Ma thèse s'inscrit dans l'étude des modifications du globule rouge humain induites par P. falciparum. Ces modifications qui représentent une remarquable adaptation du parasite à un environnement plus complexe qu'il n'y paraît au premier abord et expliquent sa persistance chez l'Homme sont détaillées dans une revue et un chapitre de livre dont je suis co-auteur. Mes travaux de recherche ont porté sur la caractérisation fonctionnelle des structures de Maurer, un compartiment membranaire exporté par le parasite dans le globule rouge parasitaire et directement lié à la physiopathologie du paludisme grave. J'ai contribué à la caractérisation fonctionnelle de nouvelles protéines de ces structures, codées par trois familles multigéniques sub-télomériques en cluster avec la famille Pfmc-2tm, et présentant de façon étonnante un fort degré de conservation (article 1). La diminution d'expression de ces gènes, obtenue par titration d'un facteur transcriptionnel, entraine un défaut de libération des mérozoïtes. Mon deuxième projet porte sur l'identification des modalités d'export de la protéine transmembranaire résidente des structures de Maurer PfSBP1. Mes travaux montrent que PfSBP1 est exportée sous forme soluble dans le cytoplasme érythrocytaire, en interaction avec le complexe chaperon parasitaire PfTCP1 (article 2). / Plasmodium falciparum causes the most severe forms of human malaria, a pathology associated with the erythrocytic asexual stages of the parasite. My work focused on the remodeling of the infected erythrocytes induced by P. falciparum and detailed in a review and a book chapter that I co-authored. These modifications illustrate a remarkable adaptation of P. falciparum resulting in its persistence in humans. My PhD thesis was dedicated to the functional characterization of Maurer's clefts, a membrane compartment transposed by the parasite in the cytoplasm of its host cell, and central to the export of virulence factors to the host cell surface. I have conducted two projects and contributed first to the functional characterization of novel exported protein encoded by three highly conserved multigene sub-telomeric families in cluster with the Pfmc-2tm family. Down regulation of these gene families by promoter titration impacted the release of infectious merozoites from the host cell (annex 1). My second project was dedicated to the identification of the modality of export of the resident and Maurer's clefts transmembrane protein PfSBP1. I have shown that PfSBP1 is exported as a soluble protein in the host cell cytoplasm in interaction with the parasite Thermosome complex protein 1 (PfTCP1) chaperone complex (annex 2).

Made available in DSpace on 2016-04-29T13:30:59Z (GMT). No. of bitstreams: 1 Celia Maria Marcondes Ferraz Silva.pdf: 899850 bytes, checksum: 8bf9aec6a377cbb7b8ce5bddb05ec61c (MD5) Previous issue date: 2012-08-14 / The subject for the present project is to contribute for the history of the Social Psychology in Brazil showing that Silvia Tatiana Maurer Lane (1933-2006) has an important contribution for the theoretical propositions concerning the Brazilian social psychology that was adopted for other social psychologists, professors and social scientists. To work as a professor has a key influence for Silvia s thoughts and ideas. She has often been criticism of the psychology with American influence, as well as in relation to the classic methods of teaching in Brazil. The PUC-SP institution where she works for forty years provides her a freedom and an open environment that enhance her way. In order to study Silvia s publications and live had been used personal documents, books, interviews and biographies made by other authors. The personal documents found in the Núcleo de Estudos em História da Psicologia-NEHPSI give us an important contribution for our conclusions and show her strong image as a professor and scientist in Brazil and abroad. The analysis of Silvia s productions demonstrates a strong relationship among the socio historic environment and her ideas over the course of lifetime work. In order to analyze Silvia s thoughts and ideas has a key importance a non-edit text named My way wrote before her death with the intention to prepare a book with a collection of writings published or not, which ones was difficult to achieve. This text allows us to understand the structure given by her to her own thoughts. We discovered that the language psychology, the theoretical bases for a Brazilian social psychology, the community psychology, the studies concerning the process to become a group and the emotional mediation, represents subjects that have been present throughout the course of her life s generating researches, texts, courses and presentations. Time pass and new views and considerations have been added to these themes. The work was not finished before her death living space for other texts and studies in future / Nosso propósito ao elaborar esta tese é contribuir com o estudo da Psicologia Social no Brasil, mostrando que Silvia Tatiana Maurer Lane (1933-2006) teve importância relevante na formulação das bases teóricas de uma Psicologia Social Brasileira, adotada por psicólogos sociais, professores e pesquisadores. A atividade docente foi fundamental para a formação do pensamento da intelectual respeitada, tendo se desenvolvido por meio de uma postura crítica, permanente, à psicologia social de influência americana e aos métodos tradicionais de ensino. A PUC de São Paulo, instituição na qual trabalhou durante quarenta anos, proporcionou à Silvia um ambiente de liberdade intelectual que favoreceu o seu trajeto. Escolhemos para estudar a autora um caminho ainda não trilhado por outros pesquisadores que falaram a respeito da ilustre professora, conduzindo a nossa pesquisa, em especial, a partir dos documentos pessoais encontrados no acervo deixado na PUC de São Paulo sob a guarda do Núcleo de Estudos em História da Psicologia-NEHPSI, além de livros, entrevistas e biografias escritas por outros autores. A análise do percurso de Silvia nos mostrou conexões importantes entre o seu trabalho e o contexto sócio-histórico e revelaram o prestígio da professora no Brasil e no exterior. Para o estudo das ideias, tomamos por base um texto ainda não publicado, denominado: Caminhos percorridos , escrito pouco tempo antes da sua morte e cuja finalidade era preparar uma coletânea dos seus textos, publicados ou não, mas de difícil acesso. A leitura nos permitiu entender a estrutura dada por ela ao seu próprio pensamento. Constamos que a psicologia da linguagem, as bases teóricas para formulação de uma psicologia social brasileira, a psicologia comunitária, o processo grupal e a mediação emocional são temas que estão presentes ao longo de toda a obra, gerando pesquisas, textos, cursos e apresentações, recebendo ao longo do tempo, novos olhares e releituras que fizeram avançar a compreensão dos temas. A obra não se encerra com a sua morte, deixando espaço para novos estudos e textos a serem produzidos

Darbe nagrinėjamos simetrinės trečiosios eilės liestinės sluoksniuotės, kurios apibrėžiamos kaip 3 - džetų aibės. Surasta simetrinės erdvės izotropijų grupė, o taip pat jos izomorfijų grupė. Gautos izomorfijų grupės struktūrinės lygtys, surasti erdvės Maurerio – Kartano lygčių analogai, įrodytos formulės, išreiškiančios indukuotosios afiniosios sieties kreivumo tenzorių komponentes izomorfijų grupės struktūrinėmis konstantomis. Taip pat gauta visa eilė tapatybių, siejančių kreivumo objektus ir izomorfijų grupės struktūrines konstantas (apibendrintos Ričio ir Bianchi tapatybės). / The paper examined the symmetric third order tangent bundle, defined as 3- jet space. Found symmetric space isotropy group, as well as its isomorphy group. The resulting structural equation of isomorphy group, find this area Maurer - Cartan analogues of equations, an established formula, expressing inducted affines connection component of curvature tensors of the isomorphy group structural constants. Also received identities connecting the curvature objects structural constants of isomorphy group (generalized in Riči and Bianchi identity).

Made available in DSpace on 2016-04-29T13:31:56Z (GMT). No. of bitstreams: 1 Esther Alves de Sousa.pdf: 1082518 bytes, checksum: 06f4b8846c46c6b39047823cfa844db7 (MD5) Previous issue date: 2008-06-06 / This manuscript is a historical study of Sílvia Lane s production in Social Psychology, focusing on her role of advisor for both master and doctoral students. To accomplish this study I chose to work with dissertations and theses she mentored and guided while she was in the Post Graduate Social Psychology Program at the Catholic University of São Paulo (PUCSP). The study worked not only with these dissertations and theses, but also with the topics presented, as well as the bibliography that was used. In order to show the value she attributed to her students research which was significant to her line of research her academic and scientific production is presented. The study also identified the authors used in the dissertations and theses during her period in the Program and highlighted the authors most referred to. Marx was present throughout, directly or indirectly, which proves that Lane was faithful to her line of research which she diffused in the area of Social Psychology. The same can be said for the presence of Vigotski and Leontiev, who founded their reflections and established the fundamental categories for the human psyche which she and all those she advised worked with. Findings indicate that Sílvia Lane was the author most referred to by her advisees, substantiating their research and providing subsidies for their reflections. Lane advised 33 dissertations and 30 theses in Social Psychology, based on different theoretical categories related to several areas of social life, which reveal the breath of her production and coherence with a critical theoretical perspective of a socially committed psychological practice / Este trabalho realiza um estudo histórico sobre a produção de Silvia Lane, em Psicologia Social, enfocando seu papel como orientadora de mestrado e doutorado. Para a realização deste estudo optou-se por trabalhar com as dissertações e teses por ela orientadas ao longo de sua trajetória no Programa de Estudos Pós-graduados em Psicologia Social da PUC de São Paulo. São tratadas as dissertações e teses orientadas, os assuntos abordados em cada uma delas e a bibliografia utilizada. É apresentada também sua produção acadêmica e científica, no intuito de mostrar a importância que Lane atribuía às pesquisas desenvolvidas por seus alunos, como produção significativa para sua linha de pesquisa. Foram identificados os autores utilizados nas dissertações e teses ao longo de todo o período e destacados os autores mais referenciados. Percebeu-se que Marx se faz presente o tempo todo, direta ou indiretamente, o que comprova que Lane foi sempre fiel à linha que difundiu na Psicologia Social, assim como à presença de Vigotski e Leontiev, que fundamentaram suas reflexões e forneceram as categorias fundamentais do psiquismo humano com as quais ela e seus orientandos trabalharam.. Destaca-se que Silvia Lane foi a autora mais referenciada por seus orientandos, fundamentando suas pesquisas e fornecendo subsídios para suas reflexões. Sílvia Lane orientou 33 dissertações e 30 Teses em Psicologia Social, baseadas em diferentes categorias teóricas e relacionadas a vários campos da vida social, o que mostra a amplitude de sua produção e a coerência com uma perspectiva teórica crítica de uma prática psicológica socialmente comprometida

Dans cette thèse on a étudié plusieurs problèmes<br />algébriques relatifs à une superalgèbre de Lie qui peuvent être<br />réduits à la résolution d'une équation fonctionnelle. Cette<br />technique a permis d'obtenir des résultats qui sont nouveaux<br />aussi pour une algèbre de Lie ordinaire et qui sont indépendants<br />de la classification des algèbres de Lie.