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Introduction: Foot over-pronation, attributable to Tibialis Posterior (TP) muscle weakness, is a possible cause of medial tibial stress syndrome (MTSS)3. Taping may provide a viable alternative for a dysfunctional TP and its associated navicular drop (ND). The most commonly used Augmented LowDye (ALD) technique has shown to prevent ND, but is time- and cost- intensive, leading us to explore an alternative technique. The purpose of this study was to assess the effectiveness of a new, anti-pronation (AP) taping technique, as compared to the ALD, to (a) reduce or prevent ND and (b) cause a lateral shift in the center of pressure (COP) measures. Methods: This is a 2 (tape techniques) by 3 (time: baseline, tape/pre-exercise, and tape/post-exercise) controlled laboratory study design. Twenty symptomatic (ND >/= 10 mm) college-age subjects were prepared with one of the 2 tape techniques and/or control and performed the ND test three times and walk across a pressure mat five times. Then the participants fatigued the tape by walking on a treadmill for 15 minutes at 3.0 mph at 0% grade and ND and pressure mat readings were recorded again. A within and within ANOVA allowed for the examination of between and within comparisons and a functional analysis (lateral shift as a function of time) on the mat-generated data were done p<.05. Results: Results revealed significant differences across times, and a times-by-tape technique interaction but differences between tape techniques were not significant. M and SD and indicate that while both taping techniques reduced ND, only the AP technique was significantly different (HSDTukey (3,76)=1.44, p<.01) for every comparison other than AP pre-exercise, the mean lateral shift for the treatment was not significantly different from the control across any part of the normalized stance phase, but was significantly lower than the control in the 30-90% interval in the AP pre-exercise. Discussion: The AP technique not only controlled ND but also resulted in an increase in lateral excursion of the COP line during that portion of the stance phase associated with the structures and functions of the TP. Both techniques can be appropriately used but that the AP can be used with more confidence in its effectiveness. The MatScan has allowed examination of forefoot pronation in the horizontal plane, not just the vertical plane, yielding a more holistic analysis of forefoot pronation. Being able to analyze data in a functional fashion (i.e., lateral shift as a function of time) could allow researchers greater insights to the complex relationships between biomechanical movement and appropriate interventions.

Introduction: The New Balance Core Low Cut Sock (New Balance Athletic Shoe, Inc. · Boston, MA United States) is one of many arch support socks out in the market. These socks have an elastic portion, called a Stability Fit Arch Support & Hold technology, which has been incorporated into the arch area of the sock. The company makes the following claim that the socks provide, "Gentle compression to support the arch, relieving arch-related pain and discomfort."1 If these socks do provide adequate arch support, then they would allow individuals the ability to have an inexpensive method of arch support that is easy to apply and use. The purpose of this study is to test the effectiveness of these socks in (a) navicular drop (b) static pressure insole pressure profiles and (c) dynamic (walking and running) pressure insole pressure profiles. Methods: Eighteen symptomatic, college age (age 18-26) subjects were used in this study (seven male, eleven female), with symptomatic being defined as a navicular drop greater than or equal to 10 mm. Measurements were collected for both the navicular drop, and F-Scan insole data, for both static and dynamic stance. For walking and running trials, heel strike and toe off were identified by the Tekscan System and COP excursion coordinates evaluated throughout the stance phase. The COP coordinates were exported then compared over the stance phase. A series of functional analyses was used to assess the between group differences. A paired t-test was used to assess the within group differences. Results: Results indicate that the arch support socks were not significantly different from the control (regular socks) along any part of the foot strike (95% confidence) in any of the conditions (standing, walking or running). Results from the paired t-test revealed no significant differences in navicular drop between sock types (p = .379). Discussion: This study found that the elastic band in the New Balance socks did not provide increased support to the medial arch of the foot compared to the control sock in either the navicular drop paired t-test or the functional analysis of the static and dynamic data. The authors could not find any other comparable study on these kinds of socks. Compared to other reports, using both orthotic inserts and tape, ND was reduced, unlike the results found in the present study. 2 Our data are inconsistent with the idea that increased elastic support to the midfoot by these socks provides significant arch support. The authors would suggest another form of arch support such as orthotics or taping to aid on arch support rather than these socks.

<p>Deep learning has been the driving force behind many successful data science achievements. However, the deep neural network (DNN) that forms the basis of deep learning is</p> <p>often over-parameterized, leading to training, prediction, and interpretation challenges. To</p> <p>address this issue, it is common practice to apply an appropriate penalty to each connection</p> <p>weight, limiting its magnitude. This approach is equivalent to imposing a prior distribution</p> <p>on each connection weight from a Bayesian perspective. This project offers a systematic investigation into the selection of the penalty function or prior distribution. Specifically, under</p> <p>the general theoretical framework of posterior consistency, we prove that consistent sparse</p> <p>deep learning can be achieved with a variety of penalty functions or prior distributions.</p> <p>Examples include amenable regularization penalties (such as MCP and SCAD), spike-and?slab priors (such as mixture Gaussian distribution and mixture Laplace distribution), and</p> <p>polynomial decayed priors (such as the student-t distribution). Our theory is supported by</p> <p>numerical results.</p> <p><br></p>

In this paper, we review existing classification techniques and suggest an entirely new procedure for the classification of high-dimensional vectors on the basis of a few training samples. The proposed method is based on the Bayesian paradigm and provides posterior probabilities that a new vector belongs to each of the classes, therefore it adapts naturally to any number of classes. Our classification technique is based on a small vector which is related to the projection of the observation onto the space spanned by the training samples. This is achieved by employing matrix-variate distributions in classification, which is an entirely new idea. In addition, our method mimics time-tested classification techniques based on the assumption of normally distributed samples. By assuming that the samples have a matrix-variate normal distribution, we are able to replace classification on the basis of a large covariance matrix with classification on the basis of a smaller matrix that describes the relationship of sample vectors to each other.

One very common axiom amongst Strength and Conditioning Professionals and Athletic Performance Coaches is that the least flexible athletes usually produce the fastest 40-yard dash times. Flexibility, in this case specifically refers to posterior chain flexibility (PCF). This is usually measured by athletes ability to perform a sit-and-reach test. This train of thought has been widely accepted within the human performance professions, even though it is void of any scientific investigation or measured validity. The purpose of this study is to determine if there is a relationship between posterior chain flexibility using the sit-and-reach test and speed in the 40-yard dash. All test subjects were male between the ages of 18-22, and members of a Division I university football team. All 95 test subjects had participated in at least one semester of a strength and conditioning program designed by Certified Strength and Conditioning Specialists. Similar of the study done by Johnson (2001), each athlete was placed in a group based on position, line of scrimmage groups (LOS), Skill group (receivers, cornerbacks, rover linebackers, whip linebackers, and safeties), Combo group (inside linebackers, tight ends, quarterbacks, tailbacks, fullbacks, and defensive ends), Specialist group (place- kickers, kick-off specialists, holders, and punters). Each test subject was tested in the 40-yard dash, the sit-and-reach flexibility test, as well as other tests for strength and power such as the bench press, front squat, push jerk, power clean, vertical jump, and agility tests. Body weight and height was also measured. This study used a simple linear regression on the data where the Sit-and-Reach test results were the dependent variable and the subjects timed results in a 40 yard dash was the independent variable. There appears to be no significant relationship between a low flexibility score and the sprint speed of an athlete for the entire group population. The results also show that there is no significant relationship between flexibility of the posterior chain and linear speed as measured in the 40-yard dash when looking at football players that fall under the Combo, Skill, or LOS position groups. There was however a significant relationship for the specialist group. The theory that the least flexible athletes usually produce the fastest 40-yard dash times is not true for those specific groups. / Ph. D.

<p>Improved materials for implantation as intraocular lens (IOL) devices are needed to minimize the occurrence of posterior capsule opacification (PCO). In this work, novel polydimethylsiloxane (PDMS) loaded with matrix metalloprotease inhibitors (MMPI) were developed as model IOL materials.</p> <p>PDMS was chosen as silicones are currently used successfully as IOLs. Inhibitor release rates and amount of initial burst of drug-loaded PDMS could be controlled by changing solvent when loading into elastomer base, as well as drug loading method, and release buffer.</p> <p>Two lens epithelial cell lines were characterized for in vitro tests: FHL124 and HLE B3. These cell lines produce different combinations of extracellular matrix proteins when grown on various biomaterial surfaces. Significant differences between the two cell lines were observed both in collagen VIII and α-smooth muscle actin levels, both when cells were unstimulated, and as a result of epithelial to mesenchymal transition induced by treatment with transforming growth factor β2. FHL124 cells were selected in further tests due to their consistent expression of extracellular matrix components when exposed to different materials.</p> <p>Solutions of synthetic MMPI GM6001 and MMP 2/9 Inhibitor II, known to mitigate anterior subcataract formation, were released from PDMS and found to protect in a modest but significant way against protein profile changes and to delay migration. Due to the Zn²⁺ dependence of MMPs, chelators, including EDTA, TPEN and 1-10 phenanthroline were examined as alternative inhibitors. Only the latter was found to have a significant effect on cell migration rates in vitro. Sulfadiazine, due to its chemical resemblance to synthetic MMPI was determined to be the most efficient at reducing migration rates as well as to have the lowest toxicity.</p> <p>Overall, sulfadiazine was determined in this work to be a potentially effective solution to mitigating PCO. These results indicate that releasing MMPI molecules from PDMS as a model IOL is a promising way to mitigate aspects of PCO.</p> / Thesis / Doctor of Philosophy (PhD)

Purpose: Anorectal malformations (ARM) are one of the most challenging congenital malformations in pediatric surgery. We aimed to assess the research activity on ARM over the last five decades. Methods: Data on original research publications were retrieved from the Web of Science Core Collection (1970–2020), and analyzed for countries, authors, scientific journals, and top-ten papers. Scientific quantity was assessed by the number of publications. Research quality was estimated from the number of citations, average citation rate per item (ACI), and h-index. Results: A total number of 1595 articles with 19,419 citations (ACI = 12.2; h-index = 54) were identified. The annual number of publications and citations significantly increased over time (p < 0.0001). The USA (n = 386; 24.2%), Japan (n = 153; 9.6%), and China (n = 137; 8.6%) were the most productive countries; and the USA (n = 7850; ACI = 20.3; h-index = 44), Japan (n = 1937; ACI = 12.6; h-index = 21), and the Netherlands (n = 1318; ACI = 17.3; h-index = 22) were the top cited countries. Articles were preferentially published in JPS (n = 391; 24.5%), PSI (n = 181; 11.3%), and EJPS (n = 56; 3.5%). Top-ten cited papers focused on classification (n = 1), surgical technique (n = 3), associated syndromes (n = 2), postoperative outcome (n = 3), and basic research (n = 1). Conclusion: This bibliometric study provides valuable insights into the global development of ARM research, and shows that clinical studies and international collaborations dominate in this field.

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