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Jusqu'à récemment, les patients souffrant d'épilepsie réfractaire aux traitements médicamenteux étaient destinés à un avenir incertain. Le recours à la chirurgie comme traitement alternatif offre l'espoir de mener un jour une vie normale. Pour déterminer si un patient peut bénéficier d’une intervention chirurgicale, une évaluation complète est cruciale. Les méthodes d’évaluation préchirurgicale ont connu des progrès importants au cours des dernières décennies avec le perfectionnement des techniques d’imagerie cérébrale. Parmi ces techniques, la spectroscopie proche infrarouge (SPIR), aussi connue sous le nom d’imagerie optique, présente de nombreux avantages (coût, mobilité du participant, résolution spatiale et temporelle, etc.). L’objectif principal de cette étude est de développer un protocole d'évaluation préchirurgicale de la mémoire. Une tâche de mémoire verbale incluant l’encodage, le rappel immédiat et le rappel différé de listes de mots a été administrée à dix adultes sains lors d’un enregistrement en imagerie optique. Les résultats obtenus suggèrent l’activation bilatérale des aires préfrontales antérieures et dorsolatérales ainsi que des aires temporales antérieures et moyennes. Les aires préfrontales et temporales antérieures semblent modulées par les différents processus mnésiques et la position du rappel dans le temps. La première fois qu’une liste est rappelée, l’activité hémodynamique est plus élevée que lors des rappels subséquents, et ce, davantage dans l’hémisphère gauche que dans l’hémisphère droit. Cette étude constitue la première étape dans le processus de validation du protocole à des fins cliniques auprès de patients épileptiques. / Until recently, patients with epilepsy refractory to drug treatments were intended to an uncertain future. Surgery as an alternative treatment offers hope to, one day, lead a normal life. In order to determine if a patient may benefit from a surgical intervention, a complete evaluation is essential. With the advancements in brain imagery techniques over the last few decades, preoperative evaluation methods have seen important progress. Among these techniques, near infrared spectroscopy (NIRS), also known as optical imaging, presents numerous advantages (cost, participant mobility, spatial and temporal resolution, etc.). The purpose of this study is to develop a preoperative evaluation protocol for memory assessment. During a NIRS recording, a verbal memory task including encoding, immediate and delayed free-recall of a list of words was administered to ten healthy adults. The results obtained revealed bilateral activation of anterior and dorsolateral prefrontal areas as well as anterior and median temporal areas. Prefrontal and anterior temporal areas seemed to be regulated by different memory processes and the recall location in time. The first time that a list is recalled, increased hemodynamic activity is observed in comparison to subsequent recalls, with a greater activity in the left hemisphere than in the right hemisphere. This study constitutes the first step in the validation process of the protocol for clinical needs among epileptic patients.

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

To produce high quality paper, lignin should be removed from the pulp. Quantification of lignin concentrations using standard wet chemistry is accurate but time consuming and costly, thus not appropriate for a large number of samples. The ability of hyperspectral remote sensing to predict foliar lignin concentrations could be utilized to estimate wood lignin concentrations if meaningful relationships between wood and foliar chemistry are established. LAI (leaf area index) is a useful parameter that is incorporated into physiological models in forest assessment. Measuring LAI over vast areas is labour intensive and expensive; therefore, LAI has been correlated to vegetation indices using remote sensing. Broadband indices use average spectral information over broad bandwidths; therefore details on the characteristics of the forest canopy are compromised and averaged. Moreover, the broadband indices are known to be highly affected by soil background at low vegetation cover. The aim of this study is to determine foliar and wood lignin concentrations of Eucalyptus clones using hyperspectral lignin indices, and to estimate LAI of Eucalyptus clones from narrowband vegetation indices in Zululand, South Africa Twelve Eucalyptus compartments of ages between 6 and 9 years were selected and 5 trees were randomly sampled from each compartment. A Hyperion image was acquired within ten days of field sampling, SI and LAI measurements. Leaf samples were analyzed in the laboratory using the Klason method as per Tappi standards (Tappi, 1996-1997). Wood samples were analyzed for lignin concentrations using a NIRS (Near Infrared Spectroscopy) instrument. The results showed that there is no general model for predicting wood lignin concentrations from foliar lignin concentrations in Eucalyptus clones of ages between 6 and 9 years. Regression analysis performed for individual compartments and on compartments grouped according to age and SI showed that the relationship between wood and foliar lignin concentration is site and age specific. A Hyperion image was georeferenced and atmospherically corrected using ENVI FLAASH 4.2. The equation to calculate lignin indices for this study was: L1R= ~n5il: A'''''y . 1750 AI680 The relationship between the lignin index and laboratory-measured foliar lignin was significant with R2 = 0.79. This relationship was used to calculate imagepredicted foliar lignin concentrations. Firstly, the compartment specific equations were used to calculate predicted wood lignin concentrations from predicted foliar lignin concentrations. The relationship between the laboratorymeasured wood lignin concentrations and predicted wood lignin concentrations was significant with R2 = 0.91. Secondly, the age and site-specific equations were used to convert foliar lignin concentration to wood lignin concentrations. The wood lignin concentrations predicted from these equations were then compared to the laboratory-measured wood lignin concentrations using linear regression and the R2 was 0.79 with a p-value lower than 0.001. Two bands were used to calculate nine vegetation indices; one band from the near infrared (NIR) region and the other from the short wave infrared (SWIR). Correlations between the Vis and the LAI measurements were generated and . then evaluated to determine the most effective VI for estimating LAI of Eucalyptus plantations. All the results obtained were significant but the NU and MNU showed possible problems of saturation. The MNDVI*SR and SAVI*SR produced the most significant relationships with LAI with R2 values of 0.899 and 0.897 respectively. The standard error for both correlations was very low, at 0.080, and the p-value of 0.001. It was concluded that the Eucalyptus wood lignin concentrations can be predicted using hyperspectral remote sensing, hence wood and foliar lignin concentrations can be fairly accurately mapped across compartments. LAI significantly correlated to eight of the nine selected vegetation indices. Seven Vis are more suitable for LAI estimations in the Eucalyptus plantations in Zululand. The NU and MNU can only be used for LAI estimations in arid or semi-arid areas. / Thesis (M.Sc.)-University of KwaZulu-Natal, Pietermaritzburg, 2006.

Acacia mearnsii (black wattle) is an important South African commercial forestry species, providing a source of high quality raw material (fibre) for both the domestic and international pulp and paper industries. Compared with many Pinus and Eucalyptus species, there has been very little research into the wood and pulping properties of black wattle. The ability to assess pulp yield in a non-destructive manner, using near infrared (NIR) spectroscopy, is vital from a tree improvement perspective. Destructive sampling and analysis, results in the loss of the genotype, while also being very expensive and time consuming. In order to assess some of the important characteristics that make the species desirable from a fibre perspective, this study investigates growth characteristics, wood density and pulp yield of ten trees grown on each of three different sites namely, Bloemendal, Glen Echo and Phoenix, and from each of three different age classes being 7- , 9- and 11-years-old. In total, 90 trees were sampled for this stage of the study. In general, physical characteristics such as utilisable height and diameter at breast height of the trees differed between sites and increased with age, this age effect trend was not reflected in the pulp yield or wood density results. Pulp yield measurements ranged from 52.61 to 59.91% across all sites and age classes, which, when compared to the pulp yield from many other forestry species, is relatively high. Laboratory pulp yield data was used in conjunction with NIR spectra obtained from the same wood samples to calibrate a NIR spectrophotometer to predict pulp yield. Thirty 11- year-old trees were then chosen from the Bloemendal site and sampled extensively to investigate the within-tree variation in pulp yield. The NIR model developed was used to measure the pulp yield from the numerous samples taken from within the trees. In general, pulp yield decreased from pith to bark and from the base of the tree to about 20% of the tree height and then decreased towards the top of the tree. The within-tree variation data for pulp yield was analysed to identify the best position for non-destructive sampling, and a model was then developed to predict whole tree pulp yield based on this sample, which was taken at 1.4 m up the tree. The analyses of small samples of wood meal, using near infrared spectroscopy, enabled the prediction of whole tree pulp yield. / Thesis (M.Sc.) - University of KwaZulu-Natal, Pietermaritzburg, 2009.

Roll compaction is a continuous process commonly used in the pharmaceutical industry for dry granulation of moisture and heat sensitive powder blends. It is intended to increase bulk density and improve flowability. Roll compaction is a complex process that depends on many factors, such as feed powder properties, processing conditions and system layout. Some of the variability in the process remains unexplained. Accordingly, modeling tools are needed to understand the properties and the interrelations between raw materials, process parameters and the quality of the product. It is important to look at the whole manufacturing chain from raw materials to tablet properties. The main objective of this thesis was to investigate the impact of raw materials, process parameters and system design variations on the quality of intermediate and final roll compaction products, as well as their interrelations. In order to do so, we have conducted a series of systematic experimental studies and utilized chemometric tools, such as design of experiments, latent variable models (i.e. PCA, OPLS and O2PLS) as well as mechanistic models based on the rolling theory of granular solids developed by Johanson (1965). More specifically, we have developed a modeling approach to elucidate the influence of different brittle filler qualities of mannitol and dicalcium phosphate and their physical properties (i.e. flowability, particle size and compactability) on intermediate and final product quality. This approach allows the possibility of introducing new fillers without additional experiments, provided that they are within the previously mapped design space. Additionally, this approach is generic and could be extended beyond fillers. Furthermore, in contrast to many other materials, the results revealed that some qualities of the investigated fillers demonstrated improved compactability following roll compaction. In one study, we identified the design space for a roll compaction process using a risk-based approach. The influence of process parameters (i.e. roll force, roll speed, roll gap and milling screen size) on different ribbon, granule and tablet properties was evaluated. In another study, we demonstrated the significant added value of the combination of near-infrared chemical imaging, texture analysis and multivariate methods in the quality assessment of the intermediate and final roll compaction products. Finally, we have also studied the roll compaction of an intermediate drug load formulation at different scales and using roll compactors with different feed screw mechanisms (i.e. horizontal and vertical). The horizontal feed screw roll compactor was also equipped with an instrumented roll technology allowing the measurement of normal stress on ribbon. Ribbon porosity was primarily found to be a function of normal stress, exhibiting a quadratic relationship. A similar quadratic relationship was also observed between roll force and ribbon porosity of the vertically fed roll compactor. A combination of design of experiments, latent variable and mechanistic models led to a better understanding of the critical process parameters and showed that scale up/transfer between equipment is feasible.

Pelchem, a commercial subsidiary of Necsa (South African Nuclear Energy Corporation), produces a range of commercial fluorocarbon products while driving research and development initiatives to support the fluorine product portfolio. One such initiative is to develop improved analytical techniques to analyse product composition during development and to quality assure produce. Generally the C–F type products produced by Necsa are in a solution of anhydrous HF, and cannot be directly analyzed with traditional techniques without derivatisation. A technique such as vibrational spectroscopy, that can analyze these products directly without further preparation, will have a distinct advantage. However, spectra of mixtures of similar compounds are complex and not suitable for traditional quantitative regression analysis. Multivariate data analysis (MVA) can be used in such instances to exploit the complex nature of spectra to extract quantitative information on the composition of mixtures. A selection of fluorocarbon alcohols was made to act as representatives for fluorocarbon compounds. Experimental design theory was used to create a calibration range of mixtures of these compounds. Raman and infrared (NIR and ATR–IR) spectroscopy were used to generate spectral data of the mixtures and this data was analyzed with MVA techniques by the construction of regression and prediction models. Selected samples from the mixture range were chosen to test the predictive ability of the models. Analysis and regression models (PCR, PLS2 and PLS1) gave good model fits (R2 values larger than 0.9). Raman spectroscopy was the most efficient technique and gave a high prediction accuracy (at 10% accepted standard deviation), provided the minimum mass of a component exceeded 16% of the total sample. The infrared techniques also performed well in terms of fit and prediction. The NIR spectra were subjected to signal saturation as a result of using long path length sample cells. This was shown to be the main reason for the loss in efficiency of this technique compared to Raman and ATR–IR spectroscopy. It was shown that multivariate data analysis of spectroscopic data of the selected fluorocarbon compounds could be used to quantitatively analyse mixtures with the possibility of further optimization of the method. The study was a representative study indicating that the combination of MVA and spectroscopy can be used successfully in the quantitative analysis of other fluorocarbon compound mixtures. / Thesis (M.Sc. (Chemistry))--North-West University, Potchefstroom Campus, 2012.