Made available in DSpace on 2014-06-11T19:27:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-12-19Bitstream added on 2014-06-13T20:17:13Z : No. of bitstreams: 1 menezes_tec_me_araca.pdf: 558527 bytes, checksum: fb65e2e98ca3d3c121131d0247fba076 (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / O presente estudo teve como objetivos avaliar a capacidade dos extratos de araçá e de aroeira do sertão em interferir com a microdureza do esmalte dental de ratos submetidos a desafio cariogênico, bem como avaliar o efeito desses extratos sobre a microbiota cariogênica implantada desses animais, e seus possíveis efeitos colaterais. Sessenta ratos do tipo Wistar, divididos em 4 grupos, foram submetidos a desafio cariogênico (dieta NIH-2000) e, metade deles, à cirurgia para remoção das glândulas salivares maiores. Os grupos recebiam, como solução de hidratação, água (controle), extrato de araçá (diluído em água) ou extrato de aroeira (diluída em água). Coletas da microbiota bucal dos animais foram realizadas semanalmente e, após 53 dias, os animais foram sacrificados. Os dentes dos animas foram preparados e submetidos à análise de microdureza longitudinal do esmalte, assim como os órgãos vitais de alguns animais foram removidos e submetidos à análise histopatolágica. O modelo animal e as condições experimentais se mostraram adequadas para a caracterização dos efeitos dos extratos testados sobre a microdureza do esmalte e sobre a microbiota cariogênica, sendo que os dois extratos testados produziram uma redução substancial da microbiota cariogênica nos animais experimentais e o consumo dos mesmos afetou positivamente a dureza superficial do esmalte. A ingestão dos extratos não alterou significativamente os órgãos dos animais, quando comparado com os grupos controle. / The aim of this study was to evaluate the influence of araçá and aroeira extracts on dental enamel microhardness of rats submitted to a cariogenic challenge, and on their cariogenic microflora and determine the collateral effects of the extracts in the animals. Sixty Wistar rats, divided in 4 groups, were submitted to a cariogenic diet (NIH-2000 diet) and, half of them, was submitted to surgical remotion of the major salivary glands. The groups received water (control), araçá extract (solved in water) or aroeira extract (solved in water) as hydration solution. Collections of oral specimens were performed weekly and, after 53 days, the animals were sacrified. The animals teeth were prepared and submitted to longitudinal enamel microhardness analysis, as well some vital organs of animals were removed and submitted to histopathological procedures and analysis. The animal pattern and experimental conditions were appropriated to evaluate and measure the extracts effects on the enamel microhardness and on the cariogenic microbiota. Both the extracts reduced substantially the cariogenic microbiota of the animals and the use of them affected positively the longitudinal enamel microhardness. The extracts ingestion did not affected in a significant extension the microscopic characteristics of the organs, compared with control group (water).

O conhecimento de que o exercício é benéfico na doença aterosclerótica é baseado principalmente em estudos epidemiológicos. O objetivo deste trabalho foi investigar se o treinamento físico preventivo ou terapêutico altera a evolução da placa aterosclerótica. Camundongos LDLr-/- com 16 semanas de vida foram separados em dois programas: preventivo e terapêutico. Animais do programa preventivo receberam dieta normal ou aterogênica por 14 semanas. O treinamento físico foi iniciado concomitantemente ao início da dieta. Animais do programa terapêutico receberam dieta normal ou aterogênica por 28 semanas. O treinamento físico foi iniciado após 14 semanas do início da dieta, com placas bem estabelecidas. O treinamento físico aeróbico moderado foi realizado em esteira rolante, por 60 min, 5 dias/sem, durante 14 semanas. Massa corporal, pressão arterial caudal e freqüência cardíaca foram registradas. Lipoproteínas plasmáticas foram separadas por FPLC e colesterol total foi dosado por métodos enzimáticos. Foram quantificados tamanho, conteúdo de gordura e de colágeno da placa por coloração de oil-red O e picro-sirius. Citocinas TNF-, IL-6 foram medidas por Elisa. MMP-9 plasmática foi medida por zimografia. Marcadores inflamatórios teciduais, MMP-9, CD40/CD40L e nitrotirosina, foram medidos na placa por imunohistoquímica. O treinamento físico não modificou o tamanho da placa, mas tornou a placa mais estável por aumentar o conteúdo de colágeno. O treinamento físico diminuiu o conteúdo de gordura da placa, os fatores de risco e o CD40 somente no programa preventivo. Nenhuma alteração foi notada nos marcadores inflamatórios circulantes e na expressão de MMP-9 e formação de nitrotirosina na placa aterosclerótica. / The knowledge that exercise exerts beneficial effects on atherosclerotic disease is mainly based on epidemiological studies. Our aim was to investigate the effect of preventive and therapeutic exercise programs on atherosclerotic plaque formation and development. Sixteen-week-old LDLr-/- mice were randomly divided into preventive and therapeutic programs. Preventive programs mice received normal or atherogenic diet for 14 weeks. Exercise training started at the same time of dieting. Therapeutic programs mice received normal or atherogenic diet for 28 weeks. Exercise training started after 14 weeks of dieting when atherosclerosis plaques were already established. Moderate intensity aerobic exercise training was performed on a motor treadmill for 60 min, 5 days/wk, during 14 weeks. Body mass, caudal blood pressure and heart rate were registered. Plasma lipoproteins were separated by FPLC and total cholesterol was determined by enzymatic methods. Cross sections of aortic root were stained with oil-red O for plaque size and fat content. Aorta longitudinal sections were stained with picro-sirius for collagen content. TNF- and IL-6 cytokines were measured by Elisa. Plasmatic MMP-9 was determined by zimography. Inflammatory tissue markers, MMP-9, CD40/CD40L and nitrotirosine, were measured by immunohistochemistry. We concluded that exercise training did not modify plaque size, but turned it into a more stable one by increasing its collagen content. Exercise training reduced plaque fat content, risk factors and plaque CD40 expression only in the preventive program. No difference in systemic inflammatory markers, and in plaque MMP-9 expression and nitrotirosine formation was noted.

Estudo transversal, descritivo e exploratório, com abordagem metodológica qualitativa, cujo objetivo foi identificar e avaliar a percepção da vulnerabilidade à doença, entre mulheres com diagnóstico avançado do câncer do colo do útero, tendo como referencial teórico, a vulnerabilidade, baseada no conceito proposto por Ayres et al. (2003). Os sujeitos do estudo foram doze mulheres que estavam em atendimento no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, para tratamento do câncer do colo do útero avançado, entre 08 de abril e 28 de maio de 2009. Os dados foram coletados por entrevistas. A análise dos dados se deu segundo os pressupostos da análise de conteúdo, proposta por Bardin (2006). Os resultados revelaram-se em 2 categorias centrais: Percebendo-se vulnerável e Enfrentando a doença e o tratamento. A vulnerabilidade se apresentou para as participantes deste estudo a partir do aparecimento dos primeiros sinais e sintomas da doença, crescendo à medida que o diagnóstico foi descoberto e o tratamento se fez necessário, trazendo dificuldades e sofrimento. Ao mesmo tempo, proporcionou a oportunidade de as mulheres encontrarem formas de enfrentamento e superação dos problemas, à medida do possível. Os componentes individual, social e programático da vulnerabilidade, contidos no conceito proposto por Ayres et al. (2003), mostraram-se nos fatores relacionados à cliente, aos profissionais, aos serviços, entre outros, e tornaram a mulher suscetível aos problemas e danos de sua saúde, relativos ao câncer cérvico-uterino, exacerbando sua vulnerabilidade à doença. Ficou clara a necessidade de se superar algumas deficiências no modelo de assistência e na humanização do atendimento, no grau de compromisso e na qualidade das instituições, dos recursos, do gerenciamento e do monitoramento dos programas de prevenção e detecção do câncer do colo do útero, nos diferentes níveis de atenção. / This cross-sectional, descriptive, exploratory and qualitative study aimed to identify and evaluate the perception of the vulnerability to the disease among women with delayed diagnosis of uterine cervical cancer. The theoretical framework used was the vulnerability, based in the concept proposed by Ayres et al. (2003). The subjects of the study were twelve women who were under follow-up at the Hospital das Clínicas of the University of São Paulo at Ribeirão Preto Medical School, for treatment of advanced uterine cervical cancer, between April 08th and May 28th 2009. Data were collected by interviews. The data analysis was done according to the presuppositions of content analysis, proposed by Bardin (2006). Two central categories emerged from the results: Perceiving yourself vulnerable and Facing the disease and the treatment. The vulnerability arose to the participants of this study through the emergence of the first signs and symptoms of the disease, increasing as the diagnosis was determined and treatment was needed, bringing difficulties and suffering. At the same time, women had the opportunity to find ways to face and overcome problems, to the extent possible. The individual, social and programmatic compounds of the vulnerability, included in the concept proposed by Ayres et al. (2003), were shown in the factors related to clients, professionals and services, among others, and made the women susceptible to the problems and damages of their health, related to the uterine cervical cancer, aggravating their vulnerability to the disease. The need to overcome some deficiencies in the model of care and in the humanization of care was evidenced, as well as in the level of commitment and in the quality of the institutions, resources, management, and monitoring of the programs of prevention and detection of uterine cervical cancer, in the different levels of care.

Orientador: Maria Rita Donalisio Cordeiro / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-26T19:12:10Z (GMT). No. of bitstreams: 1 VonZuben_AndreaPaulaBruno_D.pdf: 2257124 bytes, checksum: c8df8e57198bfa7318ad86e3de4af6f3 (MD5) Previous issue date: 2014 / Resumo: A Leishmaniose Visceral Americana (LVA) é uma zoonose causada pelo protozoário Leishmania (L.) infantum e transmitida predominantemente pelo flebotomíneo Lutzomyia longipalpis. No meio urbano, o cão doméstico atua como reservatório e fonte de infecção para o homem. A LVA é uma zoonose de caráter reemergente e um grave problema de saúde pública. As estratégias de controle de LVA estão contidas no Programa Brasileiro de Vigilância e Controle (PCLV) e estão centradas no controle do reservatório e vetores e na educação em saúde. Em Campinas, no final do ano de 2009, foi confirmado o primeiro caso de LVA canino autóctone em área de proteção ambiental na região leste da cidade. Após as investigações de foco foram diagnosticados casos adicionais de LVA em cães e identificada a presença do vetor. Com esta ocorrência, passou a ser considerado município com transmissão canina. O objetivo deste trabalho foi descrever a organização espacial do primeiro foco de LVA de Campinas sob as perspectivas ecológica, geográfica e social a fim de obter uma melhor compreensão das interações entre meio ambiente, sociedade, os riscos em saúde pública e as dificuldades na execução do preconizado pelo PCLV. Para avaliar tais dificuldades foi realizado também estudo qualitativo através de entrevistas semi-estruturadas com coordenadores de municípios de grande porte com transmissão canina e/ou humana (Bauru, Belo Horizonte, Campo Grande, Goiânia e Fortaleza) de LVA. Por fim, foi avaliado uso de coleiras impregnadas com deltametrina a 4% como medida para diminuição da prevalência canina e consequentemente evitar casos humanos em Campinas. Os achados neste trabalho mostram que no Brasil as intervenções de saúde pública não têm apresentado resultados positivos na prática uma vez que há descontinuidade das atividades de controle devido a recursos insuficientes para sustentabilidade das ações e há resistência dos sujeitos implicados pela doença, particularmente associados ao reservatório canino e ao controle químico. Avaliou-se também que, embora sejam consideradas estratégicas, as ações de comunicação relacionadas a esse agravo não têm conseguido alcançar os objetivos de estimular a adesão ao programa e evitar desconfortos nas comunidades atingidas. Por fim, o uso de coleiras inseticidas foi considerado positivo como medida auxiliar na diminuição da prevalência canina com boa aceitação da comunidade. E em conclusão, ficou clara a necessidade de reavaliação da política brasileira de controle de LVA para garantia de maior efetividade na prevenção e controle da doença / Abstract: American Visceral Leishmaniasis (AVL) is a zoonosis caused by Leishmania (L.) infantum protozoa and transmitted by the Lutzomyia longipalpis phlebotomus as the main vector. In urban environment, dogs act as a reservoir and source of infection for vectors. American visceral leishmaniasis is a reemerging zoonosis and a serious public health problem. The guidelines of the Brazilian Program of Surveillance and Disease Control (PCLV) have their bases in control of the reservoir, vector and in health education. Campinas was added to the list of municipalities with established canine transmission kept by the state's AVL Surveillance and Control Program in 2009, with the confirmation of the first autochthonous case of canine AVL. Disease notification occurred in a residential lot with good infrastructure and resident population with high socioeconomic status, situated in an environmental protection area of the east part of the city. The present study aims at describing the process of investigation of reservoirs, vectors and environment associated with the outbreak of canine AVL in a grand scale municipality and the difficulties in implementing the measures proposed by PCLV. In order to evaluate these difficulties a qualitative study was also performed through semi-structured interviews with coordinators of large municipalities with canine and / or human transmission (Bauru (SP), Goiania (GO), Campo Grande (MT), Fortaleza (EC) and Belo Horizonte (MG)). Finally was evaluated the use of deltamethrin impregnated collars as a measure to decrease the prevalence of canine AVL and thus avoid human cases in Campinas. The findings in this study show that in Brazil the interventions have not produced positive results in the municipal level. The main problems referred were: discontinuity of the activities and strength of subjects involved by the disease, particularly associated with canine reservoir and housing fumigation. It was evaluated also that, although considered strategic, communication actions have not been able to achieve the goals of encouraging adherence to the program and to avoid discomfort in the affected communities. In conclusion, there is a clear need for reassessment of Brazilian policy for the control and prevention of LV to ensure effectiveness of actions / Doutorado / Epidemiologia / Doutora em Saúde Coletiva

Bakgrund: Främre korsbandsskador är en av de vanligaste idrottsskadorna, speciellt bland idrottande kvinnor. Uppkomstmekanismerna bakom främre korsbandsskador är många och skadan inträffar oftast i samband med snabba riktningsförändringar, inbromsningar eller landningar. Efter en främre korsbandsskada ökar risken för återfall samt utveckling av artros. Att förebygga denna skada är av vikt då det ofta innebär negativa konsekvenser för individen och dess idrottskarriär.  Syfte: Att genom en systematisk litteraturstudie granska studier som använt neuromuskulär träning (NMT) som preventionsåtgärd för främre korsbandsskador hos idrottande kvinnor samt utvärdera ifall någon kombination av NMT visats ha bättre effekt än annan.  Metod: Litteratursökningen genomfördes i databaserna Pubmed samt Web of Science. Randomiserade kontrollerade studier (RCT) granskades enskilt samt gemensamt av författarna enligt PEDro-skalan. Tillförlitligheten av resultatet bedömdes enskilt med hjälp av GRADEstud innan gemensam bedömning genomfördes.  Resultat: Litteratursökningen resulterade i 524 träffar, dessa granskades i relation till PICO vilket resulterade i åtta inkluderade artiklar. Samtliga artiklar bedömdes ha hög kvalitet. Gällande incidensen av främre korsbandsskador presenterade endast två studier en signifikant mellangruppsskillnad. Samtliga studier redovisade en generellt minskad incidens av främre korsbandsskador, förutom en studie. Tillförlitligheten av det sammanvägda resultatet bedömdes som begränsad (++) på grund av bristande samstämmighet samt precision. Konklusion: Denna litteraturstudie bidrar inte med ett vetenskapligt underlag som tyder på att NMT bör rekommenderas för kvinnliga idrottare för att förebygga främre korsbandsskador. Ingen slutsats kan dras gällande vilken kombination av neuromuskulära övningar som kan anses mer effektiva än andra. / Background: Anterior cruciate ligament (ACL) injury is one of the most common knee injuries among female athletes. There are multiple risk factors and the injury normally occurs with quick change of direction, decelerations or landings. The risk of reinjury and developing arthritis increases considerably after a first injury. Preventing this injury is important considering the negative effects an injured athlete and their sports career will experience.  Objective: Through a systematic review, determine the effectiveness of neuromuscular training (NMT) in preventing anterior cruciate ligament injuries among athletic females. Also, explore if any specific combination of NMT exercises does have a superior outcome. Method: A literature search was made in the databases Pubmed and Web of Science. Randomised controlled studies (RCT) were reviewed separately and then jointly by the authors according to PEDro, and for assessment of reliability, with GRADEstud.  Results: The literature search resulted in 524 articles and they all were assessed by PICO. A final number of eight articles were included and were assessed to be of good quality and the level of evidence was considered limited (++). Solely two studies presented a significant result. All studies except one, presented a reduced incidence of ACL injury.  Conclusion: This systematic review does not provide a result which implies that NMT is an effective preventative measure for the incidence of ACL injuries among female athletes. No conclusion could be drawn if any combination of NMT exercises was more effective.

This thesis concerns a melanoma-derived growth regulatory factor that inhibited proliferation of several malignant human cell lines, and, in particular, a line designated UCT-BR-1, which was derived from a human breast cancer metastasis. The work is presented in four chapters. Chapter 1 provides a review of the relevant literature at the time of writing; Chapters 2 and 3 describe the experimental work that was done; and in Chapter 4 I discuss the implications of my results for current and future work in growth factors. Experimental results are presented as Charts (which may be Figures or Tables) and the methods and experimental protocols that I used are described in the Chart legends and not in the main text of the thesis. The Appendix contains details of the tissue culture techniques and descriptions of the cell lines that were used. Sources of the various laboratory materials as well as the methods that were employed for the more routine procedures are also described in the appendix.

BACKGROUND: Firearm-related violence is a significant public health issue in the US. Research has found an increase in guns used in crimes sourced from low gun law states into high gun law states. The purpose of this study is to evaluate the effect of distance from states without universal background checks (UBC), background checks at shows (BCS), or permit to purchase (PTP) laws on firearm homicide rates in states with them. METHODS: States were identified based on their enactment of laws that are designed to prevent the private sale of firearms to criminals. Demographic data for each county were obtained for the years 2014 through 2017. The border distance from a county in a state with the evaluated gun laws to the nearest border state without the gun laws was obtained using Google Maps. Multiple regression analyses were performed to test the relationship between border distance and firearm homicide rates. RESULTS: The regression model evaluating all formats found the border distance was negatively associated with firearm homicides (p=.009). The parameter estimate indicated as border distance increased, the firearm homicide rate decreased. When counties with UBC or PTP on all guns were evaluated separately from all formats model, the statistical significance was lost (p=.62). In counties where all handgun sales either require a background check or a PTP is required, the distance was also not statistically significant (p=.11). CONCLUSIONS: This study provides evidence that there may be a mitigating effect on the reduction of firearm homicides in states that require background checks or PTP on private sales when there is a state in close proximity that did not have these laws. Limited counties at certain distances may have contributed to the insignificant findings in other models.

Paraplegia or paraparesis caused by temporary cross-clamping of the aorta is a devastating sequela in patients after surgery of the thoracoabdominal aorta. No effective clinical method is available to protect the spinal cord from ischemic reperfusion injury. A small animal (rat) model of spinal cord ischemia is established to better understand the pathophysiological events and to evaluate potential treatments. Eighty-one male Sprague-Dawley rats weighing 300 g to 350 g were used for model development (45) and treatment evaluation (36). The heparinized and anesthetized rat was supported by a respirator following tracheostomy. The thoracic aorta was cannulated via the left carotid artery for post-clamping intra-aortic treatment solution administration. After thoracotomy, the aorta was freed and temporarily clamped just distal to the left subclavian artery and just proximal to the diaphragm for different time intervals: 0, 5, 10, 15, 20, 25, 30, 35, and 40 minutes (five animals per group). The motor function of the lower extremities postoperatively showed consistent impairment after 30 minutes clamping (5/5 rats were paralyzed), and this time interval was used for treatment evaluation. For each treatment, six animals per group were used, and direct local intra-aortic infusion of physiologic solution (2 mL) at different temperatures with or without buffer substances was given immediately after double cross-clamp to protect the ischemic spinal cord. Arterial blood (2 mL) was infused in the control group. The data indicate that the addition of HCO3-(20 mM) to the hypothermic (15 degrees C) solution offered complete protection of the spinal cord from ischemic injury.(ABSTRACT TRUNCATED AT 250 WORDS)

A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Masters in Science. December 2015 / Cervical cancer remains a global health related issue among females of Sub-Saharan Africa, with over half a million new cases reported each year. Different therapeutic regimens have been suggested in various regions of Africa, however, over a quarter of a million women die of cervical cancer, annually. This makes it the most lethal cancer amongst black women in this area, and makes it important to search for new effective therapeutic drugs through screening of medicinal plant extracts used by many in Sub-Saharan Africa as potential anti-cervical cancer agents. The aim of this study was to evaluate the anti-proliferative effects of Cannabis sativa extracts and its isolate, cannabidiol on cervical cancer cell lines HeLa, SiHa, and ME-180. To achieve our aim, phytochemical screening, MTT assay, cell growth analysis, flow cytometry, morphology analysis, Western blot, caspase 3/7 assay, and ATP measurement assay were conducted were conducted. Results obtained indicate that both plant extracts induced cell death at an IC50 of 50 – 100μg/ml and the Inhibition of cell growth was cell line dependent. Flow cytometry confirmed that, with or without cell cycle arrest, the type of induced cell death was apoptosis. Cannabis sativa extracts led to the up-regulation of apoptosis proteins (p53, Bax, caspase-3, and caspase-9) and the down regulation of anti-apoptosis proteins (Bcl-2 and RBBP6), signalling the execution of apoptosis. Apoptosis induction was further confirmed by morphological changes, an increase in Caspase 3/7 and a decrease in the ATP levels. In conclusion, this data implies Cannabis sativa crude extracts has the potential to inhibit growth and induce apoptosis in cervical cancer cell lines, which may be due to the presence of cannabidiol. Key words: Apoptosis, cervical cancer cells, cannabidiol, and Cannabis sativa extracts

A queda é um problema de saúde que envolve políticas públicas, sendo sua prevenção um desafio para os profissionais da saúde. Programas de exercícios físicos combinados, que envolvem dois ou mais dos seguintes componentes: resistência muscular, equilíbrio, resistência aeróbia e flexibilidade, são considerados as intervenções isoladas com maior efeito sobre o risco e a ocorrência de quedas. Por outro lado, não está claro na literatura se programas de intervenções com múltiplos fatores, ou seja, diferentes abordagens oferecidas de forma coletiva e em grupo, trazem efeitos adicionais a saúde dos idosos. Objetivo: Avaliar os efeitos do treinamento físico combinado, associado ou não a educação para prevenção de quedas, no desempenho físico-funcional e saúde mental de idosos. Métodos: participaram do presente do estudo 51 idosos, de ambos os sexos, com idade entre 60-80 anos, que foram divididos em três grupos: 1) grupo controle (GC, n=15), 2) grupo exercício (GE, n= 20) e 3) grupo intervenção múltipla (GIM, n=16). Antes e após o período de segmento, os idosos foram submetidos a 1) questionário estruturados incluindo questões sobre dados sociodemográficos, dados de saúde e histórico de quedas, 2) avaliação da saúde mental (escala de depressão geriátrica, GDS e mini-exame do estado mental, MEEM), 3) escalas sobre auto-eficácia para quedas (Falls Efficacy Scale-International, FES-I) e conhecimento sobre fatores de risco para as mesmas (Falls Risk Awareness Questionnaire, FRAQ), 4) testes físico-funcionais (timed up and go, TUG; sentar e levantar da cadeira. STS e força de preensão palmar, HG). Os grupos GE e GIM foram submetidos a duas sessões (60 min) semanais de exercícios combinados (resistência muscular, caminhada, equilíbrio e duplatarefa) por 16 semanas. O GIM participou também de 16 sessões educativas semanais sobre fatores de risco e prevenção de quedas. Para todas as análise, considerou-se um alfa de 5%. Resultados: foi observado interação entre tempo e grupo para a mobilidade, com melhora do tempo no teste de TUG para os grupos submetidos ao treinamento físico. Adicionalmente, foi constatado efeito médio e negativo da não participação das sessões de exercícios físicos na força de membros inferiores dos idosos do GC (g de Hedges: 0,54). Os idosos do GIM obtiveram, ainda, ganhos adicionais no desempenho do MEEM e na pontuação da FRAQ. Conclusão: a intervenção múltipla, envolvendo a associação entre exercícios físico combinados e atividades educativas, trás benefícios adicionais a idosos participantes de UnATI. Além da melhora na mobilidade e manutenção da força muscular dos membros inferiores, os idosos do grupo intervenção múltipla mostraram maior conhecimento sobre fatores de risco para quedas, o que pode ser útil na implementação de estratégias para identificação de fatores e redução de comportamentos de risco para quedas no dia-a-dia / Falls are a health problem involving public policies, making its prevention a challenge for health care professionals. Combined physical exercise programs, involving two or more of the following components: muscular resistance, balance, aerobic resistance and flexibility, are considered isolated interventions with greater results over the risk and occurrence of falls. Nevertheless, it is not clear in the literature, if intervention programs with multiple factors, meaning, multiple approaches offered in a group or in a collective way, bring additional results to the health of the older adults. Objective: To evaluate the effects of combined training, associated or not with education for fall prevention, on functional physical performance and mental health of older adults. METHODS: 51 older adults of both sexes (60- 80 years old), from an Open University of the Third Age (U3A) participated in a study, they were divided into 3 groups: Control Group: (CG, n=15), 2) Exercise Group (EG, n=20) and 3) Multiple Intervention Group (MIG, n=16). Before and after the follow up period, the older adults were submitted to 1) structured questionnaires including sociodemographic data, health information and any history of falls. 2) Mental health evaluation (geriatric depression scale, GDS and mini-exam of mental state, MEEM). 3) Scales pertaining to self-efficacy on falls (Falls Efficacy Scale-International, FES-I) and knowledge of risk factors on falls (Falls Risk Awareness Questionnaire, FRAQ) 4) physical-functional testes (times up and go, TUG, 5- times sit and stand up from a chair. STS and isometric grip strength, HG). The groups EG and MIG were submitted to 2 weekly sessions (60min each) of combined exercises (muscular resistance, walking, balance and dual-task) for 16 weeks. The MIG group also participated in 16 educational weekly sessions regarding risk factors and fall prevention. On all analysis, a 5% alfa was considered. Results: it was observed that interaction between time and group for mobility, with improvement in the time of the TUG test for the groups submitted to physical training. In addition, moderate and negative effects were found in the non-participation of the physical exercise sessions for lower limb strength of the older adults elderly in the CG (Hedges g = 0.54). The older adults from the MIG group obtained, moreover, additional gains in the performance of the MEEM and of the FRAQ. Conclusion: the multiple intervention, involving the association between combined physical exercises and educational activities, bring additional benefits to the older adults participating in the U3A. Besides the improvement in mobility and maintenance of the lower limb muscular strength, the older adults from the multiple intervention group demonstrated greater knowledge about risk factors regarding falls, which can be instrumental and useful in the implementation of strategies for identification factors and reduction of risk behavior on falls in the day-to-day