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<p>Recent advances in technology have allowed researchers to collect high-dimensional biological data simultaneously. In genomic studies, for instance, measurements from tens of thousands of genes are taken from individuals across several experimental groups. In time course microarray experiments, gene expression is measured at several time points for each individual across the whole genome resulting in massive amount of data. In such experiments, researchers are faced with two types of high-dimensionality. The first is global high-dimensionality, which is common to all genomic experiments. The global high-dimensionality arises because inference is being done on tens of thousands of genes resulting in multiplicity. This challenge is often dealt with statistical methods for multiple comparison, such as the Bonferroni correction or false discovery rate (FDR). We refer to the second type of high-dimensionality as gene specific high-dimensionality, which arises in time course microarry experiments due to the fact that, in such experiments, sample size is often smaller than the number of time points ($n</p> <p>In this thesis, we use the growth curve model (GCM), which is a generalized multivariate analysis of variance (GMANOVA) model, and propose a moderated test statistic for testing a special case of the general linear hypothesis, which is specially useful for identifying genes that are expressed. We use the trace test for the GCM and modify it so that it can be used in high-dimensional situations. We consider two types of moderation: the Moore-Penrose generalized inverse and Stein's shrinkage estimator of $ S $. We performed extensive simulations to show performance of the moderated test, and compared the results with original trace test. We calculated empirical level and power of the test under many scenarios. Although the focus is on hypothesis testing, we also provided moderated maximum likelihood estimator for the parameter matrix and assessed its performance by investigating bias and mean squared error of the estimator and compared the results with those of the maximum likelihood estimators. Since the parameters are matrices, we consider distance measures in both power and level comparisons as well as when investigating bias and mean squared error. We also illustrated our approach using time course microarray data taken from a study on Lung Cancer. We were able to filter out 1053 genes as non-noise genes from a pool of 22,277 genes which is approximately 5\% of the total number of genes. This is in sync with results from most biological experiments where around 5\% genes are found to be differentially expressed.</p> / Master of Science (MSc)

Yes / We examine how ties with multiple host-country political institutions contribute to MNE subsidiary performance in countries with weak formal institutions. We suggest that forging relationships between subsidiaries and host-country government actors, local chieftains, and religious leaders generates regulative, normative, and cultural-cognitive political resources. We integrate institutional and configuration theories to argue that similarity to an ideal configuration of the three political resources contributes to MNE subsidiary performance, and that the more dysfunctional host country institutions, the greater the impact on performance. We test our hypotheses using primary and archival data from 604 MNE subsidiaries in 23 Anglophone sub-Saharan African countries and find support for our hypotheses. In our conclusion we discuss the wider theoretical, managerial, and public policy implications of our findings.

Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2016-12-21T12:55:48Z No. of bitstreams: 0 / Made available in DSpace on 2016-12-21T12:55:48Z (GMT). No. of bitstreams: 0 / O reator IEA-R1 do Instituto de Pesquisas Energéticas e Nucleares (IPENCNEN/ SP) é um reator de pesquisa tipo piscina aberta, projetado e construído pela empresa norte-americana \"Babcock & Wilcox\", tendo, como refrigerante e moderador, água leve deionizada e berílio e grafite como refletores. Até cerca de 1988, os sistemas de segurança do reator recebiam alimentação de uma única fonte de energia. Nos anos de 1989 e 1990, uma reforma de modernização do sistema elétrico para aumentar a potência do reator e, também, para atender às normas técnicas da Comissão Nacional de Energia Nuclear (CNEN) e da Associação Brasileira de Normas Técnicas (ABNT) foi realizada. Este trabalho tem o objetivo de mostrar a relação entre o sistema de energia elétrica e a segurança do reator IEA-R1. Além disso, ele demonstra que, caso ocorra alguma interrupção de energia elétrica durante a operação do reator, esta ocorrência não irá começar um evento de acidente. / Dissertação (Mestrado em Tecnologia Nuclear) / IPEN/D / Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP

Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2016-12-21T17:48:50Z No. of bitstreams: 0 / Made available in DSpace on 2016-12-21T17:48:50Z (GMT). No. of bitstreams: 0 / Após o aumento de potência do reator IEA-R1 de 2 MW para 5 MW observou-se um aumento da taxa de corrosão nas placas laterais de alguns elementos combustíveis e algumas dúvidas surgiram com relação ao valor de vazão utilizada nas análises termo-hidráulicas. A fim de esclarecer e medir a distribuição de vazão real pelos elementos combustíveis que compõe o núcleo do reator IEA-R1, um elemento combustível protótipo, sem material nuclear, chamado DMPV-01 (Dispositivo para Medida de Pressão e Vazão), em escala real, foi projetado e construído em alumínio. A vazão no canal entre dois elementos combustíveis é muito difícil de estimar ou ser medida. Esta vazão é muito importante no processo de resfriamento das placas laterais. Este trabalho apresenta a concepção e construção de um elemento combustível instrumentado para medir a temperatura real nestas placas laterais para melhor avaliar as condições de resfriamento do combustível. Quatorze termopares foram instalados neste elemento combustível instrumentado. Quatro termopares em cada canal lateral e quatro no canal central, além de um termopar no bocal de entrada e outro no bocal de saída do elemento. Existem três termopares para medida de temperatura do revestimento e um para a temperatura do fluido em cada canal. Três séries de experimentos, para três configurações distintas, foram realizadas com o elemento combustível instrumentado. Em dois experimentos uma caixa de alumínio foi instalada ao redor do núcleo para reduzir o escoamento transverso entre os elementos combustíveis e medir o impacto na temperatura das placas externas. Dada a tamanha quantidade de informações obtidas e sua utilidade no projeto, melhoria e capacitação na construção, montagem e fabricação de elementos combustíveis instrumentados, este projeto constitui um importante marco no estudo de núcleos de reatores de pesquisa. As soluções propostas podem ser amplamente utilizadas para outros reatores de pesquisa. / Tese (Doutorado em Tecnologia Nuclear) / IPEN/T / Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP

There is a well-documented bidirectional relationship between pain and cognitive dysfunction, especially working memory. Despite this extensive body of research, the pain–working memory relationship is poorly understood. Pain catastrophizing – exaggerated negative cognitive and emotional responses towards pain – may contribute to working memory deficits by occupying finite, shared cognitive resources, but this has yet to be investigated. The present study sought to clarify the role of pain catastrophizing (assessed as both a trait-level disposition and state-level process) in working memory dysfunction. Healthy undergraduate participants were randomized to an ischemic pain or control task, during which they completed verbal and non-verbal working memory tests. They also completed measures of state- and trait-level pain catastrophizing. Mediation analyses indicated that state-level pain catastrophizing mediated the relationships of pain group to both verbal and non-verbal working memory, such that participants in the pain group (vs. the control group) catastrophized more about their pain, which then resulted in worse verbal and non-verbal working memory performance. In moderated mediation analyses, trait-level pain catastrophizing moderated this mediation effect for both verbal and non-verbal working memory. Those participants in the pain group who reported greater tendency to catastrophize about pain in general exhibited greater catastrophizing in-the-moment during the pain task, thereby leading to worse verbal and non-verbal working memory performance. These results provide evidence for pain catastrophizing as a putative mechanism and moderating factor of working memory dysfunction in pain. Future research should replicate these results in chronic pain samples, investigate other potential mechanisms (e.g., sleep), and develop interventions to ameliorate cognitive dysfunction by targeting pain catastrophizing.

<p> Part A Abstract </p> <p> Temperature coefficients of reactivity for an 37-element reference design of a thorium oxide fuelled, heavy water moderated and cooled reactor, are calculated. The physical processes which determine magnitude and sign of the coefficients are identified and discussed. Results are given for fresh fuel containing equilibrium concentrations of the fission product Xe-135 and with boron control in the moderator. Results are. also -given for fresh fuel with the equilibrium concentration of Xe-135 but without boron contorl for fuel with an exposue of 1.513 n/k barn and for fuel with an exposure of 3.13 n/k barn; each containing appropriate concentrations of 50 separate nuclides and one-pseudo fission product. The fuel temperature coefficient of reactivity is negative for all the cases studied, while the coolant temperature coefficient of reactivity is positive for all the cases studied. The void effect is an increase in reactivity for all cases studied. </p> ////////////////////// <p> Part B Abstract </p> <p> This work has been done with the purpose of studying the validity of Bragg Kleeman rule which states that for combinations of elements, the atomic stopping cross-sections are additive. The validity of Bragg Kleeman rule for low energy He ions has not been conclusively tested for solids. In this work, the comparison with the experimental stopping power of SiC with the additive stopping powers of Si and C has been made experimentally. </p> <p> A thick target technique in the experimental evaluation of the stopping powers is used. This method has some simplicity over the thin target techniques. </p> <p> A calibration of the McMaster University Van-de Graff accelerator was done. Experiments were conducted later using the calibration curves produced. </p> <p> The report contains a brief account on different sources of errors due to the Van-de-Graff accelerator calibration and due to stopping power experiments. </p> / Thesis / Doctor of Philosophy (PhD)

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