This thesis studied unpaved highway shoulders, and in particular shoulders of lower volume asphalt pavements being overlaid. The primary objective was to better understand how different shoulder aggregates perform on lower volume routes with asphalt surfaces and relatively narrow shoulders. A literature review and an evaluation of a full-scale test section containing five aggregate categories in nine test sections over a thirty-four-month period were the primary efforts performed to evaluate unpaved highway shoulders. The study concluded shoulder width measurements were not especially informative, and that California Bearing Ratio measurements were only modestly informative. Crushed concrete outperformed all other aggregates, though the remaining aggregate categories (gravel, limestone, steel slag, and reclaimed asphalt pavement) also had a reasonable case for being moved forward toward possible specification updates. The primary recommendation of this thesis is to use the data contained herein to further shoulder aggregate specifications for the Mississippi Department of Transportation.

Syftet med denna studie är att söka kunskap om omsorg genom att prata med förskollärare om lämningssituationer. Vi kartlägger, utforskar och fördjupar deras omsorgskunskap, var den kommer ifrån och var de placerar den i förskollärarprofessionen. Genom att ha fenomenologi som teoretisk utgångspunkt, söker vi essensen av deras kunskap genom att ta del av hela deras livsvärld. Vi använder oss också av Aristoteles kunskapsbegrepp fronesis, för att analysera vårt material. Syftet med det är att vidga normer för kunskap och professionalitet. Vårt resultat visar att essensen i förskollärares kunskaper vid lämningssituationer består av inkännande och lyhördhet eftersom varje situation och barn kräver olika bemötanden utifrån de behov som uppstår. Vi har upptäckt att dethär är en kunskapsform som har en inneboende logik som baseras på ett omsorgsetiskt förhållningssätt. Detta ser vi som vårt viktigaste resultat. Vår slutsats blir därför att omsorg är en kunskapsform som tillhör förskollärarprofessionen som bör inkluderas i förskolans kunskapsbank. Förskolans pedagogik består av omsorg, lärande och fostran och ska samtidigt vila på vetenskaplig grund och därför blir det viktigt att alla dessa delar undersöks och formuleras på ett vetenskapligt vis. / The purpose of this study is to seek knowledge about care by interviewing preschool teachers regarding daily drop-offs. We have explored what this knowledge consists of, where it comes from and how they apply it in their profession at large. By using phenomenology as our theoretical approach, we seek the essence of their knowledge by including their whole lived experience. We also use Aristotle’s concept fronesis, to analyze our material. By doing this we aim to broaden standards of knowledge and professionality. Our results show that the essence of the preschool teachers´ knowledge in the situation of daily drop-offs, comes down to the their empathetic and responsive ability, since every child and situation requires a different approach, depending on the childs different needs. We discovered that this is a form of knowledge owning its’ own logic, based on ethics of care, which we see as our most important result. Our conclusion is therefore, that caring is a form of knowledge that is a part of the preschool teacher profession and should also be included as one. Pedagogy in Swedish preschools integrates an educational and caregiving practice and should also be based on scientific methods and evidence-based practices. It is important that the educational aswell as the caregiving element become subjects of scientific research.

La tenue résiduelle à l'impact basse vitesse est un critère dimensionnant des structures composites minces pour l'aéronautique. La majorité des travaux réalisés jusqu'ici porte sur l'analyse du comportement en zone courante. Ce travail élargit le domaine d'étude aux zones de variation d'épaisseur. L'objectif est d'étudier la tolérance aux dommages d'impact d'un stratifié comportant une zone de reprise de plis (ZRP) dans le cadre d'un dialogue essai/ calcul, en menant en parallèle une campagne d'essais expérimentaux et l'adaptation d'un modèle numérique de l'endommagement des composites.Le volet expérimental étudie successivement l'impact, la compression et la fatigue à R=-l après impact (CAI et FAI) d'éprouvettes comportant une ZRP. L'analyse des essais d'impact a permis d'identifier la résistance à l'impact et le mécanisme d'endommagement des éprouvettes. Ensuite, un outillage d'essai adapté à la géométrie des éprouvettes a été conçu pour les essais de CAI et de FAI. Les essais de compression montrent une tenue résiduelle statique après impact similaire à celle des éprouvettes sans perte de plis. Les essais de fatigue menés à 60 070 de la tenue résiduelle statique montrent une propagation des délaminages d'impact (en dessous du BVID) qui mène à la rupture des éprouvettes pour un nombre de cycles relativement faible. Alors que la tolérance aux dommages d'impact des ZRP sous chargement statique est comparable à celle des zones courantes lisses, on constate une forte vulnérabilité de ces zones sous chargement de fatigue.Le volet numérique a permis de tester l'approche DPM (Discrete Ply Model), développé lors de travaux précédents, sur une configuration particulière. Un maillage spécifique a été réalisé pour tenir compte des discontinuités de la ZRP. Au niveau de la loi matériau, une formulation unifiée de la rupture de fibres en traction/compression a été implémentée. Les résultats de la simulation d'impact sont en bonne corrélation avec les données expérimentales. Le modèle est capable de prédire la réponse globale de l'éprouvette ainsi que l'étendu des dommages internes. La modélisation de la CAI a permis de confirmer les mécanismes de rupture identifiés lors des essais. Ces résultats numériques sont remarquables puisqu' aucune modélisation locale particulière n'a été faite pour les arrêts de plis. L'approche DPM s'est révélée suffisamment robuste et bien adaptée à la modélisation de l'endommagement des stratifiés unidirectionnels. / The residual strength after low velocity impact is a sizing criterion of thin composite structures in aeronautics. The majority of work on the subject is focused on the analysis of plain laminates. This study expands the field of interest to tapered area. The objective is to study the impact damage tolerance of a laminate with ply drop-off using an experiment/ modelling dialogue: on one hand carrying experimental test campaign and on other hand adapting numerical modelling of composite damage. The experimental part successively examines the impact, compression and fatigue R=-l after impact (CAI and FAI) of specimens with ply drop-off. Analysis of the impact results has enabled the identification of impact resistance and damage mechanism. Then, a testing tool for CAI and FAI was specially designed to suit the geometry of the specimens. Compression tests show a static residual strength after impact similar to plain laminates. Fatigue tests carried at 60% of CAI strength show a propagation of impact delamination (below B VID). Failure of specimens occurs after a relatively small number of cycles. While the impact damage tolerance of tapered laminates is comparable to plain laminates under static loading, high vulnerability is observed under fatigue loading. The numerical part allowed to test the Discrete Ply Model (DPM), developed in previous works, on a particular configuration. A specific meshing was realized to account for the discontinuities in the ply drop-off area. Regarding the material law, a unified formulation of the fiber breakage in tension/ compression is implemented. Impact simulation results correlated well with the experimental data. The model is able to predict the overall response of the specimen and internal damage. The modeling of the CAI enabled to confirm the failure mechanisms identified during tests. These numerical results are remarkable since no particular local modeling has been realized for the ply drop-off area. DPM approach has proven robust enough and well suited to damage modeling of unidirectional laminates.

<p>In prokaryotes, several mRNA sequences surrounding the initiation codon have been found to influence the translation process; these include the downstream region and its codon context, the Shine-Dalgarno sequence and the S1 ribosomal protein-binding site. In this thesis, the purpose has been to study the role of the downstream region and Shine-Dalgarno-like sequences on early translation elongation and gene expression in <i>Escherichia coli</i>.</p><p>The downstream region (DR) after the initiation codon (around five to seven codons), has an important role in the initiation of translation. We find that most of the codons which give very low gene expression at +2 (considering AUG as +1), reach 5 to 10 fold higher expression when those codons are positioned posteriori to +2, with the exception of the NGG codons. The NGG codons abort the translation process if located within the first five codons of the DR, due to peptidyl-tRNA drop-off. However, when the NGG codons are situated further down from the DR, the protein expression was increased at the same level of expression as in the presence of any other codon.</p><p>The Shine-Dalgarno (SD) is an important region of initiation in translation of bacteria. In spite of this, it has been found that Gram-negative bacteria could translate mRNAs with weak or non-functional SD, while the DR carries out a main role in the efficiency of translation. In addition, positions of SD and SD-like sequences are very important to direct initiation of translation in the choice between two possible initiation codons. A strong SD between two initiation sites will favor the second initiation site if it consists of a canonical start codon followed by a good DR.</p><p>The results suggest that the mRNA sequences surrounding the initiation codon: the downstream region and the Shine-Dalgarno and SD-like sequences, are very important contributors to the translation level and gene expression in <i>Escherichia coli</i>.</p>

In prokaryotes, several mRNA sequences surrounding the initiation codon have been found to influence the translation process; these include the downstream region and its codon context, the Shine-Dalgarno sequence and the S1 ribosomal protein-binding site. In this thesis, the purpose has been to study the role of the downstream region and Shine-Dalgarno-like sequences on early translation elongation and gene expression in Escherichia coli. The downstream region (DR) after the initiation codon (around five to seven codons), has an important role in the initiation of translation. We find that most of the codons which give very low gene expression at +2 (considering AUG as +1), reach 5 to 10 fold higher expression when those codons are positioned posteriori to +2, with the exception of the NGG codons. The NGG codons abort the translation process if located within the first five codons of the DR, due to peptidyl-tRNA drop-off. However, when the NGG codons are situated further down from the DR, the protein expression was increased at the same level of expression as in the presence of any other codon. The Shine-Dalgarno (SD) is an important region of initiation in translation of bacteria. In spite of this, it has been found that Gram-negative bacteria could translate mRNAs with weak or non-functional SD, while the DR carries out a main role in the efficiency of translation. In addition, positions of SD and SD-like sequences are very important to direct initiation of translation in the choice between two possible initiation codons. A strong SD between two initiation sites will favor the second initiation site if it consists of a canonical start codon followed by a good DR. The results suggest that the mRNA sequences surrounding the initiation codon: the downstream region and the Shine-Dalgarno and SD-like sequences, are very important contributors to the translation level and gene expression in Escherichia coli.

No description available.

No description available.