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Reaction-diffusion Equations with Nonlinear and Nonlocal Advection Applied to Cell Co-culture / Équation de réaction-diffusion avec advection non-linéaire et non-locale appliquée à la co-culture cellulaireFu, Xiaoming 19 November 2019 (has links)
Cette thèse est consacrée à l’étude d’une classe d’équations de réaction-diffusion avec advection non-locale. La motivation vient du mouvement cellulaire avec le phénomène de ségrégation observé dans des expérimentations de co-culture cellulaire. La première partie de la thèse développe principalement le cadre théorique de notre modèle, à savoir le caractère bien posé du problème et le comportement asymptotique des solutions dans les cas d'une ou plusieurs espèces.Dans le Chapitre 1, nous montrons qu'une équation scalaire avec un noyau non-local ayant la forme d'une fonction étagée, peut induire des bifurcations de Turing et de Turing-Hopf avec le nombre d’ondes dominant aussi grand que souhaité. Nous montrons que les propriétés de bifurcation de l'état stable homogène sont intimement liées aux coefficients de Fourier du noyau non-local.Dans le Chapitre 2, nous étudions un modèle d'advection non-local à deux espèces avec inhibition de contact lorsque la viscosité est égale à zéro. En employant la notion de solution intégrée le long des caractéristiques, nous pouvons rigoureusement démontrer le caractère bien posé du problème ainsi que la propriété de ségrégation d'un tel système. Par ailleurs, dans le cadre de la théorie des mesures de Young, nous étudions le comportement asymptotique des solutions. D'un point de vue numérique, nous constatons que sous l'effet de la ségrégation, le modèle d'advection non-locale admet un principe d'exclusion.Dans le dernier Chapitre de la thèse, nous nous intéressons à l'application de nos modèles aux expérimentations de co-culture cellulaire. Pour cela, nous choisissons un modèle hyperbolique de Keller-Segel sur un domaine borné. En utilisant les données expérimentales, nous simulons un processus de croissance cellulaire durant 6 jours dans une boîte de pétri circulaire et nous discutons de l’impact de la propriété de ségrégation et des distributions initiales sur les proportions de la population finale. / This thesis is devoted to the study for a class of reaction-diffusion equations with nonlocal advection. The motivation comes from the cell movement with segregation phenomenon observed in cell co-culture experiments. The first part of the thesis mainly develops the theoretical framework of our model, namely the well-posedness and asymptotic behavior of solutions in both single-species and multi-species cases.In Chapter 1, we show a single scalar equation with a step function kernel may display Turing and Turing-Hopf bifurcations with the dominant wavenumber as large as we want. We find the bifurcation properties of the homogeneous steady state is closed related to the Fourier coefficients of the nonlocal kernel.In Chapter 2, we study a two-species nonlocal advection model with contact inhibition when the viscosity equals zero. By employing the notion of the solution integrated along the characteristics, we rigorously prove the well-posedness and segregation property of such a hyperbolic nonlocal advection system. Besides, under the framework of Young measure theory, we investigate the asymptotic behavior of solutions. From a numerical perspective, we find that under the effect of segregation, the nonlocal advection model admits a competitive exclusion principle.In the last Chapter, we are interested in applying our models to a cell co-culturing experiment. To that aim, we choose a hyperbolic Keller-Segel model on a bounded domain. By utilizing the experimental data, we simulate a 6-day process of cell growth in a circular petri dish and discuss the impact of both the segregation property and initial distributions on the finial population proportions.
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From Ground to Ocean: Robinson and Keller at the Beginnings of DivinityBasden, Stuart Jeffrey January 1900 (has links)
Observing the movement in recent Christian theology, I examine the change in depth metaphors and theological works, as they move from tendencies of solidity and proposition-forming, to more fluid imaginations in their substance and style. I conduct an indirect comparison between John A.T. Robinson and Catherine Keller, engaging Buber, Tillich and Virginia Mollenkott, specifically focusing on themes of depth and working through a filter of social and ecological justice.Throughout the essay I acknowledge the importance of the continuing re-articulation of theology, the necessity of exploring the roots of Christianity, and I affirm the need for new language for the task of articulating an appropriate image of divinity and humanity. I contend that while Keller is well able to continue Robinson's theological project for the next generation, his work is still valuable in contributing Christology and New Testament studies, both of these being somewhat absent from Keller's work.
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Revitalization of small town community : a brownfield redevelopment study of the former Keller Manufacturing site in Corydon, IndianaWendelin, Sara M. January 2006 (has links)
This creative project studies the potential that brownfield redevelopment can have on revitalization efforts in small towns and rural areas. Three key research questions guide the study: What is a brownfield and why is it difficult to redevelop them? What approaches can be used to overcome the problem of brownfield redevelopment, specifically in small cities? and How can design apply methods that allow the redevelopment of a brownfield to play a part in community revitalization?Part II and Part III compose the main body of the project. Part II defines brownfields as "Real property, the expansion, redevelopment, or reuse of which may be complicated by the presence or potential presence of a hazardous substance, pollutant, or contaminant." The brownfield dilemma is part of the larger problem of urban decline and suburban sprawl and has many causes. A lack of environmental contributed to the formation of the brownfield problem. Other factors include changes in the global economic system, and the effects of environmental laws. CERCLA, an act enforced through the EPA, has had a particularly strong impact on the sale and redevelopment of industrial real-estate. Growing stocks of brownfields are contributing to economic, environmental, and socio-cultural problems across the country. Because the available financial resources, the culture, and the people of small towns are different from large urban areas, the brownfield problems of small towns are different. However, brownfields hold promising advantages, even for small towns when they are properly integrated into revitalization efforts. Although it is important for these efforts to be focused at the local level, success is ultimately determined by the quantity and quality of regional networking and involvement in state level programs such as voluntary cleanup programs.Key methods and strategies can also be used to help ensure the success of a brownfield as a revitalization catalyst. Raising local awareness and funding, an inventory of the area's brownfield problem, planning and outreach, environmental site assessments, clean up, and choosing appropriate end-uses are the basic steps of the process. One of the most vital elements of this process is involving the community in every step. It is especially important to have heavy public involvement in choosing the end-uses for the new development. End-uses such as public parks, waterfront development, museums, community centers, and other facilities supporting a strong civic network are shown to act as catalysts for the revitalization of surrounding commercial areas.Part III of this study discusses concepts from the design theory of multi-use and infill developments, and public and civic space design. A discussion about the Keller Manufacturing site then leads to the formation of a master plan for the redevelopment of the site. This master plan serves as an example brownfield site redevelopment in a small town. / Department of Landscape Architecture
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Motivated Learning in Introductory Online College Courses: Do Motivational Messages Matter?David, Alicia Bailey 01 January 2013 (has links)
Supporting retention, student success, and online enrollments are some of the most significant and challenging topics in higher education today. Students who fail to succeed early in their studies are less likely to be retained, and students in the online environment are more likely to fail than their campus counterparts. Motivational techniques have been shown to support course retention and success, but studies of online motivational course support methods are limited. Some evidence exists that motivational messages can affect student performance in online courses, but the message format that is most effective has yet to be definitively established.
A survey research design was employed and quantitative and qualitative data were collected to determine how motivational messages and message type affect student performance and retention in an introductory online community college course. The population consisted of students in three sections of an introductory online IT course. The data included student course grades, final course scores, responses to three surveys, and the researcher's reflexive journal of motivational message design decisions made throughout the course.
Due to low course participation levels and low survey return rates, only the descriptive data were reported. Additional exploration of the literature to explain low participation was sought. Potential causes for low survey return rates included low course participation, survey length, the number of survey contacts, inaccurate estimates of survey completion time, and the number of surveys deployed. To explain the low course participation, best practices with regard to online course design were identified in the literature and compared to the design of the course used in this study. Qualitative survey results and a reflexive journal of the researcher's design decisions are also presented.
The results suggest that students liked the motivational messages. The reaction was stronger for the personalized messages than for the general, but this was not a conclusive finding. To the contrary the findings suggest that motivational messages (regardless of type) are not by themselves effective at engaging and retaining students and should not be used as a stand-alone motivational technique.
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The Blind Heroine in Cinema History: Film and the Not-VisualSalerno, Abigail 18 December 2007 (has links)
My dissertation explores non-visual experiences of film through a study of the recurring cinematic figure of the blind heroine in three periods of US cinema - late silent, classical, post-studio. My analysis of films, multi-sensory film "spectatorship" and film production critically depart from the readings offered by semiotic and psychoanalytic film theory, in favor of theories of cinematic perception and theories of genre, namely, melodrama and suspense. My approach reorients theories of film that have explained cinema as an exclusively visual culture towards a broader consideration of sensory perception and film experience.Attention to Helen Keller, as an author and a cinematic protagonist, and to the ability of the figure of the blind heroine to reorganize the structure of the films that address her frames my discussion of modern film form. Film has attempted to represent the spatial, tactile and aural experiences of gendered blind protagonists for sighted viewers - to visually produce non-visual experiences and to move beyond the limitations of its own technologies. In each of the technological periods I examine, film uses cinematography that addresses the body, sonic and visual attention to texture and movement, and narrative and affective structures of melodrama and suspense, to create the audience's aesthetic experience. My work explores the ways in which cinema has been multi-sensory, embodied, and "not-visual" - that is, visual but also more than visual - through critical evaluation of the dominant arguments of film theory, formal analysis of films, and historical accounts of film production.Keller's work and the films I examine offer a theory of the modern phenomenological subject - a subject whose senses are not, finally, located within the body of the individual but are shared with, and borrowed from, the world of human and cinematic bodies they encounter. / Dissertation
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Partial differential equations modelling biophysical phenomenaLorz, Alexander Stephan Richard January 2011 (has links)
No description available.
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Musealer Historismus die Gegenwart des Vergangenen bei Stifter, Keller und RaabeGrätz, Katharina January 2004 (has links)
Zugl.: Freiburg (Breisgau), Univ., Habil.-Schr., 2004
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The exotics of representation in twentieth-century Korean American literaturePark, Grace Haekyung, January 2008 (has links)
Thesis (Ph. D.)--UCLA, 2008. / Vita. Includes bibliographical references (leaves 131-142).
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Apotheosen narzisstischer Individualität Dilettantismus bei Karl Philipp Moritz, Gottfried Keller und Robert GernhardtWick, Nadja January 2007 (has links)
Zugl.: Bonn, Univ., Diss., 2007
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The solidification of performance practice issues in solo percussion performance /Palter, Morris S. January 2005 (has links)
Thesis (Ph. D.)--University of California, San Diego, 2005. / An examination of the development of performance practice developed in the relationships between performers and composers, with emphasis on three works: Psappha by Iannis Xenakis, Wave/s by Thomas DeLio, and Attitudes--assumptions shattered by Derek Keller. Vita. Includes tape cassette (digital ; 2 7//8 x 2 1/8 in., 3/16 in. tape) with recording of one of the works discussed.
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