Major applied research project (Ed. D.)--Nova Southeastern University, 1996. / Vita. Includes bibliographical references (leaves 65-71).

by Arnold Barnett and Anthony J. LoFaso. / "March 1984." / Bibliography: p.35.

abstract: The Philadelphia chromosome in humans, is on oncogenic translocation between chromosomes 9 and 22 that gives rise to the fusion protein BCR-Abl. This protein is constitutively active resulting in rapid and uncontrolled cell growth in affected cells. The BCR-Abl protein is the hallmark feature of chronic myeloid leukemia (CML) and is seen in Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) cases. Currently, the first line of treatment is the Abl specific inhibitor Imatinib. Some patients will, however, develop resistance to Imatinib. Research has shown how transformation of progenitor B cells with v-Abl, an oncogene expressed by the Abelson murine leukemia virus, causes rapid proliferation, prevents further differentiation and produces a potentially malignant transformation. We have used progenitor B cells transformed with a temperature-sensitive form of the v-Abl protein that allows us to inactivate or re-activate v-Abl by shifting the incubation temperature. We are trying to use this line as a model to study both the progression from pre-malignancy to malignancy in CML and Imatinib resistance in Ph+ ALL and CML. These progenitor B cells, once v-Abl is reactivated, in most cases, will not return to their natural cell cycle. In this they resemble Ph+ ALL and CML under Imatinib treatment. With some manipulation these cells can break this prolonged G1 arrested phenotype and become a malignant cell line and resistant to Imatinib treatment. Cellular senescence can be a complicated process requiring inter-play between a variety of players. It serves as an alternate option to apoptosis, in that the cell loses proliferative potential, but does not die. Treatment with some cancer therapeutics will induce senescence in some cancers. Such is the case with Imatinib treatment of CML and Ph+ ALL. By using the S9 cell line we have been able to explore the possible routes for breaking of prolonged G1 arrest in these Ph+ leukemias. We inhibited the DNA damage sensor protein ataxia telangiectasia mutated (ATM) and found that prolonged G1 arrest in our S9 cells was broken. While previous research has suggested that the DNA damage sensor protein ataxia-telangiectasia mutated (ATM) has little impact in CML, our research indicates that ATM may play a role in either senescence induction or release. / Dissertation/Thesis / M.S. Microbiology 2011

QUIXADA, A. T. S. Avaliação da equivalência terapêutica das cópias genéricas do mesilato de imatinibe no tratamento inicial da Leucemia Mieloide Crônica em primeira fase crônica em um centro de referência. 2016. 85 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza, 2016. / Submitted by ciências farmacêuticas pgcf (pgcf.ufc@gmail.com) on 2017-07-07T13:48:34Z No. of bitstreams: 1 2016_dis_atsquixada.pdf: 4671422 bytes, checksum: ae93066211e338bd336e0125e9a28902 (MD5) / Approved for entry into archive by denise santos (denise.santos@ufc.br) on 2017-07-07T14:12:39Z (GMT) No. of bitstreams: 1 2016_dis_atsquixada.pdf: 4671422 bytes, checksum: ae93066211e338bd336e0125e9a28902 (MD5) / Made available in DSpace on 2017-07-07T14:12:39Z (GMT). No. of bitstreams: 1 2016_dis_atsquixada.pdf: 4671422 bytes, checksum: ae93066211e338bd336e0125e9a28902 (MD5) Previous issue date: 2016-07-13 / Imatinib has revolutionized the treatment of Chronic Myeloid Leukemia by modifying its natural history. Several studies have demonstrated that achieving and maintaining major molecular response is a goal that, when achieved, offers the patient life expectancy similar to that of the general population. However, there are few consistent data on the efficacy and adverse effects of generic imatinib presentations. This study aimed to evaluate the response to treatment with generic imatinib 400 mg QD day for adult patients with chronic phase CML at a university hospital, and compare it with the group that used the brand imatinibe. The study, retrospective and observational, analyzed the records of 80 patients, 40 in each group, without experimental step. The comparative analysis included 29 patients who used the brand medication and 32 who used the generic presentation for 12 consecutive months. Treatment response was assessed according to the European Leukemia Network (ELN) criteria. We analyzed the results of the monitoring tests for therapeutic response at three, six and twelve months of treatment with the brand product and generic copy. The statistical analysis used the Statistical Package Program for Social Sciences (SPSS) 22.0, and applied Kolmogorov Smirnov, Mann Whitney and Log-rank Mantel-Cox tests, with 5% significance level. With the original medicine, at three months, the optimal treatment response (BCR-ABL1IS ≤ 10%) was achieved by 62% (18/29) of patients. At six months, 41.4% (12/29) hit the optimal response with the reduction of at least 2 logs (BCR-ABL1IS ≤ 1%). Finally, at 12 months, 48.2% (14/29) of patients achieved major molecular response (MMR) which corresponds to the BCR-ABL1IS ≤ 0.1%. With the generic medication, major response at three months was achieved by 62.5% (20/32). At six months, 71.9% of patients achieved an optimal response (23/32). Finally, at twelve months, 53.1% (17/32) of patients achieved the target of RMM. A slight increase in the prevalence of non-hematological adverse events of the gastrointestinal tract in the generic group was observed. The results of this study suggests that the response profile of adult patients with CP-CML using imatinib 400 mg QD in its generic presentation is comparable in the first evaluation and even surpasses the results obtained with the brand medication. We conclude that, in this sample, does not exist inferiority of the drug in its generic presentation. / O imatinibe revolucionou o tratamento da Leucemia Mielóide Crônica (LMC) ao modificar sua história natural. Vários estudos já evidenciaram que alcançar e manter a resposta molecular maior é uma meta que, ao ser obtida, oferece ao paciente expectativa de vida semelhante à da população em geral. Entretanto, há poucos dados consistentes na literatura sobre a eficácia e efeitos adversos das apresentações genéricas do imatinibe. O presente estudo teve como objetivo avaliar a resposta ao tratamento com imatinibe genérico, 400 mg/dia em pacientes adultos de um hospital universitário, portadores de LMC em fase crônica e compará-la com a do grupo que fez uso do imatinibe de referência. O estudo, observacional e retrospectivo, analisou os registros de prontuários de 80 pacientes, 40 em cada grupo, sem incluir fase experimental. Foram incluídos na análise comparativa os 29 pacientes que usaram a medicação de referência e os 32 que fizeram uso da apresentação genérica, por 12 meses consecutivos. A resposta ao tratamento foi avaliada segundo os critérios da European Leukemia Network (ELN). Foram analisados os resultados de exames de monitorização da resposta terapêutica aos três, seis e doze meses de tratamento com o medicamento de referência e a cópia genérica. A análise estatística utilizou o programa Statistical Package for Social Sciences (SPSS), versão 22.0, empregando os testes de Kolmogorov Smirnov, Mann Whitney e Log-rank Mantel-Cox, com nível de significância de 5%. Com a medicação de referência, aos três meses de tratamento a resposta ótima (BCRABL1EI ≤ 10%) foi alcançada por 62% (18/29) dos pacientes. Aos seis meses, 41,4% (12/29) atingiu a resposta ótima com redução de pelo menos 2 logs (BCR-ABL1EI ≤ 1%) e aos 12 meses, 48,3% (14/29) dos pacientes alcançou a resposta molecular maior (RMM) que corresponde ao BCR-ABL1EI ≤ 0,1%. Com a medicação genérica, uma resposta ótima aos três meses foi atingida por 62,5% (20/32). Aos seis meses, 71,9% dos pacientes conseguiu um resultado ótimo (23/32), E por fim, aos doze meses, 53,1% (17/32) dos pacientes obteve a meta de RMM. Foi observado um discreto aumento da prevalência dos eventos adversos não hematológicos do trato gastrointestinal no grupo genérico. Os resultados deste estudo sugerem que o perfil da resposta dos pacientes adultos portadores de LMC-FC em uso de imatinibe 400 mg/dia em sua apresentação genérica se equipara na primeira avaliação, e até ultrapassa, os resultados obtidos com a medicação de referência. Concluímos que inexistiu, nesta amostra, inferioridade de ação do medicamento em sua apresentação genérica.

abstract: Few studies focus on the MOVE Organization (MOVE), let alone its presences in popular media during the years prior to the MOVE-Philadelphia Conflict (1978-1985), or pre-Conflict. To date, most information about MOVE derives from Conflict research which utilizes archival materials from the Philadelphia Special Investigation Commission (MOVE Commission) hearings. Generations of dominant representations about MOVE and its members, consequently, are mainly constructed by popular media from the MOVE Commission hearings, including video broadcasts of the proceeding. Using a Conflict documentary, I highlight concerns scholars face when heavily using archival materials from MOVE Commission hearings: (a) Archival materials from MOVE Commission hearings lack active MOVE members' voices and (b) Archival materials from MOVE Commission hearings include limited pre-Conflict information about MOVE members. Influenced by Kimberly Sanders and Judson Jeffries' (2013) work about the 1985 bombing newspaper reports' favorability, this project explores pre-Conflict popular media representations of MOVE to understand how the collective first got represented to Philadelphians and the ways which MOVE used popular media to respond to these dominant portrayals. This mix-methods project utilizes 67-piece dataset materials of various popular media texts by MOVE members and non-MOVE members. It focuses on 48 Philadelphia Tribune newspaper entries as its main text dataset, with an emphasis on the 1975 "On the MOVE" editorial column space. This investigation employs a combination of Black feminist and critical discourse analysis (CDA) methods, with Sanders and Jeffries' (2013) favorability categorizations process, to explore the racialized, gendered, and classed aspects pre-Conflict representations of MOVE. Quantitative findings suggest that MOVE got generally represented in favorable manners during the pre-Conflict years, with over 50 percent of pre-Conflict texts about MOVE portraying the collective in positive tones. Additionally, qualitative findings propose that MOVE members' authorship and presence in pre-Conflict texts within the Philadelphia Tribune functioned as a site of resistance against dominant portrayal of the collective. CDA findings propose that MOVE's racial attribute, beliefs, and culture, specifically related to self-determination, were central discussions within most pre-Conflict by MOVE members. Unlike Sanders and Jeffries (2013), this project concludes that overall pre-Conflict popular media depictions portrayed MOVE as a positive Philadelphia collective. / Dissertation/Thesis / Masters Thesis Justice Studies 2014

Central American leadership in the 1980s Philadelphia Sanctuary Movement was cultivated through long experiences with social injustice, along with deeply political religious sensibilities rooted in Latin American labor organizing and the base Christian community movement. While it is sometimes assumed that they carried with them only an undifferentiated past of victimization and violence, Central American sanctuary activists and collaborators brought refined community organizing skills, which they intentionally employed to expand solidarity and sanctuary coalitions across Northern America. This dissertation explores some of the ways in which displaced Central American human rights workers moved within this international, interreligious context to further their liberationist goals. In a religious environment steeped in long histories of racialized missionary intervention and human exploitation, Guatemalans and Salvadorans asserted a different vision of sanctuary not only concerned with personal safety, but also with the opportunity to educate the U.S. public while they transformed the practice of sanctuary from the inside out. Harnessing the resources of their own cultural and religious histories and experiences, Central American human rights workers gained access to certain critical segments of the human, social, and political capital of the Philadelphia region to advance the cause of their own survival and flourishing. / Religion

Russell Conwell’s experiment to educate the Philadelphian working man has grown into a massive university that has transformed the physical, social, and cultural environment of its surrounding North Philadelphia community. Temple University has carefully designed itself as an “urban university” and its presence and growth has had significant costs. Displacement, gentrification, and urban renewal projects have altered the neighborhood to make way for Temple. The relationship between university administration, students and faculty, and community members is negotiated through different avenues, one of which is through food. Food reflects class, culture, gender, labor, urbanization, and it acts as a unique lens into the negative and positive aspects of the new cultural landscape Temple has crafted. The stories shared in this project seek to highlight the hidden narratives that contribute to more visible events. It uncovers hidden labor, the importance of space, and the voices of protest. From the early stages of university development in the 1880s and heavier community presence to the modern-day food trucks, looking at the foodscape in Temple Town will demonstrate how the university and its students interact with the community and culture of Philadelphia and contribute to the image of an urban university. This digital project seeks to create an informative website that explores stories surrounding food on Temple’s campus using archival sources and oral histories. This paper concludes with a reflection and exploration of the next phases of the project. Website link: https://sites.temple.edu/feedingtempletown/ / History

The COVID-19 Pandemic has exemplified the weaknesses in science education. Americans struggle to understand the scientific process and why its findings change. This has caused skepticism to brew. Since museums serve their respective communities as translators of complex information, then they also must support the enhancement of science literacy. To enhance science literacy, digital content must first explain how science is relevant and then explain how the scientific process works. History institutions have the perfect opportunity to walk their audiences through a step-by-step process to understand the changing face of science better. This study accounts for a website I developed to 1.) put in practice some of the essential science literary lessons intuitions might use, and 2.) connect audiences with resources of the 1918 Flu Pandemic. The 1918 Flu Pandemic serves as a model for how history can help explain complex scientific ideas and their relevance to the present due to seasonal outbreaks of influenza and the COVID-19 Pandemic. / History

This paper uses the Woodmere Art Museum in Philadelphia as a case study to examine the origins and institutional evolution of American regional art museums, identify some of the challenges they currently face, and the important civic and cultural roles they play in their communities. The chapter “Origins” provides a basic overview of Woodmere’s founding and history and considers how, within an American context, such museums eventually evolved from private galleries to publicly engaged nonprofit organizations over the course of the twentieth century as their missions, stakeholders, and audiences evolved. Like other regional art museums that demonstrate the same model, Woodmere’s regional identity and its focus on local art deepen the ties between itself and the community it serves and creates cultural resonances that make regional art museums an irreplaceable part of the American museum industry. However, small regional art museums face important challenges as their finances are more vulnerable, and they must deal with some of the same social, institutional, and ethical issues faced by larger public-facing institutions with a smaller pool of resources. The chapter “Present Challenges” looks at the need to develop sustainable management and financial structures and inclusive strategies to understand and build on audience relationships as a way to survive and grow. The final chapter of the paper “Imagined Futures” concludes and specifically addresses the challenges and possibilities presented by the pandemic, various social justice movements, and the call for institutions to reckon with their own histories in order to form a clear path for the future of regional art museums. / Art History

During the Great Migration (1916-1970) of African Americans to the North, Philadelphia’s police department, journalists, and city officials used news media to disseminate crime narratives laced with statistics and racial stereotypes of “black invasions,” “urban neighborhood jungles,” “roving black gangs,” and the “culture of poverty” to convince the white middle-class to resist desegregation and support tough on crime policing in the inner city from 1958 to the present-day. However, African Americans experienced double victimization from the proliferation of these crime narratives. Police and journalists used crime narratives to justify the racially-biased policing tactics of hyper-surveillance, daily patrols, excessive force, and incarceration against black and poor residents. Over time, city officials developed a system of racial capitalism in which City Council financially divested from social welfare programs, invested in the police department, and promoted a tough on crime policing program that generated wealth for Philadelphia’s tax base and attempted to halt white flight from the city. My evidence consists of newspapers, archived news reel, municipal court dockets, census records, oral histories, interviews, police investigation reports, housing project pamphlets, and maps to demonstrate that a consequence of tough on crime policing was hyper-surveillance, the use of excessive force, and neglect by officers in the most disadvantaged areas of the city: poor, segregated, and black-inhabited housing projects and neighborhoods. Nevertheless, by looking through the lens of Philadelphia specifically, I emphasize that the budgetary strategy of a city government spending more money on policing and corrections than social welfare programs is ineffective and a form of racial capitalism which relies on criminal scapegoating, continues the cycle of poverty-induced crime, inflates rates of incarceration and police brutality, and marginalizes poor people of color. / History