Made available in DSpace on 2014-07-29T15:29:15Z (GMT). No. of bitstreams: 1 Dissertacao Daniela do Carmo Rassi.pdf: 1451324 bytes, checksum: b7824d166a44a37a9c0197acfc38badd (MD5) Previous issue date: 2011-04-15 / Introduction: Chagas disease is still considered a serious health and economics problem even one hundred years after its discovery in Latin American countries. In chronic phase the cardiac involvement is the most frequent and severe manifestation. The two-dimensional echocardiography provides important data for diagnosis and prognosis of this disease, mainly by evaluating the degree of ventricular impairment. Objectives: To correlate echocardiographic parameters with cardiovascular mortality (primary end-point) in a population of chagasic patients with severe ventricular dysfunction (ejection fraction <35%). Also establish the correlation between E / Em ratio, end-diastolic pressure of left ventricle (LVEDP) and plasma level of BNP in order to estimate filling pressures. Methods: This study is a retrospective analysis of a cohort of 60 patients included in Randomized Multicenter Study of Cardiac Cell Therapy in Chagas' heart disease - from February 2006 to February 2009. Echocardiographic parameters analyzed were left ventricle end diastolic and end systolic diameter (LVDD and LVSD), left ventricle diastolic and systolic volume (LVDV and LVSV), ejection fraction estimated by Simpson's method (EF), diameter of left atrium (LA), left atrial volume and left atrial volume indexed (LAV and LAV / m²), pulmonary artery systolic pressure (PASP), integral velocity of aortic flow (IVT Ao), index of myocardial performance (IMP), increase rate of left ventricular pressure (dP / dT), isovolumic relaxation time (IVRT), velocity of E , A, Em, Am and Sm waves, deceleration time of E wave (TDA), E / A ratio, E / Em ratio and mitral regurgitation (MR). Statistical analysis as performed by univariate and multivariate Cox regression model and survival curves were calculated by the KM method and compared using the log-rank test (significant p <0.05). Results: Over a mean follow up period of 24.18 months, 27 patients died. The echocardiographic parameters that correlated with primary end-point with statistical significance in univariate analysis were: EF (HR 0.932), LVDV (HR 1.005), LVSV (HR 1.005), LA (HR 1.064), LAV / m² (HR 1.036), PASP (HR 1.039 ), TDA (HR 0.993), IMP (HR 2.423), velocity of A wave (HR 0.976), velocity of E wave (HR 1.029), E / A ratio (HR 1.589), E / Em wave (HR 1.083), MR 1vs 2 (HR 0.325). For multivariate analysis were selected the variables EF, LAV/m², and E/Em, based on their clinical relevance. The results were: EF (HR 0.95 p <0.1261), LAV/m2 (HR 1.033 p <.0001) and E / Em ratio (HR 1.034 p <0.3704). ROC curve identified the best cutoff value to predict the final outcome and a LAV> 70.71 ml / m² was associated with a significant increase in mortality (log rank p <0.0001). No correlation was demonstrated between the E/Em, LVEDP and BNP Conclusions: Echocardiography has proved to be a useful test in the ability to predict mortality outcome even in a population of patients with severe prognosis. Among the variables studied left atrial volume indexed to body surface area was a significant and independent predictor of mortality in patients with heart failure due to Chagas´cardiomyophaty. / Introdução: A doença de Chagas ainda é considerada um problema grave de saúde e economia mesmo após cem anos de sua descoberta em países da América Latina. O envolvimento cardíaco é a manifestação mais frequente e grave em sua fase crônica. O ecocardiograma bidimensional fornece dados importantes para o diagnóstico e prognóstico desta patologia, principalmente quando avalia o grau do comprometimento ventricular. Objetivos: Correlacionar parâmetros ecocardiográficos com desfecho mortalidade cardiovascular, em uma população de pacientes chagásicos com disfunção ventricular importante (FE < 35%). Estabelecer possível relação entre E/Em e pressão diastólica final do ventrículo esquerdo (PDFVE) com nível plasmático do BNP, com o objetivo de estimar as pressões de enchimento do VE. Métodos: Este é um estudo de análise retrospectiva de uma coorte de 60 pacientes incluídos no Estudo Multicêntrico Randomizado de Terapia Celular em Cardiopatias-braço cardiopatia chagásica, no período de fevereiro de 2006 a fevereiro de 2009. Os parâmetros ecocardiográficos analisados foram: diâmetro diastólico e sistólico final do ventrículo esquerdo (DDFVE e DSFVE), volume diastólico e sistólico final do ventrículo esquerdo (VDFVE e VSFVE), fração de ejeção estimada pelo método de Simpson (FE), diâmetro ântero-posterior do átrio esquerdo (AE), volume do átrio esquerdo e volume indexado do átrio esquerdo (VAE e VAE/m²), pressão sistólica em artéria pulmonar (PSAP), integral da velocidade do fluxo aórtico (VTI Ao), índice de performance miocárdica (IPM), taxa de aumento da pressão do ventrículo esquerdo (dP/dT), tempo de relaxamento isovolumétrico (TRIV), medidas da velocidade das onda E, A, Em, Am e Sm, tempo de desaceleração da onda E (TDA) , relação E/A , E/Em e insuficiência mitral. Para análise dos dados foram realizadas análises univariada e multivariada pelo modelo de regressão de COX e as curvas de sobrevida foram calculadas pelo método de KM e comparadas com o teste de Log-rank (p significativo < 0,05). Resultados: Durante um seguimento médio de 24,18 meses, 27 pacientes faleceram. As variáveis ecocardiográficas com significância estatística com desfecho mortalidade na análise univariada foram: FE (HR 0,932), VDFVE (HR 1,005), VSFVE (HR 1,005), AE (HR 1,064), VAE/m²(HR 1,036), PSAP (HR 1,039), DTA (HR 0,993), IPM (HR 2,423), A(HR 0,976), E (HR 1,029), E/A (HR 1,589), E/EM(HR 1,083), IM 1vs2 (HR 0,325). Para a construção do modelo multivariado foram selecionadas as variáveis FE, AE/m² e E/Em baseado em sua relevância clínica. Os resultados foram: FE (HR 0,95 p<0,1261), VAE/m2 (HR 1,033 p<0,0001) e E/Em (HR 1,034 p<0,3704). Através da curva ROC foi identificado o melhor valor de corte para predizer o desfecho final e um VAE > 70,71ml/m² foi associado com aumento significativo na mortalidade (logrank p< 0,0001). Não foi demonstrada correlação entre a relação E/Em e PDFVE com BNP plasmático. Conclusões: O ecocardiograma mostrou ser um exame útil, com capacidade de predizer desfecho mortalidade nesta população de pacientes graves. Dentre as variáveis analisadas o volume do átrio esquerdo indexado para a superfície corpórea foi um preditor importante e independente de mortalidade, em pacientes com insuficiência cardíaca devido à cardiomiopatia chagásica.

Made available in DSpace on 2016-06-02T20:18:19Z (GMT). No. of bitstreams: 1 4834.pdf: 1020617 bytes, checksum: cb780cb6d8b726c74ca57026c48af5ed (MD5) Previous issue date: 2012-11-20 / Universidade Federal de Sao Carlos / Background: Exercise training improves exercise capacity, the performance of activities of daily living, decreases dyspnea, and enhances the inspiratory muscle strength in patients with COPD. Less is known on ventilatory and metabolic responses ( E, O2) during the execution activities of daily life (ADL) in patients going through physical training with additional or non-additional inspiratory muscle training (IMT). Aim: This study aims to compare changes on E and O2 responses, dyspnea, oxygen saturation and ADL time during a standard set of ADL tasks after two different training programs. Methods: A set of 5 ADL using a metabolic system (making bed, taking shower, brushing teeth and combing hair, lifting and lowering containers on a shelf above eye level and below the pelvic waist) was performed by 28 patients with COPD before and after the whole protocol. Patients were divided into two groups. One performed aerobic training, lower limbs (LL) resistive exercise and respiratory exercise (GPT) and the other aerobic training, resistive exercise of LL and an additional IMT (GPT+IMT). 13 composing the GPT (age 67.1±7.3yrs, FEV1 43.0±4.0%pred) and 15 patients composing the GPT+IMT (age 67.4±11.7yrs, FEV1 51.0±3.0%pred). Results: Both groups had a significant reduction (p<0.05) of E, O2 and Borg and a significant improvement of SpO2 during the ADL set within them showing benefits of physical training on performance of ADL. However, adding IMT did not show additional benefits in those variables between groups. There was a significant difference (p<0.05) in PImax in both groups and between them. On the other hand, although there are no differences between groups, both of them improved their performance in the cardiopulmonary test and six minute walking distance. Conclusion: The pulmonary rehabilitation reduces metabolic cost of common tasks of daily life as both groups improved their performance in the ADL set and, even with IMT, additional benefits were not perceived.

Dans le domaine de la santé, la mesure d'utilité permet d'exprimer la valeur que peut donner un individu à un état de santé, comprise généralement entre 0 (la mort) et 1 (meilleur état de santé envisageable). L'utilité permet de valoriser simultanément le résultat clinique et son impact sur l'état de santé du patient, et d'exprimer ainsi la qualité de vie liée à la santé. Nous nous sommes intéressés dans ce travail à l'approche indirecte d'estimation d'utilité, consistant à dériver une utilité à partir des échelles psychométriques de mesure de l'état de santé (questionnaires génériques). Cette approche permet de répéter la mesure de l'utilité dans le temps et ouvre des perspectives pour l'analyse du changement d'utilité. Les objectifs étaient de définir un seuil de changement pour l'utilité dérivée des instruments de mesure psychométrique de la qualité de vie, et de prendre en compte dans l'interprétation du seuil la présence des comorbidités ou d'un phénomène de response-shift. Afin de répondre à nos objectifs, nous avons étudié, d'une part, le changement d'utilité mesurée par le SF-6D dans une cohorte de patients atteints d'arthrose des membres inférieurs (cohorte KHOALA) et l'effet des comorbidités sur l'utilité et son changement. D'autre part, nous avons estimé l'utilité de donneur vivant de rein à partir des questionnaires EQ-5D et SF-6D avant et 3 mois après le prélèvement du rein. Un seuil de changement a été estimé et un phénomène de response-shift a été recherché. Les résultats ont montré l'effet délétère des comorbidités sur la mesure de l'utilité chez les patients atteints d'arthrose, et mis en évidence l'importance de la sévérité fonctionnelle de l'arthrose dans l'expression de l'utilité et son changement. Chez les donneurs vivants de rein nous avons mis en évidence une diminution significative de l'utilité à 3 mois, avec une proportion de plus de 30% de donneurs ayant atteint le seuil de détérioration significative. L'estimation du seuil de changement diffère selon la population étudiée, l'instrument de mesure de l'utilité, et la méthodologie appliquée pour définir ce seuil. En conclusion, l'évaluation du changement d'utilité doit tenir compte de l'existence des comorbidités ainsi que de l'adaptation du jugement de valeur que l'individu porte sur son état de santé lorsque celui-ci évolue. La complexité des méthodes psychométriques pour la mesure de l'utilité doit amener à être prudent sur leur prise en compte dans les modèles d'évaluation économique. L'identification d'un seuil pour l'interprétation du changement peut être un élément complémentaire utile dans la démarche d'analyse décisionnelle / In health economic, the concept of utility was used to describe a state of health in patients. The unit value of health state utility ranges between 0, representing "death" state, and 1 representing a "perfect" health state. It is possible to recover through the measurement of utility both the clinical outcome and their impact on the health of the patient, and thus express the quality of life related to health. In this work, we used the indirect approach for estimating utility that is derived from a generic utility scales (quality of life questionnaires). The objectives of this thesis were to define a threshold of change for the utility derived from psychometric instruments measuring quality of life, and to take into account for the change interpretation, the presence of comorbidities or a response-shift phenomenon. We used data from a cohort of patients with osteoarthritis of lower limbs (KHOALA cohort) for estimate the impact of comorbidities in utility measured by the SF-6D its change over 3 years. We are also interested in the particular case of living kidney donors. The utility was estimated by the EQ-5D and SF-6D before and 3 months after kidney donation. A threshold of significant deterioration has been estimated and the presence of a response-shift phenomenon was controlled. The results showed the deleterious effect of comorbidities on utility measurement for patients with lower limbs osteoarthritis, and highlighted the importance of the functional severity of osteoarthritis in the expression of utility and its change over time. Living kidney donors experienced a significant decrease in their utility score in the short term, and more than third of donors have reached the threshold of significant deterioration. The threshold of utility change varies depending on the population studied, the measurement instrument, and the methodology used to define the threshold. In conclusion, the assessment of utility change must take into account the existence of other diseases and the adaptation of the individual on his health state variation. The complexity of measuring individual preferences by psychometric instruments should lead to be careful about introducing them in the economic evaluation. The use of a threshold for the interpretation of utility change can be an additional element in the decision-making process

En cancérologie, la qualité de vie relative à la santé (QdV) est considérée comme second critère de jugement principal dans les essais cliniques en l’absence d’effet sur la survie globale. L’interprétation des scores de QdV et d’une différence de scores cliniquement pertinente entre deux temps de mesure est un problème majeur en QdV. Cette différence peut être significative d’un point de vue statistique sans être cliniquement significative du point de vue du patient. La différence minimale cliniquement importante (DMCI) a ainsi été définie comme la plus petite différence de score de QdV qui serait considérée comme ayant un sens clinique pour le patient. L’analyse longitudinale de la QdV est complexe, en particulier en raison de l’occurrence de l’effet « Response Shift » qui est susceptible de biaiser les résultats d’analyse longitudinal et en particulier les résultats de la DMCI. Dans ce contexte, le premier objectif de ce travail de thèse est une revue de la littérature concernant la détermination de la DMCI selon les méthodes les plus couramment utilisées : les méthodes basées sur l’ancre et les méthodes basées sur la distribution. Deuxièmement, calculer la DMCI par les méthodes basées sur l’ancre et la distribution en appliquant différents critères de distribution et plusieurs ancres différentes. L’objectif est de comparer les résultats obtenus par les différentes méthodes et de les comparer également avec les résultats obtenus par les études antérieures. Enfin, étudier l’impact de l’occurrence de l’effet Response Shift sur la détermination de la DMCI pour les questionnaires de QdV en cancérologie. / In oncology, the health-related quality of life (HRQOL) is generally considered as a second endpoint in the clinical trials. The interpretation of the results of the longitudinal analysis of such data must be made in both statistical and clinical point of view in order to produce meaningful results for both patients and clinicians. The main objective is to assess the impact of the treatment on patient’s HRQOL level over time. The minimal clinically important difference (MCID) was defined as the smallest change between two scores in a treatment outcome that a patient would identify as important. Indeed, the longitudinal analysis of HRQOL remains complex, particularly due to the potential occurrence of a Response Shift effect characterizing the process of adaptation of the patient in relation to the illness and its treatment. Hence, the first objective of this work is a literature review concerning the determination of the MCID by the most commonly used methods: anchor-based and distribution-based methods. Secondly, calculating the MCID using anchor-based and distribution-based methods by applying different distribution criteria and several different anchors. The objective is to compare the results obtained by the different methods and to compare them to others obtained by previous studies. Finally, studying the impact of the Response Shift effect on the determination of MCID for the HRQOL questionnaires in cancer research using several data corresponding to different therapeutic situations and cancer locations.

Memoria (licenciado en ciencias jurídicas y sociales) / En este trabajo daremos a conocer, principalmente al lector nacional, el contenido del texto de los Principios de UNIDROIT (“Principios”). Principios que tratan las distintas etapas de un contrato a la luz de la aplicación del principio general del derecho de la buena fe y de algunas de sus derivaciones. Partiremos introduciendo al lector en la formación y discusión del texto de los Principios. La comparación de sus cláusulas con lo que se señala en textos similares en el ámbito de los negocios internacionales. Relación de estos Principios con la lex mercatoria y los usos del comercio internacional. Posteriormente, de dichos Principios analizaremos particularmente tres instituciones que están tratadas en ellos y que pertenecen al derecho civil. Dichas instituciones corresponden a la responsabilidad precontractual; a la teoría de la imprevisión y al caso fortuito o fuerza mayor; instituciones que tienen un grado de interés para nosotros por la evolución a que se han visto expuestas con el desarrollo mismo de la economía mundial. Vamos a señalar en qué consisten esas instituciones, su análisis en el derecho nacional, su análisis relacionado con lo que señalan los Principios y qué es lo novedoso que, en lo que respecta a estas tres instituciones, aportan los Principios a las cláusulas que pueden adoptar los contratantes internacionales en sus contratos. Decimos los contratantes internacionales pero nada obsta a que sean adoptadas esas cláusulas por contratantes nacionales; es más, es eso precisamente lo que buscamos como finalidad. Que sean los propios comerciantes de nuestro país que adopten este tipo de cláusulas, beneficiándose de sus efectos, sin contrariar el orden público nacional

I microrganismi selezionati sono impiegati non solo per il processo di trasformazione della materia grezza in prodotto fermentato, ma anche per migliorare la shelf-life, il gusto, l’aroma, la sicurezza e il valore nutrizionale dei prodotti. La globalizzazione del mercato ha portato a considerare non solo i prodotti tipici popolari europei, come per esempio il vino, ma anche i prodotti tipici dei paesi non europei come la cassava. Per quanto riguarda il settore enologico lo scopo della ricerca è quello di migliorare un tipico vino: l'Ortrugo dei Colli Piacentini con ceppi autoctoni di Saccaromyces cerevisiae. Nelle fermentazioni spontanee i lieviti sono associati all'area geografica, alle condizioni climatiche e alla varietà di vitigno. Alcuni ricercatori sostengono che il micro-ambiente è caratterizzato da specifi Saccaromyces cerevisiae che possono influenzare gli aromi dell'uva. Sfortunatamente le fermentazioni spontanee possono causare aromi indesiderati e arresti fermentativi. L'inoculo del mosto con lieviti selezionati è ormai una pratica consolidata per eliminare i rischi delle fermentazioni spontanee, ma questi lieviti non riescono a enfatizzare le caratteristiche della varietà di uva in quanto derivano da ecosistemi differenti. Nasce quindi l'esigenza di utilizzare ceppi starter autoctoni selezionati, isolati dalle microaree dove i vini sono prodotti in quanto tali ceppi sono potenzialmente meglio adattati a svilupparsi in uno specifico microambiente e meglio esaltano la tipologia di un particolare prodotto. Per quanto riguarda la cassava (Manihot esculenta Crantz) microrganismi selezionati possono essere utilizzati per ridurre la concentrazione di glucoside cianogenetico (linamarina e lotaustralina), molecole tossiche. il consumo di cassava e dei suoi prodotti può causare avvelenamento da cianide con sintomi di vomito, nausea, debolezza e occasionalmente la morte. L'introduzione di cianide tramite il consumo di cassava è quasi certamente la causa dell'insorgenza di neuropatie come per esempio il Konzo (irreversibile paralisi alle gambe) che colpisce particolari zone dell'Africa. La World Health Organisation (WHO)ha stabilito il livello di sicurezza di cianide nella farina di cassava a 10 ppm (FAO/WHO, 1991). / Selected microrganisms are important as agents of the main processes of transformation of the raw materials in fermented product but also as responsible of the improvement in the shelf-life, texture, taste, aroma, as well as safety and nutritional value. The market globalization made us to consider not only popular food and/or beverage in Europe but also in non European countries. In this research I consider wine and cassava products. As regards wine the aim is to improve the Ortrugo wine typicalness by Saccaromyces cerevisiae autochtonous strains. In spontaneous fermentations the yeasts vary according to geography location, climatic conditions and/or grape variety. Some researchers believe that each micro-environment is characterised by specific Saccaromyces cerevisiae that may enhance the grape flavours. Unfortunately spontaneous fermentations may cause off-flavours and fermentation stuck. The selected yeast inoculum in must is one of the consolidated practices to eliminate the risks of spontaneous fermentation, but these yeast are not able to emphasise the characters of grape variety because they are from different ecosystems. Autochthonous yeasts e.g. yeasts isolated from a definite micro-environment are adapted to operate in a must whose characteristics are determined by the variety of the grapes and the “terroir” and, therefore, they able to enhance the peculiarities of a wine. As regards the cassava (Manihot esculenta Crantz) selected microorganisms will be used to reduce the cyanogenic glucosides (mainly linamarin and lotaustralin) toxic molecules. Consumption of cassava and its products may cause cyanide poisoning with symptoms of vomiting, nausea, dizziness, stomach pains, weakness, headache and diarrhoea and occasionally death. Cyanide intake from cassava is almost certainly the cause of Konzo (irreversible paralysis of the legs) in eastern, central and southern Africa. The World Health Organisation (WHO) has set the safe level of cyanogens in cassava flour at 10 ppm (FAO/WHO, 1991).

No description available.

GONÇALVES, Fabrício Mota. Evapotranspiração e coeficientes de cultivo (KC) da cana-de-açúcar irrigada por gotejamento subsuperficial. 2010. 64 f. : Dissertação (mestrado) - Universidade Federal do Ceará, Centro de Ciências Agrárias, Departamento de Engenharia Agrícola, Programa de Pós-Graduação em Engenharia Agrícola, Fortaleza-CE, 2010. / Submitted by demia Maia (demiamlm@gmail.com) on 2016-06-28T16:59:16Z No. of bitstreams: 1 2010_dis_fmgonçalves.pdf: 3900094 bytes, checksum: 1ad79acf1432c0de09bcbdf52cb0f8c3 (MD5) / Approved for entry into archive by demia Maia (demiamlm@gmail.com) on 2016-06-28T16:59:48Z (GMT) No. of bitstreams: 1 2010_dis_fmgonçalves.pdf: 3900094 bytes, checksum: 1ad79acf1432c0de09bcbdf52cb0f8c3 (MD5) / Made available in DSpace on 2016-06-28T16:59:48Z (GMT). No. of bitstreams: 1 2010_dis_fmgonçalves.pdf: 3900094 bytes, checksum: 1ad79acf1432c0de09bcbdf52cb0f8c3 (MD5) Previous issue date: 2010 / Sugar cane is one of the crops with the highest level of water consumption, with a high evapotranspiration demand throughout most of its cycle. Knowledge of the sugar cane water demand, the time that irrigation should be applied, and how to irrigate the crop are becoming increasingly important for the sustainable development of irrigated sugar cane cultivation, especially in areas of low water availability, as it is the case in northea stern Brazil. The experiment was carried out at the Curu Experimental Field (property of the Embrapa Tropical Agroindustry), located in the Curu-Paraipaba Irrig ation Project, city of Paraipaba-CE (3 ° 29 '20''S, 39 ° 9' 45''W and elevation 30m), in order to determine the evapotrans piration and crop coefficients (Kc) of sugarcane (Saccharum L. officinarium), subsurface drip-irrigated. It was used the SP 6949 sugar cane variety, planted in a spacing of 1.8 m between double rows and 0.4 m between rows within the double row. As to t he irrigation, we used one lateral water line for each double row, buried at a depth of 0.15 m, w ith self-compensating drip emitters, with a flow rate of 1 L h-1, spaced 0.5 m on the water line. The crop was irrigated daily and there were three fertigations per week. The irrigation de pth was periodically adjusted, keeping the soil water potential between -8 kPa to -20 kPa. The crop evapotranspiration (ETc) was determined using a wei ghing lysimeter with a surface area of 2.25 m 2. The reference evapotranspiration (ETo) was estimated by the FAO Penman-Monteith method. The durations of the phenological stages of cane sugar were estimated through analysis of soil cover, with the use of digital images. Durations of 31, 49, 237 and 118 days were observed, respectively for initial, crop development, mid-season and late season stages. The yields achieved within and outside the lysimeter were respectively 144.4 and 108.8 t ha -1 . The total ETc observed during the cycle of the sugar cane was 1074.1 m m, with maximum values of 6.6 mm d-1 during the mid-season stage. Observed Kc values for initial, mid-season and late season stages were respectively 0.23, 1 .03 and 0.50. In the crop development stage, the relationship between Kc and the (crop) soil cover was represented with good accuracy by a negative quadratic model. / A cana-de-açúcar é uma das culturas com maior consumo de água, apresentando uma alta demanda evapotranspirativa ao longo da maior parte do seu ciclo. O conhecimento das necessidades hídricas da cana-de-açúcar, do momento de aplicação da água requerida pela mesma e a forma de aplicação torna-se cada vez mais importante para o desenvolvimento sustentável da sua produção irrigada, principalmente em regiões de pouca disponibilidade hídrica, como é o caso da região Nordeste do Brasil. O experimento foi conduzido no Campo Experimental do Curu, pertencente à Embrapa Agroindústria Tropical localizado no Perímetro Irrigado Curu-Paraipaba, município de Paraipaba-CE (3° 29’ 20’’ S, 39° 9’ 45’’ W e altitude de 30 m), com o objetivo de determinar a evapotranspiração e os coeficientes de cultivo (Kc) da cana-de-açúcar (Saccharum officinarium L.), irrigada por gotejamento subsuperficial. Utilizou-se a variedade de cana SP 6949, plantada no espaçamento de 1,8 m entre fileiras duplas e 0,4 m entre linhas dentro da fileira dupla. Na irrigação utilizou-se uma linha lateral para cada fileira dupla, enterrada na profundidade de 0,15 m, com gotejadores autocompensantes, com vazão de 1 L h-1, espaçados de 0,5 m na linha. A cultura foi irrigada com freqüência diária e foram realizadas três fertirrigações por semana. A lâmina de irrigação foi ajustada periodicamente, mantendo-se o potencial de água no solo entre -8 kPa e -20 kPa. A evapotranspiração da cultura (ETc) foi determinada utilizando-se um lisímetro de pesagem com área superficial de 2,25 m2. A evapotranspiração de referência (ETo) foi estimada pelo método FAO Penman-Monteith. As durações das fases fenológicas da cana-de-açúcar foram estimadas por meio da análise da cobertura do solo pela cultura, determinada com o uso de imagens digitais. Foram observadas durações de 31, 49, 237 e 118 dias, para as fases inicial, de desenvolvimento, intermediária e final, respectivamente. A produtividade alcançada dentro e fora do lisímetro foi de 144,4 e 108,8 t ha-1, respectivamente. A ETc total observada durante o ciclo da cana-de-açúcar foi de 1.074,1 mm, com valores máximos da ordem de 6,6 mm d-1 durante a fase intermediária. Foram observados valores de Kc iguais a 0,23, 1,03 e 0,50, para as fases inicial, intermediária e final, respectivamente. Na fase de desenvolvimento vegetativo a relação entre o Kc e a cobertura do solo pela cultura foi representada com bastante exatidão por um modelo quadrático negativo.