A betaína é um trimetil derivado do aminoácido glicina. Os seus principais efeitos fisiológicos são atuar como um osmólito e como doador de radicais metil. Especulase que a betaína possa contribuir para a síntese de creatina no músculo esquelético pelo fornecimento de grupos metil, resultante da conversão de betaína em dimetilglicina, para a remetilação de homocisteína em metionina. Os efeitos da suplementação de creatina sobre o desempenho são conhecidos e relacionam-se principalmente ao aumento na ressíntese de fosforilcreatina (PCR). Autores de estudos recentes têm atribuído seus resultados positivos em relação ao aumento de força muscular a um possível efeito da betaína sobre as concentrações de PCR. Essa variável, entretanto, não foi avaliada, de maneira que os mecanismos responsáveis pelo aumento de força advindo da suplementação de betaína ainda são inexplorados em humanos. Diante disso, este estudo teve como objetivo investigar os efeitos da suplementação de betaína, combinada ou não com a suplementação de creatina, sobre as concentrações intramusculares de PCR, e a produção de força e potência muscular em indivíduos não treinados em força. Além disso, as respostas fisiológicas e ergogênicas da suplementação de betaína e creatina foram comparadas e avaliados os possíveis efeitos aditivos desses suplementos. Foi conduzido um estudo duplo-cego, randomizado, controlado por placebo. Trinta e quatro sujeitos foram divididos em quatro grupos: Betaína (BET; 2 g/dia), Creatina (CR; 20 g/dia), Betaína + Creatina (BET + CR; 2 + 20 g/dia) e Placebo (PL). No período basal (PRÉ) e após 10 dias de suplementação (PÓS), os indivíduos submeteram-se a avaliações do consumo alimentar e da composição corporal, a testes de força e potência muscular e à quantificação intramuscular de PCR. Após a intervenção, as concentrações intramusculares de PCR foram maiores nos grupos CR e BET + CR, quando comparados ao grupo PL (p = 0,004 e p = 0,006, respectivamente). Não houve diferenças significativas entre os grupos BET e PL (p = 0,78) e CR e BET + CR (p = 0,99). Os grupos CR e BET + CR apresentaram maior produção de potência muscular no exercício de agachamento, quando comparados ao grupo PL (p = 0,003 e p = 0,041, respectivamente). Resultados similares foram encontrados para o exercício de supino. Os grupos CR e BET + CR também demonstraram aumento significativo de força muscular (teste de 1-RM) do teste PRÉ para o teste PÓS nos exercícios de supino e agachamento (CR: p = 0,027 e p 0,0001; BET + CR: p = 0,03 e p 0,0001 para membros superiores e inferiores, respectivamente). Não houve diferenças significativas para os testes de força e de potência muscular entre os grupos BET e PL e os grupos CR e BET + CR. Também não houve diferença significativa entre os grupos para a composição corporal. O consumo alimentar permaneceu inalterado ao longo do estudo. Os resultados permitem concluir que a suplementação de betaína, combinada ou não com a suplementação de creatina, não aumenta o conteúdo intramuscular de PCR e não afeta o desempenho de força e de potência muscular / Betaine is a trimethyl derivative of the amino acid glycine. The main physiological functions of betaine are to act as an organic osmolyte and as a donor of methyl radicals. It is speculated that betaine may contribute to the synthesis of creatine in skeletal muscle through the donation of a methyl group, resulting from the conversion of betaine to dimethylglycine, to homocysteine to form methionine. The effects of creatine supplementation on performance are well known and are related primarily to an increase in fosforilcreatina resynthesis (PCR). Authors of recent studies have attributed its positive results regarding the increase of muscle strength to a possible effect of betaine on the concentrations of PCR. However, this variable was not assessed, so that the mechanisms responsible for the increase in muscle strength coming from betaine supplementation in humans are still unexplored. In light of this, the aim of this study was to investigate the effect of betaine supplementation combined or not with creatine supplementation on muscle PCR content, muscle strength and power output in non-resistance trained subjects. Additionally, we compared the ergogenic and physiological responses to betaine versus creatine supplementation. Finally, we also tested the possible additive effects of creatine and betaine supplementation. A randomized, double-blind, placebo-controlled study was conducted. Thirty and four subjects were assigned into four groups: Betaine (BET; 2 g/day), Creatine (CR; 20 g/day), Betaine + Creatine (BET + CR; 2 + 20 g/day) or Placebo (PL). At baseline (PRE) and after 10 days of supplementation (POST) body composition, food intake, muscle strength and power and muscle PCR were assessed. The CR and BET + CR groups presented greater increase in muscle PCR content than PL (p = 0.004 and p = 0.006, respectively). PCR content was comparable between BET versus PL (p = 0.78) and CR versus BET + CR (p = 0.99). CR and BET + CR presented greater muscle power output than PL in the squat exercise following supplementation (p = 0.003 and p = 0.041, respectively). Similarly, bench press average power was significantly greater for the CR-supplemented groups. CR and BET + CR groups also showed significant pre- to post-test increase in 1-RM squat and bench press (CR: p = 0.027 and p 0.0001; BET + CR: p = 0.03 and p 0.0001 for upper- and lower-body assessments, respectively). No significant differences for 1-RM strength and power were observed between BET versus PL and CR versus BET + CR. Body composition did not differ between the groups. Dietary intake was unchanged throughout the study. Thus, we concluded that betaine supplementation does not augment muscle PCR content and betaine supplementation combined or not with creatine supplementation does not affect strength and power performance in non-resistance trained subjects

Background: Hearing aid prescriptive recommendations for hearing losses having a conductive component have received less clinical and research interest than for losses of a sensorineural nature; as a result, much variation remains among current prescriptive methods in their recommendations for conductive and mixed hearing losses (Johnson and Dillon, 2011). Purpose: The primary intent of this brief clinical note is to demonstrate differences between two algebraically equivalent expressions of hearing loss, which have been approaches used historically to generate a prescription for hearing losses with a conductive component. When air and bone conduction thresholds are entered into hearing aid prescriptions designed for nonlinear hearing aids, it was hypothesized that that two expressions would not yield equivalent amounts of prescribed insertion gain and output. These differences are examined for their impact on the maximum power output (MPO) requirements of the hearing aid. Subsequently, the MPO capabilities of two common behind-the-ear (BTE) receiver placement alternatives, receiver-in-aid (RIA) and receiver-in-canal (RIC), are examined. Study Samples: The two expressions of hearing losses examined were the 25% ABG + AC approach and the 75% ABG + BC approach, where ABG refers to air-bone gap, AC refers to air-conduction threshold, and BC refers to bone-conduction threshold. Example hearing loss cases with a conductive component are sampled for calculations. The MPO capabilities of the BTE receiver placements in commercially-available products were obtained from hearing aids on the U.S. federal purchasing contract. Results: Prescribed gain and the required MPO differs markedly between the two approaches. The 75% ABG + BC approach prescribes a compression ratio that is reflective of the amount of sensorineural hearing loss. Not all hearing aids will have the MPO capabilities to support the output requirements for fitting hearing losses with a large conductive component particularly when combined with significant sensorineural hearing loss. Generally, current RIA BTE products have greater output capabilities than RIC BTE products. Conclusions: The 75% ABG + BC approach is more appropriate than the 25% ABG + AC approach because the latter approach inappropriately uses AC thresholds as the basis for determining the compression ratio. That is, for hearing losses with a conductive component, the AC thresholds are not a measure of sensorineural hearing loss and cannot serve as the basis for determining the amount of desired compression. The Australian National Acoustic Laboratories has been using the 75% ABG + BC approach in lieu of the 25% ABG + AC approach since its release of the National Acoustic Laboratories—Non-linear 1 (NAL-NL1) prescriptive method in 1999. Future research may examine whether individuals with conductive hearing loss benefit or prefer more than 75% restoration of the conductive component provided adequate MPO capabilities to support such restoration.

Este estudio analizó los cambios en variables cardiorrespiratorias, neuromusculares, hormonales, de composición corporal y de rendimiento en un grupo de 18 kayakistas varones de elite mundial durante una temporada completa de entrenamiento concurrente de 43 semanas, una fase de puesta a punto de 4 semanas así como los efectos de un periodo de desentrenamiento de 5 semanas en los grupos de cesión total de entrenamiento (CE) y de reducción parcial de entrenamiento (RE). El volumen y la intensidad de entrenamiento fueron cuantificados a nivel individual durante todas las fases del estudio. Un control exhaustivo sobre las variables que definen el programa de entrenamiento permitió alcanzar adaptaciones positivas tanto en las variables de fuerza como en las de resistencia durante un programa de entrenamiento concurrente en deportistas de élite mundial. Así mismo, periodos cortos de CE produjeron mayores descensos del rendimiento neuromuscular y cardiorrespiratorio comparado con la estrategia de RE. / This study was undertaken to analyze changes in selected cardiovascular, neuromuscular, hormonal, body composition and performance variables in a group of 18 male elite kayakers across an initial concurrent training program of 43-wk, a 4wk tapering phase, as well as the effects of a subsequent detraining period of 5-wk under reduced training (RT) or training cessation (TC) approach. Training volume and exercise intensity were quantified for each subject throughout the study. An exhaustive control over the training program variables allowed to highly-trained athletes achieves positive adaptations in both cardiovascular endurance and muscle strength under a concurrent training regime. Likewise, short-term TC results in large decreases in neuromuscular and cardiovascular function compared with RE strategy.

科学研究費補助金 研究種目:基盤研究(B)(2) 課題番号:09558003 研究代表者:池上 康男 研究期間:1997-1998年度

The aim of the study is to determine effects of passive warming up on muscle contraction force while performing maximum intensity short veloergometric test and vertical jumps. Untrained healthy males took part in both experiments within the study. Subjects (n=13) had to perform maximal veloergometric effort with different resistance (3% and 10% of their own weight) for 5 seconds during first test. Then they performed passive warming up and repeated the test. Maximal motion frequency and power output were determined. Other subjects (n=14) had to perform maximal single jumps (one with squat and one without) during second test. Then they performed passive warming up and repeated the test. Maximal set off speed, strength, power output and jump height were determined. Maximal motion frequency and maximal power output after passive warming up in veloergometric test were significantly (p<0, 05) greater than before it. Maximal set off speed after passive warming up in jumping test was significantly (p<0, 05) greater, but maximal set off strength did not differ significantly performing both types of jumps. However jump height significantly increased in both cases. In conclusion, the results indicate that in untrained subjects, passive warming up improves muscles’ power output in both experiments. Another conclusion is that passive warming up has much greater effect on contraction speed than on muscles’ strength.

Submitted by Renata Lopes (renatasil82@gmail.com) on 2017-06-22T14:27:00Z No. of bitstreams: 1 arthurhenriquesouzanetobossi.pdf: 861040 bytes, checksum: c3c1cec3feee16cacb22f14eb9d27f1c (MD5) / Rejected by Adriana Oliveira (adriana.oliveira@ufjf.edu.br), reason: on 2017-06-22T14:35:05Z (GMT) / Submitted by Renata Lopes (renatasil82@gmail.com) on 2017-06-22T14:39:20Z No. of bitstreams: 1 arthurhenriquesouzanetobossi.pdf: 861040 bytes, checksum: c3c1cec3feee16cacb22f14eb9d27f1c (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-08-07T19:21:44Z (GMT) No. of bitstreams: 1 arthurhenriquesouzanetobossi.pdf: 861040 bytes, checksum: c3c1cec3feee16cacb22f14eb9d27f1c (MD5) / Made available in DSpace on 2017-08-07T19:21:44Z (GMT). No. of bitstreams: 1 arthurhenriquesouzanetobossi.pdf: 861040 bytes, checksum: c3c1cec3feee16cacb22f14eb9d27f1c (MD5) Previous issue date: 2014-08-22 / Para maior empregabilidade do protocolo de teste contra-relógio (CR) de 20 min em campo, é necessária a compreensão (1) de como o desempenho em percurso de subida se relaciona com as medidas laboratoriais típicas e (2) do perfil de pacing adotado. Separados por pelo menos 48 horas, 15 ciclistas moderadamente treinados, incluindo 1 do sexo feminino (30,8±4,8 anos; 176,5±8,0 cm; 78,9±14,5 kg; 56,1±7,7 ml.kg-1.min-1; média ± desvio padrão), realizaram inicialmente um teste anaeróbio Wingate, um teste de esforço incremental até a exaustão e um contrarelógio de campo por 20 min em percurso de subida com 2,7% de inclinação média. Após 5 semanas de treinamento não supervisionado, 10 dos 15 voluntários realizaram um segundo CR para comparação do pacing adotado. As regressões lineares múltiplas stepwise demonstraram que 91% da variação na potência média produzida no CR (W.kg-1) pode ser explicada pelo pico do consumo de oxigênio (ml.kg-1.min-1) e pelo ponto de compensação respiratória (W.kg-1), com coeficientes beta padronizados de 0,64 e 0,39 respectivamente. A realização do CR em aclive pressupõe um ajuste de 94,6% da potência média, de modo a aperfeiçoar a concordância com a potência referente ao ponto de compensação respiratória, em que o diagrama de Bland-Altman demonstrou um viés ± erro aleatório de 0,4±49,7 W ou -0,1±19,7 %. A ANOVA two-way (CR X tempo) para medidas repetidas revelou efeito principal dos intervalos de tempo (p < 0,001) na potência média produzida em cada trecho (122,2±10,0; 97,8±1,2 e 95,1±7,1% para os trechos 0-2, 2-18 e 18-20 min, respectivamente) caracterizando perfil de pacing positivo, tanto no primeiro, quanto no segundo teste (p = 0,116). Em conjunto, estas informações indicam que o protocolo de teste CR de 20 min realizado em subida, aparentemente, seja robusto para monitorar o desempenho de ciclistas de diferentes níveis competitivos. Entretanto, novos estudos mais específicos são importantes para confirmar a reprodutibilidade do desempenho e para verificar a influência do feedback instantâneo da potência produzida. / For a wider applicability of the 20-min time trial (TT) testing protocol in field, it is necessary to understand (1) how performance in an uphill course relates with typical laboratory measures and (2) the pacing profile adopted. Separated by at least 48 hours, 15 moderately trained cyclists, including 1 female (30.8±4.8 years; 176.5±8.0 cm; 78.9±14.5 kg; 56.1±7.7 ml.kg-1.min-1; mean ± standard deviation), initially performed a Wingate anaerobic test, a graded exercise test to exhaustion and a 20-min field time trial in a 2.7% gradient uphill course. After 5 weeks of nonsupervised training, 10 from 15 volunteers performed a second TT for comparison of the pacing adopted. Stepwise multiple linear regressions demonstrated that 91% of TT mean power output variation (W.kg-1) can be explained by peak oxygen consumption (ml.kg-1.min-1) and respiratory compensation point (W.kg-1), with standardized beta coefficients of 0.64 and 0.39 respectively. Performing TT on ascents premises a 94.6% mean power output adjustment in order to improve the agreement with respiratory compensation point power output, which Bland-Altman plot showed a bias ± random error of 0.4±49.7 W or -0.1±19.7 %. Repeated measures two-way ANOVA (TT X time) revealed a main effect of the time intervals (p < 0.001) on the power output of each portion (122.2±10.0; 97.8±1.2 e 95.1±7.1% for the portions 0-2, 2-18 e 18-20 min, respectively) characterizing a positive pacing profile, either in the first and in the second test (p = 0.116). Together, this information indicates that the 20-min TT testing protocol performed on ascent is apparently robust for performance monitoring of different competitive level cyclists. However, more specific new studies are important to confirm performance reproducibility and to verify the influence of power output instant feedback.

Introduction Researchers have, for decades, contributed to an increased collective understanding of the physiological demands in cross-country skiing; however, almost all of these studies have used either non-elite subjects and/or performances that emulate cross-country skiing. To establish the physiological demands of cross-country skiing, it is important to relate the investigated physiological variables to the competitive performance of elite skiers. The overall aim of this doctoral thesis was, therefore, to investigate the external validity of physiological test variables to determine the physiological demands in competitive elite cross-country skiing. Methods The subjects in Study I – IV were elite male (I – III) and female (III – IV) cross-country skiers. In all studies, the relationship between test variables (general and ski-specific) and competitive performances (i.e. the results from competitions or the overall ski-ranking points of the International Ski Federation (FIS) for sprint (FISsprint) and distance (FISdist) races) were analysed. Test variables reflecting the subject’s general strength, upper-body and whole-body oxygen uptake, oxygen uptake and work intensity at the lactate threshold, mean upper-body power, lean mass, and maximal double-poling speed were investigated. Results The ability to maintain a high work rate without accumulating lactate is an indicator of distance performance, independent of sex (I, IV). Independent of sex, high oxygen uptake in whole-body and upper-body exercise was important for both sprint (II, IV) and distance (I, IV) performance. The maximal double-poling speed and 60-s double-poling mean power output were indicators of sprint (IV) and distance performance (I), respectively. Lean mass was correlated with distance performance for women (III), whereas correlations were found between lean mass and sprint performance among both male and female skiers (III). Moreover, no correlations between distance performance and test variables were derived from tests of knee-extension peak torque, vertical jumps, or double poling on a ski-ergometer with 20-s and 360-s durations (I), whereas gross efficiency while treadmill roller skiing showed no correlation with either distance or sprint performance in cross-country skiing (IV). Conclusion The results in this thesis show that, depending on discipline and sex, maximal and peak oxygen uptake, work intensity at the lactate threshold, lean mass, double-poling mean power output, and double-poling maximal speed are all externally valid physiological test variables for evaluation of performance capability among elite cross-country skiers; however, to optimally indicate performance capability different test-variable expressions should be used; in general, the absolute expression appears to be a better indicator of competitive sprint performance whereas the influence of body mass should be considered when evaluating competitive distance performance capability of elite cross-country skiers.

A betaína é um trimetil derivado do aminoácido glicina. Os seus principais efeitos fisiológicos são atuar como um osmólito e como doador de radicais metil. Especulase que a betaína possa contribuir para a síntese de creatina no músculo esquelético pelo fornecimento de grupos metil, resultante da conversão de betaína em dimetilglicina, para a remetilação de homocisteína em metionina. Os efeitos da suplementação de creatina sobre o desempenho são conhecidos e relacionam-se principalmente ao aumento na ressíntese de fosforilcreatina (PCR). Autores de estudos recentes têm atribuído seus resultados positivos em relação ao aumento de força muscular a um possível efeito da betaína sobre as concentrações de PCR. Essa variável, entretanto, não foi avaliada, de maneira que os mecanismos responsáveis pelo aumento de força advindo da suplementação de betaína ainda são inexplorados em humanos. Diante disso, este estudo teve como objetivo investigar os efeitos da suplementação de betaína, combinada ou não com a suplementação de creatina, sobre as concentrações intramusculares de PCR, e a produção de força e potência muscular em indivíduos não treinados em força. Além disso, as respostas fisiológicas e ergogênicas da suplementação de betaína e creatina foram comparadas e avaliados os possíveis efeitos aditivos desses suplementos. Foi conduzido um estudo duplo-cego, randomizado, controlado por placebo. Trinta e quatro sujeitos foram divididos em quatro grupos: Betaína (BET; 2 g/dia), Creatina (CR; 20 g/dia), Betaína + Creatina (BET + CR; 2 + 20 g/dia) e Placebo (PL). No período basal (PRÉ) e após 10 dias de suplementação (PÓS), os indivíduos submeteram-se a avaliações do consumo alimentar e da composição corporal, a testes de força e potência muscular e à quantificação intramuscular de PCR. Após a intervenção, as concentrações intramusculares de PCR foram maiores nos grupos CR e BET + CR, quando comparados ao grupo PL (p = 0,004 e p = 0,006, respectivamente). Não houve diferenças significativas entre os grupos BET e PL (p = 0,78) e CR e BET + CR (p = 0,99). Os grupos CR e BET + CR apresentaram maior produção de potência muscular no exercício de agachamento, quando comparados ao grupo PL (p = 0,003 e p = 0,041, respectivamente). Resultados similares foram encontrados para o exercício de supino. Os grupos CR e BET + CR também demonstraram aumento significativo de força muscular (teste de 1-RM) do teste PRÉ para o teste PÓS nos exercícios de supino e agachamento (CR: p = 0,027 e p 0,0001; BET + CR: p = 0,03 e p 0,0001 para membros superiores e inferiores, respectivamente). Não houve diferenças significativas para os testes de força e de potência muscular entre os grupos BET e PL e os grupos CR e BET + CR. Também não houve diferença significativa entre os grupos para a composição corporal. O consumo alimentar permaneceu inalterado ao longo do estudo. Os resultados permitem concluir que a suplementação de betaína, combinada ou não com a suplementação de creatina, não aumenta o conteúdo intramuscular de PCR e não afeta o desempenho de força e de potência muscular / Betaine is a trimethyl derivative of the amino acid glycine. The main physiological functions of betaine are to act as an organic osmolyte and as a donor of methyl radicals. It is speculated that betaine may contribute to the synthesis of creatine in skeletal muscle through the donation of a methyl group, resulting from the conversion of betaine to dimethylglycine, to homocysteine to form methionine. The effects of creatine supplementation on performance are well known and are related primarily to an increase in fosforilcreatina resynthesis (PCR). Authors of recent studies have attributed its positive results regarding the increase of muscle strength to a possible effect of betaine on the concentrations of PCR. However, this variable was not assessed, so that the mechanisms responsible for the increase in muscle strength coming from betaine supplementation in humans are still unexplored. In light of this, the aim of this study was to investigate the effect of betaine supplementation combined or not with creatine supplementation on muscle PCR content, muscle strength and power output in non-resistance trained subjects. Additionally, we compared the ergogenic and physiological responses to betaine versus creatine supplementation. Finally, we also tested the possible additive effects of creatine and betaine supplementation. A randomized, double-blind, placebo-controlled study was conducted. Thirty and four subjects were assigned into four groups: Betaine (BET; 2 g/day), Creatine (CR; 20 g/day), Betaine + Creatine (BET + CR; 2 + 20 g/day) or Placebo (PL). At baseline (PRE) and after 10 days of supplementation (POST) body composition, food intake, muscle strength and power and muscle PCR were assessed. The CR and BET + CR groups presented greater increase in muscle PCR content than PL (p = 0.004 and p = 0.006, respectively). PCR content was comparable between BET versus PL (p = 0.78) and CR versus BET + CR (p = 0.99). CR and BET + CR presented greater muscle power output than PL in the squat exercise following supplementation (p = 0.003 and p = 0.041, respectively). Similarly, bench press average power was significantly greater for the CR-supplemented groups. CR and BET + CR groups also showed significant pre- to post-test increase in 1-RM squat and bench press (CR: p = 0.027 and p 0.0001; BET + CR: p = 0.03 and p 0.0001 for upper- and lower-body assessments, respectively). No significant differences for 1-RM strength and power were observed between BET versus PL and CR versus BET + CR. Body composition did not differ between the groups. Dietary intake was unchanged throughout the study. Thus, we concluded that betaine supplementation does not augment muscle PCR content and betaine supplementation combined or not with creatine supplementation does not affect strength and power performance in non-resistance trained subjects

Abstract available in the Journal of Strength and Conditioning Research

Abstract available in the Journal of Strength and Conditioning Research