charles E. Ives. J’aborde aussi l’importance de la spatialisation musicale et de la notion de paysage sonore composé. Je retrace également quelques exemples de dissociation des éléments dans le répertoire et je fais un parallèle avec la musique électroacoustique. Le chapitre II s’attarde à la dissociation "élémentielle" tant en ce qui a trait aux procédés techniques qu’à l’écriture et à la mise en forme. Le chapitre III traite de la perception auditive en situation "élémentielle" et spatialisée au regard de la psychoacoustique ainsi que des pistes de recherches ultérieures possibles. Les chapitres suivants ont pour objet les analyses des quatre œuvres présentées : 21 courtes pièces sur des textes d’Étienne Lalonde, L’Être et la réminiscence, Les passants et L’autre (le cor étranger). / The primary focus of this thesis is the notion of what I have termed elemential (élémentiel) dissociation associated with spatialization, particularly in instrumental music. It includes four compositions accompanied by scores and recordings, as well as a written text comprising the analyses of the four works presented. In Chapter I, the text presents the notion of elemential (élémentiel) dissociation, explains that it arises from the autonomy of musical elements in relation to each other, and contextualizes the influence of the composer Charles E. Ives' approach upon my own. I also address the importance of musical spatialization and the concept of the complex sound landscape. Additionally, I delineate some examples of the dissociation of elements in the repertoire and draw a parallel to electroacoustic music. Chapter II elaborates upon elemential (élémentiel) dissociation as much in terms of technical processes as of writing and formal structure. Chapter III deals with auditory perception in elemential (élémentiel) and spatialized contexts with regard to psychoacoustics, as well as possible areas for further research. The following chapters are comprised of the analyses of the four works presented: 21 courtes pièces sur des textes d’Étienne Lalonde, L’Être et la réminiscence, Les passants et L’autre (le cor étranger).

Doctor of Philosophy / Department of Physics / Itzhak Ben-Itzhak / Present advances in laser technology allow the production of ultrashort (≲5 fs, approaching single cycle at 800 nm), intense tabletop laser pulses. At these high intensities laser-matter interactions cannot be described with perturbation theory since multiphoton processes are involved. This is in contrast to photodissociation by the absorption of a single photon, which is well described by perturbation theory. For example, at high intensities (≳5×10[superscript]13 W/cm[superscript]2) the fragmentation of molecular hydrogen ions has been observed via the absorption of three or more photons. In another example, an intriguing dissociation mechanism has been observed where molecular hydrogen ions seem to fragment by apparently absorbing no photons. This is actually a two photon process, photoabsorption followed by stimulated emission, resulting in low energy fragments. We are interested in exploring these kinds of multiphoton processes. Our research group has studied the dynamics and control of fragmentation induced by strong laser fields in a variety of molecular targets. The main goal is to provide a basic understanding of fragmentation mechanisms and possible control schemes of benchmark systems such as H[subscript]2[superscript]+. This knowledge is further extended to more complex systems like the benchmark H[subscript]3[superscript]+ polyatomic and other molecules. In this dissertation, we report research based on two types of experiments. In the first part, we describe laser-induced fragmentation of molecular ion-beam targets. In the latter part, we discuss the formation of highly-excited neutral fragments from hydrogen molecules using ultrashort laser pulses. In carrying out these experiments, we have also extended experimental techniques beyond their previous capabilities. We have performed a few experiments to advance our understanding of laser-induced fragmentation of molecular-ion beams. For instance, we explored vibrationally resolved spectra of O[subscript]2[superscript]+ dissociation using various wavelengths. We observed a vibrational suppression effect in the dissociation spectra due to the small magnitude of the dipole transition moment, which depends on the photon energy --- a phenomenon known as Cooper minima. By changing the laser wavelength, the Cooper minima shift, a fact that was used to identify the dissociation pathways. In another project, we studied the carrier-envelope phase (CEP) dependences of highly-excited fragments from hydrogen molecules. General CEP theory predicts a CEP dependence in the total dissociation yield due to the interference of dissociation pathways differing by an even net number of photons, and our measurements are consistent with this prediction. Moreover, we were able to extract the difference in the net number of photons involved in the interfering pathways by using a Fourier analysis. In terms of our experimental method, we have implemented a pump-probe style technique on a thin molecular ion-beam target and explored the feasibility of such experiments. The results presented in this work should lead to a better understanding of the dynamics and control in molecular fragmentation induced by intense laser fields.