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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Palladium complexes of imino acids

Freund, Kurt Alfredo 01 January 1969 (has links) (PDF)
The nature of this study involves the preparation of coordination compounds of palladium (II) and three imino acids, namely pipecolinic acid, pyrrolidine-20Carbozylic acid and azetidine carboxylic acid.
12

Synthesis of Azomethine Imines via Alkene Aminocarbonylation and their Derivatization into Pyrazolones

Lavergne, Kaitlyn January 2015 (has links)
Nitrogen-containing heterocyclic compounds are very important to the pharmaceutical and agrochemical industries, among others. Over the past few years, the Beauchemin group has been exploring reactivity of N-substituted isocyanates and as part of this has developed a metal-free alkene aminocarbonylation process relying on imino-isocyanates to form azomethine imines. The azomethine imines formed are interesting since they contain a cyclic β-aminocarbonyl motif. Catalysis of this reaction using basic additives allowed milder reaction conditions with electron-rich C=C bonds such as enol ethers. Efforts have also been made towards the derivatization of these azomethine imines into useful products. It was discovered that upon reduction and aromatization of azomethine imines, pyrazolones could be obtained. This is providing a novel modular approach to these compounds, which have relevance in pharmaceuticals and agrochemicals. This reactivity was extended to include imino-isothiocyanates.
13

Mechanistic Studies of Peptidylglycine Alpha-Amidating Monooxygenase (PAM)

McIntyre, Neil R 26 March 2008 (has links)
Peptide hormones are responsible for cellular functions critical to the survival of an organism. Approximately 50% of all known peptide hormones are post-translationally modified at their C-terminus. Peptidylglycine alpha-amidating monooxygenase (PAM) is a bi-functional enzyme which catalyzes the activation of peptide pro-hormones. PAM also functionalizes long chain N-acylglycines suggesting a potential role in signaling as their respective fatty acid amides. As chain length increases for N-acylglycines so does the catalytic efficiency. This effect was probed further by primary kinetic isotope effects and molecular dynamics to better resolve the mechanism for improved catalytic function. The 1°KIE showed a linear decrease with increasing chain length. Neither the minimal kinetic mechanism nor the maximal rate for substrate oxidation was observed to be altered by substrate hydrophobicity. It was concluded that KIE suppression was a function of 'Pre-organization' - more efficient degenerate wave function overlap between C-H donor and Cu(II)-superoxo acceptor with increased chain length. Substrate activation is believed to be facilitated by a Cu(II)-superoxo complex formed at CuM. Benzaldehyde imino-oxy acetic acid undergoes non-enzymatic O-dealkylation to the corresponding oxime and glyoxylate products. This phenomena was further studied using QM/MM methodology using different Cu/O species to determine which best facilitated the dealkylation event. It was determined that radical recombination between a Cu(II)-oxyl and a substrate radical to form an unstable copper-alkoxide intermediate was best suited to carry out this reaction. Structure-function analysis was used to rationalize the electronic features which made a variety of diverse imino-oxy acetic acid analogues such unexpectedly good PAM substrates (104-5 M-1s-1). To observe the effect oxygen insertion and placement had on substrates between N-benzoylglycine and benzaldehyde imino-oxy acetic acid structures, PAM activity was correlated with NBO/MEP calculations on selected PHM-docked structures. This work concluded that the imino-oxy acetic acid was a favored substrate for PAM because its oxime electronically is very similar to the amide present in glycine-extended analogues.
14

Synthesis of beta-lactam-4-ylidenes and their application as synthons for novel beta-lactam synthetic methodologies.

Zoghbi, Michel. Warkentin, John. Unknown Date (has links)
Thesis (Ph.D.)--McMaster University (Canada), 1991. / Source: Dissertation Abstracts International, Volume: 54-02, Section: B, page: 0835.
15

Radical cyclization to the imino functional group.

Tomaszewski, Miroslaw Jerzy. Warkentin, John. Unknown Date (has links)
Thesis (Ph.D.)--McMaster University (Canada), 1992. / Source: Dissertation Abstracts International, Volume: 54-12, Section: B, page: 6173. Adviser: J. Warkentin.
16

Design, synthesis and characterization of new ligands and activators for the oligomerization of ethylene by iron complexes / Design, synthese et caracterisation de nouveaux ligands et activateurs pour l'oligomerisation de l'ethylene par les complexes de fer

Boudier, Adrien 24 September 2012 (has links)
Cette thèse décrit le développement de nouveaux systèmes catalytiques à base de fer ainsi que l'étude de leur réactivité vis-à-vis de l'éthylène. Dans un premier temps, nous nous sommes intéressés au développement de précurseurs de fer(III) associés à des ligands monoanioniques tridentes. Deux voies de synthèse ont été envisagées. La première décrit la complexation d'un ligand anionique sur le précurseur FeCl3 et la seconde passe par l’oxydation d'un complexe de fer(II) associé à un ligand neutre conduisant à une espèce binucléaire. Activés par le MAO, ces catalyseurs de fer(III) constituent les premiers complexes du genre permettant l’oligomérisation de l'éthylène. L’accent a également été porté sur la recherche de nouveaux activateurs. Des complexes d’aluminium répondant à nos attentes ont été obtenus par réaction entre un alcool et le triméthylaluminium. Selon la nature de l'alcool, la structure des activateurs peut être soit binucléaire ou trinucléaire. Enfin, des complexes de fer et de nickel associés à des ligands imino-imidazoles possédant un bras hémilabile ont été synthétisés. Une fois activés, les systèmes à base de nickel ont montré de bonnes activités en catalyse. / This thesis describes the development of new catalytic systems based upon iron complexes and their reactivity toward ethylene. First, we focused our interest on the synthesis of iron(III) precursors chelated by monoanionic ligand. Those complexes were obtained either by reaction of the monoanionic ligand with FeCl3 or through oxidation of the iron(II) complex. The second reaction led to binuclear complexes. Then, another aim of the thesis was to design new well-defined cocatalysts for the activation of iron complexes. The study of the reaction between an alcohol and the trimethylaluminum allowed us to reach this aim. Aluminum complexes adopted either a binuclear framework or a trinuclear one, depending on the nature of alcohol reagent. Besides this work, new iron(II) and nickel(II) complexes chelated by imino-imidazole ligands bearing a pendant donor function L were synthesized. All complexes have been evaluated for the oligomerization of ethylene in the presence of EtAlCl2 or MAO as cocatalyst. Only nickel complexes were active toward ethylene transformation.
17

Récepteurs auto-assemblés pour des molécules d’intérêt biologique / Self-assembled receptors for biologically relevant molecules

Héloin, Alexandre 05 July 2019 (has links)
Depuis la fin du XXème siècle, la chimie combinatoire dynamique permet de synthétiser sous contrôle thermodynamique des récepteurs macrocycliques pour des molécules invités cibles. Ainsi, de nombreux hôtes supramoléculaires capables d’effectuer de la reconnaissance de molécules d’intérêt biologique dans l’eau ont été reportés dans la littérature. Nous avons décrit une nouvelle famille de récepteurs macrocycliques hydrosolubles appelés dyn[n]arènes polycarboxylates. Leur propriété de reconnaissance moléculaire vis-à-vis des polyamines, des métaux et des acides aminés ont permis d’envisager des applications biologiques. D’un point de vue fondamental, le rôle des divers paramètres, dont le solvant, a été étudié pour identifier les forces motrices responsables des associations. Des expériences in cellulo ont permis de démontrer un effet cytostatique anti-prolifératif transitoire du dyn[4]arène sur les cellules cancéreuses HeLa. Dans le but de moduler leurs propriétés de reconnaissance moléculaire, des réactions d’extrusion de soufre ont été envisagées pour synthétiser des dérivés plus robustes des dyn[n]arènes. Enfin, une famille d’objets macrocycliques apparentée a été envisagée basée sur le motif imino-1,5-dithiocines. Des études synthétiques et physico-chimiques pour l’élaboration de ces nouveaux cavitands laissent entrevoir de possibles applications biologiques similaires à celle de leurs analogues, les bases de Tröger / Since the end of the 20th century, dynamic combinatorial chemistry under thermodynamic control has enabled the synthesis of macrocyclic receptors towards targeted guest. So, many supramolecular hosts have been reported to be efficent in the molecular recognition of biologically relevant molecules in water. We describe a new family of hydrosoluble macrocycles called polycarboxylated dyn[n]renes. Their molecular recognition properties with polyamines, amino acids and metals allow biological studies. From the fundamental view, the role of each parameters, including the solvent, has been deeply studied to identify the strength of the association. In cellulo experiments have shown an antiproliferative and cytostatic effect of the dyn[4]arene on HeLa cancer cells for several hours. In order to modulate their molecular recognition properties, sulfur extrusion process has been carried out to synthesize more robust derivatives of dynarenes. Finally, a new family of similar macrocycles has been studied, based on imino-1,5-dithiocines. Syntheses and physico-chemical studies for the design of futurs cavitands pave the way for similar biological applications as described for Tröger’s bases
18

Lithiumamide, -hydrazonide und -ketazide als Bausteine acyclischer, cyclischer und spirocyclischer Bor-, Phosphor- und Siliciumverbindungen sowie monomerer und dimerer Amino-imino-borene / Lithiumamide, -hydrazonides and -ketazides as components for acyclic, cyclic, and spirocyclic boron-, phosphorus, and silicon compounds and monomeric, and dimeric amino-imino-borens

Görth, Martin 22 January 2009 (has links)
No description available.
19

Nouvelles méthodologies de synthèse et évaluation biologique d’analogues de glycosides et de glycosyl phosphates en série iminosucre / New methods of synthesis and biological evaluation of glycosides and glycosyl phosphates analogs in the iminosugar series

Cocaud, Chloé 12 December 2016 (has links)
Les glycosylamines sont des précurseurs très utiles pour préparer une grande diversité de produits naturels et leurs analogues d’intérêts biologiques. Elles ont été particulièrement utilisées comme imines latentes dans des réactions avec différents nucléophiles principalement organométalliques pour former des imino-C-glycosides. Considérant les avantages des t-butanesulfinyl imines d’Ellman en tant qu’électrophiles pour l’addition stéréocontrôlée de différents réactifs pour former des amines, nous avons synthétisé puis exploré la réactivité des t-butanesulfinyl glycosylamines encore peu connues. Nous rapportons ici nos résultats sur la préparation de plusieurs glycosylamines et leur réactivité vis-à-vis de dérivés de magnésium et de lithium, y compris des réactifs fluorés, pour former des amines sous forme de chaîne ouverte. Des détails sont donnés sur les effets de stéréochimie à l’oeuvre dans cette méthode. Nous présentons également la transformation des amines intermédiaires en imino-C-glycosides, incluant des composés importants comme des mimes de glycosyl phosphates portant une aglycone fluorée. L’évaluation biologique de plusieurs de ces composés a été réalisée sur la GlfT2, une cible enzymatique ayant fort un potentiel pour le traitement de la tuberculose. / Glycosylamines are convenient precursors of a diversity of natural products and analogs of biological interest. In particular they have been used as latent imine equivalents in reactions with various organometallic nucleophiles to prepare imino-C-glycosyl compounds. Considering the advantages of Ellman t-butanesulfinyl imines as convenient electrophiles for the stereocontrolled addition of various groups to form amines, we explored the synthesis and reactivity of yet little known t-butanesulfinyl glycosylamines. We report herein our results on the preparation of various glycosylamines and their reactivity towards magnesium and lithium derivatives, including fluorinated reagents, to give open-chain amines. Details are given on the stereochemical effects involved in this process. We also present the transformation of the intermediate amines into imino-C-glycosyl products, including such significant compounds as glycosyl phosphate mimics bearing a fluorinated aglycone. Biological evaluation of number of compounds has been performed on GlfT2, an enzyme of importance regarding to its potential as target for the treatment of tuberculosis disease.
20

Charting New Territory in Bis(imino)pyridine Coordination Chemistry

Jurca, Titel 17 July 2012 (has links)
This work was initially launched to study the synthesis of low-valent group 13 compounds bearing the bis(imino)pyridine ligand framework. Since its inception, this project has grown beyond the boundaries of group 13 to include low valent tin, silver, and rhenium. Alongside the reports of novel coordination compounds, we utilized computational chemistry to uncover unprecedented interactions which challenge conventional concepts of bonding. Synthesis, characterization, and complimentary computational studies are presented herein. Chapter 1 presents a historical overview of the bis(imino)pyridine ligand as well as our synthetic methodology and characterization of new ligand variants we have contributed to the literature. Chapter 2 presents the synthesis of a series of In(I) and In(III) bis(imino)pyridine complexes with varied sterics. Ligand-metal interaction and effect of ligand steric bulk on complex stability, as well as computational studies highlighting weak covalent interactions will be discussed. Chapter 3 presents the synthesis of Ga(III) bis(imino)pyridine complexes. Reactivity with “GaI” synthon as well as varied-stoichiometry one-pot synthesis attempts to generate low valent Ga-bis(imino)pyridine complexes will be discussed. Chapter 4 presents the synthesis of a series of Tl(I) bis(imino)pyridine complexes with varied sterics analogous to the approach taken with indium(I). Unprecedented weak ligand-metal as well as Tl-arene interactions will be discussed. Chapter 5 presents the synthesis of a series of Sn(II) bis(imino)pyridine complexes with varied sterics and halide substituents. Preferential cation-anion pair formation and attempted reactivity will be discussed. Chapter 6 presents the synthesis of a series of Ag(I) bis(imino)pyridine complexes with varied sterics. Resulting ligand-metal interactions as well as reactivity towards Lewis basic donor ligands will be discussed. Chapter 7 presents the synthesis of first crystallographically authenticated examples of rhenium(I) pincer complexes utilizing the bis(imino)pyridine ligand. Chapter 8 presents a general conclusion to the work.

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