In recent years, there has been a ood of continuously changing information from a variety of web resources such as web databases, web sites, web services and programs. Online Social Networks (OSNs) represent such a eld where huge amounts of information are being posted online over time. Due to the nature of OSNs, which o er a productive source for qualitative and quantitative personal information, researchers from various disciplines contribute to developing methods for extracting data from OSNs. However, there is limited research which addresses extracting data automatically. To the best of the author's knowledge, there is no research which focuses on tracking the real time changes of information retrieved from OSN pro les over time and this motivated the present work. This thesis presents di erent approaches for automated Data Extraction (DE) from OSN: crawler, parser, Multi Agent System (MAS) and Application Programming Interface (API). Initially, a parser was implemented as a centralized system to traverse the OSN graph and extract the pro- le's attributes and list of friends from Myspace, the top OSN at that time, by parsing the Myspace pro les and extracting the relevant tokens from the parsed HTML source les. A Breadth First Search (BFS) algorithm was used to travel across the generated OSN friendship graph in order to select the next pro le for parsing. The approach was implemented and tested on two types of friends: top friends and all friends. In case of top friends, 500 seed pro les have been visited; 298 public pro les were parsed to get 2197 top friends pro les and 2747 friendship edges, while in case of all friends, 250 public pro les have been parsed to extract 10,196 friends' pro les and 17,223 friendship edges. This approach has two main limitations. The system is designed as a centralized system that controlled and retrieved information of each user's pro le just once. This means that the extraction process will stop if the system fails to process one of the pro les; either the seed pro le ( rst pro le to be crawled) or its friends. To overcome this problem, an Online Social Network Retrieval System (OSNRS) is proposed to decentralize the DE process from OSN through using MAS. The novelty of OSNRS is its ability to monitor pro les continuously over time. The second challenge is that the parser had to be modi ed to cope with changes in the pro les' structure. To overcome this problem, the proposed OSNRS is improved through use of an API tool to enable OSNRS agents to obtain the required elds of an OSN pro le despite modi cations in the representation of the pro le's source web pages. The experimental work shows that using API and MAS simpli es and speeds up the process of tracking a pro le's history. It also helps security personnel, parents, guardians, social workers and marketers in understanding the dynamic behaviour of OSN users. This thesis proposes solutions for web database processing on data extraction from OSNs by the use of parser and MAS and discusses the limitations and improvements. / Taibah University

Uppsatsens syfte är att studera hur Victoria Mas roman De galna kvinnornas bal (2022) anspelar på traditionen female gothic och motivet den galna kvinnan i en kontext av 1800-talets patriarkala strukturer. Romanen studeras därför i relation till Charlotte Brontës Jane Eyre (1847), Charlotte Perkins Gilmans The Yellow Wallpaper (1892) och Selma Lagerlöfs Spökhanden (1898), för att urskilja hur motivet den galna kvinnan har använts i 1800-talets klassiska gotiska litteratur, och om några signifikanta skillnader förekommer i Mas (2022) moderna roman. Den komparativa och intertextuella studien utförs med en kvalitativ textanalys som inbegriper närläsningar och tolkningar av materialet i syfte att tolka och förstå den galna kvinnans framställning och funktion. Yvonne Hirdmans teori om genussystem och genuskontrakt tillämpas för att analysera hur den galna kvinnan underordnas en manlig auktoritetsfigur, och vilka oönskade egenskaper som hon fångar upp. Slutsatserna visar framför allt hur den galna kvinnan i De galna kvinnornas bal (Mas 2022) fyller en samhällskritisk funktion, eftersom romanen med en samtida röst slagkraftigt kritiserar den manliga auktoritetsfiguren till skillnad från jämförelsematerialet. Den galna kvinnans oönskade egenskaper framställs heller inte som orimliga eller farliga, vilket särskiljer sig från Jane Eyre (Brontë 1847) där den galna kvinnan framställs med aggressiva och farliga egenskaper. En annan signifikant skillnad i Mas (2022) roman är att den galna kvinnan framställs som ett intressant forskningsobjekt att experimentera på och visa upp för allmänheten, till skillnad från de galna kvinnorna i 1800-talstexterna.

京都大学 / 新制・課程博士 / 博士(薬科学) / 甲第24553号 / 薬科博第170号 / 新制||薬科||19(附属図書館) / 京都大学大学院薬学研究科薬科学専攻 / (主査)教授 金子 周司, 教授 生田 宏一, 教授 伊藤 貴浩 / 学位規則第4条第1項該当 / Doctor of Pharmaceutical Sciences / Kyoto University / DFAM

Groat oil content and composition are important quality traits in oats (Avena sativa L). These traits are controlled by many genes with additive effects. The chromosomal regions containing these genes, known as quantitative trait loci (QTL), can be discovered through their close association with markers. This study investigated total oil content and fatty acid components in an oat breeding population derived from a cross between high oil ('Dal') and low oil ('Exeter') parents. A genetic map consisting of 475 DArT (Diversity Array Technology) markers spanning 1271.8 cM across 40 linkage groups was constructed. QTL analysis for groat oil content and composition was conducted using grain samples grown at Aberdeen, ID in 1997. QTL analysis for multiple agronomic traits was also conducted using data collected from hill plots and field plots in Ottawa, ON in 2010. QTLs for oil content, palmitic acid (16:0), stearic acid (18:0), oleic acid (18:1), linoleic acid (18:2) and linolenic acid (18:3) were identified. Two of the QTLs associated with oil content were also associated with all of the fatty acids examined in this study, and most oil-related QTL showed similar patterns of effect on the fatty acid profile. These results suggest the presence of pleiotropic effects on oil-related traits through influences at specific nodes of the oil synthesis pathway. In addition, 12 QTL-associated markers (likely representing nine unique regions) were associated with plant height, heading date, lodging, and protein content. The results of this study will provide information for molecular breeding as well as insight into the genetic mechanisms controlling oil biosynthesis in oat.

This master thesis focuses on factors concerning the quality of cooperation between municipalities and regions with emphasis on the influence of local actors. The case study focuses specifically on the Local Action Groups (LAG)s within the Český Krumlov region. We applied the concept of social capital as a tool to clarify the importance of endogenous conditions of regions, and endogenous factors that influence the quality of cooperation between personalities and institutions. The concept of social capital has gained the attention of foreign and Czech researchers during the last twenty years and it is considered to be an important element of comprehensive regional development. The research was held in two phases. The first phase was a pilot analysis based on publicly available sources. We compared scores of LAGs based on various factors including their success in grant applications. Based on information collected from this, we continued the research in the form of structured interviews with key actors in concerned LAGs. The structure of these interviews followed chosen aspects of social capital, such as social networking and cooperation between personalities. The research demonstrated the importance of social capital in the process of regional development. The impact of collective form of social...

Presented diploma thesis deals with issues of rural development. The thesis specifically concerns activities of local action group Český Západ and its influencing of area development during last programming period 2007 to 2013. Activity of local action groups should lead to bigger effort of public, non-profit and private sector to develop rural areas, which should also contribute to creation of social capital. The goal of this thesis is to evaluate up to now activity of local action group Český Západ and mainly evaluate objectives and priorities determined in Strategic Plan LEADER for programming period 2007 to 2013. Objectives evaluation was executed using several methods, firstly by content analysis of documents, especially analysis of the Strategic Plan or Integrated Area Development Strategy. Followed by analysis of placement of the implemented projects in territory of LAG. Further was executed a questionnaire survey by questioning the general public from all over the area of activity of local action group. The last evaluation method used was method structured interview with experts participating in local action group Český Západ as a whole. Keywords: Local Action Group, LEADER, rural development, LAG Český západ, social capital

Cette recherche se place dans le domaine de l’ingénierie industrielle, plus exactement aux premières étapes du processus d´innovation (Fuzzy Front-End). Aujourd´hui dans un monde globalisé, où la technologie est à la portée de tous, les entreprises cherchent de nouvelles techniques permettant de se distinguer de la concurrence, et offrent de nouveaux et meilleurs produits ou services ; une manière de conserver leurs avantages comparatifs ou d’en acquérir de nouveaux, pour des clients toujours plus exigeants, et dont les besoins changent constamment. Partant de ce constat, l’innovation se définit comme un processus long et continu, au sein duquel s’utilisent différents modèles. Du fait de la complexité du processus, il n’existe pas de modèle unique réunissant tous les besoins des clients. C’est pourquoi le processus d’innovation, implique différents acteurs de l’entreprise et de son environnement. Ces acteurs, dont l’importance varie, sont souvent d’origines diverses et possèdent des compétences variées. Ils ont des besoins différents, et sont soumis à des contraintes de travail différentes (ressources technologiques et financières, réglementations, etc...). Il paraît ainsi essentiel pour l’entreprise de créer un modèle unique, capable d’identifier les besoins de toutes les parties prenantes, avant d’entamer le processus de développement de nouveaux produits. C’est pour l’entreprise une manière de renforcer le processus d’innovation, et de réduire le taux d´échec lors du lancement de nouveaux produits. Ainsi l’objectif de cette étude est de proposer une nouvelle méthode d’analyse des impacts de l’innovation (A.I), afin de permettre aux entreprises d’identifier les besoins dynamiques des acteurs. Celles-ci pourront ainsi mieux définir leurs nouveaux produits et s’adapter plus facilement aux évolutions du marché. Cet outil fait partie d´une méthodologie de gestion des projets innovants, et doit être utilisé avant la définition des caractéristiques fonctionnelles du nouveau produit. Ceci nous ramène aux premières phases du développement, avant la conception du produit, qui comprennent toutes les étapes depuis la définition des besoins et opportunités pour l´innovation, jusqu’à la prise de décision pour le développement du nouveau produit, appelée Fuzzy Front-End. L’apport théorique de notre travail : Il n´existe pas de définition des impacts de l’innovation (I_n), nous avons donc fait un travail bibliographique sur le concept d’impact. Celui-ci a permis d’explorer les différentes définitions d´impact au sein de différentes disciplines (ingénierie, écologie, psychologie, etc.). Nous avons proposé de cette manière, notre propre définition de l’impact adaptée au contexte de l´innovation. Cette recherche bibliographique, nous a aussi permis d’identifier les différents types d´impacts et de justifier l´utilisation de différentes méthodologies. La contribution méthodologique : l’approche proposée pour l´analyse des impacts de l´innovation (A.I) se décompose en deux étapes. La première vise à modéliser l’« écosystème d´innovation », sur la base des relations, de l´importance et des besoins individuels de chacun des acteurs face au nouveau produit. Ceci grâce à une Analyse des Besoins Dynamiques (A.B.D), qui permettra d´obtenir les besoins agrégés permettant de représenter le système complet, sans considérer les possibles perturbations du milieu extérieur ou les impacts de la même innovation. Pour bien identifier et décrire les besoins des acteurs, nous avons basé la méthodologie sur l´observation de leurs activités. Ainsi, nous avons pu identifier les différents besoins des acteurs de l´innovation sur la base de l’analyse RAR (Ressources, Activités, Résultat), ensuite nous avons classifié les besoins grâce au modèle de KANO et ses améliorations réalisées par Tontini. Une méthode originale d’agrégation des besoins de tous les acteurs est proposée.[...] / This research belongs to the industrial engineering field, focusing on the first stages of the innovation process (Fuzzy Front-End). In a globalized world, where the technology is near to everyone, enterprises are looking for new technologies to be different from their competitors, offering new and better products / services as a strategy to keep or acquire new competitive advantages. Moreover, innovation is a large and continuous process, where different management models are used. But, because of the complexity of the process, no general model is suitable for situations and projects. Thus, the innovation process involves different stakeholders from the company and its environment. These individuals come from different origins (field of knowledge), have different needs, abilities, importance and work under different restrictions (technological or financial resources, work rules, etc.). Consequently, it is essential for the enterprise to identify all the needs of the parts involved in the products. And, a model is required in order to identify the stakeholder’s needs before starting design tasks. This model aims at more robustness in the new product development process and at the reduction of the failure rate when launching new products. Thus, the objective of this PhD thesis is to propose a new method to analyze the impact of the innovation, allowing companies to identify the dynamic actors' needs, to improve the definition of their new products and to adapt to the possible changes of the market. This tool is part of an innovative projects management methodology, used before the elaboration of the functional specifications of a new product. This locates the research in the first stages of development called Fuzzy Front-End: before the genesis of the product. Fuzzy front ends integrate among others the opportunity / needs identification for innovation to the development of the new product decision taking. The proposed approach for the innovation impact analysis (A.I) consists of two stages: the first one intends to model an innovation ecosystem, integrating the relations, the importance of each stakeholder and their individual necessities in regard to the new product. Through a Dynamic Needs Analysis (A.B.D) it will be possible to get the global needs, which represent the whole system, without considering the disturbances of the environment or the impact of the same innovation. Thus, the second stage of the model, through the generation of innovation impact scenarios (S.I.I), evaluates the impact of the innovation the new product may face at its market launching. Due to a new product emergence changes emerge: actors’ performance, their interrelations, the importance and their own needs about the product [...]

Submitted by admin tede (tede@pucgoias.edu.br) on 2016-09-05T14:46:38Z No. of bitstreams: 1 LUCIANO NUNES DA SILVA.pdf: 814867 bytes, checksum: eaeace88d325760adf2688c0cd58d28b (MD5) / Made available in DSpace on 2016-09-05T14:46:38Z (GMT). No. of bitstreams: 1 LUCIANO NUNES DA SILVA.pdf: 814867 bytes, checksum: eaeace88d325760adf2688c0cd58d28b (MD5) Previous issue date: 2015-12-18 / The purpose of this essay is to analyze the principle of common but differentiated responsibilities, in the field of international debates about the climate as a guidance principle of debates. The differentiated responsibility, which came out in the establishment of goals to equalize the levels of emission of greenhouse gases only to developed countries (Parties in the Annex I), is based on the principle of common but differentiated responsibilities adopted by the Framework Convention, and it usually commands the relations between developed and developing countries and even the global hope to create a new agreement post-Kyoto. Beyond this principle, we will also study others that help in understanding the environmental protection in the international field. The essay also has the purpose to analyze the practices and perspectives for the common but differentiated responsibilities in a global scope, especially the developments of the principle in the new series of climate negotiations; / Esta dissertação tem por escopo a análise do princípio das responsabilidades comuns, porém diferenciadas, no âmbito das negociações internacionais do clima, como princípio balizador das discussões. A responsabilização diferenciada, que resultou no estabelecimento de metas de estabilização dos níveis de emissão de gases do efeito estufa apenas para os países desenvolvidos (Partes do Anexo I), é baseada no princípio da responsabilidade comum, porém diferenciada, adotado pela Convenção-Quadro, e que rege usualmente as relações entre os países desenvolvidos e os países em desenvolvimento e ainda a expectativa global na construção de um novo acordo pós Kyoto. Além deste princípio estudaremos também outros que ajudam na compreensão à proteção ao meio ambiente no cenário internacional. A dissertação visa também analisar as práticas e perspectivas para as responsabilidades comuns, mas diferenciadas em âmbito global especialmente os desdobramentos do princípio nas novas rodadas de negociação do clima;

Small quantities of amorphous content can have a profound influence on the properties of a material, however their instability means that quantifying amorphous content over time is important for proving the stability of a drug. Quantifying amorphous content in α-lactose monohydrate by solid state 13C CP MAS NMR, has been carried out by use of proton saturation recovery relaxation and differentiating between spectra by partial least squares (PLS), however these techniques have not proved sensitive on their own, this work investigates their sensitivity in combination. Crystalline α-lactose monohydrate and a rapidly quenched melt were combined to create a set of calibration mixes, whose spectra were recorded using proton saturation recovery relaxations ranging from 2 to 60 seconds. This technique showed a limit of detection of 0.17% (LOD = intercept + 3xSy/x), with a relaxation delay of 15 s and was able to recognise amorphous materials generated by spray and freeze drying. The atmospheric effects on the proton saturation recovery relaxation times of different amorphous lactose preparations were investigated. This found that an oxygen atmosphere reduced the relaxation times, of amorphous lactose that was prepared from a rapidly quenched melt. The loss of moisture from spray dried and freeze dried samples to less than 1% removed the significance of this effect. Lactose is an important excipient in pharmaceuticals and a key ingredient of confectionary, very little research has been carried out in to the quantification of the isomers of different preparations of amorphous lactose. This work quantifies the isomer content by Gas Chromatography with Flame Ionisation Detection (GC-FID) using a DB-17 15m 0.53mm 1.00 μm column and derivatisation with N- (trimethylsilyl)imidazole.

L'objet de ma thése est la conception rationnelle d'une bobine utilisable par une sonde de RMN pour des échantillons solides d'origine biologique, tels que les milieux membranaires ou les biopsies. L'étude de la distribution du champ électromagnétique créée pendant l'impulsion radiofréquence s'est avérée indispensable pour permettre d'une part une meilleure homogénéité du champ B1 et d'autre part une redistribution du champ électrique dans un plan normal à l'axe principal de la bobine. Auparavant, cette distribution de champ avait été considérée homogène au centre de l'échantillon, et seule la composante axiale était prise en compte. La démarche scientique suivie ici est originale en cela qu'elle se sert d'une résolution numérique des équations de Maxwell, et permet la mise en évidence des composantes radiales du champ B1 jusqu'alors ignorées. La première partie présente les caractéristiques instrumentales de la méthode HR-MAS. Il s'en suit une partie plus théorique sur les concepts d'électromagnétisme nécessaires pour aborder la cartographie de champ radiofréquence B1 dans une bobine. Ce travail utilise une résolution de l'équation maîtresse de l'évolution des spins (Liouville von Neumann) où l'Hamiltonien de champ B1 est construit en tenant compte de la forme particulière du champ magnétique dans une bobine hélicoïdale. Une étude de l'impact du champ électrique sur un échantillon aqueux dispersif est introduite dans la quatrième partie. Finalement une bobine innovante a été conçue, celle-ci permet d'éloigner le champ électrique du centre de l'échantillon, où le champ magnétique est dominant et homogène ses performances sont décrites à travers une série d'expériences sur les bicelles.