This work deals with analysis of phonation in patients with Parkinson’s disease (PD). Approximately 90% of patients with Parkinson’s disease suffer from speech motor dysfunction called hypokinetic dysarthria. System for Parkinson’s disease analysis from speech signals is proposed and several types of features are examined. Czech Parkinson’s speech database called PARCZ is used for classification. This dataset consists of 84 PD patients and 49 healthy controls. Results are evaluated in two ways. Firstly, features are individually analysed by Spearman correlation, mutual information and Mann-Whitney U test. Classification is based on random forests along with leave-one-out validation. Secondly, SFFS algorithm is employed for feature selection in order to get the best classification result. Proposed system is tested for each gender individually and both genders together as well. Best result for both genders together is expressed by accuracy 89,47 %, sensitivity 91,67% and specificity 85,71 %. Results of this work showed that the most important vowel realizations for phonation analysis are sustained vowels pronounced with maximum or minimum intensity (not whispering).

This thesis is about design and implementation of application for computing speech parameters on people with Parkinson disease. At the beginning is generaly described Parkinson disease and Hypokinetic dysarthria and how it affects the speech and speech parameters when it occurs. Mainly there are described areas of speech like phonation, prosody, articulation and fluent speech. As a part of next topic this thesis describes specific speech parameters with bigger meaning during diagnosis Parkinson disease and it's progress over the time. There are also mentioned few significant studies dealing with examination of speech of the subjects with diagnoses of Parkinson disease and computing some speech parameters in order to analyze their speech impairments. Part of the thesis is description of implemented standalone application for calculating, exporting and visualizing of speech parameters from selected sound records.

The main topic of this thesis is the work of Karel Čapek in actual historical, political and social context with focus on the dramas The White Disease and The Mother. The aim of this paper is to decode the ethical aspects and the heritage to the moral values connected to the deterioration of the whole situation in democratic Europe in between the world wars inside Čapek's work. Keywords Karel Čapek, The Mother, The White Disease, apocryphas, stories, pragmatism, relativism, ethics, philosophy

This thesis is focused on the use of olfactory tests in neuropsychological diagnostics of Alzheimer's disease and on the cognitive correlates of these tests. The literature review briefly summarizes current knowledge of the diagnostics of Alzheimer's disease and its dynamically developing criteria. Attention is also paid to the olfactory impairment that occurs during the course of this disease, as well as to specific psychophysical olfactory tests. The research part summarizes the results of research within the grant GACR 17-05292S, 01. 01. 2017 - 31. 12. 2019 - New blood biomarkers for early diagnosis, prognosis and course of Alzheimer's disease held at the Psychiatric Clinic of the First Faculty of Medicine and General Teaching Hospital. The exploratory analysis examines possible cognitive correlates of the olfactory Sniffin' Sticks test. Practical experience with olfactory test is evaluated in the discussion. Keywords Alzheimer's disease, olfactory deficit, smell tests, Sniffin'-Sticks, neuropsychological diagnostics

This thesis "Disease from the perspective of selected world religions" first defines related terms, such as health, illness and religion, and then presents the problem of disease in the Buddhist, Judaic, Christian and Islamic concepts. Information is obtained from the basic religious texts and then from considerations of experts who dealt with the issue. The main objective of this thesis is to show how the religion looks at the causes of disease and how these causes have been associated with human sin. There are also reflected differences that result from the historical development and the different currents of thought within each religion. The study also examined the impact that a religious basis for the practical life of the faithful in the medical and social. In conclusion, the positions of the various religions are compared.

My diploma thesis deals with issues of gender relations and the construction of identities of lived experiences of parents caring for a child (children) with a chronic illness. For my qualitative research, I have chosen the method of semi-structured interviews with both parents of the child (children). Subsequent analysis of the data in this empirical study examines the way in which care for a child with chronic illness affects, due to its demanding character, gender relations and whether it leads to more balanced gender relations or vice versa. I also deal with the process of identifying both parents in the day care of a child with chronic illness in the context of a combination of paid work and home care and children. In my work, I see how my communication partners are conceptualizing the chronic illness of the child as a differentness and the care of a child with a chronic illness as a burden. I focus on the emotional plane of parenthood and also analyze the processes of negotiation within different institutions (health and education organizations, state authorities). Key words: Chronic illness, child, parenthood, differentness, burden, care, gender relations

Huntington's disease is a dominantly-inherited autosomal neurodegenerative disease manifested by disorders of motility, cognitive function, behaviour, and weight loss, which is conditioned multifactorially. The aim of the study was to determine whether there are eating disorders in Huntington's disease, as well as its etiology and severity. Neurological scaling, anthropometric examinations, evaluation of three-day diet records, measurements with a manual dynamometer, bioimpedance analyses, indirect colorimetry and predictions of energy expenditure were performed on 10 patients. Algorithms were applied for the diagnosis of sarcopenia and malnutrition. Unwanted weight loss was observed in all patients and 4 out of 10 showed malnutrition. No difference was found between the values of measured resting metabolism and calculated according to the predictive equation. However, it has been shown that strict nutritional recommendations based on this data can be misleading for some patients with HN, as real energy consumption can be significantly higher. All our patients had a positive energy balance. A new diagnostic algorithm for the early diagnosis of sarcopenia has proven its worth. Using bioimpedance analysis and examination of the force of the handshake, we identified possible sarcopenia and already-present...

Compensation for the bereaved in the case of work accidents and occupational diseases Abstract The topic of my diploma thesis is compensation for the bereaved in the case of work accidents and occupational diseases. It is a topic with a relatively settled legislation and a subject which is present - nevertheless, ground-breaking changes in this issue cannot be really anticipated any more. Introductory part of my thesis deals primarily with a theoretical definition of a term liability and liability in labor law. It deals with the conditions of inception of liability, the reasons that allow release from liability and finally, with the obligation of an employer to compensate damages or non-material damage in the cases of work accidents and occupational diseases. I also devote myself to define terms work accident and occupational disease, and for better understanding and explanation of disputable questions, I refer to judicature of the Supreme Court and the Constitutional Court. The mainstay of my thesis is dedicated to the particular types of compensation provided either directly to the aggrieved employees as the consequence of work accident or occupational disease, or to the bereaved in the case of death due to the work accident or occupational disease. I also compare the labor law regulation to the...

Nutrition of both professional and occasional climbers in high altitude is often discussed topic in sports nutrition. Specially with latest studies showing connection between poor nutrition and high altitude sickness development. Dehydration in particular has a huge effect on the body at these altitudes and can be responsible for many of the symptoms previously attributed to hypoxia. The research was focused on the theoretical part, in which basic issue of nutrition and hydration are shown, as well as the acute issues that climbers may have experience on their journey to high altitude. The practical part was evaluated by a quantitative approach with the help of a questionnaire survey and its evaluation. The questionnaire was anonymous, nonstandardized with open and closed questions. A total of 68 respondents participated in the research. The results of the investigation are evaluated and discussed in the final parts of the thesis. The main objective of the thesis was focused on the dietary habits of respondents during their stay in high altitude, their awareness of the risks resulting from poor nutrition and dehydration and assess how much care respondents take about nutrition and hydration during their travels. Four hypotheses were set for the thesis. Key words: Nutrition; hydratation; acute...

This thesis analyses Ingeborg Bachmann's posthumously published texts in the volume Male oscuro. Aufzeichnungen aus der Zeit der Krankheit and their relations to her literary work. Two central themes are elaborated through the analysis of the volume: illness and writing. The focus is on Bachmann's conception of writing and the issues arising from it. A comparison between Male oscuro and the author's work, the short story Undine geht and two poems Keine Delikatessen and Böhmen liegt am Meer, shows analogies on several different levels. The concept of utopia indicates continuity in Bachmann's work and the existential condition for her writing in relation to the metaphor of 'desert'. Key words: Ingeborg Bachmann, Male oscuro, illness, writing, metaphoric, contrariness, comparison, utopia