Ce manuscrit décrit d'une part la synthèse et la fonctionnalisation de dérivés de types azacalix[4]arènes et d'autre part l'élaboration d'une nouvelle voie de synthèse des ligands benzoquinonediimines.La première partie, consacrée aux azacalix[4]arènes, détaille les différents procédés utilisés pour fonctionnaliser des azacalix[4]arènes après leur macrocyclisation. L'introduction de groupes amides a généré des récepteurs d'anions qui présentent une sélectivité non usuelle pour les ions chlorures. Les complexes hotes-invités formés reposent sur des intercations supramoléculaires et constituent l'une des principales thématiques de ce manuscrit.La seconde part du manuscrit porté sur une nouvelle voie de synthèse des ligands benzoquinonediimines qui reposent sur la transamination du 1,2,4,5-tétraaminobenzène en présence d'un excès d'amine primaire. La simplicité de cette procédure permet d'obtenir une grande variété de benzoquinondiimines diversement substiuées. L'impact de cette substiution est illusté via l'étude de nouveaux complexes bimétalliques contenant un ligand benzoquinonediimine pontant. / The first pat of this manuscrit deals with the synthetis and fonctionalization of azacalix[4]arnes derivatives while the second part describes a new syntetic access of benzoquinonediimines ligands.In the first part, differents approaches were used to introduce fonctional groups on the peripheral positions of alrealdy formed azacalix[4]arenes. the introduction of hydrogen donor groups such as amides groups generated azacalix[4]arnes based anions receptor that preferentially bind chloride anions. These host-guest complexes are built on supramolecular interations and are one of the main topic of this manuscrit.In the second part, a new synthetic procedure of benzoquinonediimines is described and studied. The simple and efficient one-pot reaction involves a transamination between 1,2,4,5-tetraaminobenzene and primary amine and allows to prepare a large range of N-substituted benzoquinonediimines derivatives. The impact of the N-substitution is enlightened through the study on bimetallic complexes containing a bridging benzoquinonediimine unit.

Au cours de ce travail, nous avons préparé des clips moléculaires efficaces à partir de dimères de cuivre(I) ou d'or(I) portant des ligands organophosphorés en tirant parti des interactions métallophiles. Dans un premier temps, un complexe de cuivre(I) portant des ligands bis(2-pyridyl)phospholes a été utilisé comme clip moléculaire pour organiser des systèmes pi monotopiques à fonction cyano et portant divers fragments pi-conjugués. Ces dimères formés par assemblage pis'auto-organisent à l'état solide en colonnes pi infinies. Dans un deuxième temps, un complexe d'or(I) portant un ligand biphosphole a été utilisé comme clip moléculaire pour organiser des unités éthynyl[6]helicenes en dimères. Ces dimères ont montré une augmentation des propriétés chiroptiques par rapport au ligand éthynyl[6]helicene libre. Dans un troisième temps, un complexe bimétallique de cuivre(I) portant des ligands 1,1-bis(diphénylphosphino)méthane (dppm) s'est révélé être un clip moléculaire efficace pour la conception d'architectures supramoléculaires auto-assemblées par réaction avec des cyanométallates. Ces dérivés supramoléculaires ont des topologies différentes et sont émissifs dans le domaine visible après excitation dans l'UV. Dans certains cas, ils ont montré des propriétés de luminescence thermochromique intéressantes. / In this work, we have prepared organophosphorated ligands based copper(I) or gold(I) dimers that act as efficient molecular clips thanks to metallophilic interactions. Firstly, a bimetallic copper(I) complex bearing bis(2-pyridyl)phosphole ligands was used as a molecular clip to organize monotopic cyano-capped pi-systems carrying various pi-conjugated fragments into self-assembled pi-stacked dimers. These dimers organized in the solid state within infinite columnar pi-stacks. Secondly, a bimetallic gold(I) complex bearing a biphosphole ligand was used as a molecular clip to organize ethynyl-capped [6]helicene moieties into self-assembled dimers. These dimers showed an enhancement of the chiroptical properties as compared to the free ethynyl[6]helicene ligand. Thirdly, a bimetallic copper(I) complex bearing 1,1-bis(diphenylphosphino)methane (dppm) ligands has revealed a powerful molecular clip to design self-assembled supramolecular architectures by reaction with different cyanometallates. These supramolecular derivatives have different topologies and are emissive in the visible spectrum upon UV excitation and in some cases they showed intriguing thermochromic luminescence properties.

Orientador: Celso Luiz Figueiredo Bodstein / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem e Laboratório de Estudos Avançados em Jornalismo / Made available in DSpace on 2018-08-27T09:24:37Z (GMT). No. of bitstreams: 1 Duarte_CristianeDelfinaSantos_M.pdf: 52168426 bytes, checksum: 9696051ddf4abd8b9ea024d046b5b080 (MD5) Previous issue date: 2015 / Resumo: O presente trabalho busca a construção, em audiovisual e em texto, do perfil da arqueóloga Niéde Guidon, pesquisadora premiada e condecorada internacionalmente. Atualmente com 82 anos, Niéde é neta de franceses e de um casal de militar brasileiro com índia Kaingang. Ela tem sido uma forte atuante em pesquisas e ações sociais na região do sudeste do Piauí desde 1973, quando visitou pela primeira vez sítios arqueológicos de pinturas rupestres encontrados por moradores da área, que a levaram, então, à formação da primeira missão Franco-Brasileira de pesquisas e, posteriormente, do Parque Nacional Serra da Capivara e da Fundação Museu do Homem Americano. Com a captação em vídeo de mais de dez horas de entrevistas diretas com a pesquisadora e mais de 40 horas de material audiovisual, entre imagens e entrevistas com pessoas envolvidas em sua vida, seu trabalho e na construção do Parque Nacional Serra da Capivara, apresenta-se aqui um perfil de Niéde, administrando sua expressão pública controversa e tratando também dos sentidos produzidos na entrevistadora/documentarista; frutos deste processo sem o vínculo direto com a verdade e com maior interesse na manipulação estética dos sentidos e memórias. As entrevistas são organizadas e comentadas em paralelo à polifonias de autores e participantes da vida da pesquisadora e funcionam como disparadores de reflexões sobre História, Política, Autoria e temas que perpassam os diálogos e as relações estabelecidas no processo de produção do documentário "A Mulher Original" / Abstract: This paper builds, with audiovisual and text, a profile of Niéde Guidon, an eighty two years old Brazilian archaeologist, granddaughter of french immigrants and a couple of a Brazilian army officer and a Kaingang native. After building a strong career in research in France, in 1973 Guidon first visited archaeological sites of rock paintings in the southeastern region of Piauí¿Brazil, found by residents of the area, which led her to the organization of the first French¿Brazilian mission research, and later to the foundation of the National Park Serra da Capivara, the Museum of the American Man Foundation and a path of many social works around the park.?With over ten hours of direct interviews with the researcher, captured on video, and 40 hours of images and interviews with people involved in her life, her work and the construction of the National Park Serra da Capivara; also with citations of interviews conducted by different authors and institutions in recent years, I introduce a character profile and her public controversy image, dealing with the feelings and impressions developed on me as interviewer/documentarist, without the direct link with the truth and facts, but higher interest on handling aesthetic senses and memories of the process itself. Inspired by essays and literary journalism, the interviews will be arranged and discussed in parallel to the polyphony from various authors and participants in the life of the researcher. The Original Woman intends to trigger thoughts on history, politics, authorship and themes that pervade the dialogues and the relationships established in the process of documentary production and construction of this text; assuming an establishment of exchanges and interactions between interviewer and interviewees, and also discussing the documentary production process / Mestrado / Divulgação Científica e Cultural / Mestra em Divulgação Científica e Cultural

A leishmaniose é uma doença parasitária de ampla distribuição, para a qual se dispõe de um limitado arsenal terapêutico. Trabalhos recentes mostraram que tamoxifeno é eficaz no tratamento de leishmaniose experimental. Nesse trabalho, avaliamos a terapia combinada de tamoxifeno com os fármacos utilizados atualmente no tratamento desta enfermidade. A interação entre os fármacos mostrou-se aditiva, tanto in vitro como in vivo. Em paralelo, analisamos os efeitos de tamoxifeno na biossíntese de esfingolipídios em Leishmania, sendo identificada a redução da síntese de fosfatidilinositol e inositolfosforil ceramida (IPC) e acúmulo de ceramida acilada. A redução na biossíntese de IPC não pode ser atribuída a redução no transporte de inositol, mas provavelmente está relacionada à inibição da enzima IPC sintase. Estes resultados indicam novas estratégias para superar as deficiências encontradas no tratamento de leishmaniose utilizando tamoxifeno, um fármaco clinicamente bem conhecido que exerce ações em múltiplos alvos em Leishmania. / Leishmaniasis is a parasitic disease with wide distribution and limited treatment. Recent reports demonstrate that tamoxifen is an effective drug for experimental leishmaniasis treatment. In this work, we evaluated the combined therapy of tamoxifen with current drugs used in leishmaniasis chemotherapy. The drug interaction was additive both, in vitro and in vivo. We also evaluated tamoxifen effect on in Leishmania sphingolipids biosynthesis. We found a reduction in phosphatidylinositol and inositol phosphorylceramide (IPC) synthesis and an accumulation of acilceramide. The reduction in IPC biosynthesis could not be assigned to the reduction observed in inositol transport, but probably is related to IPC synthase inhibition. These results show new strategies to circumvent shortcomings of leishmaniasis treatment using tamoxifen, a multitarget drug in Leishmania and widely used in the chemotherapy of breast cancer.

This work deals with the problem of visual representation of Pi-calculus expressions. The theoretical part of this paper discusses general principles of process algebras as well as specific properties of individual models, with a focus on Pi-calculus. Also included is the comparison of several text and graphical representations of expressions. The main part of the thesis deals with the design and implementation of an application for converting text representation of expressions into graphical representation. In addition to the text and graphical representation, an internal tree representation designed to work with expressions within the application is also proposed. The thesis also describes algorithms for finding feasible reductions, performing reductions and expression simplification that operate with the proposed tree representation.

This work is focused on the design and construction of component parts of resistance saw. Mechanical parts consist of a movable bracket and a taut cutting wire of Constantan. Electrical parts are designed to supply and control temperature of the cutting wire. The current intensity in the cutting wire is compared with the required current intensity. The difference of these two measurements is fed into a PI - controller. The next part is a PWM generator which generates the square wave signal. The pulse ratio of this signal is proportional to the required temperature of the cutting wire. This signal switches a switching converter that consists of a power transistor P-MOSFET IRF5210 and a diode MBR20100CT. Choking coil with a ferrite E core and with the cutting wire is connected to the output of the converter.

Context. During the usage of a product, evaluating its performance quality is a crucial procedure. Web servers are one of the most used technological products in today’s modern world[1]. Thus, in this thesis we will evaluate and compare the performances of two web servers. The servers that are tested in the experiment are a raspberry pi 3B and a personal HP laptop. Objectives. The main objective of the study is to evaluate the performance of a raspberry pi 3B as a web server. In order to give a clearer image of how the raspberry pi performs, the laptop will also be evaluated and its performance will be used as a contrast during the study. Realization. To fulfill our objective, an experiment was conducted with the help of a performance testing tool called apache bench. To provide comprehensive performance results, the served content and the server software were altered throughout the experiment. The number of simulated users sending the requests were also altered. Results. The results were gathered by sending more than 1000 HTTP-requests to the two servers that served static and dynamic websites. The number of served requests per second and the CPU consumption of the servers were the recorded results. The raspberry pi exhibited response times as high as 1164 requests per second and CPU consumption that varied between ≈6% and ≈40%. In comparison to the laptop, on one occasion it exhibited a better processor utilization serving HTTPrequests of one user. Conclusions. Regardless of the used server software, although the laptop was slightly performing better, the raspberry pi had a closer response time in comparison to the laptop when both of them were serving a static website. On the contrary, when both were serving dynamic content the raspberry pi had a very low response time in the comparison. Out of the two used server software, nginx gave it a better CPU consumption in contrast to the laptop that had a better processor. That is irrespective of the served content type.

This thesis uses previously proposed methodology for simulations of all-trans- polyenes with conjugated systems. Dynamic properties, especially the mean lifeti- mes of the excited states, of these molecules were systematically simulated. Obta- ined data shows that the method is still too time-consuming for polyene molecules with more than 20 carbon atoms, including most carotenoids. Thus, a study of active space reduction was performed with the model tetradecaheptaene molecule with regards to excited state mean lifetimes. A new, less time-consuming method would need further simulation studies. Moreover, static spectra of the these mo- lecules were studied as well, yielding a comparison of different DFT and ab-initio approaches. 1

Edge AI is a growing area. The use of deep learning on low cost machines, such as the Raspberry Pi, may be used more than ever due to the easy use, availability, and high performance. A quantized pretrained SSD object detection model was deployed to a Raspberry Pi 4 B to evaluate if the throughput is sufficient for doing real-time object recognition. With input size of 300x300, an inference time of 185 ms was obtained. This is an improvement as of the previous model; Raspberry Pi 3 B+, 238 ms with a input size of 96x96 which was obtained in a related study. Using a lightweight model is for the benefit of higher throughput as a trade-off for lower accuracy. To compensate for the loss of accuracy, using transfer learning and tensorflow, a custom object detection model has been trained by fine-tuning a pretrained SSD model. The fine-tuned model was trained on images scraped from the web with people in winter landscape. The pretrained model was trained to detect different objects, including people in various environments. Predictions shows that the custom model performs significantly better doing detections on people in snow. The conclusion from this is that web scraping can be used for fine-tuning a model. However, the images scraped is of bad quality and therefore it is important to thoroughly clean and select which images that is suitable to keep, given a specific application. / Användning av djupinlärning på lågkostnadsmaskiner, som Raspberry Pi, kan idag mer än någonsin användas på grund av enkel användning, tillgänglighet, och hög prestanda. En kvantiserad förtränad SSD-objektdetekteringsmodell har implementerats på en Raspberry Pi 4 B för att utvärdera om genomströmningen är tillräcklig för att utföra realtidsobjektigenkänning. Med en ingångsupplösning på 300x300 pixlar erhölls en periodtid på 185 ms. Detta är en stor förbättring med avseende på prestanda jämfört med den tidigare modellen; Raspberry Pi 3 B+, 238 ms med en ingångsupplösning på 96x96 som erhölls i en relaterad studie. Att använda en kvantiserad modell till förmån för hög genomströmning bidrar till lägre noggrannhet. För att kompensera för förlusten av noggrannhet har, med hjälp av överföringsinlärning och Tensorflow, en skräddarsydd modell tränats genom att finjustera en färdigtränad SSD-modell. Den finjusterade modellen tränas på bilder som skrapats från webben med människor i vinterlandskap. Den förtränade modellen var tränad att känna igen olika typer av objekt, inklusive människor i olika miljöer. Förutsägelser visar att den skräddarsydda modellen detekterar människor med bättre precision än den ursprungliga. Slutsatsen härifrån är att webbskrapning kan användas för att finjustera en modell. Skrapade bilder är emellertid av dålig kvalitet och därför är det viktigt att rengöra all data noggrant och välja vilka bilder som är lämpliga att behålla gällande en specifik applikation.

As the world population ages, the healthcare system is facing new challenges in treating more patients at a lower cost than today. One trend in addressing this problem is to increase the opportunities of in-home care. To achieve this there is a need for safe and cost-effective monitoring systems. Biosignal PI is an ongoing open-source project created to develop a flexible and affordable platform for development of stand-alone devices able to measure and process physiological signals. This master thesis project, performed at the department of Medical Sensors, Signals and System at the School of Technology and Health, aimed at further develop the Biosignal PI software by constructing a new flexible software framework architecture that could be used for measurement and processing of different types of biosignals. The project also aimed at implementing features for Heart Rate Variability(HRV) Analysis in the Biosignal PI software as well as developing a graphical user interface(GUI) for the Raspberry PI hardware module PiFace Control and Display. The project developed a new flexible abstract software framework for the Biosignal PI. The new framework was constructed to abstract all hardware specifics into smaller interchangeable modules, with the idea of the modules being independent in handling their specific task making it possible to make changes in the Biosignal PI software without having to rewrite all of the core. The new developed Biosignal PI software framework was implemented into the existing hardware setup consisting of an Raspberry PI, a small and affordable single-board computer, connected to ADAS1000, a low power analog front end capable of recording an Electrocardiography(ECG). To control the Biosignal PI software two different GUIs were implemented. One GUI extending the original software GUI with the added feature of making it able to perform HRV-Analysis on the Raspberry PI. This GUI requires a mouse and computer screen to function. To be able to control the Biosignal PI without mouse the project also created a GUI for the PiFace Control and Display. The PiFace GUI enables the user to collect and store ECG signals without the need of an big computer screen, increasing the mobility of the Biosignal PI device.   To help with the development process and also to make the project more compliant with the Medical Device Directive a couple of development tools were implemented such as a CMake build system, integrating the project with the Googletest testing framework for automated testing and the implementation of the document generator software Doxygen to be able to create an Software Documentation.    The Biosignal PI software developed in this thesis is available through Github at https://github.com/biosignalpi/Version-A1-Rapsberry-PI / Allt eftersom världens befolkning åldras, ställs sjukvården inför nya utmaningar i att behandla fler patienter till en lägre kostnad än idag. En trend för att lösa detta problem är att utöka möjligheterna till vård i hemmet.För att kunna göra detta finns det ett ökande behov av säkra och kostnadseffektiva patientövervakningssystem. Biosignal PI är ett pågående projekt med öppen källkod som skapats för att utveckla en flexibel och prisvärd plattform för utveckling av fristående enheter som kan mäta och bearbeta olika fysiologiska signaler. Detta examensarbete genomfördes vid institutionen för medicinska sensorer, signaler och system vid Skolan för Teknik och Hälsa. Projektet syftade till att vidareutveckla den befintliga mjukvaran för Biosignal PI genom att skapa ett nytt flexibelt mjukvaruramverk som kan användas för mätning och bearbetning av olika typer av biosignaler.Projektet syftade också till att utvidga mjukvaran och lägga till funktioner för att kunna genomföra hjärtfrekvensvariabilitets(HRV) analys i Biosignal PIs mjukvara, samt att utveckla ett grafiskt användargränssnitt(GUI) för hårdvarumodulen PiFace Control and Display. Projektet har utvecklat ett nytt flexibelt mjukvaruramverk för Biosignal PI. Det nya ramverket konstruerades för att abstrahera alla hårdvaruspecifika delar in i mindre utbytbara moduler, med tanken att modulerna ska vara oberoende i hur de hanterar sin specifika uppgift. På så sätt ska det vara möjligt att göra ändringar i Biosignal PIs programvara utan att behöva skriva om hela mjukvaran.Det nyutvecklade Biosignal PI ramverket implementerades i det befintliga hårdvaru systemet, som består av en Raspberry PI, liten och prisvärd enkortsdator, ansluten till ADAS1000, en analog hårdvarumodul med möjlighet att registrera ett elektrokardiografi(EKG/ECG). För att kontrollera Biosignal PI programmet har två olika grafiska användargränssnitt skapats.Det ena gränssnitt är en utvidgning av original programvaran med tillagd funktionalitet för att kunna göra HRV-Analys på Raspberry PI, detta gränssnitt kräver dock mus och dataskärm för att kunna användas.För att kunna styra Biosignal PI utan mus och skärm skapades det även ett gränssnitt för PiFace Control and Display. PiFace gränssnittet gör det möjligt för användaren att samla in och lagra EKG-signaler utan att behöva en stor datorskärm, på så sätt kan man öka Biosignal PI systemets mobilitet. För att underlätta utvecklingsprocessen, samt göra projektet mer förenligt med det medicintekniska regelverket, har ett par utvecklingsverktyg integrerats till Biosignal PI projektet såsom CMake för kontroll av kompileringsprocessen, test ramverket Googletest för automatiserad testning samt integrering med dokumentations generatorn Doxygen för att kunna skapa en dokumentation av mjukvaran.