Instrumentos descritivos de avaliação funcional para portadores de distrofia muscular de Duchenne são limitados, pois classificam e não qualificam e/ou quantificam o desempenho motor. OBJETIVO: Elaborar escala de avaliação funcional do subir e descer escada para portadores de distrofia muscular de Duchenne e analisar confiabilidade intra e inter-examinadores. MÉTODO: 1. Elaboração de guia de avaliação a partir de revisão da literatura. 2. Avaliação do subir e descer escada de 120 registros filmados de 30 crianças com DMD (5 a 11 anos), utilizando o guia. 3. Elaboração da escala considerando grau de dificuldade. 4. Avaliação por peritos e reajustes para geração da versão final da escala e seu manual. 5. Análise estatística utilizando Índice de Correlação Intra-Classe e Correlação de Kappa Ponderado. RESULTADOS: A escala abrange cinco fases para o subir e quatro para o descer escada. Deve ser aplicada por profissional treinado, conforme normas do manual. Encontrou-se classificação excelente na análise da confiabilidade intra e interexaminadores, com valores da Correlação de Kappa Ponderado (> 0.78) e ICC > (0.89), com p < 0.05 entre todas as fases. CONCLUSÃO: A escala pode ser utilizada como ferramenta de avaliação fisioterapêutica descritiva e quantitativa com excelente repetibilidade e reprodutibilidade / Descriptive instruments of functional evaluation for carriers of duchenne muscular dystrophy are limited, because, they classify and do not qualify and/or quantify the motor performance. OBJECTIVE: To elaborate a scale of functional evaluation of going up and down stairs for DMD carriers and to analyze the realibility intra and inter examiner. METHODS: Elaboration of an evaluation guide from the literature review. 2. Evaluation of 120 registers filmed from 30 children (5 to 11 years) with duchenne muscular dystrophy going up and down stairs, using the guide. 3. Elaboration of the scale considering the degree of difficulty. 4. Evaluation by connoisseurs and readjustments for generation of the final version of the scale and its manual. 5. Statistical analysis using Intra-class Correlation Coefficient and Weighed Kappa. RESULTS: The scale encloses five phases for going up and four for going down stairs. It has to be applied by a trained professional, as norms of the manual. It was found an excellent classification on the reliability analysis intra and inter examiner, with values of Weighed Kappa Coefficient (> 0.78) and ICC > (0.89), with p < 0.05 between all phases. CONCLUSION: The scale can be used as a tool of physical therapy evaluation descriptive and quantitative with excellent repeatability and reproducibility

Instrumentos descritivos de avaliação funcional para portadores de distrofia muscular de Duchenne são limitados, pois classificam e não qualificam e/ou quantificam o desempenho motor. OBJETIVO: Elaborar escala de avaliação funcional do subir e descer escada para portadores de distrofia muscular de Duchenne e analisar confiabilidade intra e inter-examinadores. MÉTODO: 1. Elaboração de guia de avaliação a partir de revisão da literatura. 2. Avaliação do subir e descer escada de 120 registros filmados de 30 crianças com DMD (5 a 11 anos), utilizando o guia. 3. Elaboração da escala considerando grau de dificuldade. 4. Avaliação por peritos e reajustes para geração da versão final da escala e seu manual. 5. Análise estatística utilizando Índice de Correlação Intra-Classe e Correlação de Kappa Ponderado. RESULTADOS: A escala abrange cinco fases para o subir e quatro para o descer escada. Deve ser aplicada por profissional treinado, conforme normas do manual. Encontrou-se classificação excelente na análise da confiabilidade intra e interexaminadores, com valores da Correlação de Kappa Ponderado (> 0.78) e ICC > (0.89), com p < 0.05 entre todas as fases. CONCLUSÃO: A escala pode ser utilizada como ferramenta de avaliação fisioterapêutica descritiva e quantitativa com excelente repetibilidade e reprodutibilidade / Descriptive instruments of functional evaluation for carriers of duchenne muscular dystrophy are limited, because, they classify and do not qualify and/or quantify the motor performance. OBJECTIVE: To elaborate a scale of functional evaluation of going up and down stairs for DMD carriers and to analyze the realibility intra and inter examiner. METHODS: Elaboration of an evaluation guide from the literature review. 2. Evaluation of 120 registers filmed from 30 children (5 to 11 years) with duchenne muscular dystrophy going up and down stairs, using the guide. 3. Elaboration of the scale considering the degree of difficulty. 4. Evaluation by connoisseurs and readjustments for generation of the final version of the scale and its manual. 5. Statistical analysis using Intra-class Correlation Coefficient and Weighed Kappa. RESULTS: The scale encloses five phases for going up and four for going down stairs. It has to be applied by a trained professional, as norms of the manual. It was found an excellent classification on the reliability analysis intra and inter examiner, with values of Weighed Kappa Coefficient (> 0.78) and ICC > (0.89), with p < 0.05 between all phases. CONCLUSION: The scale can be used as a tool of physical therapy evaluation descriptive and quantitative with excellent repeatability and reproducibility

Past research suggests that social organisation in Australian rodent species is determined by the predictability of resources in the environment (Happold 1976a). Notomys alexis (the spinifex hopping mouse or tarrkawarra) is widely distributed throughout the Australian arid-zone (Breed 1998a; Watts & Aslin 1981). Large groups of animals have been found sharing burrows in the wild and laboratory observations suggest that the species is highly social (Happold 1976a; Stanley 1971). A closely related species, Notomys mitchelli (Mitchell’s hopping mouse or pankot) is relatively common throughout the southern semi-arid zone (Watts 1998a; Watts & Aslin 1981). Much less is known about N. mitchelli; field studies have been subject to low recapture rates and few laboratory studies have involved this species (Baverstock 1979; Cockburn 1981a; Crichton 1974). Following Happold (1976a), it was hypothesised that the socio-ecology of N. mitchelli will be qualitatively different to that of N. alexis. Studying wild populations of Notomys mitchelli in the Middleback Ranges, South Australia and N. alexis outside the desert township of Roxby Downs, S.A., this research aimed to describe the socio-ecology of these species, with reference to the predictability of their environments. Uniquely, bioclimatic modelling of the species’ known distributions was also conducted to confirm that the study’s underlying assumption that the two rodents inhabit essentially different environments was correct. These studies were complemented by the observation of captive groups of N. alexis. This work confirmed that the habitats of Notomys mitchelli and N. alexis are distinct; the more arid habitat of N. alexis is subject to greater environmental fluctuations than that of the semi-arid dwelling N. mitchelli. Contrary to expectations, however, observation of free-living animals characterised N. mitchelli social groups as highly unstable; while particular individuals remained in the population for long periods, many animals appeared to be transients. Further, burrow groups appeared to be much smaller than predicted by Happold (1976a), and based on loose aggregations of male animals rather than small groups of females. While decidedly social in the laboratory, free-living N. alexis lived in groups no bigger than N. mitchelli and these groups were equally ephemeral in constitution. Moreover, free-living N. alexis appeared to utilise activity areas that were no larger than those used by N. mitchelli, despite occupying a more unpredictable and apparently less well-resourced habitat. As a whole, this research represents a comprehensive examination of the principal behavioural theory commonly applied to Australian native rodent species, untested since its publication three decades ago. From the data collected during this work, it cannot be said that the environmental predictability hypothesis for native rodent social organisations as proposed by Happold (1976a) is adequate to differentiate the social behaviour of these semi-arid and arid-dwelling species. Instead, it is suggested that, while both N. mitchelli and N. alexis are undoubtedly socially tolerant, predation and/or parasite load, driving burrowing behaviour, has a greater influence on the social behaviour of free-living rodent populations than habitat predictability. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1373743 / Thesis (Ph.D.) - University of Adelaide, School of Earth and Environmental Sciences, 2009

Past research suggests that social organisation in Australian rodent species is determined by the predictability of resources in the environment (Happold 1976a). Notomys alexis (the spinifex hopping mouse or tarrkawarra) is widely distributed throughout the Australian arid-zone (Breed 1998a; Watts & Aslin 1981). Large groups of animals have been found sharing burrows in the wild and laboratory observations suggest that the species is highly social (Happold 1976a; Stanley 1971). A closely related species, Notomys mitchelli (Mitchell’s hopping mouse or pankot) is relatively common throughout the southern semi-arid zone (Watts 1998a; Watts & Aslin 1981). Much less is known about N. mitchelli; field studies have been subject to low recapture rates and few laboratory studies have involved this species (Baverstock 1979; Cockburn 1981a; Crichton 1974). Following Happold (1976a), it was hypothesised that the socio-ecology of N. mitchelli will be qualitatively different to that of N. alexis. Studying wild populations of Notomys mitchelli in the Middleback Ranges, South Australia and N. alexis outside the desert township of Roxby Downs, S.A., this research aimed to describe the socio-ecology of these species, with reference to the predictability of their environments. Uniquely, bioclimatic modelling of the species’ known distributions was also conducted to confirm that the study’s underlying assumption that the two rodents inhabit essentially different environments was correct. These studies were complemented by the observation of captive groups of N. alexis. This work confirmed that the habitats of Notomys mitchelli and N. alexis are distinct; the more arid habitat of N. alexis is subject to greater environmental fluctuations than that of the semi-arid dwelling N. mitchelli. Contrary to expectations, however, observation of free-living animals characterised N. mitchelli social groups as highly unstable; while particular individuals remained in the population for long periods, many animals appeared to be transients. Further, burrow groups appeared to be much smaller than predicted by Happold (1976a), and based on loose aggregations of male animals rather than small groups of females. While decidedly social in the laboratory, free-living N. alexis lived in groups no bigger than N. mitchelli and these groups were equally ephemeral in constitution. Moreover, free-living N. alexis appeared to utilise activity areas that were no larger than those used by N. mitchelli, despite occupying a more unpredictable and apparently less well-resourced habitat. As a whole, this research represents a comprehensive examination of the principal behavioural theory commonly applied to Australian native rodent species, untested since its publication three decades ago. From the data collected during this work, it cannot be said that the environmental predictability hypothesis for native rodent social organisations as proposed by Happold (1976a) is adequate to differentiate the social behaviour of these semi-arid and arid-dwelling species. Instead, it is suggested that, while both N. mitchelli and N. alexis are undoubtedly socially tolerant, predation and/or parasite load, driving burrowing behaviour, has a greater influence on the social behaviour of free-living rodent populations than habitat predictability. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1373743 / Thesis (Ph.D.) - University of Adelaide, School of Earth and Environmental Sciences, 2009

The purpose of this essay is to analyse the Christian democrats and the Sweden democrats’ ideological changes regarding their law and order and migration policies based on their election manifests from 2002-2018. The aim is then to explain these changes with the help of Downs (1957) based on cooperation, ideological superiority, and internal party changes. The question is whether the political parties have become ideologically and politically similar and if Downs (1957) theory will be able to explain this. The chosen method for the study is a theory testing case-study with an ideological analysis compared over time. The political parties’ ideological changes are shown in a descriptive analysis upon which Downs (1957) theory is applied. The study’s conclusion is that the theory can be used to explain the political parties ideological and political convergence. However, it cannot conclude which aspect that has been the most significant to explain the ideological changes that have occurred.

An integrated experimental and numerical research program investigating the elastic and inelastic performance as well as the kinematic behaviour of shearwalls with openings is presented in this study. The influence of the geometrical dimensions of the wall configurations and the mechanical properties and configurations of hold-downs on both elastic and inelastic behaviours including the possible kinematic modes of the shearwalls are investigated. The research also proposes the concept of equivalent-frame-model applicable for shearwalls where openings are cut-out from CLT panels. Are also presented, five racking tests performed on full scale CLT walls in order to validate the numerical models as well as the equivalent frame model. From review of the available literature emerges that for CLT shearwalls with openings, studies are not at the same level of abundance in research compared to walls without openings, due to the simple reason that SSW is generally a widespread technique. Thus, the kinematic behaviour and the coupling effect are inexistent and presented here. The investigations of the wall’s behaviour in the elastic and inelastic ranges demonstrate the important effect of the lintel and wall segment slenderness as well as the hold-down stiffness effect on the mechanical behaviour and the global kinematic behaviour as well. It is found that the kinematic modes can change when the walls are stressed beyond their elasticity limit. The failure mode and the global ductility are highly dependent on the hold-down configurations particularly for walls with door openings. The degree of coupling decrease with increased hold-down stiffness and the wall segment width. With regards to the equivalent frame model, a reasonable fit is found between the proposed EFM and a detailed 2D area element model when the global elastic stiffness and tensile load in the hold-down were compared. The model is successfully validated through five full-scale tests on CLT shearwalls with door or window opening as well as two published studies on walls with door openings. The EFM is capable of predicting the behaviour in the wall with reasonable accuracy, especially for walls whose behaviour was dominated by the hold-down behaviour.

Syfte: Syfte med denna litteraturstudie var att undersöka oral hälsa hos barn och ungdomar med Downs syndrom    Metod: Studien är en allmän litteraturstudie där sökningarna genomfördes i databaserna CINAHL, MEDLINE och Dentistry &amp; oral sciences source (DOSS). Vetenskapliga artiklar som svarade på studiens syfte valdes utifrån inklusions- och exklusionskriterier samt relevanta sökord. Resultat: Totalt granskades 22 kvantitativa studier som visade att barn och ungdomar med Downs syndrom hade sämre munhygien, fler orala sjukdomar och bettavvikelser jämfört med barn och ungdomar utan Downs syndrom. De redovisade orala sjukdomarna/ tillstånden var karies, gingivit, parodontit, oral candidos, bettavvikelser, attrition, agenesi och dental erosion. Riskfaktorer som kan påverka utveckling av orala sjukdomar och bettutvecklings störningar var exempelvis munhygienvanor och oralmotoriska faktorer. Slutsats: Barn och ungdomar med Downs syndrom har en ökad risk att drabbas av orala sjukdomar och bettavvikelser. Genom ökad kunskap om den orala hälsan hos barn och ungdomar med Downs syndrom kan tandhygienister arbeta förebyggande och motivera till stöd och omhändertagande för denna riskgrupp. / Aim: The aim of this literature study was to investigate oral health in children and adolescents with Down syndrome. Method: The study is a general literature study where the searches were carried out in the databases CINAHL, MEDLINE and Dentistry &amp; oral sciences source (DOSS). Scientific articles that responded to the purpose of the study were selected based on inclusion and exclusion criteria and relevant keywords. Results: A total of 22 quantitative studies were reviewed which showed that children and adolescents with Down syndrome had poorer oral hygiene, more oral diseases and malocclusions compared to children and adolescents without Down syndrome. The reported oral diseases/conditions were caries, gingivitis, periodontitis, oral candidosis, malocclusions, attrition, agenesis and dental erosion. Risk factors that can influence the development of oral diseases and malocclusions, for example, oral hygiene habits and oral motor factors. Conclusion: Children and young people with Down syndrome have an increased risk of suffering from oral diseases and malocclusions. Through increased knowledge about the oral health of children and young people with Down syndrome, dental hygienists can work preventively and motivate support and care for this risk group.

Never before has the learning experience of incarcerated persons been captured by one of their fellow inmates. Public perception is that prisoners should be denied access to educational opportunities and be punished for the crimes committed. In this groundbreaking study, situated in the qualitative paradigm, I recorded the learning experiences of a group of inmates who are studying at undergraduate level, via distance learning. This phenomenological study originated from my experience of studying while incarcerated, and is aimed at increasing our knowledge of, and enhancing our understanding of incarcerated persons. The study focuses on the learning experiences and challenges encountered by these students. Data was collected from the participants using qualitative methods and analysed using content analysis. Interpretation of the data revealed a number of factors which impede the studies of these students. The investigation is of importance to all persons involved in the Corrections environment but also the general public as inmates return to their communities upon release. / Curriculum and Instructional Studies / M. Ed. (Curriculum Studies)

Down syndrome (DS) is associated with psychomotor retardation, short stature and endocrine dysfunction. Statural growth is a well-known indicator of health. The growth in DS differs markedly from that of other children and there is a 20 cm reduction of final height as compared to target height. We developed growth charts specific for Swedish children with DS, in order to facilitate early diagnosis of concomitant diseases that influence growth. The growth charts are available for paediatricians and child health care professionals in Sweden. The mechanism underlying the impaired growth in DS is unknown. Height is influenced by parental factors, energy intake, hormone balance and general health. In DS, genetic factors deriving from the extra chromosome 21 further affect growth. Children with DS seem to have reasonable levels of growth hormone (GH), even though GH treatment for limited periods of time improves growth velocity. Within the present project, the subjects of a previous study on early GH therapy in DS were followed up regarding late effects. We found a larger adult head circumference and better psychomotor abilities in the previously treated subjects despite a lack of effect on final height. In adult life, GH has effects on psychological well-being and metabolism. The clinical features in adults with DS might indicate impaired GH secretion. Ten young adults with DS were studied and compared with ten healthy controls. The GH secretion in the DS subjects did not differ from that in the controls. The fat body mass percentage was increased in DS, in line with the high prevalence of overweight/obesity. The finding of an increased HOMA index as well as a high relative rate of hepatic glucose production in DS indicates reduced insulin sensitivity both peripherally and in the liver. Thyroid dysfunction is common in DS. There is a 30-fold increase in congenital hypothyroidism, and acquired hypothyroidism has been reported to be present in up to 50% of adults with DS. We collected neonatal screening results and hospital records for the first ten years of life of 68 children with DS. The mean TSH concentration was increased neonatally, indicating marginal hypothyroidism early in life in DS. However, the neonatal TSH level did not predict development of manifest hypothyroidism later in life. / Downs syndrom (DS) är en vanlig kromosomavvikelse. Kortvuxenhet och psykomotorisk utvecklingsstörning är kardinaltecken vid DS. Endokrina avvikelser är också frekvent förekommande. Tillväxt är en bra indikator på barns hälsa. Nyfödda barn med DS är kortare än andra nyfödda, och skillnaden i längd ökar under barndomen. Sjukdomar som påverkar tillväxten upptäcks ofta via ett förändrat tillväxtmönster. Detta kan lätt förbises vid DS eftersom tillväxten redan är avvikande. Användning av syndromspecifika tillväxtkurvor ökar möjligheterna till diagnostik av sjukdomar som stör längdtillväxten. Vi har framställt tillväxtkurvor för barn med DS, vilka finns tillgängliga inom svensk barnsjukvård och barnhälsovård. Längdtillväxt styrs av nedärvda faktorer från föräldrarna liksom av nutrition, hälsa och hormoner. Genetiska faktorer, kopplade till kromosom 21, kan påverka tillväxten vid DS, men tillväxtstörningens exakta bakgrund är inte känd. I vuxen ålder är personer med DS ungefär 20 cm kortare än förväntat med hänsyn till föräldralängder. Trots att barn med DS har relativt normala nivåer av tillväxthormon (STH eller GH) förbättras deras tillväxt vid STH-behandling. Inom avhandlingsarbetet följde vi upp ungdomar med DS, vilka behandlats med STH i tidig barndom. Vi kunde påvisa större huvudomfång samt förbättrad kognitiv och motorisk förmåga, trots avsaknad av effekt på slutlängden. Tillväxthormon har i vuxen ålder effekt både på ämnesomsättning och psykologiskt välbefinnande. Vuxna individer med DS uppvisar flera tecken förenliga med STH-brist. Vi jämförde tio unga vuxna med DS med tio friska kontrollindivider avseende förmågan att insöndra STH. STH-insöndringen hos individerna med DS skiljde sig inte från den hos kontrollerna. Vid samtidig undersökning av kroppssammansättning påvisades en ökad andel kroppsfett hos individerna med DS, resultat i linje med den frekventa förekomsten av övervikt/fetma. Individerna med DS hade en förhöjd glukosproduktion, som tillsammans med ett ökat HOMA-index talar för förekomst av minskad insulinkänslighet både på levernivå och perifert. Brist på sköldkörtelhormon är mycket vanligt vid DS och upp till hälften av vuxna med DS kan ha hypotyreos. Vi studerade 68 barn med DS avseende nivåer av tyroideastimulerande hormon (TSH) vid PKU-provtagning. Vi följde också barnens journalhandlingar från de tio första levnadsåren i syfte att undersöka om den neonatala TSH-nivån kan prediktera framtida underfunktion av sköldkörteln. Resultaten visade att barn med DS har en förhöjd nivå av TSH neonatalt, vilket indikerar en brist på sköldkörtelhormon redan i nyföddhetsperioden, men nivån förutsäger inte utveckling av manifest hypotyreos senare under barndomen.

From the Proceedings of the 1975 Meetings of the Arizona Section - American Water Resources Assn. and the Hydrology Section - Arizona Academy of Science - April 11-12, 1975, Tempe, Arizona / The concept of a step -drawdown test was first introduced by Jacob, and further modifications in the technique were made by Rorabaugh. Analysis of step -drawdown test data enables the quantification of the components of drawdown due to formation or aquifer loss, and due to well losses in a pumped well. This technique has been used to test approximately 100 wells that were drilled in crystalline and basalt formations in central India. Test data have been analyzed by Rorabaugh's method and by a graphical method, and the results of a number of tests are presented and discussed. Anomalies in the test analysis often proved helpful for interpreting aquifer irregularities. In general, the well loss constant decreases with an increase in specific capacity and the aquifer loss constant decreases with increasing transmissivity. Significant reductions in specific capacity during a step test occur in wells with high well losses. An attempt is made to quantify the well losses in a consolidated rock well, and a number of practical applications of step -drawdown tests are discussed.