La presente investigación realizada en la Empresa FAMESA S.R.L, empresa especializada en la fabricación de utensilios de cocina, reconocida por su participación en producción en ollas, su objetivo general es diseñar puestos de trabajo basados en análisis de factores ergonómico, para aumentar su productividad. El primer objetivo es utilizar el cuestionario de Cornell para diagnosticar la situación actual y poder identificar enfermedades musculo esqueléticas. Luego la atención se centra en una matriz de evaluación basado en factores de riesgos ergonómicos para elegir el método correcto. En este caso REBA. Asimismo, mediante el uso de un luxómetro y un sonómetro, se realizaron evaluaciones ambientales de iluminación y ruido. El segundo objetivo es diseñar el puesto de trabajo en el proceso de producción, teniendo en cuenta las condiciones físicas y ambientales antes mencionadas. De esta manera, el diseño del puesto de trabajo contribuyó al aumento de la productividad laboral en un 20,91% y la productividad global en un 0,04 lo que significa un 3,5%. Finalmente, como tercer objetivo, se realizó un análisis de costo-beneficio, se invirtieron un total de 35.698,03 soles y se obtuvo un costo-beneficio de 2,74, para que el nuevo diseño sea rentable, contribuyendo a mejorar la ergonomía de los trabajadores.

We have examined potential influences of gender, age, and nutrition on the expression of circadian locomotor activity rhythms in the flesh fly Sarcophaga crassipalpis. We found no significant differences in endogenous circadian period under constant dark conditions resulting from gender, nutrition, or age. Male and female flesh flies were predominantly diurnal under light-dark cycles, but their entrainment patterns differed. Females displayed higher activity levels and increasing activity with age, unlike males. Moreover, females exhibited an extraordinary, but transient, departure from diurnality which we characterize as “extended dark activity” (EDA), a continuous bout of locomotor activity extending three hours, or longer, into the dark phase at twice the median of the individual’s overall locomotor activity. EDA occurred as an age-dependent response to liver consumption. Our results suggest a linkage between physiological events associated with egg provisioning and locomotor activity as well as multiple influences on the expression of circadian clock-regulated behavior.

No description available.

No description available.

No description available.

No description available.

No description available.

No description available.

No description available.

<p>Parkinson’s Disease (PD) and Alcohol Use Disorder (AUD) are neurodegenerative conditions that involve similar neurobiological pathways and affect motivation and reward dysregulations. This project aims to explore whether PD-related insults affect alcohol-related motivation and reward. We utilized paraquat (PQ) exposure as a neurotoxicant-induced model for PD and mice selectively bred for a differential in alcohol preference as a model for genetic and neurobiological susceptibility for high/low alcohol consumption. In Experiment 1, binge-like alcohol drinking after three weeks of PQ exposure (10 mg/kg, i.p. once per week) or saline was assessed in HAP male and female mice. The four-day Drinking in the Dark (DID) procedure was used to induce binge-like alcohol drinking. Dorsal (DS) and ventral (VS) striatal catecholamines were analyzed after DID. Overall, PQ-treated HAP males had significantly lower alcohol intake than saline-treated males. This effect was absent in female HAP mice. Catecholamine quantification showed lower DOPAC levels in VS of PQ-treated vs. saline-treated HAP male mice. Experiment 2 assessed alcohol-induced locomotor sensitization in adult male and female high (HAP) and low-alcohol-preferring (LAP) mice after PQ exposure. Following the same 3 weeks of PQ or saline exposure, mice received 6 sensitization induction days with either 3 g/kg i.p. EtOH or saline. On test day, an alcohol challenge dose of 2 g/kg in all mice was used to determine the expression of locomotor sensitization. PQ exposure had no significant effect on locomotor activity and sensitization. However, PQ-treated mice showed great variability in their alcohol-induced locomotor activity compared to other groups. These data suggest a sex difference in PQ’s effect on alcohol binge-like drinking. However, PQ’s effect on alcohol-induced locomotor sensitization is not conclusive. This project will elucidate potential mechanisms behind PD-related neuropsychiatric comorbid conditions like AUD. Such findings may assist in early diagnosis and treatment refinement, as these comorbidities precede the motor manifestation of PD by decades and significantly impact the quality of life.</p>