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Muscarinic M3 Knockdown is Associated with Cardiovascular and Nodal CiliaDysfunctionLey, Sidney T. January 2020 (has links)
No description available.
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Direct Injection of Substance P-antisense Oligonucleotide Into the Feline NTS Modifies the Cardiovascular Responses to Ergoreceptor but Not Baroreceptor Afferent InputWilliams, Carole A., Ecay, Tom, Reifsteck, Angela, Fry, Bonnie, Ricketts, Brian 14 February 2003 (has links)
Substance P (SP) is released from the feline nucleus tractus solitarius (NTS) in response to activation of skeletal muscle afferent input. However, there are differing results about SP release from the rostral NTS in response to baroreceptor afferent input. An anti-sense oligonucleotide to feline SP (SP-asODN) was injected directly into the rostral NTS of chloralose-anesthetized cats to determine whether blood pressure or heart rate responses to ergoreceptor activation (muscle contraction) or baroreceptor unloading (carotid artery occlusion) were sensitive to SP knockdown. Control injections included either buffer alone or a scrambled-sequenced oligonucleotide (SP-sODN). Both muscle contractions and carotid occlusions were performed 3, 6 and 12 h after the completion of the oligonucleotide injections. The cardiovascular responses to contractions were significantly attenuated 3 and 6 h after SP-asODN, but not by the injection of the SP-sODN. The cardiovascular responses to contractions returned to control levels 12 h post anti-sense injection. No detectable release of SP (using antibody-coated microprobes) was measured 3 and 6 h after SP-asODN injections and the expression of SP-immunoreactivity (SP-IR) in the NTS was significantly attenuated, as determined by immunohistochemistry procedures. In contrast, neither the injection of SP-asODN nor the s-ODN attenuated the cardiovascular responses to carotid occlusions, or altered the pattern of release of SP from the brainstem. Injection of the SP-sODN did not affect the expression of SP-IR. These results suggest that the SP involved with mediating the peripheral somatomotor signal input to the rostral NTS comes from SP-containing neurons within the NTS. Our results also suggest that SP in the rostral NTS does not play a direct role in mediating the cardiovascular responses to unloading the carotid baroreceptors. We suggest that the SP released during isometric contractions excites an inhibitory pathway modulating baroreceptor input, thus contributing to the increase in mean blood pressure.
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Syntheses and Characterization of Nanoparticles Applied as either Sensors or Therapeutic AgentsNogueira e Silva, Rebecca 24 May 2022 (has links)
No description available.
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Transcriptional and genetic profiling of human uveal melanoma from an immunosuppressed rabbit modelMarshall, Jean-Claude. January 2007 (has links)
No description available.
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Investigations into the design and dissection of genetic networksLibby, Eric. January 2007 (has links)
No description available.
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Branchpoints as potential targets of exon-skipping therapies for genetic disorders / ブランチポイントは遺伝性疾患に対するエクソンスキッピング療法の有望な標的であるOhara, Hiroaki 23 January 2024 (has links)
京都大学 / 新制・課程博士 / 博士(医学) / 甲第24996号 / 医博第5030号 / 新制||医||1069(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 齊藤 博英, 教授 滝田 順子, 教授 小川 誠司 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
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HIV Drug Resistance Polymorphism Analysis Using Ligase DiscriminationLalonde, Matthew Scott 19 June 2009 (has links)
No description available.
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NANOPARTICLE DRUG DELIVERY SYSTEMS FOR CANCER THERAPYYung, Bryant Chinung January 2014 (has links)
No description available.
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Spectroscopic methods for drug-discovery targeting RNA thermometersSieg, Jacob P. 26 April 2017 (has links)
No description available.
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Expression and Function of microRNA in Human CancerLee, Eun Joo 11 September 2008 (has links)
No description available.
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