This project reconsiders nineteenth-century hysteria and recovery in selected works of 1990s historiographical Canadian fiction. Using a material feminist perspective, I develop an understanding of the "archival hysteric": a figure whose permeable mindbody reacts in eccentric ways to her environment. The material mindbody becomes a physiological archive of intersubjective interactions, social expectations, and past traumas. Expanding the concept of the archive to include the human subject, the family home, and the landscape, the fictions provide models for personal and social change. Chapter One explores the eccentric nature of the female body as viewed in nineteenth-century documents and in Alice Munro's "Meneseteung." This chapter focuses its analysis on the hysteric's eccentric mindbody as the site of partial recovery. I propose that moving from hysteria to sanity involves a transformation to health of the mindbody that can occur through the ethical relationship and an acknowledgement of the permeable nature of intersubjective boundaries. The nineteenth-century concept of female flow is replaced by a model of viscous porosity. Chapter Two explores how the archive functions as a metaphor for hysterical subjectivity. Following Kelly Oliver's theory of witnessing, I show how the act of shared witnessing reveals the permeable boundaries between researcher and research subject. Margaret Atwood's Alias Grace provides a case study of an archival hysteric that illustrates the ways in which shared witnessing can lead to both illness (reactivity) and health (response-ability). Chapter Three explores Away, in which Jane Urquhart mobilizes the figure of the love-mad hysteric in postcolonial and environmental contexts. The archival hysteric here represents permeability not only between human subjects, but also between human and non-human subjects. The archival hysteric illustrates human subjects' unfixed positions in the world: relying upon the binary of mental health and illness, diagnostic labels therefore misrepresent the complexity of states of being. / Thesis / Doctor of Philosophy (PhD)

Membrane bound AChE from calf brain caudate nucleus was solubilized by use of ion-free media in presence of 10~ M EDTA and 10“5M tetracaine. The irreversible release of AChE was more effectively inhibited by divalent ions compared to monovalent ions added to the medium. EDTA appears to chelate divalent ions released from the tissue while tetracaine competes with the same ions at the membrane. The tetracaine effect is restricted to the procaine series of local anesthetics. Small amounts of soluble AChE are present in the cytosol fraction. In fresh preparations most of the enzyme appeared in a form having a molecular weight of 80.000 daltons as determined by gel filtration. The enzyme seems to be released in this form. It is proposed that this form represents the monomer form of the enzyme. In solution the AChE aggregates seemingly together with a factor that is released from the membrane in amounts stafchio- metric to the enzyme. By treatment with DEAE-Sephadex the enzyme preparation can be made non-aggregating. A highly purified nonaggregating monomeric AChE Specific activity 17150 micromoles acetylthiocholine hydrolyzed per minute at 27° C per mg protein) was obtained by affinity chromatography. Some anomalous binding phenomena was observed during the affinity chromatographic purification. The main observation was that edrophonium eluted crude enzyme preparation adsorbed to the affinity gel in a biphasic manner. It was found that in the crude preparation there is present besides unspecific material competing with the enzyme for the affinity gels a factor that increases the affinity of AChE to certain cholinergic ligands. Since the enzyme could be titrated by the factor it seems to have a very high affinity to the enzyme and the biphasic elution curve is explained by the presence of free as well as factor- bound enzyme in the preparation. In search for compounds having a similar effect it was found that fluoride ion too increased the affinity of AChE to the same ligands as the factor. The affinity of edrophonium to the site defined by the binding of AChE to MTA-CH (65x10“5m) is lower than that defined by the enzyme inhibitory constant (1.8xlO“7M). As an explanation of this finding it is proposed that the substrate induces a conformation having high affinity to edrophonium, a conformation that has a comparatively low relaxation rate. Thus acetylcholinesterase may be added to the list of enzymes that have hystere- tic properties. / <p>S. 1-54: sammanfattning, s. 55-100: 4 uppsatser</p> / digitalisering@umu

Made available in DSpace on 2016-04-28T14:16:35Z (GMT). No. of bitstreams: 1 Monica Goncalves Bohmer.pdf: 366047 bytes, checksum: a17489d4c4c43ef7d0abcec370075e80 (MD5) Previous issue date: 2008-10-10 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / In this research, we have investigated the way of thinking of Sigmund Freud about pain, based on Studies in Hysteria, published in 1895. This work aproaches histery specifically, and has a grantee source for studying the proposed theme, as one of the major sympthoms in hysterical patients was some kind of pain. The painful sympthoms showed in the presented clinical cases inside the book were not identified with ease, as the nature of hystery on its own turned it difficult. Freud started to investigate the causes for hysteric pain, by hearing the patients lives history. This new way of treating the patient enabled Freud to create some theories on the origin of the painful sympthoms, as long as the clinical tasks were being developed. As a way of identifying the pressuposed facts for creating these hypothesis, we have analysed some texts which, according to the theme, would be opportunities to reflect about pain. These texts were written by Freud and are previous and contemporary to the book Studies in Hysteria. We have also analysed the researches that were happening during the 19th century, aiming to put in the context Freud s findings and to check the relation of these same findings to the medical thoughts of that time / Nesta pesquisa investigamos o pensamento de Sigmund Freud sobre a dor, utilizando, para isso, a obra Estudos sobre a Histeria, publicada em 1895. Esse livro, que aborda especificamente a histeria, contém uma privilegiada fonte para estudo do tema proposto, pois um dos principais sintomas em pacientes histéricos era algum tipo de dor. Os sintomas dolorosos, que são apresentados nos casos clínicos relatados no decorrer do livro, não eram facilmente diagnosticados, uma vez que a própria natureza da histeria dificultava o trabalho. Freud começou, então, a investigar as causas das dores histéricas, por meio da escuta da história de vida dos pacientes. Essa nova forma de tratar o doente possibilitou que Freud elaborasse algumas hipóteses sobre as origens dos sintomas dolorosos, à medida que avançava com o trabalho clínico. A fim de identificarmos os pressupostos para a elaboração dessas hipóteses, analisamos alguns textos que seriam, pelo tema, ocasiões para se refletir sobre a dor. Esses textos foram escritos por Freud e são anteriores e contemporâneos ao livro Estudos sobre a Histeria. Analisamos, também, as pesquisas que estavam sendo realizadas sobre a dor no decorrer do século XIX, com o propósito de contextualizar as descobertas de Freud e verificar as possíveis relações dessas descobertas com o pensamento médico da época

No description available.

This is an explication of Lacan’s Seminar XVII. The introduction situates the Seminar in its time and in relation to other theories of discourse. In part one I examine the changes which it brings to a variety of ideas already known in Lacan’s oeuvre such as Jouissance, Master Signifier(s) and Oedipus. Part two looks the four discourses in detail after considering the positions common to each. I provide accounts of each discourse as taking place internally to a subject and between subjects. The coda examines areas where further research is possible, reviews and critiques some scholarship on this seminar and inquires into the use value of the discourse theory, both generally and as a means of getting beyond Lacan.

According to the 2019 Canadian infrastructure report card, a concerning amount of municipal infrastructure is in poor or very poor condition. The infrastructure in this condition requires immediate action for rehabilitation or replacement. For concrete infrastructure, an effective repair can extend its service life and ensure that the services it provides continue to meet the community expectations. However, unfavorable environmental factors such as repeated/cyclic loads and freezing and thawing cycles adversely affect the bond between substrate concrete and repair materials, which lowers the structural capacity of repaired structures. So far, researchers have found that bond strength of repair can be affected by surface roughness, surface moisture, chemical adhesion or cohesion, curing regime, properties of substrate and repair materials, use of bond agent, and curing regimes. These findings are mostly based on the studies that focused on cold-jointed cylinders or beams, but in real-life repair situations, repairs of beams or slabs are located at either tension or compression side of the structure. Currently, there is no comprehensive study that investigates the bond of concrete repair under a combination of freezing and thawing and repeated/cyclic loading conditions. In addition, it is challenging to provide a rapid and non-destructive evaluation of the bond deterioration of repair materials. To address these issues systematically, this dissertation breaks the task into four phases. Phase (I) focuses on the development of an engineered “crack-free” repair mix that contains polypropylene (PP) fiber. A novel method is used to surface treat the PP fibers with supplementary cementitious materials. The effectiveness of surface-treating fibers for improved bond strength and reduced cracking is investigated. The compressive, tensile, and flexural strength of this engineered repair mix are determined and compared with two commercially available repair materials. The results from Phase I show that by adding 0.2% (by weight) Metakaolin-treated fibers into concrete mix, the compressive strength improves by up to 15.7% compared to mixes with untreated fibers. This study achieved a strength increase of 13.5% as compared to the reported 3.3% in other studies that use 25 times the amount of metakaolin used in this study. The experimental results confirm that at 0.2% dosage level, the use of novel surface treating technique is a cost-effective way to improve the strength of repair materials. Phase (II) focuses on characterizing the bond strength of various repair systems after freezing-thawing (FT) damage using both non-destructive and destructive methods. Two innovative sounding methods, which overcome the subjectivity of the traditional chain drag method, are used to evaluate FT damage non-destructively. In the experimental study, beams with a U-shaped cut are made to simulate conditions experienced by a concrete structure during a typical repair project. Three types of repair materials are used including cementitious repair concrete, cementitious repair mortar, and polymer-modified cementitious mortar. After up to 300 cycles of freeze-thaw exposure, resonant frequency and bond flexural strength of the prismatic specimens are determined. The empirical equations relating Non-destructive test (NDT) measurements and flexural bond strength of the repaired structures after freeze-thaw (FT) exposure are proposed. The results from Phase II show that the change in dynamic modulus of elasticity determined from NDTs agrees well with the change in other measurements including flexural bond strength, interfacial crack width, and mass loss after freeze-thaw exposure. In this study, linear relationships are established between dynamic modulus of elasticity and flexural bond strength for both cementitious and polymer-modified cementitious repair mortar with a coefficient of determination ranging between 0.87 and 0.95. The proposed empirical models can be used to predict bond flexural strength of repaired structures based on NDT measurement. Also, it was found that the samples repaired with polymer-modified cementitious mortar (Mix P) have superior FT resistance compared to other repaired samples. Phase (III) focuses on investigating the structural capacity and bond performance of repaired beams after cyclic/repeated loading. To accelerate the test process, a novel modified loading regime consisting of cycle groups of increasing cyclic/repeated stress amplitude is proposed. The models proposed by literature and current codes and standards are used to validate the results. Phase (IV) focuses on the development of the damage models for both individual and combined FT and cyclic loading exposure on repaired concrete structures. The results in phase III show the feasibility of using the Palmgren-Miner rule and Goodman linear model to estimate the fatigue life of repaired structures. This was confirmed within the context of this study. This study established the usefulness of using groups of increasing cyclic stress amplitude to accelerate the fatigue test process. The two-million cycle fatigue endurance limit estimated using cycle groups of Mix S (70.8%) was very similar to what was reported in the literature (71%) using the traditional time-consuming cyclic loading method. This study found that the formulas proposed by CSA 23.3 can effectively predict the moment resistance of both intact (control) and repaired RC beams. The ratio of experimental moment resistance values to its predictions ranges from 0.91 to 1.04. Based on the experimental results of previous three phases, an empirical model that predicted the fatigue service life of FT-damaged concrete structures is proposed. Future research requires a more comprehensive study on the FT performance of various polymer-modified cementitious mortars of different mix designs in repairing concrete structures. By increasing the number of tested specimens, a better relationship could be established between destructive and NDT methods. Future research is also required to explore the combined effect of FT and cyclic loading on repaired RC structures experimentally. / Graduate / 2023-03-22