A solo-quartet by Hoffmeister previously unpublished was discovered by the author in the archives of the Gesellschaft der Musikfreunde in Vienna. This work contributes to the modern solo repertoire for double bass, and has considerable musical merit. It is a well written work using cleverly overlapped phrases, counterpoint and imitative writing, and effective juxtaposition of contrasting instrumentation. It lies well on the bass and provides an excellent solo vehicle for advanced bassists.

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The aim of this thesis is to present the life and work of Adolf Hoffmeister and show its relationship to the book from the perspective of the reader and author. The thesis is divided into three main parts. The first part relating to significant events in the life of Adolf Hoffmeister is followed by an overview of his creative and literary works related to the book and book culture. The substantial point of this work is to discribe and analyze Hoffmeister's library and his reading interests.

Made available in DSpace on 2015-07-22T20:50:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-07-29 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / A quitosana (Chi), a (1-4)-amino-2-desoxi-ƒÒ-glicana, e a forma desacetilada da quitina, um polissacarideo das conchas de crustaceos. As suas caracteristicas unicas como a carga positiva, biodegradabilidade, biocompatibilidade, atoxicidade e estrutura rigida fazem com que esta macromolecula seja ideal para uso como sistema oral de entrega de vacinas. Foram preparadas vesiculas unilamelares grandes (REVs) envoltas por dentro e por fora (como um sanduiche) com quitosana (Chi) e poli-vinil alcool (PVA). Entretanto, existem alguns problemas as serem superados com relacao a estabilizacao da proteina durante este processo. Durante a fase de formacao de micelas reversas, no processo de nanoencapsulacao da proteina, expandem-se as interfaces hidrofobicas que entao levam as adsorcoes interfaciais seguidas por desenovelamento e agregacao das proteinas. Aqui, observaram-se atraves de tecnicas espectroscopicas e imunologicas, o uso dos sais da serie de Hoffmeister durante a fase de formacao de micela reversa para estudar a conformacao estavel do toxoide difterico (Dtxd). Foi estabelecida uma correlacao entre os sais usados na fase aquosa e as variacoes na solubilidade e conformacao de Dtxd. Como o conteudo em helice-ƒÑ foi praticamente estavel concluiu-se que a encapsulacao de Dtxd ocorreu sem agregacao ou sem exposicao de residuo hidrofobico na proteina. A agregacao de Dtxd foi evitada em 98 % quando se usou o cosmotropico PO2-4. Este ion foi usado para se preparar uma formulacao de Dtxd em REVs-Chi-PVA estavel e com identidade imunologica reconhecida na presenca de PO2-4. Entao, obteve-se uma solubilidade e estabilidade maxima de Dtxd depois de seu contacto com CH3CO2C2H5 para comecar a sua nanoencapsulacao em condicoes ideais. Este foi um avanco tecnologico importante porque uma solucao simples, como e a adicao de sais, evitou o uso de proteinas heterologas (Rescia et alii, 2009a). A proteina estabilizada foi entao encapsulada dentro de REVs como o descrito. Os lipossomas tem sido descritos como adjuvantes desde 1974 (Allison e Gregoriadis, 1974). A maior limitacao de seu uso em vacinas orais e a sua instabilidade estrutural causada pelas atividades enzimaticas do meio. O objetivo aqui foi combinar lipossomas, que podem encapsular antigenos (Dtxd, Diphtheria toxoid) com quitosana que protege estas particulas e promove a mucoadesibilidade. Empregaram-se tecnicas fisicas para se entender o processo pelo qual lipossomas (SPC: Cho, 3: 1) podem ser recobertos (interna e externamente) com quitosana (Chi) e PVA (poly-vinilic-alcohol) que sao polimeros biodegradaveis e biocompativeis. Obtiveram-se particulas de REVs-Chi (vesiculas preparadas por evaporacao de fase reversa recobertas interna e externamente com Chi) redondas e com as superficies rugosas e estabilizadas ou nao com PVA. As eficiencias de encapsulacao (Dtxd foi usada como antigeno) foram diretamente dependentes da presenca de Chi e PVA na formulacao. A adsorcao de Chi a superficie de REVs foi acompanhada por um aumento no potencial ƒê. Em contraste, a adsorcao de PVA a surperficie de REVs-Chi foi acompanhada por uma diminuicao do potencial . A presenca de Dtxd aumentou a eficiencia de adsorcao de Chi as superficies. A afinidade de PVA pela mucina foi 2000 vezes maior do que a observada somente com Chi e nao depende se a molecula esta em solucao ou se esta adsorvida a superficie lipossomal. A liberação do Dtxd foi retardada por sua encapsulação dentro de REVs-Chi-PVA. Concluiu-se que estas novas vesículas estabilizadas foram hábeis em se adsorverem às superfícies intestinais, resistiram às degradações e controlaram a liberação do antígeno. Assim, as partículas de REVs-Chi-PVA podem ser usadas como um veículo oral com capacidade adjuvante (Rescia et alii, 2009b). Os lipossomas revstidos por quitosana (REVs-Chi) como veículos orais para transporte de vacinas foram bem caraterizados neste laboratório. Estas partículas foram desenhadas para serem capturadas pelo muco, para interagirem com surperfícies orais e para resistirem às enzimas do trânsito gástrico. Foram usadas três formulações diferentes contendo o Dtxd (toxoide diftérico) para imunizar camundongos: REVs [Vesículas unilamelares obtidas por evaporação de fase reversa produzidas com SPC: Cho (3:1)]; REVs-Chi (REVs recobertas por Chi) e REVs-Chi-PVA (REVs recobertas por Chi e estabilizadas por PVA). Através do teste de adesibilidade e dos experimentos com anti-toxoide diftérico observou-se que houve uma correlação direta entre a complexidade da partícula (antígeno livre < REVs < REVs-Chi < REVs-Chi-PVA) e a produção de anticorpos (IgA, IgG1 and IgG2a) em todos os ensaios (R= 0,91766- 0,99718). O resultado mais interessante foi a total ausência da produção de IgA nos camundongos imunizados com o antígeno livre, provando então a excelência das partículas engenheiradas. Além do aumento da produção dos anticorpos de mucosa, ambas formulações com Chi ou com Chi-PVA estimularam tanto a produção de anticorpos humorais quanto a seletividade. Demonstrou-se que é possível de se estabelecer uma correlação entre REVs-Chi/Dtxd and REVs-Chi-PVA/Dtxd e o aumento da imunidade de mucosa. Estas partículas podem ser usadas como veículo geral tanto para transporte de drogas quanto de vacinas (Rescia et alli, 2009c). / Chitosan, - (1-4)-amino-2-deoxy-D-glucan) is a deacetylated form of chitin, a polysaccharide from crustacean shells. Its unique characteristics such as positive charge, biodegradability, biocompatibility, non-toxicity, and rigid structure make this macromolecule ideal for oral vaccine delivery system. We prepared reverse phase evaporation vesicles (REVs) sandwiched by chitosan (Chi) and polyvinylic alcohol (PVA). However, in this method there are still some problems to be circumvented related to protein stabilization. During the inverted micelle phase of protein nanoencapsulation, hydrophobic interfaces are expanded leading to interfacial adsorption followed by protein unfolding and aggregation. Here, spectroscopic and immunological techniques were used to ascertain the effects of the Hoffmeister series ions on Diphtheria toxoid (Dtxd) stability during the inverted micelle phase. A correlation was established between the salts used in aqueous solutions and the changes in Dtxd solubility and conformation. Dtxd α-helical content was quite stable what led us to conclude that encapsulation occurred without protein aggregation or without exposition of hydrophobic residues. Dtxd aggregation was 98 % avoided by the kosmotropic PO2-4. This ion was used to prepare a stable Dtxd and immunologically recognized REVs-Chi-PVA formulation in the presence of 50 mM PO42-. Under these conditions the Dtxd retained its immunological identity. Therefore, we could obtain the maximum Dtxd solubility and stability after contact with CH3CO2C2H5 to begin its nanoencapsulation within ideal conditions. This was a technological breakthrough because a simple solution like salt addition avoided heterologous proteins usage (Rescia et al., 2009a). The stabilized protein was as encapsulated within REVs as described. Liposomes have been used as adjuvants since 1974 (Allison and Gregoriadis, 1974). One major limitation for the use of liposomes in oral vaccines is the lipid structure instability caused by enzyme activities. Our goal was to combine liposomes which can encapsulate antigens (Dtxd, diphtheria toxoid) with chitosan which protects the particles and promotes mucoadhesibility. We employed physical techniques to understand the process by which liposomes (SPC: Cho, 3:1) can be sandwiched with chitosan (Chi) and stabilized by PVA (Poly-vinylic alcohol) which are biodegradable and biocompatible polymers. Round and smooth surfaced particles of REVs-Chi (Reversed phase vesicles sandwiched by Chi) stabilized by PVA were obtained. The REVs encapsulation efficiencies (Dtxd was used as the antigen) were directly dependent on the Chi and PVA present in the formulation. Chi adsorption on REVs surface was accompanied by an increase of &#61562; otential. In contrast, PVA adsorption on REVs-Chi surface was accompanied by a decrease of potential. The presence of Dtxd increased the Chi surface adsorption efficiency. The PVA affinity by mucine was 2000 higher than that observed with Chi alone and did not depend on the molecule being in solution or adsorbed on the liposomal surface. The liberation of encapsulated Dtxd was retarded by encapsulation within REVs-Chi-PVA. These results lead us to conclude that these new and stabilized particles were to able to adsorb to intestinal surfaces, resisted degradation and controlled the antigen release. Therefore, REVs-Chi-PVA particles can be used as an oral delivery adjuvant (Rescia et al., 2009b). Liposomes sandwiched by chitosan (REVs-Chi) as vehicles for oral vaccines have been well characterized in our laboratory. These particles were designed to be captured by mucus, to interact with oral surfaces and to withstand the enzymes of the gastric transit. Three different formulations containing Dtxd (diphtheria toxoid): REVs [reverse phase evaporation vesicles of SPC: Cho (3: 1)]; REVs-Chi (REVs sandwiched by chitosan) and REVs-Chi-PVA were used to immunize mice. Through adhesibility assays and antibody anti-diphtheria experiments we observed a direct correlation between particle complexity (free antigen < REVs < REVs-Chi < REVs-Chi-PVA) and antibody production (IgA, IgG1 and IgG2a) in all the assays (R= 0,91766- 0,99718). The most striking result was the absence of IgA production in those mice immunized with the free antigen, proving the excellence of the engineered particles. In addition to enhancement of mucosal antibodies production, the formulations with Chi and PVA stimulated both, humoral antibody production and selectivity. We have shown that it was possible to establish a correlation between REVs-Chi/Dtxd and REVs-Chi-PVA/Dtxd and the enhancement of mucosal immunity. These particles can be used as a general vehicle for oral drug or vaccine delivery systems (Rescia et al., 2009c). / TEDE / BV UNIFESP: Teses e dissertações

Illustration of Czech popular music sheet covers in the first half of the 20th century Abstract This diploma thesis focuses on the visual form of popular music sheet covers published in selected publishers in the first half of the 20th century, especially on small formats of the twenties to forties. Many Czech as well as several foreign artists influenced by various artistic tendencies took part in the artistic processing of the covers. The creation of a large part of them is closely connected with illustration, poster creation and advertising activities. Some artists have been creating covers systematically and we can find their work in several publishers, but for some this activity was only a short episode in their work. The resulting prints of music sheet covers obtained in the institutions that collect them are documented and evaluated here - especially the Music Department of the National Library and the Czech Museum of Music belonging to the National Museum in Prague. In some cases, this section also records the original illustrations stored in the Museum of Applied Arts in Prague, which were very helpful in identifying the artistic practices. It is clear from this diploma thesis that the illustrations of these sheet music, which have not been given space in the literature so far, are an important...

It is well known that ions affect polymers in specific ways not solely based on electric charge, usually referred to as the Hoffmeister effect or ion specific effects. Poly(N-isopropylacrylamid) (PNIPAM) is a thermosensitive polymer with a LCST at 32℃. PNIPAM is a well studied polymer due to its similarities with denaturation of proteins in aqueous solutions. Utilizing diffusion NMR this report studied the effect different Hoffmeister anion concentrations have on the configuration of pre-transitional PNIPAM. A fractionation process was developed for PNIPAM, yielding a product of about 87 000 g/mol, used for diffusion measurements. Diffusion coefficients for PNIPAM in saline solutions ranging from 0 to 800 mM were measured for NaCl, NaClO4, NaSCN and NaI. Diffusion coefficients for PNIPAM were also measured at some concentrations of NaF, Na2SO4 and Na2CO3. Hydrodynamic radius was calculated from the diffusion coefficients. The report found a pre-transitional chain collapse of PNIPAM which increased with ionic concentrations of NaCl, NaClO4, NaSCN, NaF and Na2CO3, but not for NaI and Na2SO4. At 800 mM the hydrodynamic radius decreased with 9% for NaCl, 13% for NaClO4 and 5% for NaSCN. The hydrodynamic radius decreased with 19% at 300 mM Na2CO3 and with 10% at 400 mM NaF. There was a significant decrease in hydrodynamic radius for high concentrations of NaCl and NaClO4 but exact decrease needs to be replicated to validate the findings due to an unexpected large decrease in hydrodynamic radius already at 50 mM. Values for NaF and Na2CO3 should be replicated with internal standard to accomodate for possible precipitation of the longer polymer chains within the fraction.

Studies on Canadian Army military intelligence remain sparse in Canadian military historiography. This study is unique in that it focuses on the development, doctrine, and influence of intelligence within the I Canadian Corps throughout the Liri Valley battles during the Italian Campaign. It will be argued that I Canadian Corps intelligence achieved notable overall success in helping to break the Hitler Line by providing comprehensive and relatively up-to-date information on enemy dispositions and strengths which helped commanders and staff planners properly prepare for the operation. This success was attributable to three main factors: excellent intelligence personnel selection and training; the successful mentorship of I Canadian Corps intelligence by Eighth Army's intelligence cadre; and the overall effectiveness of 1st Canadian Infantry Division's intelligence organization which had been in the Mediterranean theatre since July 1943. Notwithstanding these successes, a number of faults within the Canadian Corps intelligence system must also be explained, including the poor performance of 5th Canadian Armoured Division's intelligence organization during the pursuit up the Liri–Sacco Valleys, and the mediocre execution of Corps counter-battery and counter-mortar operations. This study will demonstrate how an effective intelligence organization must augment existing army doctrine and how it can mitigate, though not completely eliminate, battlefield uncertainty. Further, it will also demonstrate that a comprehensive lessons-learned process must be undertaken to continually refine existing intelligence doctrine and procedures, with frequent training programs inculcating personnel in this doctrine. Taken as a whole, this study is unique as it is one of only several studies devoted solely to developing a greater understanding of a little-understood, and often forgotten, staff function within the Canadian Army during the Second World War.

Studies on Canadian Army military intelligence remain sparse in Canadian military historiography. This study is unique in that it focuses on the development, doctrine, and influence of intelligence within the I Canadian Corps throughout the Liri Valley battles during the Italian Campaign. It will be argued that I Canadian Corps intelligence achieved notable overall success in helping to break the Hitler Line by providing comprehensive and relatively up-to-date information on enemy dispositions and strengths which helped commanders and staff planners properly prepare for the operation. This success was attributable to three main factors: excellent intelligence personnel selection and training; the successful mentorship of I Canadian Corps intelligence by Eighth Army's intelligence cadre; and the overall effectiveness of 1st Canadian Infantry Division's intelligence organization which had been in the Mediterranean theatre since July 1943. Notwithstanding these successes, a number of faults within the Canadian Corps intelligence system must also be explained, including the poor performance of 5th Canadian Armoured Division's intelligence organization during the pursuit up the Liri–Sacco Valleys, and the mediocre execution of Corps counter-battery and counter-mortar operations. This study will demonstrate how an effective intelligence organization must augment existing army doctrine and how it can mitigate, though not completely eliminate, battlefield uncertainty. Further, it will also demonstrate that a comprehensive lessons-learned process must be undertaken to continually refine existing intelligence doctrine and procedures, with frequent training programs inculcating personnel in this doctrine. Taken as a whole, this study is unique as it is one of only several studies devoted solely to developing a greater understanding of a little-understood, and often forgotten, staff function within the Canadian Army during the Second World War.

Studies on Canadian Army military intelligence remain sparse in Canadian military historiography. This study is unique in that it focuses on the development, doctrine, and influence of intelligence within the I Canadian Corps throughout the Liri Valley battles during the Italian Campaign. It will be argued that I Canadian Corps intelligence achieved notable overall success in helping to break the Hitler Line by providing comprehensive and relatively up-to-date information on enemy dispositions and strengths which helped commanders and staff planners properly prepare for the operation. This success was attributable to three main factors: excellent intelligence personnel selection and training; the successful mentorship of I Canadian Corps intelligence by Eighth Army's intelligence cadre; and the overall effectiveness of 1st Canadian Infantry Division's intelligence organization which had been in the Mediterranean theatre since July 1943. Notwithstanding these successes, a number of faults within the Canadian Corps intelligence system must also be explained, including the poor performance of 5th Canadian Armoured Division's intelligence organization during the pursuit up the Liri–Sacco Valleys, and the mediocre execution of Corps counter-battery and counter-mortar operations. This study will demonstrate how an effective intelligence organization must augment existing army doctrine and how it can mitigate, though not completely eliminate, battlefield uncertainty. Further, it will also demonstrate that a comprehensive lessons-learned process must be undertaken to continually refine existing intelligence doctrine and procedures, with frequent training programs inculcating personnel in this doctrine. Taken as a whole, this study is unique as it is one of only several studies devoted solely to developing a greater understanding of a little-understood, and often forgotten, staff function within the Canadian Army during the Second World War.