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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
121

Muscarinic M3 Knockdown is Associated with Cardiovascular and Nodal CiliaDysfunction

Ley, Sidney T. January 2020 (has links)
No description available.
122

Direct Injection of Substance P-antisense Oligonucleotide Into the Feline NTS Modifies the Cardiovascular Responses to Ergoreceptor but Not Baroreceptor Afferent Input

Williams, Carole A., Ecay, Tom, Reifsteck, Angela, Fry, Bonnie, Ricketts, Brian 14 February 2003 (has links)
Substance P (SP) is released from the feline nucleus tractus solitarius (NTS) in response to activation of skeletal muscle afferent input. However, there are differing results about SP release from the rostral NTS in response to baroreceptor afferent input. An anti-sense oligonucleotide to feline SP (SP-asODN) was injected directly into the rostral NTS of chloralose-anesthetized cats to determine whether blood pressure or heart rate responses to ergoreceptor activation (muscle contraction) or baroreceptor unloading (carotid artery occlusion) were sensitive to SP knockdown. Control injections included either buffer alone or a scrambled-sequenced oligonucleotide (SP-sODN). Both muscle contractions and carotid occlusions were performed 3, 6 and 12 h after the completion of the oligonucleotide injections. The cardiovascular responses to contractions were significantly attenuated 3 and 6 h after SP-asODN, but not by the injection of the SP-sODN. The cardiovascular responses to contractions returned to control levels 12 h post anti-sense injection. No detectable release of SP (using antibody-coated microprobes) was measured 3 and 6 h after SP-asODN injections and the expression of SP-immunoreactivity (SP-IR) in the NTS was significantly attenuated, as determined by immunohistochemistry procedures. In contrast, neither the injection of SP-asODN nor the s-ODN attenuated the cardiovascular responses to carotid occlusions, or altered the pattern of release of SP from the brainstem. Injection of the SP-sODN did not affect the expression of SP-IR. These results suggest that the SP involved with mediating the peripheral somatomotor signal input to the rostral NTS comes from SP-containing neurons within the NTS. Our results also suggest that SP in the rostral NTS does not play a direct role in mediating the cardiovascular responses to unloading the carotid baroreceptors. We suggest that the SP released during isometric contractions excites an inhibitory pathway modulating baroreceptor input, thus contributing to the increase in mean blood pressure.
123

Syntheses and Characterization of Nanoparticles Applied as either Sensors or Therapeutic Agents

Nogueira e Silva, Rebecca 24 May 2022 (has links)
No description available.
124

Transcriptional and genetic profiling of human uveal melanoma from an immunosuppressed rabbit model

Marshall, Jean-Claude. January 2007 (has links)
No description available.
125

Investigations into the design and dissection of genetic networks

Libby, Eric. January 2007 (has links)
No description available.
126

Branchpoints as potential targets of exon-skipping therapies for genetic disorders / ブランチポイントは遺伝性疾患に対するエクソンスキッピング療法の有望な標的である

Ohara, Hiroaki 23 January 2024 (has links)
京都大学 / 新制・課程博士 / 博士(医学) / 甲第24996号 / 医博第5030号 / 新制||医||1069(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 齊藤 博英, 教授 滝田 順子, 教授 小川 誠司 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
127

HIV Drug Resistance Polymorphism Analysis Using Ligase Discrimination

Lalonde, Matthew Scott 19 June 2009 (has links)
No description available.
128

NANOPARTICLE DRUG DELIVERY SYSTEMS FOR CANCER THERAPY

Yung, Bryant Chinung January 2014 (has links)
No description available.
129

Spectroscopic methods for drug-discovery targeting RNA thermometers

Sieg, Jacob P. 26 April 2017 (has links)
No description available.
130

Expression and Function of microRNA in Human Cancer

Lee, Eun Joo 11 September 2008 (has links)
No description available.

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