<p>Simulators provide great promises of pedagogical utility in a wide array of practices. This study focuses on the use of a full-scale mannequin simulator in training of personnel at an intensive care unit at a Swedish hospital. In medicine, simulators are a means of doing realistic training without risks for the patient. Simulators for use in intensive care medicine are built to resemble as closely as possible the human physiology. In the studied sessions the simulator (a Laerdal SimMan) is set up to be an as-authentic-as-possible replication of the nurses regular, day-to-day practice.</p><p>In examining the training-sessions, it was found that the participants often did other things than “proper” simulation, such as joking or making comments about the simulation. These “transgressional activities” were studied from a perspective of ethnomethodology, using video-recordings of the session. These were transcribed and analyzed in detail using ethnomethodologically informed interaction analysis.</p><p>Several themes were developed from the recordings and transcripts. These have in common that they demonstrate the participants’ own achievement and maintenance of the simulation as a distinct activity. The analysis provides an account of how the local order of the simulation is upheld, how it is breached and how the participants find their way back into doing “proper” simulation. It is an overview of the interactional methods that participants utilize to accomplish the simulation as a simulation.</p><p>This study concludes with a discussion of how this study can provide a more nuanced view of simulations, in particular the relation between simulated and “real” practices. Notions of realism, authenticity and fidelity in simulations can all be seen to be the participants’ own concern, which informs their activities in the simulation.</p>

<p>“To be, or not to be” surely constitutes a strange walk on the tight rope between delusion and reality, and apparently, Robert Fleming is a man with immense problems. Who is Ziggy Stardust, and who is Stephen Dedalus? Is it relevant to claim that there is more of David Bowie’s true personality inside Ziggy than of, for instance Charles Dickens’ great expectations within Pip? By examining Nick Hornby’s novel High Fidelity and it’s main character from a Freudian perspective using Freud’s theories and ideas of the oedipal concept, this is basically a plain attempt in search for a better psychological knowledge and understanding of the musical world of illusion, which finally ends up in a serious effort to interpret the true and inner meanings of Rob’s dreams and personality.</p>

For more than two decades, special education teacher shortages and attrition have concerned policymakers and administrators who work to recruit and retain special educators. It is imperative, therefore, to investigate the possible causes underlying the decision of special educators to leave the field. The aim of this current study was to explore teacher commitment to model philosophy and burnout across two well-established preschool treatment models for children with ASD: TEACCH (Treatment and Education of Autistic and Related Communication-Handicapped Children) and LEAP (Learning Experiences and Alternative Program for Preschoolers and their Parents). Additionally, these constructs were explored in Business As Usual (BAU) classroom models. Results indicated that LEAP teachers were significantly more committed to LEAP philosophy and practice relative to the TEACCH and BAU teachers and TEACCH teachers were not significantly more committed to TEACCH philosophy relative to the LEAP and BAU teachers. Additionally, BAU teachers are not significantly more committed to either LEAP or TEACCH, but do share commitment to both classroom approaches. Lastly, post hoc analyses provided support for a quadratic relationship between teacher commitment and aspects of teacher burnout. Implications for school districts and teachers working within the field of special education are discussed.

In this thesis, a novel approach is presented for blade loss simulation of an aircraft gas turbine rotor mounted on rolling element bearings with squeeze film dampers, seal rub and enclosed in a flexible housing. The modal truncation augmentation (MTA) method provides an efficient tool for modeling this large order system with localized nonlinearities in the ball bearings. The gas turbine engine, which is composed of the power turbine and gas generator rotors, is modeled with 38 lumped masses. A nonlinear angular contact bearing model is employed, which has ball and race degrees of freedom and uses a modified Hertzian contact force between the races and balls and for the seal rub. This combines a dry contact force and viscous damping force. A flexible housing with seal rub is also included whose modal description is imported from ANSYS. Prediction of the maximum contact load and the corresponding stress on an elliptical contact area between the races and balls is made during the blade loss simulations. A finite-element based squeeze film damper (SFD), which determines the pressure profile of the oil film and calculates damper forces for any type of whirl orbit is utilized in the simulation. The new approach is shown to provide efficient and accurate predictions of whirl amplitudes, maximum contact load and stress in the bearings, transmissibility, thermal growths, maximum and minimum damper pressures and the amount of unbalanced force for incipient oil film cavitation. It requires about 4 times less computational time than the traditional approaches and has an error of less than 5 %.

“To be, or not to be” surely constitutes a strange walk on the tight rope between delusion and reality, and apparently, Robert Fleming is a man with immense problems. Who is Ziggy Stardust, and who is Stephen Dedalus? Is it relevant to claim that there is more of David Bowie’s true personality inside Ziggy than of, for instance Charles Dickens’ great expectations within Pip? By examining Nick Hornby’s novel High Fidelity and it’s main character from a Freudian perspective using Freud’s theories and ideas of the oedipal concept, this is basically a plain attempt in search for a better psychological knowledge and understanding of the musical world of illusion, which finally ends up in a serious effort to interpret the true and inner meanings of Rob’s dreams and personality.

Each cell division, the nuclear DNA must be replicated efficiently and with high accuracy to avoid mutations which can have an effect on cell function. There are three replicative DNA polymerases essential for the synthesis of DNA during replication in eukaryotic cells. DNA polymerase α (Pol α) synthesize short primers required for DNA polymerase δ (Pol δ) and DNA polymerase ε (Pol ε) to carry out the bulk synthesis. The role of Pol δ and Pol ε at the replication fork has been unclear. The aim of this thesis was to examine what role Pol ε has at the replication fork, compare the biochemical properties of Pol δ and Pol ε, and to study the function of the second largest and essential subunit of Pol ε, Dpb2. To identify where Pol ε replicates DNA in vivo, a strategy was taken where the active site of Pol ε was altered to create a mutator polymerase leaving a unique error-signature. A series of mutant pol ε proteins were purified and analyzed for enzyme activity and fidelity of DNA synthesis. Two mutants, M644F and M644G, exhibited an increased mutation rate and close to normal polymerase activity. One of these, the M644G gave rise to a specific increase of mismatch mutations resulting from T-dTMP mis-pairing during DNA synthesis in vitro. The M644G mutant was introduced in yeast strains carrying a reporter gene, URA3, on either side of an origin in different orientations. Mutations which inactivated the URA3 gene in the M644G mutant strains were analyzed. A strand specific signature was found demonstrating that Pol ε participates in the synthesis of the leading strand. Pol δ and Pol ε are both stimulated by the processivity clamp, PCNA, in in vitro replication assays. To clarify any differences they were challenged side by side in biochemical assays. Pol ε was found to require that single-stranded template (ssDNA) was entirely coated with RPA, whereas Pol δ was much less sensitive to uncoated ssDNA. The processivity of Pol δ was stimulated to a much higher degree by PCNA than of Pol ε. In presence of PCNA the processivity of Pol δ and Pol ε was comparable. In contrast, Pol ε was approximately four times slower than Pol δ when replicating a single-primed circular template in the presence of all accessory proteins and an excess of polymerase. The biochemical characterization of the system suggests that Pol ε and Pol δ are loaded onto the PCNA-primer-ternary complex by separate mechanisms. A model is proposed where the loading of Pol ε onto the leading strand is independent of the PCNA interaction motif which is required by enzymes acting on the lagging strand. The essential gene DPB2 encodes for the second largest subunit of Pol ε. We carried out a genetic screen in S.cerevisiae and isolated a lethal mutant allele of dpb2 (dpb2-200). When over-expressed together with the remaining three subunits of Polε, Pol2, Dpb3 and Dpb4, the dpb2-201 did not copurify. The biochemical property of Pol2/Dpb3/Dpb4 complex was compared with wild-type four-subunit Pol ε (Pol2/Dpb2/Dpb3/Dpb4) and a Pol2/Dpb2 complex in replication assays. The absence of Dpb2 in the complex did not significantly affect the specific activity or the processivity, but gave a slightly reduced efficiency in holoenzyme assays when compared to wild-type four-subunit Pol ε. We propose that Dpb2 is not essential for the enzyme activity of Pol ε.

Developing appropriate management plans for species at risk requires information about their population structure and abundance. For most cetacean populations, few reliable population estimates are available and even fewer distributions have been mapped. Accurate abundance estimates can be determined from capture-recapture data if assumptions are met, however this can be difficult when the animal in question demonstrates both strong site fidelity and large-scale migrations, and different models can result in dramatically different results. I explored these issues by examining a 15-year dataset (1992-2006) of photo-identifications of humpback whales (Megaptera novaeangliae) in British Columbia (BC), Canada. I used multiple capture-recapture models to compare how the definition of population and variation in effort affected estimates of population size, and I explored means to correct for these biases. I also considered stock structure by examining individual breeding ground destinations, movement, and localized site-fidelity within BC. Across the six models considered, the BC humpback whale abundance in 2006 ranged between 1,428 and 3,856 individuals. The Lincoln-Petersen estimate (1,428-1,892) likely best described the number of humpback whales in BC during summer 2006. The effort-standardized Jolly-Seber model (1,970-2,331) is more representative of the larger population of humpback whales that uses or passes through BC over multiple years. Ultimately, selecting the best estimation model requires defining the ‘population’ of interest and accounting for spatial and temporal distribution of sampling effort. British Columbia provides feeding habitat and a potential migratory corridor for whales that breed in the northeastern Pacific Ocean. Forty-four percent of the 1,986 humpback whales considered were sighted in BC in more than one year. Identifications were highest from May to October, with a peak in September, but humpback whales were present in BC in all months of the year. Whales showed strong site fidelity with a median re-sighting distance of 75 km between years, and a maximum re-sighting distance that ranged from 0.41 km to 842 km. Matching rate within BC decreased as a function of north-south distance, though no clear north-south boundary could be established. Stock structure of humpback whales in British Columbia is complex and should be considered in managing this population.

The effects of program fidelity, gender, socioeconomic status, and school level were tested on various outcomes of a dating violence prevention program, Expect Respect. Fidelity data was collected from program facilitators, and individual posttest scores were gathered for individuals nested within each programmatic site. Multiple HLM models indicated that main effects for fidelity were present for the knowledge gained outcome scale, such that higher program fidelity led to higher posttest scores for participants. No other site level predictors affected outcomes or the fidelity-outcome relationship. Results from this study point towards the importance of implementing program fidelity when cognitive gains are a central goal of the program, whereas a more flexible program approach may be more optimal in conveying other programmatic components.

Program evaluations are increasingly assessing the impact of treatment delivery and program processes on outcomes. The current study examined the effects of program fidelity, measured across various dimensions, and relationship quality on behavior change and knowledge gained outcomes in 241 middle and high school students who were participating in Expect Respect, an evidence-based dating violence prevention program. Cross-level, hierarchical linear modeling (HLM) analyses found that program fidelity was not a significant predictor of participant outcomes. However, main effects for relationship quality were present for the knowledge gained outcome measure. Subsequent cross-level interactions provided further support for the importance of relationship quality in prevention program outcomes.

As more evidence-based programs are implemented in community settings, there is a strong need to ensure those models are implemented with integrity. Implementation of programs should be evaluated for fidelity, the degree of adherence to treatment protocols, and competence, the level of skill in implementation (Schoenwald et al., 2011). The purpose of this study was to review audio recordings of SafeCare home visiting sessions to discover the relationship between the measures of fidelity and competence. Six coders were assigned 209 SafeCare home visiting audiotapes to be coded for fidelity and competence. A sample of audios were double coded to evaluate fidelity and competence scores for inter-rater reliability. Fidelity and competence items were classified into process and content categories, forming the six main variables of process fidelity, content fidelity, total fidelity, process competence, content competence, and total competence. Total fidelity correlated with total competence at a level of .615, with process fidelity and process competence correlating at a much lower level than content items. The total correlation level can be interpreted as that fidelity and competence are strongly related measures, but are not identical constructs. The goal for SafeCare coders would be to continue refining competence definitions and attempting to remove the subjective nature from the competence coding process. With these two efforts, competence reliability should increase to an acceptable level. Given the main fidelity and competence correlation level, it is advisable for SafeCare coders to continue to code both fidelity and competence to avoid missing valuable components of the session. Additional research may be needed once the competence scale becomes better established.