Thesis (Ph. D.)--University of Washington, 2005. / Vita. Includes bibliographical references (leaves 189-196).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1953. / Typescript. Vita. Includes bibliographical references (leaves [86]-88).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1975. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (p. 150-175).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1971. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1956. / Typescript. Abstracted in Dissertation abstracts, v. 16 (1956) no. 11, p. 2224. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 65-69).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1974. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 105-109).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1954. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 34-35).

Made available in DSpace on 2012-09-05T18:24:04Z (GMT). No. of bitstreams: 2 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) 316.pdf: 1405673 bytes, checksum: 442a2a93e9c2d02b5b4d40ef2bbfe3a1 (MD5) Previous issue date: 2008 / (...) O objetivo deste estudo é fornecer informações para essas lacunas. Nós investigamos a cinética do antimoniato de meglumina (AM) em macacos Rhesus; avaliamos a transferência para o leite materno e lactentes quando ratas lactantes foram tratadas com AM; e estudamos a expressão e atividade de citocromos P450 (CYP) hepáticos em ratos machos tratados com AM. Macacos Rhesus foram tratados com injeções diárias intramusculares durante 21 diasconsecutivos e os níveis de antimônio no sangue, durante e após o tratamento, foram determinados. Níveis de antimônio residual (24 ou 48 horas) após a última injeção foram maiores em hemácias que no plasma. Tireóide, fígado, baço, vesícula, pulmões, pele e rins apresentaram níveis detectáveis de antimônio 60 dias após o fim dotratamento. Níveis detectáveis de antimônio foram encontrados no leite materno de ratas Wistar tratadas por via subcutânea com AM. As ninhadas das mães tratadas também apresentaram níveis detectáveis de Sb, sugerindo que o antimônio é transferido para o leite e absorvido pelos filhotes. Ratos machos adultos foram tratados com AM (300 mgSbV/ kg peso corpóreo/dia por via subcutânea) ou apenas com o veículo, durante 20 dias. As atividades de etoxiresorufina-O-desetilase (EROD), benziloxiresorufina-Odesbenzilase(BROD) erithromicina N-desmetilase (END) (marcadores de CYP1A1/2,CYP2B1/2 e CYP3A, respectivamente) estavam diminuídas nos microssomos hepáticos de ratos tratados com AM. Uma vez que as atividades de N-nitrosodimeilamina desmetilase (NDMA) e anilina 4-hidroxilase (A4H), marcadores de CYP2E1, estavamdiminuídas e a de p-nitrofenol-hidroxilase (PNPH) estava aumentada, sugerimos que a PNPH no fígado de ratos seja catalisada não somente CYP2E1, mas outras isoformas deCYP. As alterações encontradas e os resultados de immunoblotting e PCR real-time sugerem que o tratamento com AM altera as atividades de CYP através de mecanismos pós-traducionais.

Natal dispersal may have considerable social, ecological and evolutionary consequences. While speciesspecific dispersal strategies have received much attention, individual variation in dispersal decisions and its fitness consequences remain poorly understood. We investigated causes and consequences of natal dispersal age in rhesus macaques (Macaca mulatta), a species with male dispersal. Using long-term demographic and genetic data from a semi-free ranging population on Cayo Santiago, Puerto Rico, we analysed how the social environment such as maternal family, group and population characteristics affected the age at which males leave their natal group. While natal dispersal age was unrelated to most measures of group or population structure, our study confirmed earlier findings that sons of high-ranking mothers dispersed later than sons of low-ranking ones. Natal dispersal age did not affect males\\\' subsequent survival, but males dispersing later were more likely to reproduce. Late dispersers were likely to start reproducing while still residing in their natal group, frequently produced extra-group offspring before natal dispersal and subsequently dispersed to the group in which they had fathered offspring more likely than expected. Hence, the timing of natal dispersal was affected by maternal rank and influenced male reproduction, which, in turn affected which group males dispersed to.

No description available.