Magister Scientiae - MSc / This project "An application of multiple regression in exchange rate arrangement" focused on the processes followed by different countries when choosing an exchange rate regime for currency stabilization. It analyses the consequences faced by emerging markets as a result of changes in volatility of developed countries’ currencies (American Dollar, Japanese Yen, EURO, British Pound and the Canadian Dollar). / South Africa

Au vu de l'omniprésence des oxydes de fer dans le milieu naturel, et en particulier la goethite et l'hématite qui sont les formes les plus stables, mais aussi de la prolifération des contaminants émergents dans l'environnement, comme les fluoroquinolones, notre objectif a été d'étudier leur réactivité et de définir les mécanismes de sorption et d'oxydoréduction à l'interface oxyde/solution dans des conditions statiques (batch) et hydrodynamiques contrôlées (colonne) en couplant une étude macroscopique (techniques chromatographiques, LC/MS, LC/UV) avec une approche microscopique (spectroscopie vibrationnelle et XPS) et de modélisation mécanistique (TPM et CD-MUSIC). Ces travaux mettent en évidence les principaux mécanismes responsables de la transformation des molécules organiques à la surface d'un oxyde de fer, et donc fournissent des informations nécessaires à la compréhension du devenir des contaminants émergents dans l'environnement. / Given the ubiquity of iron oxides in environmental settings, particularly goethite and hematite, the most stable forms, but also the proliferation of emerging contaminants, such as fluoroquinolones, in the environment, our goal was to study their reactivity and describe mechanisms of sorption and redox at oxide /solution interfaces in static batch) and hydrodynamic conditions (column) by coupling a macroscopic study (LC/MS, LC/UV) with a microscopic/molecular approach (vibrational spectroscopy and XPS) and mechanistic modeling (TPM and CD-MUSIC).. These works highlight the main mechanisms responsible of the transformation of organic molecules on iron oxide surfaces and thus provide valuable information necessary for the understanding of the fate of emerging contaminants in the environment.

Contaminants of emerging concern (CECs) are continuously being released into the environment mainly because of their incomplete removal in the sewage treatment plants (STPs). The CECs selected for the study include antibiotics (macrolides, sulfonamides and ciprofloxacin), sucralose (an artificial sweetener) and dioctyl sulfosuccinate (DOSS, chemical dispersant used in the Deepwater Horizon oil spill). After being discharged into waterways from STPs, photo degradation is a key factor in dictating the environmental fate of antibiotics and sucralose. Photodegradation efficiency depends on many factors such as pH of the matrix, matrix composition, light source and structure of the molecule. These factors exert either synergistic or antagonistic effects in the environment and thus experiments with isolated factors may not yield the same results as the natural environmental processes. Hence in the current study photodegradation of 13 CECs (antibiotics, sucralose and dicotyl sulfosuccinate) were evaluated using natural water matrices with varying composition (deionized water, fresh water and salt water) as well as radiation of different wavelengths (254 nm, 350 nm and simulated solar radiation) in order to mimic natural processes. As expected the contribution of each factor on the overall rate of photodegradation is contaminant specific, for example under similar conditions, the rate in natural waters compared to pure water was enhanced for antibiotics (2-11 fold), significantly reduced for sucralose (no degradation seen in natural waters) and similar in both media for DOSS. In general, it was observed that the studied compounds degraded faster at 254 nm, while when using a simulated sunlight radiation the rate of photolysis of DOSS increased and the rates for antibiotics decreased in comparison to the 350 nm radiation. The photo stability of the studied CECs followed the order sucralose > DOSS > macrolides > sulfonamides > ciprofloxacin and a positive relationship was observed between photo stability and their ubiquitous presence in natural aquatic matrices. An online LC-MS/MS method was developed and validated for sucralose and further applied to reclaimed waters (n =56) and drinking waters (n = 43) from South Florida. Sucralose was detected in reclaimed waters with concentrations reaching up to 18 µg/L. High frequency of detection (> 80%) in drinking waters indicate contamination of ground waters in South Florida by anthropogenic activity.

This dissertation offers two essays on the engendering and the consequences of employee brand behavior. The first essay addresses the impact of employee brand behavior on customer experience in the retail environment. Retailers, with some exceptions, paid relatively little attention to the role that employees play in the experience they provide to their customers. While there seems to be a general consensus regarding both the importance of customer experience and the role of employees in delivering it, there has been no study attempting to measure the impact front-line employees have on the overall customer experience process from the consumer point-of-view. In essay two the antecedents that make up the customer experience construct are explored through the usage of a previously tested model with the addition of two new components: the employee in-role brand-building behavior construct and the expansion of the word-of-mouth construct to include social media word-of-mouth. The second essay complements essay one by focusing on the importance of employee branding behavior and examining its two variants: in-role and extra-role brand-building behavior. Both behaviors are engendered within the firm but companies are still struggling to differentiate between the two. The distinction between the two types is important because when developed correctly these behaviors can help companies build a competitive advantage. Since the differentiation gap between companies nowadays continues to shrink, companies must strive to develop a unique competitive advantage that cannot be easily copied by their rivals. The tailoring of such a specific set of brand oriented behaviors to be performed by employees is one potential solution to this challenge. By directing the behavior of employees that come into direct contact with customers, a firm has a unique opportunity to align all its branding promotional initiatives with those of its representatives in the front lines resulting in a more consistent customer experience.

The Florida manatee (Trichechus manatus latirostris) is a protected species that is vulnerable to both anthropogenic and natural causes of mortality. The ability of wildlife managers to oversee regulation of this species is based on available abundance estimates and mortality data. Using existing manatee mortality data collected by Florida Fish and Wildlife Conservation Commission (FWC) from 1974-2012, this study focuses on identifying significant spatial clusters of high values or “hotspots” of manatee mortality and the temporal patterns of these hotspots using the novel “emerging hotspot analysis” ArcGIS tool. The categories of manatee mortality included in this analysis were watercraft-related, perinatal, cold-stress, and other natural (which includes red tide) and were classified into five hotspot pattern categories. Of interest were the locations where consecutive or new hotspot patterns were identified among the four categories of manatee mortality included in this analysis. Consecutive hotspot clusters were found near Tampa Bay (which includes parts of Pinellas, Hillsborough, and Manatee Counties) and in the counties of Hernando/Pasco, Monroe, Palm Beach/Broward/Miami-Dade, St. Johns/Flagler, and Citrus. New hotspot clusters were found in Tampa Bay (which includes parts of Pinellas, Hillsborough, and Manatee Counties) and in the counties of Nassau, Wakulla, Charlotte/Lee, St. Lucie/Martin, Levy, Duval, Dixie, Volusia/Seminole, and Citrus. These mortality hotspots frequently overlapped areas of higher manatee and human population densities. These hotspot clusters indicate emerging patterns that highlight areas to focus future research by wildlife managers; specifically, on the relationship between human population density and concentration of watercraft activities in coastal areas, as well as the influence coastal development has on the vital resources utilized by manatees.

China and Russia – two giants in the group of emerging markets – continue to attract wide attention as evolving science and technological superpowers. However, both countries demonstrate mixed success in innovation development and are struggling to overcome the legacies of the former state planning system and accelerate their transition to effective national innovation systems. This study employs a number of theoretical constructs and evidence sources to evaluate the existing path dependencies and compare the achievements of China and Russia in fostering development and effective systems of innovation and governance. A detailed analysis of the state planning legacies is provided together with a study of innovation system transformation and the role of public policy in (re)building national innovation capabilities in China and Russia. The system-evolutionary approach is applied to provide a detailed assessment of the strategic effort undertaken by the governments of both countries. Several government failures and path dependencies seem to prevent the nations from implementing a more effective reform. Yet, there are a number of complementarities and opportunities for mutual learning where both countries can benefit from closer collaboration. The challenges of turning universities into research institutions, increasing productivity of state-owned enterprises, constructing effective science parks, promoting indigenous innovation, ensuring more even distribution of innovation development across regions, turning ‘brain drain’ into ‘brain gain’, and improving intellectual property rights protection are common in Russia and China. As a lens through which to identify and assess innovation systems transformation, the thesis examines emerging nanotechnology development in China and Russia. Nanotechnology is a new science and technology area where policies seem to be independent of many system weaknesses and contribute to breaking existing development lock-ins due to its explorative nature and assumed transformative capacity. Yet, a number of path dependencies do exist in this area but seem to play a marginal role in its progression. An early assessment is provided of nanotechnology impacts on broader socioeconomic development of China and Russia in six key areas: institutional development, knowledge flows, and network efficiency; research and education capabilities; industrial and enterprise growth; cluster and network development; regional spread; and product innovation.The conclusion summarizes the main findings, revisits the major research questions, links the analysis to the conceptual framework, and offers a number of policy recommendations that seem relevant to both Russia and China with a need to increase the transparency of innovation policy, improve the regulation for innovation process, and promote growth of the private sector to ensure effective technology transfer.Results from this study have been reported in various forms in the author’s articles published in Research Policy, Science and Public Policy, Review of Policy Research, International Journal of Economics and Business Research, and European Journal of Development Research as well as presented at a number of international conferences (see Appendix).

Understanding financial asset return correlation is a key facet in asset allocation and investor’s portfolio optimization strategy. For the last decades, several studies have investigated this relationship between stock and bond returns. But, fewer studies have dealt with multi-asset return dynamics. While initial literature attempted to understand the fundamental pattern of comovements, later studies model the economic state variables influencing such time-varying comovements of primarily stock and bond returns. Research widely acknowledges that return distributions of financial assets are non-normal. When the joint distributions of the asset returns follow a non-elliptical structure, linear correlation fails to provide sufficient information of their dependence structure. In particular two issues arise from this existing empirical evidence. The first is to propose a more reliable alternative density specification for a higher-dimensional case. The second is to formulate a measure of the variables’ dependence structure which is more instructive than linear correlation. In this work I use a time-varying conditional multivariate elliptical and non-elliptical copula to examine the return comovements of three different asset classes: financial assets, commodities and real estate in the US market. I establish the following stylized facts about asset return comovements. First, the static measures of asset return comovements overestimate the asset return comovements in the economic expansion phase, while underestimating it in the periods of economic contraction. Second, Student t-copulas outperform both elliptical and non-elliptical copula models, thus confirming the ii dominance of Student t-distribution. Third, findings show a significant increase in asset return comovements post August 2007 subprime crisis ... [cont.].

Les Henipavirus sont des paramyxovirus zoonotiques émergents hautement pathogènes. Ils sont capables d’infecter un large spectre d’hôtes incluant notamment la chauve-souris frugivore (réservoir naturel), le porc et l’homme. Etant donné leur très grande dangerosité et en l’absence de traitements curatifs ou prophylactiques efficaces, ces virus doivent être manipulés dans un laboratoire de classe P4. Dans une première partie, nous étudions l’effet de composés glyco-amino-glycanes sur l’infection par les Henipavirus ainsi que leur potentielle application en tant que traitement. Dans une seconde partie, nous nous attachons à comprendre les interactions entre le système immunitaire de l’hôte et le virus. Afin de mieux comprendre ces interactions, nous avons utilisé une approche basée sur l’utilisation de souris déficientes pour certaines voies de l’immunité. En effet, bien que les récepteurs cellulaires au virus (EFN B2 et B3) soient fonctionnels chez la souris, celle-ci est résistante à l’infection par voie intrapéritonéale. Nous avons analysé la susceptibilité au virus Nipah (NiV) de souris privées de différentes voies du système immunitaire inné et adaptatif. Les résultats obtenus permettent d’envisager certaines lignées de ces souris comme nouveaux modèles animaux pour l’étude de l’immunopathogénèse du NiV. Cette étude suggère aussi que le système interféron de type I joue un rôle crucial dans la limitation de la propagation virale vers le cerveau et que les lymphocytes T sont nécessaires à la complète élimination du virus. Les macrophages jouent, quant à eux, un rôle central et indispensable, à l’interface entre système inné et adaptatif. Enfin, nous abordons les prémices d’un projet visant à identifier les différences d’interactions au niveau moléculaire entre les protéines non-structurales du virus et les protéines du système immunitaire inné chez l’Homme et la souris afin de voir s’il se dégage des différences d’interactions pouvant expliquer les différences de pathogénie. Ces travaux ont donc permis d’identifier de nouveaux modèles animaux et de mieux caractériser les interactions entre le pathogène et le système immunitaire de l’hôte, de l’échelle moléculaire à l’échelle de l’organisme entier. Néanmoins, les mécanismes précis de ces interactions restent à élucider et permettront certainement de mieux comprendre la grande diversité de pathogénie des Henipavirus. / Henipaviruses are highly pathogenic emerging zoonotic paramyxoviruses. They can infect a broad spectrum of mammals including flying foxes (Pteropus fruit bats), its reservoir, pigs and humans. As there are neither therapeutic drugs nor efficient prophylactic treatment towards these highly lethal viruses, they have to be manipulated in biosafety level-4 laboratories. In the first part of this thesis, we study the role of glyco-amino-glycans on Henipavirus infection and their potential use as treatment. In the second part, we describe the interaction between the host immune system and the pathogen. To investigate these interactions, we took advantage of different transgenic mouse models deficient for some immune pathways. Indeed, although mice possess the viral entry receptor for Henipaviruses, they do not succumbed to intraperitoneal infection. We analyzed the susceptibility to Nipah virus (NiV) infection of mice deleted for different components of innate and adaptive immune systems. Obtained results showed that some of these mice can be used as new models for NiV immunopathogenesis study. This study also suggests that type I interferon system plays a major role in limitation of viral spreading to the brain and that T cells are necessary for full viral clearance. Macrophages act at the crossroad of immunity, between innate and adaptive system. Finally, we deal with the preliminary phases of a project which aims to identify the differences, at a molecular level, of interaction between non-structural viral proteins and innate immunity proteins in mice and human. Such differences could explain the different clinical patterns that are observed in these species. In conclusion, this thesis allowed to identify new animal models and to better characterize host-pathogen interactions, from molecular to whole organism level. However, the precise mecanisms of these interactions remain to be elucidated and would probably help to understand the great diversity of pathogeny of Henipaviruses.

In times of scarce resources, frugal innovation can be a driving engine for growth and market success, as it is a practical concept established in developing countries. Nonetheless, the available literature also emphasizes a potential importance for Western countries. Accordingly, our thesis and research add to the lack of literature that connects frugal innovation to developed countries and its specific underlying conditions. The review of available literature and further discussions led to the following research questions: 1. What is the current application status of frugal innovation in Germany? 2. What characteristics should frugal innovations have to serve the BoP in the context of the German market? A preliminary theoretical framework was created from the relevant literature streams stressing the fragmented nature of frugal innovation. As the concept and research addressing this issue are in a nascent stage, one unifying definition was not found. For the course of this thesis, the definition of frugal innovation was therefore chosen to be "thrifty, modest and affordable innovations, valuable for BoP customers”. One major derivation from the literature review is that frugal innovation can be of major importance in developed countries, not only for customers for getting access to certain products, but also for companies addressing untapped markets. The empirical investigation and explorative data collection was undertaken within the market context of Germany based on eight companies from different industry backgrounds. Therefore, interviews were held with representatives of companies that offer frugal products (thereafter also including services) according to the definition from above. Within the scope of the grounded theory analyzation techniques, the interviews supported our aim to gain rich and meaningful data to extend the substantive theory about the concept of frugal innovation. Our study results (based on our eight interviews) prove the existence of frugal products in the German market, while the term and the concept have previously been unknown. Even though frugal innovations were still to be confirmed, they were not labeled as such to connect them to the concept. The study also indicates the existence of a bottom of a pyramid in Germany, despite its original connection to emerging market population. Our findings resulted in a revised framework that connects relevant fragments to a logical comprehension of the concept of frugal innovation. Finally, characteristics for frugal products and requirements could be validated and improved to be economically successful in developed market contexts. The major contribution of our thesis is its general investigation of a rather unknown concept and its presence in other markets than originally laid down. The thorough literature review, the creation and revision of the framework and our study results will serve as a fruitful ground for further exploration of this innovation type.

In the first part of the thesis, the present state of the Prague theatre network is introduced and the preconditions and possibilities of its further development are discussed. The introduction is followed by the analysis of the funding of the Prague theatres and cultural policy focusing on the system of subsidies and grants, transformation of the theatre network and other means of support. In the second part of the thesis, a thorough analysis of the six theatre venues that have emerged in the last six years, namely Studio Hrdinů, Company.cz in Divadlo Komedie, Venuše ve Švehlovce, Vila Štvanice, Jatka 78 and Panoptikon Barikáda, is provided. The analysis focuses on various factors influencing the venues: their location, relationship with the lawful owner of the property, legal form, their relationship with the audience, and last but not least the way they are funded. In the conclusion, the comparison of the situation of the six venues is provided.