A sense of place is important to the construction, believability and success of regional mystery novels. Authentic representation of place is challenging if an author is not originally from the area being portrayed. Despite this, some authors are able to depict foreign places more comprehensively and realistically than others. Professor Gary Hausladen of the University of Nevada, Reno identifies: narrative description, dialogue, iconography, and attention to detail as the basic literary devices that convey sense of place. This thesis questions the manner in which successful mystery novelists writing about foreign places meet Hausladen's model. Specifically, do they use all four of the literary devices, which are most commonly used, which are consciously used, and what research methods and resources do they use to incorporate the literary devices. Primary and secondary data are collected through interviews and literary analyses. It is found that these authors use all four of the prescribed literary devices, that some of the literary devices are more challenging to use than others, that place establishing literary techniques are important to the authors and that the authors seek to incorporate sense of place through diverse types of intensive research.

This dissertation suggests that burgeoning public discourse on contraception in Britain and the United States between 1915 and 1940 created a paradigm shift in perceptions of women’s sexuality that altered the ways that women could be represented in literary texts. It offers readings of texts by women on both sides of the Atlantic who responded to birth control discourse not only by referencing contraceptive techniques, but also by incorporating arguments and dilemmas used by birth control advocates into their writing. The introductory chapter, which frames the later literary analysis chapters, examines similarities in the tropes Margaret Sanger and Marie Stopes, the British and American “Mothers of Birth Control” used in their advocacy. These include images such as mothers dying in childbirth, younger children in large families weakened by their mothers’ ill-health, and sexual dysfunction in traditional marriages. In addition to this chapter on birth control advocates’ texts, the dissertation includes four chapters meant to demonstrate how literary authors used and adapted the tropes and language of the birth control movement to their own narratives and perspectives. The first of these chapters focuses on Charlotte Perkins Gilman’s Herland, a 1915 political allegory about a nation populated only by women who have gained the ability to reproduce asexually. Gilman adopted pro-birth control language, but rejected the politically radical ideas of the early birth control movement. In addition to radical politics, the birth control movement was associated with racist eugenicist ideas, an association that the third chapter, on Nella Larsen’s 1928 novel Quicksand examines in detail by comparing birth control and African-American racial uplift rhetoric. Crossing the Atlantic, the fourth chapter looks at the influence of the English birth control movement on Irish novelist Kate O’Brien’s 1931 Without My Cloak, a novel that challenges Catholic narratives as well as the heteronormative assumptions of birth control discourse itself. The final chapter analyzes Virginia Woolf’s Mrs. Dalloway (1925) and Three Guineas (1938), illuminating Woolf’s connections between feminist reproductive politics and conservative pro-eugenics agendas. Acknowledging the complexity of these writers’ engagements with the birth control movement, the project explores not simply the effects of the movement’s discourse on writers’ depictions of sexuality, reproduction, and race, but also the dialogue between literary writers and the birth control establishment, which comprises a previously overlooked part of the formation of both the reproductive rights movement and the Modernist political project.

“Human/Nature: American Literary Naturalism and the Anthropocene” examines works of fiction from the genre of American literary naturalism that sought to represent the emergence of the environmental crisis known today as the Anthropocene. Reading works by Jack London, Frank Norris, Charlotte Perkins Gilman, and Charles W. Chesnutt, I show how the genre’s well-known tropes of determinism, atavism, and super-individual scales of narration were used to create narratives across vast scales of space and time, spanning the entire planet as well as multi-epochal stretches of geologic time. This reading expands existing definitions of American literary naturalism through a combination of literary analysis, engagement with contemporary theory, and discussion of the historical context of proto-Anthropocenic theories of the late-19th and early-20th centuries. Whereas most earlier understandings of naturalism have focused on human nature as it is determined by environmental conditions, I follow the inverse: the impact of collective human action on the physical environment. Previous definitions of naturalism have only told part of the story of determinism, making it impossible to recognize until now the genre’s unusual capacity to aesthetically capture humanity’s pervasive impact on the planet. Each of the dissertation’s four chapters focuses on a single author, a single aesthetic strategy, and a single problematic in Anthropocene discourse. My first chapter argues that Jack London’s late work (1906–1916) balanced his attempts to understand the human as a species with a growing interest in sustainable agriculture, resulting in a planetary theorization of environmental destruction through careless cultivation. But London’s human-centered environmental thinking ultimately served his well-known white supremacism, substantiating recent critiques that the Anthropocene’s universalism merely reproduces historical structures of wealth and power. Rather than the human per se, Frank Norris put his focus on finance capitalism in his classic 1901 novel The Octopus, embodying the hybrid human/natural force that he saw expanding over the face of the planet in the figure of the Wheat, a cultivated yet inhuman force that is as much machine as it is nature. I show how Norris turned Joseph LeConte’s proto-Anthropocenic theory of the Psychozoic era (1877) into a Capitalocene aesthetics, a contradictory sublimity in which individuals are both crushed by and feel themselves responsible for the new geologic force transforming the planet. While London and Norris focus on the destructive capacities of human agency, Charlotte Perkins Gilman’s 1915 novel Herland takes a utopian approach, depicting a society of women with total control of their environment that anticipates conceptions of a “good Anthropocene.” Gilman built on the theories of sociologist and paleobotanist Lester Ward as well as her own experience in the domestic reform movement to imagine a garden world where the human inhabitants become totally integrated into the non-human background. Yet Gilman’s explicitly eugenic system flattens all heterogeneity of culture, wealth, and power into a homogenous collective. My final chapter builds on the critique of the Anthropocene’s universalism that runs through the preceding chapters by asking whether and how the Anthropocene can be approached with more nuance and less recourse to universals. I find an answer in the stories of Charles W. Chesnutt’s The Conjure Woman (1899) and the theory of the Plantationocene, which sees the sameness of the Anthropocene not as “natural” but as produced by overlapping forms of racial, economic, and biological oppression. Registering this production of homogeneity and its counterforces at once, Chesnutt models what I call Anthropocene heteroglossia, juxtaposing multiple dialects and narrative forms in stories set on a former plantation, depicting heterogeneous social ecologies as they conflict and coexist in markedly anthropogenic environments.

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Les romans *Herland* de Charlotte Perkins Gilman (1915), *The Female Man* de Joanna Russ (1975) et *Chroniques du Pays des Mères* d'Élisabeth Vonarburg (1992) mettent tous les trois en scène une société utopique exclusivement composée de personnages féminins. Considérant que la science-fiction imagine des mondes autres en reprenant souvent des conceptions stéréotypées, voire sexistes, des femmes, diverses écrivaines, dont Gilman, Russ et Vonarburg, ont repensé la société sous forme d'utopie afin d'illustrer leur capacité à voir le monde autrement, c'est-à-dire dans des contextes où elles ne seraient pas reléguées au second plan. Notre mémoire cherche à prendre la mesure de l'évolution de la représentation des femmes dans les utopies féministes et incidemment à souligner ses liens avec les préoccupations féministes contemporaines à leur parution. Ce mémoire propose une analyse des différents discours qui sont tenus dans les romans, dans les écrits non fictionnels des écrivaines ainsi que dans les entretiens qu'elles ont réalisées au cours de leur carrière afin de déterminer si ceux-ci peuvent être associés aux mouvances féministes de chacune des époques concernées. En nous penchant sur les rôles sociaux, la maternité et les pratiques sexuelles au sein de ces récits, nous interrogeons la manière dont ces auteures remettent en question ou perpétuent les stéréotypes de genre dans la science-fiction.

En collaboration avec les Laboratoires Servier, nous présentons la synthèse d'une nouvelle famille d'inhibiteurs portant un groupe thiol ou carboxyle, développé comme antagoniste du TAFIa en vue d'une nouvelle thérapie antithrombotique et thrombolytique. L'étape clé de cette synthèse consiste en la formation de motifs β-lactames gem-difluorés. Dans ce but, la synthèse chimio- et stéréosélective de β-aminoesters et de β-lactames gem-difluorés à partir du bromodifluoroacétate d'éthyle et d'imines par réaction de Reformatsky a été étudiée. L'influence de paramètres réactionnels variés, la nature de l'amine et de l'aldéhyde, la nature de l'auxiliaire chiral ont été évaluées. De hauts degrés de stéréosélectivité (jusqu'à 98%) ont été obtenus pour les gem-difluoro-β-aminoesters et les gem-difluoroazétidin-2-ones en employant soit le (R)-phénylglycinol soit le (R)-méthoxyphénylglycinol. Nous avons également développé une procédure efficace pour effectuer la synthèse de gem-difluoro-β-lactames racémiques. Ces composés ont été obtenus par réaction de Reformatsky entre le bromodifluoroacétate d'éthyle et diverses imines de la p-méthoxybenzylamine. La synthèse de gem-difluoro-β-aminoesters racémiques est accomplie par réaction de Gilman-Speeter entre un sel d'iminium généré selon la procédure de Katritzky et le bromodifluoroacétate d'éthyle. Après une déprotection efficace de ces gem-difluoro-β-aminoesters et gem-difluoro-β-lactames, nous avons étudié la N-alkylation et la N-acylation pour l'introduction du groupe chélateur du zinc, e.g. un groupe portant un acide carboxylique ou un thiol, ainsi qu'un groupe espaceur. Après déprotection, ces composés ont été évalués pour l'inhibition de la carboxypeptidase U par la Division Angiologie de l'IdRS. Malheureusement tous ces dérivés n'ont présenté qu'une IC50 supérieure à 33 rM. Néanmoins, nous avons développé une méthode générale et efficace pour synthétiser des dérivés pseudopeptidiques gem-difluorés comme des building blocks originaux, avec une large gamme d'application.

<p>This dissertation examines Charles Darwin’s major texts together with literary works by turn-of the-century American women writers—Nella Larsen, Charlotte Perkins Gilman, and Kate Chopin—in order to trace how evolutionary theory shaped transatlantic cultural ideas of race, particularly black identity, and gender. I focus on the concept of “descent” as the overarching theme organizing categories of the human in evolutionary terms. My perspective and methods—examining race and gender from a black feminist perspective that draws on biopolitics theory, as well as using close reading, affect theory, and attention to narrative in my textual analysis—comprise my argument’s framework. By bringing these perspectives and methods together in my attention to the interplay between Darwinian discourse and American literature, I shed new light on the turn-of-the-century transatlantic exchange between science and culture. Throughout this dissertation, I argue that descent constitutes a central concept and point of tension in evolutionary theory’s inscription of life’s development. I also show how themes of human-animal kinship, the Western binary of rationality and materiality, and reproduction and maternity circulated within this discourse. I contribute to scholarly work relating evolutionist discourse to literature by focusing on American literature: in the context of turn-of-the-century American anxieties about racial and gender hierarchies, the evolutionist paradigm’s configurations of human difference were especially consequential. Moreover, Larsen, Gilman, and Chopin offer responses that reveal this hierarchy’s varied effects on racialized and gendered bodies. I thus demonstrate the significance of examining Darwinian discourse alongside American literature by women writers, an association in need of deeper scholarly attention, especially from a feminist, theoretical perspective. </p><p>This dissertation begins with my application of literary analysis and close reading to Darwin’s major texts in order to uncover how they formed a suggestive foundation for late nineteenth- to early twentieth-century ideologies of race and gender. I use this analysis as the background for my investigation of Larsen’s, Gilman’s, and Chopin’s literary texts. In Chapter 1, I conduct a close reading of Darwin’s articulation of natural selection in <i>The Origin of Species</i>and focus on how Darwin’s syntactical and narrative structure imply evolution as an agential force aimed at linear progress. In Chapter 2, I analyze Darwin’s articulation of the development of race and gender differences in <i>The Descent of Man</i>, as well as Thomas Henry Huxley’s <i>Evidence as to Man’s Place in Nature</i>, and argue that Darwin’s and Huxley’s accounts suggest how anxiety over animal-human kinship was alleviated through structuring nonwhite races and women as less developed and hence inferior. In Chapter 3, I argue that Larsen’s novel <i>Quicksand </i>interrogates and complicates aesthetic primitivism and biopolitical racism and sexism, both rooted in evolutionist discourses. Finally, in Chapter 4, I focus on Gilman’s utopian novel <i>Herland</i>and select short stories by Chopin. While Gilman unambiguously advocates for a desexualized white matriarchy, Chopin’s stories waver between support for, and critique of, racial hierarchy. Reading these authors together against the backdrop of white masculine evolutionist theory reveals how this theory roots women as materially bound reproducers of racial hierarchy.</p>

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