Although healthcare information systems improve healthcare and efficiency they are often complex and provide a limited service. For these and other similar reasons, users often take it upon themselves to create their own solutions. These user created solutions are called feral information systems. It is not always that these feral information systems meet the standard requirements of healthcare information systems and as a result of this they have the potential to create risk that might put the patient, management and the organization at risk. This is an undergraduate thesis that aims to research the risks that can rise when feral information systems fail to meet the standard requirements of healthcare information systems. The report is an interpretive case study that focuses on three different feral information system within a regional healthcare organization. Ten standard requirements of healthcare information systems are described and written from three distinctive divisions – Technique oriented, information oriented and user oriented requirements. Information is gathered using a semi-structured interview with the developer of the three systems, a user of one of the systems and two managers from the maintenance department of the organization. The data gathered about the feral information system is then interpreted and analyzed using the ten requirements of IT system in healthcare from the perspective of the three different divisions. As a result of the research we have come to the conclusion that the failure to meet the user and information and technical oriented requirements have the potential to create certain risk in some aspects but not all. Feral information systems in health care services can pose a risk to patient safety and that there are probably several of these systems that violate the patient data act or personal data law. Failure to handle data integrity and follow the patient data law in feral information systems often results in lacking user traceability. In addition, there is an extra cost to maintain systems that are usually not analyzed by the operations. We see that feral information systems often uses self- defined healthcare terminology which obstructs the ability to integrate with other systems. The lack of documentation obstructs the use of the system without a special training. These trainings take time, resources and are often not free. Making the organization more and more dependent on the experienced users. Furthermore, the lack of documentation also obstructs the possibility of further developing the system.  However, the potential of feral information system to cause risk is often neglected and underestimated. This is because feral information systems often fulfill only a small and particular need within a certain division of the organization. / IT-system inom hälso- och sjukvård förbättrar vården och effektiviteten. De är dock ofta komplexa och ger en begränsad service. Av detta och andra liknande skäl skapar ofta användarna egenutvecklade IT-system. Dessa användarskapade IT-system kallas feral information systems. Det är inte alltid så att dessa feral information system uppfyller de krav som ställs på IT-system inom hälso- och sjukvård och som ett resultat av detta har de potential att skapa risker för patienten, förvaltningen och organisationen i helhet. Denna kandidatuppsats syftar till att undersöka de risker som kan uppstå när feral information systems inte uppfyller de krav som ställs på IT-system inom hälso- och sjukvård. Studien är en tolkande fallstudie som fokuserar på tre olika feral information systems inom en regional hälsovårdsorganisation. Vi har tagit fram tio kriterier som vi anser IT-system inom hälso- och sjukvård bör uppfylla. Dessa kriterier beskrivs och uttrycks från tre kategorier: teknikorienterade, informationsorienterade och användarorienterade krav. Vårt empiriska material samlas in med hjälp av semistrukturerade intervjuer med utvecklaren av de tre systemen, en användare av ett av systemen samt två chefer från organisationens förvaltningsorganisation. Insamlade data om dessa feral information systems tolkas och analyseras sedan med hjälp av de tio kriterierna vi tagit fram för IT-system inom hälso- och sjukvård och summeras i de tre kategorierna. Feral information systems i vårdverksamheter kan innebära risk för patientsäkerheten och att det troligen är flera av dessa system som bryter mot patientdatalagen eller personuppgiftslagen. Brister i att hantera dataintegritet och patientdatalagen leder till att feral information systems ofta saknar spårbarhet. Dessutom finns en kostnad för att underhålla systemen som oftast inte är analyserade av verksamheterna. Vi ser att feral information systems ofta följer sina egna definitioner av begrepp vilket försvårar integrationen med andra system. Avsaknaden av dokumentation leder till svårigheter i att använda systemen utan utbildning. Utbildningen tar tid, så denna resurs är oftast inte gratis. Detta gör att verksamheten blir beroende av de mer erfarna användarna. Avsaknaden av dokumentation skapar även svårigheter i övertagandet av existerande feral information systems samt vid behovet av vidareutveckling. Eftersom feral information systems oftast uppfyller små och nischade behov inom en verksamhet, försummas och underskattas systemets potential att skapa risk.

59 Civil Responsibility on Skiing Slopes Abstract This diploma thesis deals with civil liability on skiing slopes. Besides gathering valid standards in the Czech Republic, it also provides insight into foreign legal systems with the greatest emphasis on the French regulation and legal system. A part of the thesis is devoted to the rules of the International Ski Federation, which are widely respected important source of rules in skiing. Examples of their application are illustrated with the case law that inferred their validity, while in other countries the rules were reflected directly in legislation. In the first chapter there is a general anchoring of responsibility in Czech civil law, followed by a brief excursion into the sports law of individual sports, in the third chapter we find a summary of legal and non-legal regulations that apply to activities on domestic skiing slopes, including a bill that in the end did not pass in the Chamber of Deputies. The FIS rules of conduct are introduced by the story of their genesis and international cooperation on their final wording, followed by an official commentary issued by the International Ski Federation for the reason of clarification and interpretation. In the fourth chapter follows the analysis of the application of FIS rules by judicial authorities using...

Gamma-ray and Fluorescence Lifetime Spectroscopies are driving the development of non-imaging silicon photon sensors and, in this context, Silicon Photo-Multipliers (SiPM)s are leading the starring role. They are 2D array of optical diodes called Single Photon Avalanche Diodes (SPAD)s, and are normally fabricated with a dedicated silicon process. SPADs amplify the charge produced by the single absorbed photon in a way that recalls the avalanche amplification exploited in Photo-Multiplier Tubes (PMT)s. Recently 2D arrays of SPADs have been realized also in standard CMOS technology, paving the way to the realization of completely custom sensors that can host ancillary electronic and digital logic on-chip. The designs of scientific apparatus have been influenced for years by the bulky PMT-based detectors. An overwhelming interest in both SiPMs and CMOS SPADs lies in the possibility of displacing these small sensors realizing new detectors geometries. This thesis examines the potential deployment of SiPM-based detector in an apparatus built for the study of the Time-Of-Flight (TOF) of Positronium (Ps) and the displacement of 2D array of CMOS SPADs in a lab-on-chip apparatus for Fluorescence Lifetime Spectroscopy. The two design procedures are performed using Monte-Carlo simulations. Characterizations of the two sensor have been carried out, allowing for a performance evaluation and a validation of the two design procedures.

Peak profiles in X-ray Diffraction (XRD) patterns from nanocrystalline materials are affected by static and dynamic disorder which is specific of the size and shape of the nanocrystalline domains. Owing to their intrinsic differences, the two types of disorder can be separated, providing independent information from the modelling of the XRD patterns. In the present thesis a model for the static strain created by the nanoparticle surface is proposed. The model is built within the frame of the Whole Powder Pattern Modelling (WPPM) approach for XRD line profile analysis, developed at the University of Trento in the past 20 years. The WPPM approach is decribed in details. Based on a complex Fourier Transform of the diffraction profiles, the model leads to general equations to be used with the WPPM approach to represent the distorted atomic configuration with respect to the reference bulk one. The model was also implemented in TOPAS, a commercial and very popular software, developing a specific macro allowing a larger community of users to benefit of this new opportunity of studying nanocrystalline materials. The thesis work also extended to a more traditional and general description of strain broadening of XRD peak profiles, involving invariant forms under the Laue group symmetry operations of the material under study. As for the dynamic strain, the fundamentals of the Thermal Diffuse Scattering (TDS) contribution to the peak profiles are reviewed. Starting from the original work of B.E. Warren, the theory is generalized to account for surface effects, leading to a particular model developed recently at the University of Trento. This model was thoroughly reviewed and corrected. To test the model a parallel computer code in C was written, exploiting Molecular Dynamics simulations for obtaining reliable and independent estimates of static and dynamic disorder in nanocrystals.

The absence of a cheap and easily scalable synthesis technique for nitrogen-vacancy (NV) centers enriched nanodiamonds (NDs) is a critical factor for the development of devices based on this very peculiar nanoparticle. Indeed, the combination between the unique NV fluorescence properties and NDs characteristics allow to obtain a tool having quantum sensing capabilities, with nanometric spatial resolution, which is able to operate in a wide range of temperature, pressures and in harsh chemical conditions. NVenriched NDs applications in nanothermometry, nanomagnetometry and in bio-imaging have already been reported. However, most of the standard fluorescent NDs production techniques present common drawbacks: poor control in NDs size distribution and in nitrogen concentration, as well as the need of post-synthesis process to clean the NDs surface from impurities and to increase the NV density. In this thesis, an alternative method for fluorescent NDs synthesis based on pulsed laser ablation (PLA) of graphite is demonstrated. After the introductory chapters on NV-centers physics and NDs properties (Chapter 2 and 3), the demonstration that PLA is a viable route for synthesis of NDs is given in Chapter 4. In particular, PLA of graphite and of diamond-like carbon is performed in water. Here, a thermodynamic model taking into account the peculiar physical processes occurring during PLA is developed to explain NDs formation. Then, synthesis of NV-enriched NDs is demonstrated through PLA of graphite in a nitrogen atmosphere (Chapter 5) and in liquid nitrogen (Chapter 6). In both chapters, the thermodynamic model is adapted to explain diamond phase formation in a gaseous environment and in a cryogenic liquid. Furthermore, NV centers optical properties are fully characterized with optically detected magnetic resonance (ODMR) spectroscopy. Finally, in Chapter 7, fluorescent NDs are produced by laser ablation of N-doped graphite in water. This particular target is then used for a quantitative comparison between the other fluorescent NDs laser-synthesis, with the aim of establishing in which condition the highest NV-center formation efficiency is achieved.

Bacteria have small, streamlined genomes and evolve rapidly. Their large population sizes allow selection to be the main driver of evolution. With advances in sequencing technologies and precise methods for genetic engineering, many bacteria are excellent models for studying elementary questions in evolutionary biology. The work in this thesis has broadly been devoted to adaptive evolution and fitness effects of different types of mutations. In Paper I we experimentally tested the fitness constrains of horizontal gene transfer (HGT), which could be used to predict how the fixation of HGT events are affected by selection and fitness effects. We found that the majority of the examined HGT inserts were indistinguishable from neutral, implying that extra DNA transferred by HGT, even though it does not confer an immediate selective advantage, could be maintained at transfer-selection balance and serve as a reservoir for the evolution of novel beneficial functions. Paper II examined why four synonymous mutations in rpsT (encoding ribosomal protein S20) reduced fitness, and how this cost could be genetically compensated. We found that the cause for the fitness reduction was low S20 levels and that this lead to a defective subpopulation of 30S subunits lacking S20. In an adaptive evolution experiment, these impairments were compensated by up-regulation of S20 though various types of mutations. In Paper III we continued the studies of how the deleterious rpsT mutations could be compensated. The mutations either down-regulated the global regulator Fis or altered a subunit of the RNA polymerase (rpoA). We found that the decreased S20 levels in the cells causes an assembly defect of the 30S particles and that the fis and rpoA mutations restored the skewed S20:ribosome ratio by both increasing S20 levels and decreasing other ribosomal components. Paper IV examined adaptation of two bacterial species to different growth media. A total of 142 different adaptive mutations were identified and 112 mutants were characterized in terms of fitness. We found that the experimental variation in fitness measurements could be reduced 10-fold by introducing some adaptive mutations prior to the experiment, allowing measurements of fitness differences as small as 0.04%.

With the development of three-dimensional (3D) technologies, the demand for high-quality 3D content, 3D visualization, and flexible and natural interactions are increasing. As a result, semi-transparent Augmented-Reality (AR) systems are emerging and evolving rapidly. Since there are currently no well-recognized models to evaluate the performance of these systems, we proposed a Quality-of-Experience (QoE) taxonomy for semi-transparent AR systems containing three levels of influential QoE parameters, through analyzing existing QoE models in other related areas and integrating the feedbacks received from our user study. We designed a user study to collect training and testing data for our QoE model, and built a Fuzzy-Inference-System (FIS) model to estimate the QoE evaluation and validate the proposed taxonomy. A case study was also conducted to further explore the relationships between QoE parameters and technical QoS parameters with functional components of Microsoft HoloLens AR system. In this work, we illustrate the experiments in detail and thoroughly explain the results obtained. We also present the conclusion and future work.

Les mécanismes de l'adaptation des bactéries à leur environnement ont été étudiés par une stratégie d'évolution expérimentale. Douze populations, fondées à partir d'une cellule ancêtre d'Escherichia coli, ont évolué indépendamment pendant 20 000 générations par transferts journaliers dans un milieu constant. Au cours de cette évolution, la capacité reproductive des cellules augmente de 70% dans les 12 populations. L'objectif du travail est d'identifier et d'analyser les mutations conduisant à cette adaptation afin de comprendre les mécanismes à la base de l'évolution. Des mutations bénéfiques responsables d'une augmentation parallèle et systématique de la superhélicité de l'ADN ont été identifiées dans deux gènes impliqués dans sa régulation : fis, codant un régulateur global de l'expression des gènes, et topA, codant la topoisomérase I responsable du relâchement de l'ADN. L'évolution de ces populations se caractérise par un degré important de parallélisme phénotypique associé à un fort parallélisme génétique : seuls deux gènes impliqués dans la régulation de la topologie de l'ADN sont les cibles de la sélection naturelle. De plus, les mutations apparues au sein du gène fis, bien qu'affectant la transcription, la traduction, ou la fixation à l'ADN de la protéine Fis, mènent toutes au même résultat : une diminution de l'activité de la protéine. Le parallélisme phénotypique observé s'explique donc par un degré exceptionnel de parallélisme génétique et moléculaire.

<p>Examensarbetet som beskrivs i denna rapport handlar om en ny teknik för att förbättra säkerheten för flygplan i luften och i närheten av flygplatser. Denna teknik benämns ADS-B (Automatic Dependent Surveillance Broadcast), och är tänkt att göra det möjligt för piloter att själva få information om trafik i närområdet. Nuvarande system baserar sig i huvudsak på visuella observationer från flygledare i kontrolltorn samt radarspaning omkring flygplatserna. Med det nuvarande systemet kommer det att bli både dyrt och svårt att upprätthålla en acceptabel nivå på flygsäkerheten när trafiken ökar. </p><p>Arbetet har bedrivits i AerotechTelubs regi i Linköping samt med hjälp ifrån företaget Sectra Wireless Technologies AB. Huvuddelen av arbetet inriktar sig på implementerandet av C-funktioner för att hantera kommunikationen och sammankopplandet av ett tidigare skapat system, för grafikvisning, med en transponder som hanterar ADS-B (tillverkad av Sectra). Målet med detta var att göra förberedande arbete åt AerotechTelub som de förhoppningsvis kommer att kunna använda i ett eventuellt kommande projekt. Rapporten tar upp några standarder som hör till konceptet GP&C (Global Positioning & Communication), samt beskriver de delar som ligger till grund för programmets funktion. </p><p>Examensarbetet har resulterat i ett demonstrationsprogram för att visa hur en lösning av problemet kan se ut. Det har tyvärr inte gått att säkerställa om programmet fungerar till fullo, men genom simuleringar och andra tester har huvuddelen av programmets funktioner gått att verifiera.</p>

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