Lesioned axons do not regenerate in the adult mammalian central nervous system, owing to the overexpression of inhibitory molecules such as myelin-derived proteins or chondroitin sulphate proteoglycans. In order to overcome axon inhibition, strategies based on extrinsic and intrinsic treatments have been developed. For myelin-associated inhibition, blockage with NEP1-40, receptor bodies or IN-1 antibodies has been used. In addition, endogenous blockage of cell signalling mechanisms induced by myelin-associated proteins is a potential tool for overcoming axon inhibitory signals. We examined the participation of glycogen synthase kinase 3 (GSK3beta) and ERK1/2 in axon regeneration failure in lesioned cortical neurons. We also investigated whether pharmacological blockage of GSK3beta and ERK1/2 activities facilitates regeneration after myelin-directed inhibition in two models: i) cerebellar granule cells and ii) lesioned entorhino-hippocampal pathway in slice cultures, and whether the regenerative effects are mediated by Nogo Receptor 1 (NgR1). We demonstrate that, in contrast to ERK1/2 inhibition, the pharmacological treatment of GSK3beta inhibition strongly facilitated regrowth of cerebellar granule neurons over myelin independently of NgR1. Lastly these regenerative effects were corroborated in the lesioned EHP in NgR1 -/- mutant mice. These results provide new findings for the development of new assays and strategies to enhance axon regeneration in injured cortical connections. On the other hand, and focused in the OMgp, by using recording electrophysiological nano-devices we found that, OMgp has a role in synaptic transmission, since it can induce excitatory postsynaptic potentials (EPSPs) in cultured hippocampal neurons.

La tesis se centra en el desarrollo de técnicas numéricas específicas para la resolución de problemas de mecánica de sólidos, tomando como referencia aquellos que involucran geomateriales (suelos, rocas, materiales granulares,...). Concretamente, se tratan los siguientes puntos: 1) formulaciones Arbitrariamente Lagrangianas Eulerianas (ALE) para problemas con grandes desplazamientos del contorno; 2) métodos de resolución para problemas no lineales en el campo de la mecánica de sólidos y 3) modelización del comportamiento mecánico de materiales granulares mediante leyes constitutivas elastoplásticas. Las principales aportaciones de la tesis son: el desarrollo de una formulación ALE para modelos hyperelastoplásticos y el cálculo de operadores tangentes para distintas leyes constitutivas y esquemas de integración temporal no triviales (uso de esquemas de derivación numérica, técnicas de subincrementación y modelos elastoplásticos con endurecimiento y/o reblandecimiento dependientes del trabajo plástico o la densidad). Se presentan diversas aplicaciones que muestran las principales características de los desarrollos presentados (análisis del ensayo del molinete para arcillas blandas, del ensayo triaxial para arenas, de la rotura bajo una cimentación, del proceso de estricción de una barra metálica circular y de un proceso de estampación en frío), dedicando una especial atención a los aspectos computacionales de la resolución de dichos problemas. Por último, se dedica un capítulo específico a la modelización y la simulación numérica de procesos de compactación fría de polvos metálicos y cerámicos. / Numerical modelling of problems involving geomaterials (i.e. soils, rocks, concrete and ceramics) has been an area of active research over the past few decades. This fact is probably due to three main causes: the increasing interest of predicting the material behaviour in practical engineering situations, the great change of computer capabilities and resources, and the growing interaction between computational mechanics, applied mathematics and different engineering fields (concrete, soil mechanics...). This thesis fits within this last multidisciplinary approach. Based on constitutive modelling and applied mathematics and using both languages the numerical simulation of some complex geomechanical problems has been studied.The state of the art regarding experiments, constitutive modelling, and numerical simulations involving geomaterials is very extensive. The thesis focuses in three of the most important and actual ongoing research topics within this framework: 1) the treatment of large boundary displacements by means of Arbitrary Lagrangian-Eulerian (ALE) formulations; 2) the numerical solution of highly nonlinear systems of equations in solid mechanics; and 3) the constitutive modelling of the nonlinear mechanical behaviour of granular materials. The three topics have been analysed and different contributions for each one of them have been developed. Moreover, some of the new developments have been applied to the numerical modelling of cold compaction processes of powders. The process consists in transforming a loose powder into a compacted sample through a large volume reduction. This problem has been chosen as a reference application of the thesis because it involves large boundary displacements, finite deformations and highly nonlinear material behaviour. Therefore, it is a challenging geomechanical problem from a numerical modelling point of view.The most relevant contributions of the thesis are the following: 1) with respect to the treatment of large boundary displacements: quasistatic and dynamic analyses of the vane test for soft materials using a fluid-based ALE formulation and different non-newtonian constitutive laws, and the development of a solid-based ALE formulation for finite strain hyperelastic-plastic models, with applications to isochoric and non-isochoric cases; 2) referent to the solution of nonlinear systems of equations in solid mechanics: the use of simple and robust numerical differentiation schemes for the computation of tangent operators, including examples with several non-trivial elastoplastic constitutive laws, and the development of consistent tangent operators for different substepping time-integration rules, with the application to an adaptive time-integration scheme; and 3) in the field of constitutive modelling of granular materials: the efficient numerical modelling of different problems involving elastoplastic models, including work hardening-softening models for small strain problems and density-dependent hyperelastic-plastic models in a large strain context, and robust and accurate simulations of several powder compaction processes, with detailed analysis of spatial density distributions and verification of the mass conservation principle.

Submitted by Bruna Rodrigues (bruna92rodrigues@yahoo.com.br) on 2017-10-02T13:02:18Z No. of bitstreams: 1 DissLADGB.pdf: 1548410 bytes, checksum: ca54122f2b96c487bc173d22135e8a0f (MD5) / Approved for entry into archive by Ronildo Prado (bco.producao.intelectual@gmail.com) on 2018-02-05T16:59:56Z (GMT) No. of bitstreams: 1 DissLADGB.pdf: 1548410 bytes, checksum: ca54122f2b96c487bc173d22135e8a0f (MD5) / Approved for entry into archive by Ronildo Prado (bco.producao.intelectual@gmail.com) on 2018-02-05T17:00:12Z (GMT) No. of bitstreams: 1 DissLADGB.pdf: 1548410 bytes, checksum: ca54122f2b96c487bc173d22135e8a0f (MD5) / Made available in DSpace on 2018-02-05T17:04:31Z (GMT). No. of bitstreams: 1 DissLADGB.pdf: 1548410 bytes, checksum: ca54122f2b96c487bc173d22135e8a0f (MD5) Previous issue date: 2017-07-03 / Não recebi financiamento / Biological, physical and chemical characteristics of the soil are environmental filters that strongly influence the composition of the plant communities. The knowledge of the effect of soil conditions on the survival and growth of plant species is important for the recovery activities in degraded areas. These aspects of plant performance are directly related to the functional characteristics of species, so understanding the responses of the different resources to different soil conditions can help to choose species that are best suited to each area. We have carried out an experiment in nursery with the objective of evaluating the influence of different soil treatments on survival and functional characteristics; Leaf Area (LA), Specific Leaf Area (SLA), Leaf Dry Matter Content (LDMC), Root Mass Fraction (RMF), Specific Root Length (SRL) and Relative Height Increment (RHI) of eleven native forest species forming a seed mass gradient. The treatments used in the experiment were control soil - without the addition of any fertilizer (CT); addition of chemical fertilizer - NPK (QU); addition of organic fertilizer (OR) and the addition of chemical fertilizer and organic fertilizer (OQ). Soil chemical attributes in the four treatments were evaluated after two and seven months after planting to verify the changes that occurred over time. In addition, we evaluated soil chemical attributes of natural areas of occurrence of these species, preserved and degraded forests. The monitoring of the experiment was performed for four months and at the end of this period we recorded survival and measured the functional characteristics of all species. Chemical soil attributes used in the treatments CT and QU were more similar to the attributes of the areas used as reference, showing higher values of acidity potential (H + Al) and cation exchange capacity (CTC), and lower values of nitrogen (N) and organic matter. The seed mass heavily influenced survival in CT, QU and OR treatments and did not differed between CT and QU treatments and, furthermore, in OR treatment the survival was greater than in CT and QU treatments. The effect of seed mass on survival was not significant in OQ treatment. We detected a high positive correlation between SLA, RMF and SRL that were negatively correlated with LA and RHI. The functional properties of the species differed between treatments, but no differences were detected between treatments OR and OQ. In these two treatments, species reached higher values of LA and RHI and lower values of SRL, RMF and SLA than other treatments. Functional attributes varied between and within species. Phenotypic plasticity was higher in LA, RHI, SRL and RMF, and the variation of LA, RHI and SRL were highly correlated with each other and together were negatively related to seed mass. This study showed that limited terrestrial resources were able to modify root 12 architecture, leaf traits and the rate of growth of the aerial parts, which suggests that plants should invest more in fundraising bodies to increase the chances of survival. Intra-specific variation of LA, RHI, SRL, RHI and LDMC characteristics were correlated with each other and negatively correlated with seed mass. Smaller seed species were more plastic than larger seed species. In the treatment CT, these species reached higher values of SLA and SRL, while treatments with organic matter addition, these species reach higher values of LA and RHI. The addition of organic matter in the soil increased the survival and growth of plants, in particular small seed species. Thus, the addition of organic matter as pre-planting treatment proved to be more efficient to increase the performance of native tree species. However, experiments under field conditions are necessary to quantify the efficacy of manure on the reintroduction of native species into deforested forests. / As características biológicas, físicas e químicas do solo são filtros ambientais que influenciam fortemente a composição de comunidades vegetais. O conhecimento do efeito das condições do solo na sobrevivência e no crescimento de espécies vegetais é de grande importância para atividades de recuperação de áreas degradadas. Tais aspectos do desempenho de plantas estão diretamente relacionados aos traços funcionais das espécies, consequentemente a compreensão das respostas dos diferentes traços a diferentes condições edáficas pode auxiliar na escolha de espécies que se adaptem melhor a cada área. Nós conduzimos um experimento em viveiro com o objetivo de avaliar a influência de diferentes tratamentos de solo na sobrevivência e nos traços funcionais; Área Foliar (AF), Área foliar específica (AFE), Conteúdo de matéria seca foliar (CMSF) Fração da massa da raiz (FMR), Comprimentos especifico da raiz (CER) e Taxa de crescimento em altura (TCA) de onze espécies florestais nativas que formam um gradiente de massa de semente. Os tratamentos usados no experimento foram: solo controle – sem a adição de nenhum tipo de adubo ou fertilizante (CT); adição de fertilizante químico - NPK (QU); adição de adubo orgânico (OR) e adição fertilizante químico e de adubo orgânico (OQ). Os atributos químicos do solo nos quatro tratamentos foram avaliados após dois e sete meses da semeadura para verificar as mudanças ocorridas ao longo do tempo. Além disto, avaliamos os atributos químicos do solo de áreas naturais de ocorrência destas espécies, florestas preservadas e degradadas. O monitoramento do experimento foi conduzido por quatro meses e ao final deste período registramos a sobrevivência e as medidas dos traços funcionais de todas as espécies. Os atributos químicos dos solos usados nos tratamentos Controle e Químico foram mais semelhantes aos atributos das áreas usadas como referência, apresentando maiores valores de acidez potencial (H+Al) e Capacidade de troca catiônica (CTC), e menores valores de Nitrogênio (N) e de matéria orgânica. A massa da semente influenciou fortemente a sobrevivência nos tratamentos CT, QU e OR, e não diferiu entre os tratamentos CT e QU, por outro lado, no tratamento OR a sobrevivência foi maior em comparação com os tratamentos CT e QU. O efeito da massa da semente na sobrevivência não foi significativo no tratamento OQ. Detectamos uma alta correlação positiva entre os traços AFE, FMR e CER que foram negativamente correlacionados com AF e TCA. Os atributos funcionais das espécies diferiram entre os tratamentos, porém não foram detectadas diferenças entre os tratamentos OR e OQ. Nestes dois tratamentos as espécies alcançaram valores mais altos de AF e TCA e valores de 8 CER, FMR e AFE mais baixos do que nos demais tratamentos. Os atributos funcionais variaram entre e dentro de espécies. A plasticidade fenotípica foi maior com relação a AF, TCA, CER e FMR, sendo que a variação de AF, TCA e CER foram altamente correlacionadas entre si e juntas foram negativamente relacionadas com a massa da semente. Este estudo mostrou que a limitação de recursos do solo foi capaz de modificar a arquitetura das raízes, os traços foliares e a taxa de crescimento das partes aéreas, sugerindo que plantas devem investir mais em órgãos de captação de recursos para aumentar as chances de sobrevivência. A variação intraespecífica dos traços AF, TCA, AFE, CER e CMSF foram correlacionados entre si e negativamente correlacionados com a massa da semente. Espécies de sementes menores foram mais plásticas do que espécies de sementes maiores. No tratamento CT estas espécies alcançaram maiores valores de AFE e CER, enquanto que nos tratamentos que receberam adição de matéria orgânica, estas espécies alcançaram maiores valores de AF e TCR. A adição de matéria orgânica ao solo aumentou a sobrevivência e o crescimento das plantas, especialmente das espécies de sementes menores. Nesse sentido, a adição de matéria orgânica como tratamento pré-plantio mostrou ser mais eficiente para aumentar o desempenho de espécies arbóreas nativas. No entanto experimentos sob condições de campo são necessários para quantificar a eficácia do uso de esterco na reintrodução de espécies nativa em florestas desmatadas.

En la actualidad, la funcionalidad de pavimentos flexibles se ve afectada por la deficiencia de información detallada de los parámetros de Diseño de Pavimentos. Las fallas internas, desencadenan problemas de desplazamientos y deformaciones, los cuales afectan directamente en la funcionalidad de la estructura del pavimento. En el Perú, el desarrollo del uso de materiales de construcción ha originado que se incrementen las cantidades de residuos de vidrio y se produzca un impacto ambiental negativo. Sin embargo, estos residuos, poseen un potencial para ser usados, incorporándose como agentes estabilizantes de suelos en subrasante de pavimentos, por las útiles propiedades mecánicas de resistencia a la compresión y corte que poseen. Esto permite, reducir el impacto medioambiental y contribuir a la ejecución de pavimentos eco-sostenibles. En ese contexto, la presente investigación, está orientada en desarrollar una estabilización de suelo, un diseño de pavimentos bajo la metodología AASHTO, y un posterior análisis del comportamiento mecánico del diseño de pavimentos realizado. Por un lado, la estabilización de suelo de subrasante arcillosa se realiza mediante la aplicación de polvo de residuos de vidrio. Por otro lado, se hace uso de la metodología AASHTO 1993, con el fin de diseñar el paquete estructural y obtener valores de espesores de capa en escenarios de suelo estabilizado con piedra Over propuesto por JNR y otro en el que el suelo se encuentre estabilizado con polvo de fibra de vidrio reciclado, propuesto por la presente investigación. Posteriormente, se realizó un análisis comparativo de espesores y la influencia directa del valor de CBR en muestras no estabilizadas y estabilizadas, para la determinación del número estructural en el Diseño de pavimentos. Finalmente, se realizó un modelado del comportamiento mecánico de cada capa de la estructura del pavimento, mediante el uso del software computacional 3D Move, con el fin de obtener valores de esfuerzos normales, esfuerzos cortantes y desplazamientos en cada capa del pavimento para suelos no estabilizados y estabilizados. / Currently, the functionality of flexible pavements is affected by the deficiency of detailed information in the Pavement Design parameters. Internal failures trigger displacement and deformation problems, which directly affect the functionality of the pavement structure. In Peru, the development of the use of construction materials has led to an increase in the amounts of glass waste and a negative environmental impact. However, these residues have a potential to be used, being incorporated as soil stabilizing agents in subgrade of pavements, due to the useful mechanical properties they possess. This allows reducing the environmental impact and contributing to the implementation of eco-sustainable pavements. In this context, the present research is aimed at developing soil stabilization, a pavement design under the AASHTO methodology and a subsequent analysis of the mechanical behavior of the pavement design carried out. On the one hand, clay subgrade soil stabilization is carried out by applying glass waste powder. On the other hand, the Empirical AASHTO 1993 methodology is used, in order to design the structural package and obtain layer thickness values ​​in scenarios of stabilized soil with the proposed material and another in which the soil is stabilized with other type of material. Subsequently, a comparative analysis of thicknesses and the direct influence of the CBR value in non-stabilized and stabilized samples will be carried out in the pavement design carried out to determine the structural number. Finally, a mechanical behavior modeling is carried out, applying the use of the Windepav computer software to obtain deformation and deflection values ​​in each layer of the pavement for unstabilized and stabilized soils / Tesis

La arquitectura desde sus inicios estuvo en constante cambios, dependiendo del lugar donde se desarrollaba. Por ejemplo, la arquitectura brasileña se desarrolló a finales del siglo XX, en la cual tuvo como características, la elaboración a partir de su cultura, su identidad nacional, sus experiencias propias, hasta de la naturaleza. Por tal motivo, el presente trabajo de investigación consiste en el desarrollo de “La arquitectura de Oscar Niemeyer”, teniendo como objetivo el desarrollo de una colección Primavera Verano 2022 a partir del análisis teórico y visual de la arquitectura del arquitecto mencionado. Para validar el trabajo de investigación, se optó por indagar diversas fuentes confiables como el caso de tesis, doctorados, artículos, libros online, entrevistas, entre otros. Para poder realizar un análisis exhaustivo y claro, esto nos ayudó al entendimiento de los términos encontrados en la Facultad de Arquitectura, se procedió al planteamiento de los objetivos referente a investigación y diseño. Luego, se procedió a la elaboración de moodboard de figura, color, texturas, antecedente de diseño, usuario, prototipos, y estructura. Después, a la elección del usuario “Ambos géneros, apasionado por el arte y la moda, que se encuentren dentro del rango de edad de 26-41 años de edad, el tipo de producción “Pret a Porter” y el estilo a desarrollar “Sporty Chic” Finalmente, se obtuvo como resultado bocetos y figurines inspirados en la arquitectura de Oscar Niemeyer, con sus especificaciones de forma, color y texturas a incorporar. / The architecture from its beginnings, was in constant changes, depending on the place where it was developed. For example, Brazilian architecture developed at the end of the 20th century, in which its characteristics were the elaboration based on its culture, its national identity, its own experiences, even from nature. For this reason, this research work consists of the development of "The architecture of Oscar Niemeyer", aiming at the development of a Spring Summer 2022 collection based on the theoretical and visual analysis of the architecture of the aforementioned architect. To validate the research work, it was decided to investigate various reliable sources such as the case of theses, doctorates, articles, online books, interviews, among others. In order to carry out an exhaustive and clear analysis, this helped us to understand the terms found in the faculty of architecture, we proceeded to the approach of the objectives regarding research and design. Then, we proceeded to the development of moodboard of figure, color, textures, design background, user, prototypes, and structure. Then, at the user's choice "Both genres, passionate about art and fashion, that are within the age range of 26-41 years old, the type of production" Pret a Porter "and the style to develop" Sporty Chic” Finally, the result was sketches and figurines inspired by Oscar Niemeyer's architecture, with their specifications of shape, color, and textures to be incorporated. / Trabajo de investigación

[EN] This PhD in Fine Arts is the introduction to a Yantric Theory of Drawing as a result of researching plastic forms from the universal principles present in perceptive reality. Based on the yantra as an active element in the drawing of a integral mandalic vision, Drawing re-presents a vision of the world based on aesthetic distance, in which the sum and multiplication of all the parts is contemplated from one point of view, a naked eye. This perspective is transdimensional, whereby co-creative man is capable of making his own vision real, enjoying the aesthetic experience through the practice of Art. Art is the fifth element in which contact with Beauty takes place in a disinterested way. This thesis in its Form and Consciousness explores the fundaments of these aesthetic formulations through its most yogic roots in India. We will add a metaphor to such aesthetic formulations and explain them through the voice of the artist, in which the process of transmutation of the matter, the transformation of the Nature into Art takes place. The shilpi yogi is the inspiration and aspiration of the being which indwells the imagery artist who develops images of himself, the imprints of personal consciousness transcended through transpersonal art forms. Its being, its Presence, can be modulated through plasticity, from the purest abstraction to the finest figurative art. This thesis represents a plastic voyage to the very heart of India, in which an artist and a sadhu go hand in hand as a symbolic encounter between indosophy and the sublime plastic representative of the tragedy of duality, sunk in life under the weight of chiaroscuro. Light is the Great Symbolic Metaphor and the primordial object of the mystery of Science. The space of the heart is the fifth plastic element on which we base our Yantric Theory of Drawing. We use this to reintegrate the coherence of Art from all times and places, reinterpreting it from an optimistic historical standpoint. Drawing gives us the power to make this real (maya-magic), through the yantric vision. This thesis is the foundational preface to a way to make real the dream of the imagined, a function which Art, the original inoculant, has had throughout history. Such a possibility of form-function-power is endorsed by the most ancient foundations of civilization: the great symbolic potential which was crystalised in Man, the complex system of ancient times which doesn't respond to limits, but rather to constellations, the tantra, inspiration and aspiration of quantic meta-physics. / [ES] Esta tesis doctoral en Bellas Artes es la introducción de una Teoría Yántrica del Dibujo como resultado de una investigación de la forma plástica desde principios universales presentes en la realidad perceptiva. Basada en el yantra como elemento activo dibujístico de una visión mandálica integral, el Dibujo viene a re-presentar una visión del mundo basada en la distancia estética, en la que la suma y multiplicación de todas las partes es contemplada desde un punto de vista y un ojo genuino, transdimensional, en el que el hombre co-creativo es capaz de realizar su propia visión y disfrutar de la experiencia estética a través de la práctica del Arte. El Arte es el quinto elemento en el que el contacto con la Belleza de modo desinteresado tiene lugar. Esta tesis, como Forma y Consciencia explora los fundamentos de estas formulaciones estéticas, a través de sus raíces más yóguicas, en India. A tales formulaciones estéticas les añadimos una metáfora y las explicamos a través de la voz del artista, en el que se da el proceso de transmutación de la materia, la transformación de la Naturaleza en Arte. El silpi yogui es la inspiración y aspiración del ser que habita en el artista imaginero, quien desarrolla sus propias imágenes o la huella de la consciencia personal que se supera a sí misma a través de la plástica de lo trans-personal. Su ser, solo Presencia, se deja modular en el vehículo plástico desde la más pura abstracción a la más fina figuración. Esta tesis representa un viaje plástico al corazón de la India, en el que van de la mano una artista y un sadhu como encuentro simbólico de la indosofía y el sublime representante plástico de la tragedia de la dualidad, sumido en la vida y el peso del claroscuro. La Luz es la Gran Metáfora simbólica y el objeto de misterio primordial de la Ciencia. El espacio del corazón es el quinto elemento plástico en el que se basa nuestra Teoría Yántrica del Dibujo para reintegrar la coherencia del Arte de todos los tiempos y lugares, desde un punto de vista histórico optimista que está en nuestras manos hacer real (magia-maya), a través de la visión yántrica para el Arte, a que da pie el Dibujo. Esta tesis es el prolegómeno fundacional de una vía de hacer real el sueño de lo imaginado, como ha venido haciendo el Arte como inóculo original a lo largo de la Historia. Tal posibilidad de forma-función-poder está avalada por los más antiguos fundamentos de la civilización, el gran potencial simbólico que fue posible cristalizar en el Hombre, el sistema complejo de la antigüedad que no responde a límites, sino a constelaciones, el tantra, inspiración y aspiración de la meta-física cuántica. CLARA M. SEVILLA SEGUÍ / [CA] Aquesta tesi doctoral en Belles Arts és la introducció d'una Teoria Iàntrica del Dibuix com a resultat d'una investigació de la forma plàstica des de principis universals presents en la realitat perceptiva. Basada en el iantra com a element actiu del dibuix d'una visió integral del mandala, el Dibuix vindria a re-presentar una visió del món basada en la distància estètica, en què la suma i multiplicació de totes les parts és contemplada des d'un punt de vista i un ull genuí, "transdimensional", en què l'home co-creatiu és capaç de realitzar la pròpia visió i gaudir de l'experiència estètica a través de la pràctica de l'Art. L'Art és el cinquè element en què el contacte amb la Bellesa hi té lloc de forma desinteressada. Aquesta tesi, en tant que Forma i Consciència, explora els fonaments d'aquestes formulacions estètiques mitjançant unes arrels basades en sistema del ioga, pel que fa a l'Índia. A aitals formulacions estètiques els afegim una metàfora, i les expliquem per mitjà de la veu de l'artista, l'individu en qui es produeix el procés de transmutació de la matèria, la transformació de la Natura en Art. El silpi iogui és la inspiració i aspiració de l'ésser que habita en l'artista imaginer, qui desenvolupa les seves pròpies imatges o l'empremta de la consciència personal que se supera a si mateixa a través de la pràctica d'allò trans-personal. El seu ésser, tan sols Presència, es deixa modular en el vehicle plàstic des de la més pura abstracció fins a la figuració més fina. Aquesta tesi representa un viatge plàstic al cor de l'Índia, en què una artista i un sadhu, plegats, conflueixen de manera simbòlica en la indosofia i el sublim representant plàstic de la tragèdia de la dualitat, immers en la vida i el pes del clarobscur. La Llum és la Gran Metàfora simbòlica i l'objecte primordial de la ciència. L'espai del cor és el cinquè element plàstic en què es basa la nostra Teoria Iàntrica del Dibuix, el propòsit del qual consisteix a reintegrar la coherència de l'Art de tots els temps i llocs, des d'un punt de vista històric i optimista, que tenim a les nostres mans convertir en real (màgia-maia) a través de la visió iàntrica per a l'Art, a què dóna peu el Dibuix. Aquesta tesi és el prolegomen fundacional d'una via per tal de materialitzar el somni respecte d'allò imaginat, com ha vingut fent l'Art com a inòcul originari al llarg de la Història. Aquesta possibilitat de forma-funció-poder és avalada pels més antics fonaments de la civilització, el gran potencial simbòlic que fou possible cristal·litzar en la figura de l'Home, el sistema complex de l'antiguitat que no respon a límits, sinó a constel·lacions, el tantra: inspiració i aspiració de la meta-física quàntica. / Sevilla Seguí, CM. (2016). Forma y Consciencia: Fundamentos para una Teoría Yántrica del Dibujo [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/63259