This thesis is focused on the optimization of distributed IP flow information collector. Nowadays, the centralized collector is a frequently used solution but is already reaching its performance limits in large scale and high-speed networks. The implementation of the distributed collector is in its early phase and it is necessary to look for solutions that will use it to its full potential. Therefore this thesis proposes a shared nothing architecture without a single point of failure. Using the above proposed architecture, the distributed collector is tolerant to the failure of at least one node. A distributed flow data analysis software, whose performance scales linearly with the number of nodes, is also part of this thesis.

The main objektive of my thesis is a knowledge of social environment of prague district Karlín, one of the most dynamic part of inner Prague, which is undergoing a transformation of a physical, funcional and social structure. The concept of social environment is used in this work, whereby the social environment is consisted of a social structure and a social climate of a locality. By an analyse of the social, physical and funcional structure and a research of daily rhythms it tries to identify main pacemakers, to deeply learn about proceses and key moments during the day, which structurated the locality, and to capture social groups of users of the locality. The research is focused on three selected basic administrative units: 'Karlín - západ', 'Rohanský ostrov' and 'Za Invalidovnou'. Each of these localities has its own daily rhythm, which is structurated by the resident population and the temporarily present population,and different social environments, which influence each other, are dependent on each other and create the whole character of the prague district Karlín.The work tries to deepen and criticaly evaluate a current metodology. Keywords Karlín, Prague, social environment, social climate, social structure, daily rhythm, pacemaker, locality, mobility, time geography.

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Ce travail consiste à développer un système convertissant une partie de l’énergie mécanique du cœur en électricité pour alimenter les stimulateurs cardiaques de nouvelle génération, implants sans sonde ni batteries implantés directement dans la cavité cardiaque. Après études de différentes sources d’énergies et concept associés, l’option liée à la pression sanguine, appliquant sur une partie souple du boîtier de l’implant des efforts transmis à un transducteur interne les convertissant en électricité, s’est révélée la plus prometteuse. Cette solution présente les avantages principaux suivants par rapport aux systèmes inertiels usuels : grande densité de puissance, adaptabilité au rythme cardiaque et potentiel de miniaturisation. Un boîtier ultra-souple électro-déposé de 10 µm d’épaisseur en forme de soufflet a été modélisé, fabriqué et caractérisé, validant ainsi le concept de récupérateur proposé. Un transducteur électrostatique novateur (3D multicouche à peignes interdigités et à chevauchement hors-plan), étudié par des modélisations analytiques et numériques, est en cours de fabrication. Selon l’électronique associée, ce transducteur promet une grande densité d’énergie extraite. Un transducteur piézoélectrique micro-usiné en forme de spirale et à électrodes micro-structurées, est également présenté. Les défis spécifiques des spirales dontla flexibilité permet d’augmenter l’énergie mécanique d’entrée sont étudiés notamment par simulation numériques, et des prototypes ont été micro-fabriqués et caractérisés. Au final, une énergie de 3 µJ/cm3/cycle est obtenue et de nombreuses perspectives d’amélioration permettent d’envisager une puissance au moins 10 fois supérieure. / This work consists in the development and design of an energy harvesting device to supply power to the new generation pacemakers, miniaturized leadless implants without battery placed directly in heart chambers. After analyzing different mechanical energy sources in the cardiac environment and associated energy harvesting mechanisms, a concept based on regular blood pressure variation stood out: an implant with a flexible packaging that transmits blood forces to an internal transducer. Advantages compared to traditional inertial scavengers are mainly: greater power density, adaptability to heartbeat frequency changes and miniaturization potential. Ultra-flexible 10-µm thin metal bellows have been designed, fabricated and tested. These prototypes acting as implant packaging that deforms under blood pressure actuation have validated the proposed harvesting concept. A new type of electrostatic transducer (3D multi-layer out-of-plane overlap structure with interdigitated combs) has been introduced and fully analyzed. Promising numerical results and associated fabrication processes are presented. Also, large stroke optimized piezoelectric spiral transducers including their complex electrodes patterns have been studied through a design analysis, numerical simulations, prototype fabrication and experimental testing. Apower density of 3 µJ/cm3/cycle has been experimentally achieved. With further addressed developments, the proposed device should provide enough energy to power autonomously and virtually perpetually the next generation of pacemakers.

People suffering from certain types of arrhythmia may benefit from the implantation of a cardiac pacemaker. Pacemakers artificially stimulate the heart by applying short electrical pulses to the cardiac tissue to restore and maintain a steady heart rhythm. By adjusting the pulse delivery rate the heart is stimulated to beat at desired pace. The stimulation pulses are transferred from the pacemaker to the heart via an electrode, which is implanted into the cardiac tissue. Additionally, the electrode must also sense the cardiac response and transfer those signals back to the electronics in the pacemaker for processing. The communication between the electrode and the tissue takes place on the electrode/electrolyte (tissue) interface. This interface serves as the contact point where the electronic current in the electrode is converted to ionic currents capable to operate in the body. The stimulation/sensing signals are transferred across the interface via three electrochemical mechanisms: i) non-faradaic charging/discharging of the electrochemical double layer, ii) reversible and iii) irreversible faradaic reactions. It is necessary to study the contribution of each mechanism to the total charge transferred to evaluate the pacing/sensing performance of the pacemaker electrode. In this thesis, the electrochemical properties and performance of stimulation/sensing electrodes for pacemaker applications have been investigated by electrochemical impedance spectroscopy, cyclic voltammetry and transient electrochemical techniques. All measurements were performed in synthetic body fluid with buffer capacity. Complementary surface analysis was performed with scanning electron microscopy, energy dispersive spectroscopy and X-ray photoelectron spectroscopy. The results reveal different interfacial behaviour and stability for electrode materials such as Pt, TiN, porous carbon, conducting oxides (RuO2 and IrO2 and mixed oxides) and porous Nb2O5 oxide. The influence of the charge/discharge rate on the electrode characteristics also has been evaluated. Although the rough and porous electrodes provide a high interfacial capacitance, the maximum capacitance cannot be fully employed at high charge/discharge rates because only a small part of the effective surface area is accessible. The benefit of pseudo-capacitive material properties on charge delivery was observed. However, these materials suffer similar limitations at high charge/discharge rate and, hence, are only utilising the surface bound pseudo-capacitive sites. Porous Nb2O5 electrodes were investigated to study the performance of capacitor electrodes. These electrodes predominantly deliver the charge via reversible non-faradaic mechanisms and hence do not produce irreversible by-products. They can deliver very high potential pulses while maintaining high impedance and, thus, charge lost by faradaic currents are kept low. By producing Nb oxide by plasma electrolysis oxidation a porous surface structure is obtained which has the potential to provide a biocompatible interface for cell adherence and growth. This thesis covers a multidisciplinary area. In an attempt to connect diverse fields, such as electrophysiology, materials science and electrochemistry, the first chapters have been attributed to explaining fundamental aspects of the respective fields. This thesis also reviews the current opinion of pacing and sensing theory, with special focus on some areas where detailed explanation is needed for the fundamental nature of electrostimulation/sensing. / QC 20101014

La presente Tesis Doctoral tiene como objetivo profundizar en los conocimientos sobre ritmos biológicos y comportamiento alimentario de tres especies de peces teleósteos de interés en acuicultura: tenca (Tinca tinca), trucha alpina (Salvelinus alpinus) y lubina (Dicentrarchus labrax).Con este fin se ha investigado la influencia de factores bióticos y abióticos en la sincronización de los ritmos de actividad locomotora y alimentaria, así como el carácter endógeno y/o exógeno de estos ritmos. A su vez, se ha profundizado en el comportamiento individual de truchas alpinas mantenidas en grupo, mediante una nueva metodología que permite estudiar los ritmos de demanda voluntaria de alimento y la autoselección dietaria de los individuos. Asimismo, se ha analizado la influencia de los niveles endógenos de melatonina, modificados mediante la administración de melatonina exógena y de su aminoácido precursor (triptófano) en la dieta, sobre la concentración de cortisol y el ritmo de actividad locomotora en lubina. / This Doctoral Thesis deeps into the knowledge about biological rhythms and feeding behaviour in three teleostean fish species of interest in aquaculture: tench (Tinca tinca), Arctic charr (Salvelinus alpinus) and European sea bass (Dicentrarchus labrax). With this aim, the influence of biotic and abiotic factors has been researched in the field of synchronization of locomotor and feeding rhythms, as far as the endogenous or exogenous character of these rhythms. Moreover, individual feeding behaviour of Arctic charr kept in groups has been studied trying a new methodology which allows the monitoring of feeding demands and dietary self-selection of individuals. Furthermore, influence of endogenous melatonin modified through exogenous melatonin and its precursor amino acid (tryptophan) administration in the diet, in the cortisol levels and locomotor activity rhythms in sea bass were analysed.

This diploma thesis is concerned with possibilities of patient data transfer from a pacemaker or implantable cardioverter-defibrillator to physician over GSM. Theoretical part describes options of data transfer in GSM networks, data appropriate for sending and a structure of message is proposed. A device, that is able to send medical data in a form of SMS messages is designed and constructed. The device uses a Freescale MC68HC908GP32 microcontroller, character display with a Hitachi HD44780 controller and a cell phone Sony CMD-J70. The program for microcontroller is written in assembler for HC08. For tabular view of received messages, an application software for PC was created.