Over half of patients with gastroesophageal reflux disease (GERD) report nocturnal symptoms. Proton pump inhibitors (PPIs) are the main medications used to treat GERD. Multichannel intraluminal impedance with pH (MII-pH) monitoring is the most sensitive method for detection and characterization of GERD. The aim of this study was to assess and compare reflux frequency in patients with refractory GERD symptoms on and off PPI therapy during the nocturnal recumbent period, as assessed by MII-pH testing. We analyzed 24-hour MII-pH studies performed in 200 patients monitored either on twice-daily (n=100) or off (n=100) PPI therapy. Demographic analysis of the on-therapy group revealed a mean age of 52 years (24-78 years) with 37% males, and the off-therapy group revealed a mean age of 49 years (18-84 years) with 40% males. All studies were interpreted to assess and characterize the number of acid and nonacid reflux episodes in the nocturnal recumbent period identified by each patient on an overnight recorder (Zephyr, Sandhill Scientific, Inc., Highlands Ranch, CO, USA). The nocturnal recumbent period was the period documented by patients during which they lie in the recumbent period at night to sleep with average periods lasting 456 and 453 minutes for patients on and off PPI therapy. There were more mean recumbent reflux episodes in the on-therapy group in comparison with the off-therapy group (3.76 mean reflux episodes [mre] per patient in the recumbent vs. 2.82 mre); the difference was not statistically significant (P=0.187). When the reflux events are classified into acid and non-acid reflux episodes, the relative occurrence of acid reflux events is less in the on-therapy group (P=0.047), while the off-therapy group have fewer nonacid reflux episodes (P=0.003). PPIs decrease the acidity of esophageal refluxate but do not decrease the relative frequency of reflux episodes in the recumbent position in patients with refractory GERD despite twice-a-day treatment with PPI therapy. The explanation for the finding of numerically increased, although not statistically significant, amount of reflux episodes in the PPI treatment group in this study, and previous studies is unclear and warrants further evaluation.

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Purpose - The purpose of this thesis is to first describe and secondly to create a deeper understanding of what purpose a store has in omnichannel retailing. It is important to clarify that the study is to be of use for companies as to help them understand their customers' perspective. And how to adapt their omnichannel strategy when one of their channels gets affected. This is to see if a new model is viable in a post pandemic world. Methodology - The study applied a qualitative method where semi-structured interviews was held with employees and with consumers. Findings - The stores’ main purpose during the pandemic has been to act as a hybrid warehouse where you can view the product before fully purchasing it or to utilise BOPIS. The store has also had to change and adapt accordingly. Ultimately the store has proven to stand firm and showed that it still has a place in the market. Practical Implications - The current pandemic has made it more important for retailers to identify when showrooming or reverse showrooming is used. Therefore, a more in-depth analysis on the different approaches to minimise the usage of showrooming and reverse showrooming is necessary. As our findings from data and literature both cases suggest that price and product evaluation are the main reasons why consumers are showrooming. We can draw the conclusion that showrooming, and reverse showrooming is used mainly because of the price and evaluation of the product. Retailers should therefore introduce sales strategies to gain customers in the competitive market and minimise the risk for customers to use showrooming or reverse showrooming. Contribution - This study contributes to the young research area by assessing the effects that showrooming and reverse showrooming may have on retailers. And how to adapt their omnichannel strategy when one of their channels gets affected.

As If It Were One Day is a multimedia art installation that chronicles patterns of light, movement, and sound, channeling the fluidity of time within the newborn phase of familial living. After giving birth to my daughter, I spent the next seven weeks observing these elements and recording them via video. The resulting art installation acknowledges my efforts to navigate my current life as an artist and a mother, my past battle with postpartum depression, and my consequent gravitation toward light.

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