A questão central deste trabalho refere-se à institucionalização da mediação no âmbito do Judiciário e às condições necessárias para uma boa relação entre a mediação e o processo judicial. Esta questão foi analisada sob as perspectivas processual e institucional. A primeira recai sobre as bases do processo de mediação, em especial o devido processo legal mínimo, e a sua interação com o processo judicial, diferenciando a justiça do processo e a justiça do resultado. A segunda recai sobre o desenho dos programas de mediação que funcionam junto ao Judiciário e os papéis assumidos pelos diferentes atores que participam destes programas: juízes, mediadores, partes, advogados e funcionários dos Tribunais. Sob esta última perspectiva, foi realizada pesquisa empírica e comparada em programas de mediação que funcionam junto ao Judiciário no Brasil e nos EUA. / The main issue of this work is the institutionalization of mediation within the Courthouse and the pre-conditions for having a good relationship between mediation and the Judiciary. This issue is analyzed from both procedural and institutional points of view. The procedural perspective falls on the mediation due process (minimal but meaningful due process standards) and on the differences between the procedural and substantial justices. The institutional perspective falls on the design of the Court-Connected Mediation Programs and on the roles of the players who participated in these programs: judges, mediators, plaintiff and defendant, attorneys, and Court workers. An empirical research was also done about the Court-Connected Mediation Programs in Brazil and in the United States.

More than one million fetal deaths occur in the United States every year [1]. Monitoring the long-term heart rate variability provides a great amount of information about the fetal health condition which requires continuous monitoring of the fetal heart rate. All the existing technologies have either complex instrumentation or need a trained professional at all times or both. The existing technologies are proven to be impractical for continuous monitoring [2]. Hence, there is an increased interest towards noninvasive, continuous monitoring, and less expensive technologies like fetal phonocardiography. Fetal Phonocardiography (FPCG) signal is obtained by placing an acoustic transducer on the abdomen of the mother. FPCG is rich in physiological bio-signals and can continuously monitor the fetal heart rate non-invasively. Despite its high diagnostic potential, it is still not being used as the secondary point of care. There are two challenges as to why it is still being considered as the secondary point of care; in the data acquisition system and the signal processing methodologies. The challenges pertaining to data acquisition systems are but not limited to sensor placement, maternal obesity and multiple heart rates. While, the challenges in the signal processing methodologies are dynamic nature of FPCG signal, multiple known and unknown signal components and SNR of the signal. Hence, to improve the FPCG based care, challenges in FPCG signal processing methodologies have been addressed in this study. A comparative evaluation was presented on various advanced signal processing techniques to extract the bio-signals with fidelity. Advanced signal processing approaches, namely empirical mode decomposition, spectral subtraction, wavelet decomposition and adaptive filtering were used to extract the vital bio-signals. However, extracting these bio-signals with fidelity is a challenging task in the context of FPCG as all the bio signals and the unwanted artifacts overlap in both time and frequency. Additionally, the signal is corrupted by noise induced from the fetal and maternal movements as well the background and the sensor. Empirical mode decomposition algorithm was efficient to denoise and extract the maternal and fetal heart sounds in a single step. Whereas, spectral subtraction was used to denoise the signal which was later subjected to wavelet decomposition to extract the signal of interest. On the other hand, adaptive filtering was used to estimate the fetal heart sound from a noisy FPCG where maternal heart sound was the reference input. The extracted signals were validated by obtaining the frequency ranges computed by the Short Time Fourier Transform (STFT). It was observed that the bandwidths of extracted fetal heart sounds and maternal heart sounds were consistent with the existing gold standards. Furthermore, as a means of additional validation, the heart rates were calculated. Finally, the results obtained from all these methods were compared and contrasted qualitatively and quantitatively.

The objective of this research was to apply a previously recommended laboratory testing protocol to specific aggregate base materials that are also the subject of ongoing full-scale field testing. The scope of this research involved three aggregate base materials selected from three sites where full-scale field testing programs have been established. The first and second field sites included five different geogrid types, categorized as either biaxial or triaxial, in a singlelayer configuration, while the third site included only the triaxial geogrid type in either a singleor double-layer configuration. Geogrid-stabilized and unstabilized control specimens were evaluated using the American Association of State Highway and Transportation Officials T 307 quick shear testing protocol. Measurements of load and axial displacement were recorded and used to develop a stress-strain plot for each specimen tested. The peak axial stress, the modulus to the peak axial stress, the modulus of the elastic portion of the curve, and the modulus at 2 percent strain were then calculated. Statistical analyses were performed to investigate differences between geogridstabilized specimens and unstabilized control specimens and to investigate differences between individual geogrid products or geogrid configurations. Depending on the method of data analysis, the quick shear test results indicate that geogrid stabilization, with the effect of geogrid stabilization averaged across all of the geogrid products evaluated in this study, may or may not improve the structural quality of the aggregate base materials evaluated in this study. The results also indicate that, regardless of the method of analysis, one geogrid product or configuration may be more effective than another at improving the structural quality of a given aggregate base material as measured using the quick shear test. All results from this research are limited in their application to the aggregate base material types, geogrid products, and geogrid configurations associated with this study. Additional research is needed to compare the results of the laboratory quick shear testing obtained for this study with the structural capacity of the geogrid-stabilized and unstabilized control sections that have been constructed at corresponding full-scale field testing sites. Specifically, further research is needed to determine which method of laboratory data analysis yields the best comparisons with field test results. Finally, correlations between the results of quick shear testing and resilient modulus need to be investigated in order to incorporate the findings of the quick shear test on geogrid-stabilized base materials into mechanistic-empirical pavement design.

Doctor of Philosophy / Over the past decade, population-based cancer registry data have been used increasingly worldwide to evaluate and improve the quality of cancer care. The utility of the conclusions from such studies relies heavily on the data quality and the methods used to analyse the data. Interpretation of comparative survival from such data, examining either temporal trends or geographical differences, is generally not easy. The observed differences could be due to methodological and statistical approaches or to real effects. For example, geographical differences in cancer survival could be due to a number of real factors, including access to primary health care, the availability of diagnostic and treatment facilities and the treatment actually given, or to artefact, such as lead-time bias, stage migration, sampling error or measurement error. Likewise, a temporal increase in survival could be the result of earlier diagnosis and improved treatment of cancer; it could also be due to artefact after the introduction of screening programs (adding lead time), changes in the definition of cancer, stage migration or several of these factors, producing both real and artefactual trends. In this thesis, I report methods that I modified and applied, some technical issues in the use of such data, and an analysis of data from the State of New South Wales (NSW), Australia, illustrating their use in evaluating and potentially improving the quality of cancer care, showing how data quality might affect the conclusions of such analyses. This thesis describes studies of comparative survival based on population-based cancer registry data, with three published papers and one accepted manuscript (subject to minor revision). In the first paper, I describe a modified method for estimating spatial variation in cancer survival using empirical Bayes methods (which was published in Cancer Causes and Control 2004). I demonstrate in this paper that the empirical Bayes method is preferable to standard approaches and show how it can be used to identify cancer types where a focus on reducing area differentials in survival might lead to important gains in survival. In the second paper (published in the European Journal of Cancer 2005), I apply this method to a more complete analysis of spatial variation in survival from colorectal cancer in NSW and show that estimates of spatial variation in colorectal cancer can help to identify subgroups of patients for whom better application of treatment guidelines could improve outcome. I also show how estimates of the numbers of lives that could be extended might assist in setting priorities for treatment improvement. In the third paper, I examine time trends in survival from 28 cancers in NSW between 1980 and 1996 (published in the International Journal of Cancer 2006) and conclude that for many cancers, falls in excess deaths in NSW from 1980 to 1996 are unlikely to be attributable to earlier diagnosis or stage migration; thus, advances in cancer treatment have probably contributed to them. In the accepted manuscript, I described an extension of the work reported in the second paper, investigating the accuracy of staging information recorded in the registry database and assessing the impact of error in its measurement on estimates of spatial variation in survival from colorectal cancer. The results indicate that misclassified registry stage can have an important impact on estimates of spatial variation in stage-specific survival from colorectal cancer. Thus, if cancer registry data are to be used effectively in evaluating and improving cancer care, the quality of stage data might have to be improved. Taken together, the four papers show that creative, informed use of population-based cancer registry data, with appropriate statistical methods and acknowledgement of the limitations of the data, can be a valuable tool for evaluating and possibly improving cancer care. Use of these findings to stimulate evaluation of the quality of cancer care should enhance the value of the investment in cancer registries. They should also stimulate improvement in the quality of cancer registry data, particularly that on stage at diagnosis. The methods developed in this thesis may also be used to improve estimation of geographical variation in other count-based health measures when the available data are sparse.

The broad objective of this study is to examine how assortment factors and category performance are related within the context of specialty retailing. This study formulates two clusters of research questions. The first cluster of research questions focuses on product assortment in general, for example assortment variety and composition. The second cluster of research questions concentrates on a specific area of product assortment, that is, private label products. An organic retailer in Australia collaborates by providing its assortment records and sales reports. The Australian organic retailing industry is an ideal candidate for this study for 1) it is specialty retailing, and 2) the supply situation allows organic retailers considerable flexibility to experiment with different assortment compositions. This study analyses store level cross sub category data and, to supplement this, it conducts a qualitative study and collects field data. Included in the cross sub category analyses are approximately 140 to 180 organic sub categories. The results show that assortment variety has a positive influence on sub category sales. The strength of this positive relationship varies across different sub category types, for example food or non-food. For the private label analyses, the results show that, within the focal store, private label SKUs are more likely to be present in sub categories with larger sales and with supermarket competition present. This study also finds that a deeper manufacturer brand assortment hurts private label performance. This study contributes to a body of cross category empirical generalisations about the complex decisions retailers face by examining the effects of assortment decisions within the context of specialty retailing. It provides some clear empirical evidence for how assortment factors and sub category performance are related through an empirical investigation in a bricks and mortar retail environment. In addition, it tests the generalisability of extant private label research beyond the much discussed conventional supermarket industry and convenience consumer goods contexts. Keywords: assortment, private label, store brand, specialty retailing, cross category, sub category, empirical investigation, organic retailing, Australia

<p>Reports of software a development projects that miss schedule, exceeds budget and deliver products with poor quality are abundant in the literature. Both researchers and the industry are seeking methods to counter these trends and improve software quality.</p><p>Software Process Improvement is a systematic approach to improve the capabilities and performance of software organizations. One basic idea is to assess the organizations’ current practice and improve their software process on the basis of the competencies and experiences of the practitioners working in the organization. A major challenge is to create strategies and mechanisms for managing relevant and updated knowledge about software development and maintenance. Insights from the field of knowledge management are therefore potentially useful in software process improvement efforts to facilitate the creation, modification, and sharing of software processes in any organization.</p><p>In the work presented in this thesis, we have made an overview of empirical studies on the effect of knowledge management in software engineering. We have categorized these studies according to a framework and we report findings on the major concepts that have been investigated empirically, as well as the research methods applied within the field. We have also investigated two main strategies for knowledge management, codification and personalization, through the application of four concrete methods in a software process improvement setting: Mentoring, Rational Unified Process, Process Workshops and Post Mortem Analysis.</p><p>We have classified the work in this thesis within three main themes:</p><p>RT1: Previous research on knowledge management in software engineering.</p><p>RT2: Application of knowledge management to improve the software process through codification of knowledge.</p><p>RT3: Application of knowledge management to improve the software process through personalization of knowledge.</p><p>The main contributions are:</p><p>C1: An overview of the research literature on empirical studies of knowledge management in software engineering.</p><p>C2: A method for tailoring the Rational Unified Process to the development process of a software consulting company.</p><p>C3: Improvements of the Process Workshops method by contextualization.</p><p>C4: Improvement of the root-cause analysis phase of the lightweight Post Mortem Analysis for more effective project retrospectives.</p><p>C5: Proposed methods to increase the learning effect of mentor programs in software engineering.</p>

Medical cost has received increasing interest recently in Biostatistics and public health. Statistical analysis and inference of life time medical cost have been challenging by the fact that the survival times are censored on some study subjects and their subsequent cost are unknown. Huang (2002) proposed the calibration regression model which is a semiparametric regression tool to study the medical cost associated with covariates. In this thesis, an inference procedure is investigated using empirical likelihood ratio method. The unadjusted and adjusted empirical likelihood confidence regions are constructed for the regression parameters. We compare the proposed empirical likelihood methods with normal approximation based method. Simulation results show that the proposed empirical likelihood ratio method outperforms the normal approximation based method in terms of coverage probability. In particular, the adjusted empirical likelihood is the best one which overcomes the under coverage problem.

Bei der hier vorzustellenden Arbeit handelt es sich um eine qualitative Langzeitstudie, die sich mit dem politischem Interesse von acht jungen Frauen in Brandenburg im Alter von 16 bis 20/21 Jahren, dem Alter, in dem sich die bisher ausgebildete individuelle politische Identität stabilisiert, beschäftigt. Die politische Identitätsbildung jugendlicher Schüler und Schülerinnen zu unterstützen, sie auf die Übernahme der Rolle eines mündigen Bürgers bzw. einer mündigen Bürgerin vorzubereiten und demokratisches Bewusstsein zu fördern, gilt als wichtiges Ziel politischer Bildung in der Bundesrepublik Deutschland. In diesem Konzept verbinden sich die aus psychologischer Sicht zu bewältigenden Entwicklungsaufgaben, die mit der Suche nach einem Platz in der Gemeinschaft (Erikson 1950, 1959, 1968) verbunden sind, mit einer Sicht des politischen Systems, nach der dessen Stabilität maßgeblich von der Legitimation seiner Mitglieder und deren Bereitschaft zur politischen Beteiligung abhängt (Easton 1965, 1975).<br><br> Die Herausbildung politischer Identität und die damit verbundenen Einstellungen und Verhaltensweisen Jugendlicher werden durch die Jugendforschung auf vielfältige Art und Weise untersucht. Nach dem politischen Identitätskonzept von Fend (1991) können politische Einstellungen und Verhaltensweisen nach affektiv-motivationalen, kognitiven und Verhaltensaspekten differenziert betrachtet werden. „Politisches Interesse“ kann als ein Konstrukt gesehen werden, welches im Schnittpunkt dieser drei Dimensionen liegt, da es sowohl motivationale, kognitive als auch handlungsbezogene Aspekte beinhaltet. Ihm kommt als motivationale Basis eine wichtige Bedeutung für die politische Exploration und politische Partizipation, und damit für die politische Identitätsentwicklung zu.<br><br> In empirischen Untersuchungen wird immer wieder festgestellt, dass das für die politische Identitätsentwicklung so bedeutsame politische Interesse bei jungen Frauen im Vergleich zu jungen Männern niedriger ausfällt. Junge Frauen zeigen eine geringere Bereitschaft, sich mit Politik zu beschäftigen, sie fühlen sich politisch inkompetenter und glauben in stärkerem Maße als ihre männlichen Altersgenossen, keinen Einfluss auf die Politik nehmen zu können (vgl. z.B. Fend 1991; Hoffmann-Lange 1995; Verba et al. 1995; Gille et al. 2000; Torney-Purta et al. 2001; Jugendwerk der Deutschen Shell 2000; 2002; Brandenburger Jugendlängsschnitt). Diese vorgefundenen Geschlechtsunterschiede werden auf unterschiedliche Art und Weise erklärt.<br><br> In der empirischen Jugendforschung wird im Allgemeinen eine Single-Item-Frage zur Erfassung von politischem Interesse genutzt. Diese kann nicht als ausreichend angesehen werden, wenn es darum geht, der These nachzugehen, dass weibliche Jugendliche nicht unbedingt politisch weniger, sondern politisch anders interessiert sind als männliche Jugendliche. Arbeiten, die das politische Interesse differenzierter erfassen, belegen dies bereits (vgl. z.B. Kuhn et al. 1998; Oesterreich 2002; Albert et al. 2003; Kuhn/Schmid 2004) <br><br> Diese Arbeit soll dazu beitragen, dass politische Interesse von weiblichen Jugendlichen mittels qualitativer Daten weiterführend zu erklären. Anhand verschiedener Fragen wird dem politischen Interesse weiblicher Gymnasiastinnen aus Brandenburg in seinem Zusammenhang mit dem Informationsverhalten und dem Stellenwert, den Vertrauen in Politik und gegenüber Politikern für die Jugendlichen hat, nachgegangen. / The essay (qualitative long term study) presents perspectives on the political interest of eight young women in the federal state of Brandenburg/Germany between the age of 16-21, an age by which they have achieved an individual political identity.<br><br> German politics aim at supporting, inspiring and preparing adolescents in order to create responsible citizens and to promote a democratic awareness. From a psychological perspective, this concept includes developmental tasks to be coped with as for example the search for a place in society (Erikson 1950, 1959, 1968) and an understanding of the political system as the warrant of stability depending on the legitimate members of the system and their readiness to participate in it (Easton 1965, 1975).<br><br> There are many different critical approaches towards understanding the development of political identity as well as the attitudes and behaviour of adolescents. According to the concept of identity developed by Fend (1991), political identity and behaviour are differentiated into affective-motivational and cognitive aspects. Political interest is attributed to both motivational and cognitive aspects and thus can serve as a central indicative concept for the process of the forming of a political identity. On the one hand, political interest constitutes an important motivational precondition to a maintained interest in political processes and participation. On the other hand, the motivation to stay informed about ongoing political issues promotes the perpetual increase of knowledge as well as the growth of the competence to analyse and act. <br><br> In empirical research, the political interest of young women, which is essential for the development of a political identity, has been repeatedly characterized as lower than that of young men. In comparison to their male contemporaries females show less motivation to deal with politics, they feel less politically competent and are more ready to believe in having no influence on politics (cp. Fend 1991; Hoffmann-Lange 1995; Verba et al. 1995; Gille et al. 2000; Torney-Purta et al. 2001; Jugendwerk der deutschen Shell 2000; 2002; Brandenburger Jugendlängsschnitt). These differences between the genders have received multiple explanations.<br><br> In empirical youth research, one particular question is generally used to assess political interest. Yet, this procedure is inadequate when it comes to finding evidence for the idea that female adolescents are not necessarily less interested in politics, but that they have a different kind of interest than their male counterparts. Essays that approach political interest in a more differentiated way have already provided evidence for this(cp. Kuhn et al. 1998; Oesterreich 2002, Albert et al. 2003, Kuhn/Schmid 2004).<br><br> This essay shall provide further insight into the political interest of female adolescents on the basis of qualitative data. Using different types of questions, the political interest of high school students in the federal state of Brandenburg, studying towards A-level is evaluated with regard to the behaviour concerning the level of concern, trust and appreciation invested in politics and politicians by female adolescents.

Reports of software a development projects that miss schedule, exceeds budget and deliver products with poor quality are abundant in the literature. Both researchers and the industry are seeking methods to counter these trends and improve software quality. Software Process Improvement is a systematic approach to improve the capabilities and performance of software organizations. One basic idea is to assess the organizations’ current practice and improve their software process on the basis of the competencies and experiences of the practitioners working in the organization. A major challenge is to create strategies and mechanisms for managing relevant and updated knowledge about software development and maintenance. Insights from the field of knowledge management are therefore potentially useful in software process improvement efforts to facilitate the creation, modification, and sharing of software processes in any organization. In the work presented in this thesis, we have made an overview of empirical studies on the effect of knowledge management in software engineering. We have categorized these studies according to a framework and we report findings on the major concepts that have been investigated empirically, as well as the research methods applied within the field. We have also investigated two main strategies for knowledge management, codification and personalization, through the application of four concrete methods in a software process improvement setting: Mentoring, Rational Unified Process, Process Workshops and Post Mortem Analysis. We have classified the work in this thesis within three main themes: RT1: Previous research on knowledge management in software engineering. RT2: Application of knowledge management to improve the software process through codification of knowledge. RT3: Application of knowledge management to improve the software process through personalization of knowledge. The main contributions are: C1: An overview of the research literature on empirical studies of knowledge management in software engineering. C2: A method for tailoring the Rational Unified Process to the development process of a software consulting company. C3: Improvements of the Process Workshops method by contextualization. C4: Improvement of the root-cause analysis phase of the lightweight Post Mortem Analysis for more effective project retrospectives. C5: Proposed methods to increase the learning effect of mentor programs in software engineering.

The reaction mechanisms for the hemoglobin degrading enzymes in the Plasmodium falciparum malaria parasite, plasmepsin II (Plm II) and histo-aspartic protease (HAP), have been analyzed by molecular simulations. The reaction free energy profiles, calculated by the empirical valence bond (EVB) method in combination with molecular dynamics (MD) and free energy perturbation (FEP) simulations are in good agreement with experimental data. Additional computational methods, such as homology modelling and automated substrate docking, were necessary to generate a 3D model and a reactive substrate conformation before the reaction mechanism in HAP could be investigated. HAP is found to be an aspartic protease with a peptide cleaving mechanism similar to plasmepsin II. The major difference between these enzymes is that the negatively charged tetrahedral intermediate is stabilized by the charged histidine in HAP while in Plm II it is a neutral aspartic acid. Also the reaction mechanism for two other aspartic proteases, cathepsin D and HIV-1 protease, was simulated. These enzymes are relevant both for the inhibitor selectivity and for obtaining a general picture of catalysis in aspartic proteases. Another project involves inhibitor design towards plasmepsins. In particular, Plm II directed inhibitors based on the dihydroxyethylene scaffold have been characterized computationally. Molecular dynamics (MD) simulations were used to propagate the investigated system through time and to generate ensembles used for the calculation of free energies. The ligand binding affinities were calculated with the linear interaction energy (LIE) method. The most potent inhibitor had a Ki value of 6 nM and showed 78 % parasite inhibition when tested on red blood cells infected by malaria parasite P. falciparum. Citrate synthase is part of the citric acid cycle and is present in organisms that live in cold sea water as well as hot springs. The temperature adaptation of citrate synthase to cold and heat was investigated in terms of the difference in transition state stabilization between the psychrophilic, mesophilic and hyperthermophilic homologues. The EVB, FEP and MD methods were used to generate reaction free energy profiles. The investigated energetics points toward the electrostatic stabilization during the reaction as the major difference between the different citrate synthase homologues. The electrostatic stabilization of the transition state is most effective in the following order of the citrate synthase homologues: hyperthermophile, mesophile, psycrophile. This could be a general rule for temperature adaptation of enzyme catalysis.