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Simulation and experiment on laser-heated pedestal growth of yttrium-aluminum-garnet single-crystal fibersChen, Peng-Yi 20 August 2009 (has links)
Recently the computational speed and the functions of the numerical methods are advancing rapidly. It is the future trend that using the computational fluid dynamics (CFD) to perform simulation for making up the experimental deficiency, reducing the risk, improving the quality of the product, and saving the cost of research and development.
A two-dimensional simulation was employed to study the melt/air and melt/solid interface shapes of the miniature molten zone formed in the laser-heated pedestal growth (LHPG) system. Using non-orthogonal body-fitting grid system with control-volume finite difference method, the interface shape can be determined both efficiently and accurately. During stable growth, the dependence of the molten-zone length and shape on the heating CO2 laser is examined in detail under both the maximum and the minimum allowed powers with various growth speeds. The effect of gravity for the miniature molten zone is also simulated, which reveals the possibility for a horizontally oriented LHPG system. Such a horizontal system is good for the growth of long crystal fibers.
After comparing with the shape of the molten zone in terms of the experiment and the analysis of the simulation shown as above. Heat transfer and fluid flow in the LHPG system are analyzed near the deformed interfaces. The global thermal distributions of the crystal fiber, the melt, and the source rod are described by temperature and its axial gradient within length of ~10 mm. As compared with the growth of bulk crystal of several centimeters in dimension, natural convection drops six orders in magnitude due to smaller melt volume; therefore, conduction rather than convection determines the temperature distribution in the molten zone. Moreover, thermocapillary convection rather than mass-transfer convection becomes dominant. The symmetry and mass flow rate of double eddy pattern are significantly influenced by the molten-zone shape due to the diameter reduction and the large surface-tension-temperature coefficient in the order of 10-4~10-3. According to the analysis shown as above, the results could be further extended for the analysis of the concentration profile and study of horizontal growth.
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Analysis of anti-cancer drug penetration through multicell layers in vitro : the development and evaluation of an in vitro model for assessing the impact of convective fluid flow on drug penetration through avascular cancer tissuesMakeen, Hafiz Antar Mohammad January 2012 (has links)
High interstitial fluid pressure (IFP) in tumours is recognized as a barrier to drug delivery resulting in reduced efficacy. High IFP impedes the normal process of convective fluid flow (CFF) from blood vessels into the interstitium. The aim of this study was to develop an in vitro model that could be used to measure CFF and to study its effects on drug delivery. The model consists of a transwell cell culture insert which supports the growth of multicell layers (MCL) on collagen coated membranes. A graduated tube is inserted into the transwell and a pressure gradient is applied across the membrane by raising the volume of medium in the tube above that of the bottom chamber. CFF is determined by measuring the weight of medium in the bottom chamber as a function of time. CFF was inversely proportional to MCL thickness and 41.1±3.6µm thick MCL has completely stopped CFF. Using a physiologically relevant hydrostatic pressure of 28mmHg, a CFF of 21µL/min was recorded using a DLD-1 MCL that was 12.21±3.2µm thick. Under these conditions, the rates of penetration of doxorubicin, imatinib and gefitinib were respectively 42, 26 and 13 folds greater than when no CFF exists. Reversing the CFF so that it opposed the drug diffusion gradient significantly impairs drug penetration. In conclusion, a novel in vitro model for assessing the impact of CFF on drug delivery has been developed. This model could be used to evaluate strategies designed to increase drug delivery to solid tumours by modifying the CFF.
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Mechanical, failure and flow properties of sands : micro-mechanical modelsManchanda, Ripudaman 12 July 2011 (has links)
This work explains the effect of failure on permeability anisotropy and dilation in sands. Shear failure is widely observed in field operations. There is incomplete understanding of the influence of shear failure in sand formations. Shear plane orientations are dependent on the stress anisotropy and that view is confirmed in this research. The effect of shear failure on the permeability is confirmed and calculated. Description of permeability anisotropy due to shear failure has also been discussed.
In this work, three-dimensional discrete element modeling is used to model the behavior of uncemented and weakly cemented sand samples. Mechanical deformation data from experiments conducted on sand samples is used to calibrate the properties of the spherical particles in the simulations. Orientation of the failure planes (due to mechanical deformation) is analyzed both in an axi-symmetric stress regime (cylindrical specimen) and a non-axi-symmetric stress regime (right cuboidal specimen). Pore network fluid flow simulations are conducted before and after mechanical deformation to observe the effect of failure and stress anisotropy on the permeability and dilation of the granular specimen.
A rolling resistance strategy is applied in the simulations, incorporating the stiffness of the specimens due to particle angularity, aiding in the calibration of the simulated samples against experimental data to derive optimum granular scale elastic and friction properties. A flexible membrane algorithm is applied on the lateral boundary of the simulation samples to implement the effect of a rubber/latex jacket. The effect of particle size distribution, stress anisotropy, and confining pressure on failure, permeability and dilation is studied.
Using the calibrated micro-properties, simulations are extended to non-cylindrical specimen geometries to simulate field-like anisotropic stress regimes. The shear failure plane alignment is observed to be parallel to the maximum horizontal stress plane. Pore network fluid flow simulations confirm the increase in permeability due to shear failure and show a significantly greater permeability increase in the maximum horizontal stress direction. Using the flow simulations, anisotropy in the permeability field is observed by plotting the permeability ellipsoid. Samples with a small value of inter-granular cohesion depict greater shear failure, larger permeability increase and a greater permeability anisotropy than samples with a larger value of inter-granular cohesion. This is estimated by the number of micro-cracks observed. / text
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Temperature proton exchange membrane fuel cells in a serpentine designMaasdorp, Lynndle Caroline January 2010 (has links)
<p>The aim of my work is to model a segment of a unit cell of a fuel cell stack using numerical methods which is classified as computational fluid dynamics and implementing the work in a commercial computational fluid dynamics package, FLUENT. The focus of my work is to study the thermal distribution within this segment. The results of the work aid in a better understanding of the fuel cell operation in this temperature range. At the time of my investigation experimental results were unavailable for validation and therefore my results are compared to previously published results published. The outcome of the results corresponds to this, where the current flux density increases with the increasing of operating temperature and fixed operating voltage and the temperature variation across the fuel cell at varying operating voltages. It is in the anticipation of determining actual and or unique material input parameters that this work is done and at which point this studies results would contribute to the understanding high temperature PEM fuel cell thermal behaviour, significantly.</p>
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Insights into the distribution and mobility of metals in the sheeted dike complex formed at fast-spreading ridges (Pito Deep, EPR)Zoeller, Khalhela 17 April 2014 (has links)
Hydrothermal fluid circulation is an important process in the formation and evolution of ocean crust. A tectonic window located at Pit Deep (NE corner Easter Microplate) provides an ideal location to examine a 3-dimensional view of ocean crust formed at the fast-spreading East Pacific Rise. This study focuses on the base metal (Cu, Ni, Mn, Co, Zn, and Pb) content of the bulk rock and mineral components in the sheeted dike complex. There is no observable trend of metal mobility with depth, geographic location, or dominant alteration phase. Secondary mineral analyses (using LA-ICP-MS) show that metals are redistributed throughout the sheeted dikes, entering into secondary sulphides, chlorite, and amphibole. Temperature and mineral stability is a primary control of metal mobility in these rocks. Due to highly variable metal concentrations and observed temperatures of alterations, the hydrothermal cell is suggested to be a continuously evolving system, and can cause the large variability observed in the metal distribution in the sheeted dikes. / Graduate / 0996 / 0411 / 0372
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Analysis of a discrete element method and coupling with a compressible fluid flow methodMonasse, Laurent 10 October 2011 (has links) (PDF)
This work aims at the numerical simulation of compressible fluid/deformable structure interactions. In particular, we have developed a partitioned coupling algorithm between a Finite Volume method for the compressible fluid and a Discrete Element method capable of taking into account fractures in the solid. A survey of existing fictitious domain methods and partitioned algorithms has led to choose an Embedded Boundary method and an explicit coupling scheme. We first showed that the Discrete Element method used for the solid yielded the correct macroscopic behaviour and that the symplectic time-integration scheme ensured the preservation of energy. We then developed an explicit coupling algorithm between a compressible inviscid fluid and an undeformable solid. Mass, momentum and energy conservation and consistency properties were proved for the coupling scheme. The algorithm was then extended to the coupling with a deformable solid, in the form of a semi-implicit scheme. Finally, we applied this method to unsteady inviscid flows around moving structures: comparisons with existing numerical and experimental results demonstrate the excellent accuracy of our method
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Differences in staurolite mode due to changes in bulk composition as an effect of mass transfer by fluids during metamorphismNilsson, Jonas January 2014 (has links)
Results from petrographic analyses, chemical analyses and mineral phase diagram calculations show that staurolite minerals grew in selvages adjacent to quartz veins. Previous studies show the same relationships between quartz veins and garnet, as well as kyanite growth. The selvages are formed as metamorphic fluids flow through cracks, altering the bulk composition by mass transfer and triggers the nucleation and growth of new minerals. A pseudosection for a staurolite absent sample has been calculated using THERMOCALC. No stability field correlates to visually observed mineralogy. This indicates that a reaction forming staurolite never was triggered since no fluids was present during metamorphism.
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Fluid Dynamics of Carbon Dioxide Disposal into Saline AquifersGarcia, Julio Enrique January 2003 (has links)
Thesis (Ph.D.); Submitted to the University of California, Berkeley, CA (US); 18 Dec 2003. / Published through the Information Bridge: DOE Scientific and Technical Information. "LBNL--54280" Garcia, Julio Enrique. USDOE Director. Office of Science. Basic Energy Sciences (US) 12/18/2003. Report is also available in paper and microfiche from NTIS.
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[en] PERMEABILITY ESTIMATION IN TURBIDITE CHANNELS CONSTRAINED BY WELL-TESTING / [pt] ESTIMATIVA DA PERMEABILIDADE EM CANAIS TURBIDÍTICOS USANDO DADOS DE TESTE DE FORMAÇÃOTAMIRES PEREIRA PINTO DA SILVA 08 January 2019 (has links)
[pt] O principal objetivo deste trabalho é preencher canais turbidíticos com alguma propriedade petrofísica, como a permeabilidade. Estes canais são geometricamente limitados por lobos turbidíticos, gerando a simulação de um sistema deposicional. Simulações numéricas são usadas para tentar ajustar a permeabilidade a um caso de referência por meio de uma função objetivo. Um simulador convencional de diferenças finitas foi usado para comparar os dados de referência com as simulações, obtendo resultados próximos. / [en] The main objective of this work is to populate turbidite channels with some petrophysical property such as permeability. These channels are geometrically constrained by turbidite lobes creating a simulated depositional system. Numerical simulations are used to try to fit the permeability field to a reference case through an objective function. A conventional finite difference simulator was used to compare the reference
data to the simulations, obtaining close results.
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[en] NUMERICAL ANALYSIS OF THE FLOW AND STABILITY OF A COPPER ORE HEAP LEACH / [pt] ANÁLISE NUMÉRICA DO FLUXO E DA ESTABILIDADE DE UMA PILHA DE LIXIVIAÇÃO DE MINÉRIO DE COBREPEDRO GABINO MENDOZA PACHECO 08 February 2006 (has links)
[pt] Esta dissertação apresenta uma análise numérica do fluxo
não saturado em uma
pilha de lixiviação de minério de cobre. Adicionalmente,
foi feito também um
estudo da estabilidade estática e sísmica da pilha de
lixiviação, por sua construção
estar planejada em região de alta sismicidade no sul do
Peru. A pilha será
construída com minério de cobre não tratado sobre base
impermeável para evitar a
contaminação do meio ambiente por fluxo da solução ácida
através da fundação.
Os resultados obtidos nas análises numéricas indicam que a
pilha de lixiviação
apresenta fatores de segurança satisfatórios considerando
sismos de magnitude até
7,5 com aceleração máxima de até 0,30g. Da mesma forma,
constatou-se que a
posição da linha freática formada pela solução de
lixiviação não atinge as
camadas previstas para proteção das tubulações de drenagem. / [en] This dissertation presents a numerical analysis for the
non saturated flow
throughout a copper ore heap leach. Additionally, static
and dynamic stability
analyses were also made because the heap leach is planned
to be built in a highly
seismic region in the south of Peru. The heap will be
constructed with non-treated
copper ore (run of mine) on impermeable pad specially
devised to avoid any
possibility of ground contamination by the flow through
the foundation of the acid
solution used for the lixiviation process. The numerical
results obtained in the
stability analyses indicate that the heap leach presents
satisfactory safety factors
even when considering earthquakes of magnitude 7.5 with
maximum acceleration
of 0.30g. It has been also observed that the phreatic line
formed by the lixiviation
fluid does not reach the layers devised to protect the
drainage pipes of the
lixiviation system.
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