Objetivo: Determinar la incidencia de osteoporosis densitométrica en mujeres adultas mayores posmenopáusicas. Material Y Métodos: Se realizó un estudio observacional, descriptivo, prospectivo de corte transversal y no probabilístico. Se incluyeron 146 pacientes mujeres adultos mayores que se realizaron un examen de densitometría ósea completa en el servicio de densitometría del centro médico Global Diagnóstico. Resultados: De los 146 casos, se encontró 8(5.48 %) densitometrías normales y 138(94.52%) anormales; de las cuales tenemos 38(26.03% casos de osteopenia y 100(68.49%) casos de osteoporosis. De los 100 casos de osteoporosis 6(6%) solamente presentaron compromiso en columna, 25(25%) solamente presentaron compromiso en antebrazo, 49(49%) presentaron compromiso en columna y antebrazo, 3(3%) presentaron compromiso en caderas y antebrazo, y únicamente 17(17%) casos comprometieron las tres regiones: columna, caderas y antebrazo. La osteoporosis es mayor a partir de los 75 años hasta los 84 años y desde los 85 años hasta los 94 años, donde ya no se encontró casos normales. Conclusión: Se concluyó que en la mayoría de exámenes densitométricos que se realizan, al sexo femenino adulto mayor, la osteoporosis es frecuente. En nuestro estudio el 68.5 % de las mujeres tienen osteoporosis. Se demostró que la osteoporosis es mayor en las mujeres posmenopáusicas que tienen mayor peso, con 51(70%) de casos y menor talla, con 68(74.7%) de casos. Se concluyó que la mayor incidencia de osteoporosis según las tres regiones evaluadas, es en el antebrazo con 95 (65.1%) casos de osteoporosis. Palabras clave: densitometría, osteoporosis, osteopenia / Objective: To determine the incidence of densitometric osteoporosis in elderly postmenopausal women. Material and Methods: We conducted an observational, prospective cross-sectional and descriptive and non-probability. 146 Patients were included women older adults who were a bone densitometry test complete in the service of densitometry of the center Global medical diagnosis. Results: Of the 146 cases, found 8 (5.48 %) and normal densitometry 138 (94.52 %) abnormal; of which we have 38 (26.03 % of the cases of osteopenia and 100 (68.49 %) cases of osteoporosis. Of the 100 cases of osteoporosis 6 (6 %) only presented commitment in column, 25 (25 %) only presented commitment in forearm, 49 (49 %) showed commitment in column and forearm, 3 (3 %) showed commitment in hips and forearm, and only 17 (17 %) cases committed the three regions: spine, hips and forearm. Osteoporosis is higher in women older than 75 years to 84 years; since the age of 85 to 94 years, where is no longer found normal cases. Conclusion: We concluded that in the majority of reviews densitometric which they are performed, the female sex older adult, osteoporosis is frequent. In our study, the 68.5 % of women have osteoporosis. It was shown that osteoporosis is higher in postmenopausal women who have greater weight, with 51 (70 %) of cases and smaller size, with 68 (74.7 %) of cases. It was concluded that the highest incidence of osteoporosis according to the three regions evaluated, is in the forearm with 95 (65.1 %) cases of osteoporosis. Key words: densitometry, osteoporosis, osteopenia / Tesis

No description available.

Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2013-06-28T12:38:26Z No. of bitstreams: 1 TESE Johelle Passos. 2011.pdf: 5613846 bytes, checksum: 85c115d2ff833d5f23b9b2a14b9dcd4e (MD5) / Approved for entry into archive by Maria Creuza Silva(mariakreuza@yahoo.com.br) on 2013-06-28T12:38:57Z (GMT) No. of bitstreams: 1 TESE Johelle Passos. 2011.pdf: 5613846 bytes, checksum: 85c115d2ff833d5f23b9b2a14b9dcd4e (MD5) / Made available in DSpace on 2013-06-28T12:38:57Z (GMT). No. of bitstreams: 1 TESE Johelle Passos. 2011.pdf: 5613846 bytes, checksum: 85c115d2ff833d5f23b9b2a14b9dcd4e (MD5) Previous issue date: 2011 / Estudos epidemiológicos e clínicos têm identificado alguns fatores sistêmicos associados com a doença periodontal, como a deficiência estrogênica resultante da menopausa. A proposta deste estudo foi investigar a associação entre a osteoporose/osteopenia e periodontite em mulheres pósmenopausadas. Os resultados dessa investigação são apresentados em formato de três artigos científicos. O 1º artigo compreendeu uma revisão sistemática combinada a meta-análise de estudos que investigaram a relação entre osteoporose/osteopenia ou seu tratamento na presença de periodontite, obtendo uma medida sumária (OR) de 1,59 (IC95%: 1,33-1,91), estatisticamente significante. Os outros dois artigos fazem parte de uma ampla investigação desenvolvida em mulheres pós-menopausadas, com idade mínima de 50 anos, convidadas nos serviços de diagnóstico de osteoporose em Feira de Santana-Bahia para avaliação e acompanhamento periodontal na Clínica de Extensão em Periodontia da Universidade Estadual de Feira de Santana. A osteoporose/osteopenia foi determinada a partir dos laudos densitométricos, seguindo os critérios definidos pela Organizaçao Mundial de Saúde, bem como o uso de medicações para osteoporose foi registrado. A definição de periodontite adotada seguiu os critérios da Academia Americana de Periodontia. No 2º artigo, através de corte transversal, são apresentados os resultados descritivos da condição bucal de 492 mulheres pós-menopausadas, segundo o uso de medicação para osteoporose, bem como razões de prevalência (RP) da associação entre uso de medicação para osteoporose e periodontite. Os achados mostraram que o grupo de usuárias da medicação apresentou melhor condição bucal do que o grupo de não usuárias. A RP ajustada para hábito de fumar, idade, renda familiar e última visita ao dentista, evidenciou que a ocorrência de periodontite foi quase 44% menor no grupo de usuárias (RPajustada=0,56; IC95%: 0,31-0,99; p=0,05). No 3º artigo, estudo caso-controle (94 casos de periodontite e 427 controles), através de regressão logística não condicional, observou-se que as mulheres com osteoporose/osteopenia tiveram uma chance em dobro de apresentar periodontite em relação aquelas sem osteoporose/osteopenia, mesmo após ajustar por hábito de fumar, idade, renda familiar e última visita ao dentista (ORajustada=2,24; IC 95%: 1,24 – 4,06; p=0,01). Quando da análise exploratória de subgrupo para uso de medicação para osteoporose e perda dentária, evidenciou-se que entre aquelas não usuárias de medicação para osteoporose (ORajustada=2,51; IC 95%: 1,33-4,73; p=0,004) e com pelo menos dez dentes remanescentes (ORajustada=2,50; IC 95%: 1,18-5,27; p=0,016), a medida de associação elevou-se, mantendo a significância estatística. Esses achados sugerem que a osteoporose/osteopenia pode contribuir para a presença de periodontite no grupo estudado, sendo que não usar medicações para seu tratamento e a perda dentária parecem ter um efeito nesta associação. No entanto, estudos adicionais prospectivos são necessários para confirmação dessas hipóteses. / Salvador

Made available in DSpace on 2014-06-11T19:23:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-06-13Bitstream added on 2014-06-13T18:09:22Z : No. of bitstreams: 1 borges_chm_me_araca.pdf: 362636 bytes, checksum: 035182442f8440ab879288b2ed1a65a6 (MD5) / Foram utilizados 45 Rattus novergicus albinus, Wistar adultos, machos, divididos em cinco grupos: C - animais controle livres em gaiolas por 21 dias; S – animais suspensos pela cauda por 21 dias; ST – suspensos pela cauda por 21 dias, concomitantemente, tratados com US; S→C– suspensos por 21 dias, depois permaneceram em solo por 21 dias; S→CT – suspensos por 21 dias, depois permaneceram em solo por 21 dias e concomitantemente foram tratados com US. O tratamento foi realizado com US com frequência de 1,5 MHz, ciclo de trabalho 1:4, 30mW/cm2, na tíbia do antímero direito, por 15 sessões de 20 minutos. Com os animais ainda vivos foram submetidos ao exame de densitometria óssea para verificação da Área, Densidade Mineral Óssea (DMO) e Conteúdo Mineral Ósseo (CMO). Após a eutanásia dos animais, as tíbias foram submetidas à análise da Força máxima (Fmáx), rigidez (R) comprimento (L) e diâmetro (D) O grupo S apresentou valores para DMO, CMO, Fmáx, R, L e D menores em relação ao grupo controle, demonstrando que a suspensão é prejudicial à manutenção das propriedades ósseas. Ao tratar os animais suspensos com o US, encontramos para este grupo (ST) valores de CMO e DMO maiores que o S e iguais ao C. Ao compararmos a Fmáx, rigidez e comprimento ósseo do ST com o S, observamos um aumento com o tratamento e ao comparar o ST com o C percebemos também um aumento significativo destes parâmetros Ao comparar o S→CT com o S→C não encontramos diferença significativa para Fmáx, R, L, D, DMO e CMO. Os resultados obtidos neste estudo fornecem a conclusão de que o US contribuiu para a prevenção da ocorrência de osteopenia nos animais submetidos à suspensão pela cauda / It was used 45 Rattus novergicus albinus, male, adult Wistar, divided in five equal groups: C – control free animals in cages for 21 days; S –animals suspended by the tail for 21 days; ST – suspended by the tail for days and concurrently, treated with US; S→C - suspended for 21 days and later remained on soil for more 21 days; S→CT - suspended for 21 days and later remained on soil for more 21 days and concurrently treatment with US. The treatment was performed with US with 1,5 MHz of frequency, work cycle 1:4, 30 2 mW/cm , on right antimere tibia, for 15 sessions of 20 minutes each.with the animals still alive they were undergone bone densitometry examination to verify the Area, Bone Mineral Density (BMD) and the Bone Mineral Content (BMC). After the euthanasia of the animals, the tibias were measurement of Maximum force (Fmax) rigidity (R), length (L) and diameter (D). The results has shown that S presented BMD, BMC, bone Fmax, R, L and D smaller compared to the control group, proving that the suspension is detrimental to the maintenance of bone’s properties. By treating the suspended animals with the US, we found for this group (ST) BMD and BMC bigger than S and equal to C. By comparing ST’s bone Fmax, R and L to S, we observed an increase with the treatment, and when we compared ST with C we also noticed a significant increase of these parameters. When we compared S→CT with S→C we didn’t find significant difference for Fmax, R, L, D BMD and BMC. There was a significant difference for area between S→CT and the groups ST and S→C. The obtained results in this study provide the conclusion that the US prevents the occurrence of osteopenia on bones of animals under suspension by the tail

Made available in DSpace on 2014-06-11T19:29:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-07-24Bitstream added on 2014-06-13T18:38:55Z : No. of bitstreams: 1 agreda_cg_me_sjc.pdf: 492552 bytes, checksum: 595c43ac7e6868cedfc37076598974b1 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Por ser a osteoporose uma enfermidade de alta prevalência mundial, tem-se a importância de estudos que avaliem a repercussão óssea proveniente de supressão hormonal, como também de influência de fármacos. Em vista disto, a proposta desta pesquisa foi realizar a comparação radiográfica mediante a avaliação da densidade óptica em tons de cinza, entre o grau de osteopenia induzida por um fármaco e pela castração de ratos em dois períodos (trinta e sessenta dias). Utilizou-se 37 ratos adultos que foram divididos em: grupo I, com 5 fêmeas sham; grupo II, com 5 machos sham; grupo III, com 6 fêmeas ovariectomizadas; grupo IV, com 6 machos orquiectomizados; grupo V, com 8 fêmeas tratadas com fenitoína a 5mg/kg/dia e grupo VI, com 7 machos tratados com fenitoína a 5mg/kg/dia. Realizou-se a radiografia da tíbia esquerda de todos os grupos no período inicial, trinta e sessenta dias após o procedimento cirúrgico. Para isso foi utilizado o aparelho de raios X digital Gendex 765DC®, com 0,032s de tempo de exposição, distância focal de 40cm, 65kVp, 7mA, com feixe incidindo perperdicularmente ao sensor do sistema digital direto RVG (Trophy). A partir das imagens obtidas realizou-se a mensuração dos valores de densidade óptica de duas áreas selecionadas da tíbia (metáfise e diáfise) mediante a ferramenta histograma do programa Adobe Photoshop®. As médias das leituras de densidade óptica foram submetidas à análise de variância (ANOVA) e teste Tukey (5%). De acordo com os resultados obtidos, concluiu-se que não houve diferenças estatisticamente significantes nos valores de densidade óptica no método de indução à osteopenia pela ovariectomia ou orquidectomia, ao passo que, na indução pela fenitoína houve a indicação da sua ocorrência tanto em machos quanto em fêmeas depois de 60 dias na região da diáfise. / The aim of this research was to compare the osteopenia degree induced by phenytoin with the castration in rats for thirty and sixty days. Thirty seven rats were divided into six experimental groups: five Sham female (I); five Sham male (II); six female ovariectomy-operated (III); six male orchidectomy-operated (IV); eight female phenytoin-treated with 5mg/kg/day (V) and seven male phenytointreated with 5mg/kg/day. Digital radiographs were taken at baseline, thirty and sixty days from the left tibiae of the all groups. The X-Ray machine used was the 765 DC® with 65 kVp, 7mA, 40 cm distance focus- sensor and exposure time of the 0,032s. The direct digital device used was the RVG® (Trophy) and the values of the optical density were obtained from metaphysis and diaphysis tibial using the histogram of the software Adobe Photoshop. The measurements were submitted to ANOVA and Tukey test (5%). The results showed no possess statistically significant difference between ovariectomy-treated and orchidectomytreated groups from osteopenia induced, however, the phenytoin medication indicates this situation in male and female for diaphysis tibial at sixty days.

Class of 2013 Abstract / Specific Aims: To determine efficacy of alendronate (ALN) and risedronate (RIS) for treatment of osteoporosis and osteopenia in men. Methods: Literature search was primarily via PubMed. Inclusion criteria were: randomized controlled trials or observational studies assessing treatment of osteoporosis in men, either of primary or secondary etiology. Exclusion criteria were: minority population with baseline osteoporosis, inclusion of women, lack of control group. Primary outcomes were bone mineral density (BMD) of femoral neck (FN) and lumbar spine (LS); secondary outcomes were vertebral or non-vertebral fractures incidence. Data were synthesized using a random effects meta-analysis. Main Results: Eleven ALN and six RIS studies were included; most provided LS and FN data, but trials longer than 1-year were infrequent (ALN 3, RIS 4) as were fracture data (ALN 4, RIS 3). For both FN and LS BMD, both drugs showed significant treatment effects at one and two-years (p<0.001). For FN BMD, 2-year treatment effects were ALN: SDM= 0.638, p<0.001; RIS: SDM= 0.391, p<0.001; heterogeneity was insignificant (p> 0.05). For LS BMD, treatment effects were: 2-year ALN: SDM= 1.206, p<0.001; 1-year RIS: SDM= 0.0.574; p<0.001; heterogeneity was insignificant (p>0.05). For fracture, both drugs showed significant treatment effects at vertebral sites: ALN: OR 0.450, p<0.05; RIS: OR 0.423, p=0.001; heterogeneity was insignificant (p>0.05). RIS also showed a promising effect at non-vertebral sites (p<0.05), however only two studies provided data at this site. Conclusion: Both ALN and RIS are effective to increase BMD and decrease vertebral fracture occurrence in men with osteoporosis or osteopenia.

No description available.

La investigación tuvo por objetivo la correlación que existe entre la pérdida del hueso alveolar y los cambios de densidad mineral ósea en pacientes mujeres. La muestra constituida por noventa mujeres mayores de 35 años de edad, fueron atendidas en el Servicio de Ginecología y Reumatología del Hospital Militar Geriátrico. Las mediciones de pérdida o reabsorción de hueso alveolar (RHA) de los pacientes, fue obtenida de zonas proximales de los premolares superiores, mediante exámenes radiográficos orales con la técnica periapical paralela; y los valores de su densidad mineral ósea (DMO) mediante exámenes del cuello femoral con la técnica de Absorciometría por rayos X de doble energía (DEXA). De acuerdo al criterio de la Organización Mundial de la Salud (OMS) en categorizar los estados óseos; Se conformaron tres grupos de 30 pacientes cada grupo en NORMAL, OSTEOPENIA, OSTEOPOROSIS, con sus variables DMO, Tscore y RHA. El análisis inicial con la media aritmética, resulto que el grupo Normal tenía mayor DMO (ξ= 1.0008) que los grupos de Osteopenia (ξ= 0.7586) y Osteoporosis (ξ= 0.7127); con un Tscore de 0.1610 DS para el grupo normal, -2.0193 DS para Osteopenia y -2.6909 DS para Osteoporosis que confirman los cambios de niveles de DMO en los grupos respectivos. La RHA fue menor en el grupo Normal (ξ= 1.12) con incremento progresivo en los grupos de Osteopenia (ξ= 1.44) y Osteoporosis (ξ=3.60). La prueba F de Levene de homogeneidad, aplicados a las pruebas anteriores, se observó la homogeneidad de la DMO (F= P>0.05) y la heterogeneidad de Tscore y RHA (F= P<0.05). El análisis de varianza (ANOVA), aplicada a la DMO se tuvo un alto nivel de significación (0.0001) y la prueba de Brown – Forsythe, utilizada para Tscore y RHA, un nivel de significación de 0.0001. Para determinar con precisión el nivel de significación entre los tres grupos (Normal, Osteopenia, Osteoporosis) y sus variables (DMO, Tscore y RHA); los resultados de ANOVA y Brown – Forsythe fueron sometidos a la prueba de comparación de Post Hoc de Turkey confirmándose el nivel de significación de 0.0001. Finalmente se aplico el Coeficiente de Correlación de Pearson con resultados concluyentes de correlación altamente significativo (P< 0.01), confirmando nuestra hipótesis: Los valores bajos de la densidad mineral ósea en pacientes mujeres determina valores altos de la reabsorción del hueso alveolar. / The investigation had for objective the correlation that exists between the loss of the alveolar bone and the changes of bony mineral density in patient women. The sample constituted by ninety women bigger than 35 years of age, the were assisted in the Service of Gynecology and Rheumatology of the Hospital Military Geriatric. The mensurations of loss or reabsorption of alveolar bone (RHA) of the patients, it was obtained of areas proximal of the superior premolars, by means of exams oral radiographies with the technical parallel periapical; and the values of their bony mineral density (DMO) by means of exams of the femoral neck with the technique of Absortiometry for rays X of double energy (DEXA). According to the approach of the World Organization of the Health (WHO) in categorizing the bony states; they conformed to three groups of patient each group in NORMAL, OSTEOPENIA, OSTEOPOROSIS, with their variable DMO, tscore and RHA. The initial analysis with the arithmetic stocking, was that the normal group had bigger DMO (AND = 1.0008) that the groups of Osteopenia (AND = 0.7586) and Osteoporosis (AND = 0.7127); with a Tscore of 0.1610 DS) for the Normal group, - 2.0193 DS for osteopenia and -2.6909 DS for Osteoporosis that confirm the changes of levels of DMO in the respective groups. The RHA was smaller in the Normal group (E=1.12) with progressive increment in the groups of Osteopenia (E = 1.44) and Osteoporosis (E=3.60). la F of levene of homogeneity proves, applied to the previous test, the homogeneity of Tscore and RHA (F=P<0.05). The variance analysis (ANOVA), applied the DMO one had a high significance level (0.0001) and the test Brown- Forsythe, used for Tscore and RHA, a level of significance of 0.0001. To determine the significance level accurately among the three groups (Normal, Osteopenia, Osteoporosis) and their variables (DMO, Tscore and RHA); the results of ANOVA and Brown- Forsythe were subjected to the comparison test of Post Hoc of turkey being confirmed the level al significance of 0.0001. Finally the highly significant Coefficient of Correlation was applied (p>0.001), confirming our hypothesis: the values low of the bony mineral density in patient women determine values high the reabsorption of the alveolar bone.

La investigación tuvo por objetivo la correlación que existe entre la pérdida del hueso alveolar y los cambios de densidad mineral ósea en pacientes mujeres. La muestra constituida por noventa mujeres mayores de 35 años de edad, fueron atendidas en el Servicio de Ginecología y Reumatología del Hospital Militar Geriátrico. Las mediciones de pérdida o reabsorción de hueso alveolar (RHA) de los pacientes, fue obtenida de zonas proximales de los premolares superiores, mediante exámenes radiográficos orales con la técnica periapical paralela; y los valores de su densidad mineral ósea (DMO) mediante exámenes del cuello femoral con la técnica de Absorciometría por rayos X de doble energía (DEXA). De acuerdo al criterio de la Organización Mundial de la Salud (OMS) en categorizar los estados óseos; Se conformaron tres grupos de 30 pacientes cada grupo en NORMAL, OSTEOPENIA, OSTEOPOROSIS, con sus variables DMO, Tscore y RHA. El análisis inicial con la media aritmética, resulto que el grupo Normal tenía mayor DMO (ξ= 1.0008) que los grupos de Osteopenia (ξ= 0.7586) y Osteoporosis (ξ= 0.7127); con un Tscore de 0.1610 DS para el grupo normal, -2.0193 DS para Osteopenia y -2.6909 DS para Osteoporosis que confirman los cambios de niveles de DMO en los grupos respectivos. La RHA fue menor en el grupo Normal (ξ= 1.12) con incremento progresivo en los grupos de Osteopenia (ξ= 1.44) y Osteoporosis (ξ=3.60). La prueba F de Levene de homogeneidad, aplicados a las pruebas anteriores, se observó la homogeneidad de la DMO (F= P>0.05) y la heterogeneidad de Tscore y RHA (F= P<0.05). El análisis de varianza (ANOVA), aplicada a la DMO se tuvo un alto nivel de significación (0.0001) y la prueba de Brown – Forsythe, utilizada para Tscore y RHA, un nivel de significación de 0.0001. Para determinar con precisión el nivel de significación entre los tres grupos (Normal, Osteopenia, Osteoporosis) y sus variables (DMO, Tscore y RHA); los resultados de ANOVA y Brown – Forsythe fueron sometidos a la prueba de comparación de Post Hoc de Turkey confirmándose el nivel de significación de 0.0001. Finalmente se aplico el Coeficiente de Correlación de Pearson con resultados concluyentes de correlación altamente significativo (P< 0.01), confirmando nuestra hipótesis: Los valores bajos de la densidad mineral ósea en pacientes mujeres determina valores altos de la reabsorción del hueso alveolar. / The investigation had for objective the correlation that exists between the loss of the alveolar bone and the changes of bony mineral density in patient women. The sample constituted by ninety women bigger than 35 years of age, the were assisted in the Service of Gynecology and Rheumatology of the Hospital Military Geriatric. The mensurations of loss or reabsorption of alveolar bone (RHA) of the patients, it was obtained of areas proximal of the superior premolars, by means of exams oral radiographies with the technical parallel periapical; and the values of their bony mineral density (DMO) by means of exams of the femoral neck with the technique of Absortiometry for rays X of double energy (DEXA). According to the approach of the World Organization of the Health (WHO) in categorizing the bony states; they conformed to three groups of patient each group in NORMAL, OSTEOPENIA, OSTEOPOROSIS, with their variable DMO, tscore and RHA. The initial analysis with the arithmetic stocking, was that the normal group had bigger DMO (AND = 1.0008) that the groups of Osteopenia (AND = 0.7586) and Osteoporosis (AND = 0.7127); with a Tscore of 0.1610 DS) for the Normal group, - 2.0193 DS for osteopenia and -2.6909 DS for Osteoporosis that confirm the changes of levels of DMO in the respective groups. The RHA was smaller in the Normal group (E=1.12) with progressive increment in the groups of Osteopenia (E = 1.44) and Osteoporosis (E=3.60). la F of levene of homogeneity proves, applied to the previous test, the homogeneity of Tscore and RHA (F=P<0.05). The variance analysis (ANOVA), applied the DMO one had a high significance level (0.0001) and the test Brown- Forsythe, used for Tscore and RHA, a level of significance of 0.0001. To determine the significance level accurately among the three groups (Normal, Osteopenia, Osteoporosis) and their variables (DMO, Tscore and RHA); the results of ANOVA and Brown- Forsythe were subjected to the comparison test of Post Hoc of turkey being confirmed the level al significance of 0.0001. Finally the highly significant Coefficient of Correlation was applied (p>0.001), confirming our hypothesis: the values low of the bony mineral density in patient women determine values high the reabsorption of the alveolar bone.

Caffeine has calciuric and osteoclasteogenesis effects. Objectives: To examine the association of caffeine cumulative dose and duration of therapy and the Osteopenia of prematurity (OP) Study design: A retrospective observational cohort study included premature infants less than 31 weeks and birth weight less than 1500 grams. OP was evaluated using chest X-rays on biweekly basis over 12 weeks hospital stay. Caffeine cumulative dose and duration of therapy, steroid dose and diuretic dose along with other maternal and neonatal risk factors were collected to examine their impact on OP. Results: The cohort included 109 infants. 51% had OP and 8% had spontaneous rib fractures. Using the generalized mixed model, Caffeine dose and duration of caffeine displayed strong association with OP. Steroids and vitamin D had significant correlation with OP while diuretic use did not show statistical significant effect. Conclusion: Caffeine cumulative dose and duration of therapy are associated with OP.