Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

<div>My PhD thesis evolves around the potential protective effects of sex hormones progesterone and testosterone against drug-induced QT interval prolongation in premenopasual women and older men.<br></div>

In the Romantic period, expanded tonality offers a creative challenge to composers as they explore new ways of establishing the hierarchy of pitches and utilizing the chromatic and diatonic resources. Prominent compositional techniques of this period include the use of linear harmony with less clearly defined root movements, the structural placement of dominant function, new approaches that redefine tonal stability, motivic treatment that generates harmony and form, flexible treatment of rhythm and meter, and functional treatment of chromatic pitches. This study explores the ways in which characteristics of the Romantic period are influenced by the upper/lower leading tone and the effects of compositional treatment on the expansion of tonality. In addition, this study includes two supportive concepts: (1) the wedge and toggle switch by David Witten and (2) The Neapolitan Complex by Christopher Wintle. In describing techniques in expanded tonality, excerpts from compositions by Robert Schumann and Johannes Brahms (both prominent composers of the Romantic period) are used to establish the significance of these techniques. In the fourth movement of Sonata in E minor "Undine," by Carl Reinecke, the structural treatment of the upper/lower leading tones to tonic and dominant are very prominent features that contribute significantly to the development of the concepts in this study.

Mass tourism being on the agenda of world tourism industry since post war period, has been facing stagnation with late 80&rsquo / s. Additionally consumer&rsquo / s preferences and tendencies towards seeking new activities regardless of sea-sun-sand type of tourism have been started to change. Therefore popular tourist destinations are in a position where to develop alternative tourist activities to sustain their market shares in world tourism market. In compliance with this trend, the purpose of this thesis is to analyze the need and the reason of Turkish Tourism Industry moving away from concentrating merely on mass tourism and accordingly to evaluate the efforts of Turkish tourism authorities in diversifying tourism activities and extending the tourist season to year round with reference to Tourism Development Regions, Amendment of Tourism Encouragement Law, etc. Additionally the importance of focusing on cultural, historical, traditional identity and unique assets of Turkey in order to sustain its ranking in the international tourism market is stressed.

COELHO, Raquel Nascimento. El alargamiento de la juventud: un análisis psicosocial de las trayectorias de jovenes en Brasil y España. 2013. 402f. – Tese (Doutorado) – Universidad Complutense de Madrid, Pós-Graduação em Psicologia Social, Madrid (ESP), 2013. / Submitted by Charles Oliveira (charles_oliveirab@outlook.com) on 2016-06-23T13:23:10Z No. of bitstreams: 1 2013_tese_rncoelho.pdf: 2782956 bytes, checksum: f1ff1a5b5cf392eb3dffadccfa2950f6 (MD5) / Approved for entry into archive by Márcia Araújo (marcia_m_bezerra@yahoo.com.br) on 2016-06-27T21:52:33Z (GMT) No. of bitstreams: 1 2013_tese_rncoelho.pdf: 2782956 bytes, checksum: f1ff1a5b5cf392eb3dffadccfa2950f6 (MD5) / Made available in DSpace on 2016-06-27T21:52:33Z (GMT). No. of bitstreams: 1 2013_tese_rncoelho.pdf: 2782956 bytes, checksum: f1ff1a5b5cf392eb3dffadccfa2950f6 (MD5) Previous issue date: 2013 / This paper aims to investigate the manifestation of the phenomenon of youth prolongation in Brazilian and Spanish youngsters and its influences on identity construction processes of these individuals. For this, we have taken as a reference group individuals aged 25 to 29 years old in the cities of Fortaleza (Brazil) and Madrid (Spain).We start from the idea that the process of social and labor precarization and flexibility currently observed in various contexts and accentuated by the economic crisis severely obstructs the social inclusion of young people, often resulting in delayed entry into the labor market and in achieving their financial stability. This would have as one of its consequences the postponing intensification of the thresholds of transition to adulthood - leaving parents’ home, pairing and having children - as a you th strategy to deal with these difficulties. This postponement would represent the opening of a larger temporary space for youth in the lives of young people producing new experiences, discourses and meanings of the very condition of being young and new possibilities of identity construction. In addition, the idea of an elongated youth tends to expand further through the media as an ideal model and it becomes a possibility of identification for a significant group of young people. To study this phenomenon we have developed a qualitative research, using an analytical - descriptive and cross - sectional design. We have chosen to work with individual in - depth and semi - structured interviews with 50 young men and women from 25 to 29 years old, half of them from Madrid / Spain and half from Fortaleza / Brazil. We chose this group because they are officially in the last years of the juvenile stage in both countries and also because they live more closely issues of the transition to adulthood and experience the possibility of youth prolongation. The interviews were recorded - with the consent of the interviewees - and transcribed. The speeches of the interviewees have been organized through the Atlas-ti ® softwear and analyzed through a semantic content analysis. The discussion of the data and presentation of the contents have been made from three macro categories: transition paths to adulthood, social identity and being young, and youth prolongation. From our analysis the phenomenon of youth prolongation would be manifes ted in two ways. On one hand, the youngsters elongate their youth by the postponement of transition thresholds to adulthood - being young - remaining in a state of less independence and autonomy. That is evident mainly among young Spanish people and Brazilians with better financial situation. On the other hand, young people tend to prolong their youth through the almost unlimited postponement of the feeling of being young - feel young - maintaining the attitudes, values and lifestyles of youth that are positively evaluated in our society and that are represented by the youthful spirit and ideal of eternal youth. This is observed more generally among young people of both countries showing the intensification of youth prolongation as a new social ideal. And as it promotes the building of a positive social identity, the youth prolongation becomes a possibility for identification for an increasingly significant group of people. / Este trabajo tiene como objetivo investigar la manifestación del fenómeno del alargamiento de la juventud entre los jóvenes de Brasil y España y su influencia sobre los procesos de construcción de identidad de estas personas. Para ello hemos tomado como grupo de referencia a individuos de 25 a 29 años en las ciudades de Fortaleza (Brasil) y Madrid (España). Partimos de la idea de que el proceso de precarización y flexibilización social y laboral observado actualmente en diversos contextos y acentuado por la crisis económica dificulta considerablemente la inserción sociolaboral de los jóvenes, resultando muchas veces en un retraso de su entrada en el mercado de trabajo y en la conquista de su estabilidad financiera. Esto tendría como una de sus consecuencias una intensificación del aplazamiento de otros umbrales de transición a la vida adulta – salida de la casa de los padres, emparejamiento y llegada de los hijos – como una estrategia de los jóvenes para lidiar con dichas dificultades. Ese aplazamiento representaría la apertura de un mayor espacio temporal para la juventud en la vida de los jóvenes originando nuevas experiencias, discursos y significados de la propia condición de ser joven y nuevas posibilidades de construcción identitaria. Además, la concepción de una juventud alargada tendería a expandirse aún más a través de los medios de comunicación como un modelo típico ideal y se convierte en una posibilidad de identificación para un grupo significativo de jóvenes. Para estudiar este fenómeno hemos desarrollado una investigación cualitativa, utilizando un método analítico - descriptivo y un diseño transversal. Hemos optado por trabajar con entrevistas individuales en profundidad y semiestructuradas con 50 hombres y mujeres jóvenes de 25 a 29 años, la mitad de ellos procedentes de Madrid / Españay la otra mitad de Fortaleza / Brasil. Hemos elegido este grupo por estar oficialmente en los últimos años de la etapa juvenil en ambos países y porque potencialmente vive de forma más cercana las cuestiones relacionadas a la transición a la vida adulta y además vive la posibilidad de prolongar su juventud. Las entrevistas fueron grabadas – con el consentimiento de los entrevistados – y transcritas. Los discursos de los entrevistados han sido organizados a través del softwear atlas-ti® y analizados a través de un análisis de contenido semántico. La discusión de los datos y presentación de los contenidos han sido hechas a partir de tres macro categorías: las trayectorias de transición a la vida adulta, la identidad social y el ser joven, y el alargamiento de la juventud. A partir de nuestros análisis el fenómeno del alargamiento de la juventud se manifestaría a través de dos formas. Por un lado los jóvenes alargan su juventud a partir de un aplazamiento de los umbrales de transición a la vida adulta – ser joven – , permaneciendo en una situación de menos independencia y autonomía. Eso se evidencia principalmente entre los jóvenes españoles y entre aquellos brasileños de mejor situación económica. Por otro lado los jóvenes tienden a alargar su juventud a través del aplazamiento casi ilimitado del sentimiento de ser joven – sentirse joven – , manteniendo las actitudes, valores y estilos de vida positivos de la juventud representados por el espíritu joven y el ideal de la eterna juventud. Eso se observa de forma más general entre los jóvenes de ambos países evidenciando la intensificación del alargamiento de la juventud como un nuevo ideal social. Y al favorecer la construcción de una identidad social positiva, el alargamiento de la juventud se convierte en una posibilidad de identificación para un grupo cada vez más significativo de personas.

Made available in DSpace on 2014-06-11T19:30:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-02-22Bitstream added on 2014-06-13T21:00:42Z : No. of bitstreams: 1 casagrande_dr_me_jabo.pdf: 395284 bytes, checksum: 72f661526d93863790c9ca71cddffce5 (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / O presente estudo foi realizado com o objetivo avaliar as características morfogênicas e o acúmulo de forragem do dossel de Brachiaria brizantha cv. Marandu em função de diferentes ofertas de forragem, em regime de desfolha intermitente, ao longo da estação chuvosa. O experimento foi realizado no setor de forragicultura da FCAV, no período chuvoso de 2005/2006. O delineamento experimental foi em blocos ao acaso, utilizando o esquema de parcelas subdivididas, com três repetições. Nas parcelas foi avaliado o efeito das ofertas de forragem (4, 7, 10 e 13 % de OF) e na subparcela o efeito dos ciclos de pastejo (CP). Foram avaliadas as seguintes variáveis: altura do dossel comprimido, massa de forragem, dinâmica de acúmulo de forragem e características morfogênicas e estruturais. Observou-se aumento da altura do dossel comprimido com acréscimo da OF. Da mesma forma foi verificado acréscimo na massa de forragem. Constatou-se aumento da massa de forragem, pós pastejo, com a sucessão dos CP, exceto para OF de 4 %, que se manteve constante (3181 kg/ha) ao longo dos CP. Apenas a taxa de alongamento de colmo, das características morfogênicas sofreu alteração em função da OF, sendo que, esta variável aumentou linearmente com a OF. A densidade de perfilhos vegetativos aumentou linearmente com a intensidade de pastejo, no entanto, a densidade de perfilhos reprodutivos e totais ajustou-se ao modelo quadrático. Observou-se tendência de maior acúmulo de forragem nas OF intermediárias (7 e 10 %). Sendo assim, concluise que OF ao redor de 8 % parece ser a mais indicada para o manejo de pastagem de capim - Marandu em pastejo rotacionado. / The present study aimed to evaluate the morphogenetic characteristics and the herbage accumulation of Brachiaria brizantha cv. Marandu swards in function different herbage allowance, managed on intermittent stocking during the summer season. The experiment was carried out at Departamento de Zootecnia, FCAV/UNESP, in the summer period of 2005/2006 year. The experimental design was the complete randomized block, with split plot scheme, and three replications. In the plot the effect of the herbage allowance was evaluated (4, 7, 10 and 13% of HA) and in the split plot the effect of the grazing cycles (GC). There were evaluated the following variables: height of the compressed sward, forage mass, forage accumulation dynamics and morphogenetic and structural characteristics. An Increase of the compressed sward height was observed with increment of HA. Thus, the increase in the herbage mass was verified. An increase herbage mass after grazing was verified with the GC succession, except for 4% of HA, which kept constant (3181 kg/ha) along GC. The stem elongation rate, was the only morphogenetic characteristics altered in function of HA and, this variable increased lineally with HA. The vegetative tiller density increased lineally with the grazing intensity. However, reproductive and total density of tillers was adjusted to the quadratic model. There was a tendency of larger forage accumulation in intermediate HA (7 and 10%). As conclusion the HA around 8% showed the most suitable for grassland management with Marandu-grassin rotational stocking.

A theory of harmony plays a determinant role in the epistemology of tonal structure in music of the common practice, a fact that Schenkerian tonal theorists have long struggled to account for because of the polemical denials issued by Heinrich Schenker regarding the role that harmonic concepts derived from Rameau play in his theoretical frameworks (Schenker [1930] 2014). Attempts have been made recently to rectify the incongruity between Schenker’s uncompromisingly monist musical philosophy and the often-unspoken harmonic premises his ideas rely on (Yust 2015, 2018), but many aspects of how theories of functional harmony relate to the hierarchical structuration of musical time through prolongational processes remain undefined and underexamined. In this thesis, I fill in the lacuna of harmonic accounts in post-Schenkerian frameworks of tonal structure through Harmonic Regional Theory, which defines tonal harmonic process as a containment hierarchy of timespans. Using this framework, I outline a discovery process for properties of tonal stability (Yust 2018, 32) possessed by events and prolongational processes that understands these qualities as the product of stabilizing “forces” (Larson 2012) propagated by the structural influence harmonic-regional “fields” (Quinn 2020). The result is an epistemic model with tremendous analytical utility in both formal and informal analyses of tonal structure, the proof-of-concept for which is provided through the implementation of harmonic-regional theory in an automated analysis of tonal-melodic structure in Beethoven, op. 13, ii.

No description available.

Le canal Kv11.1, dont l’inhibition occasionne une prolongation de l’intervalle QT, est directement impliqué dans des cas d’effets secondaires cardiotoxiques. Depuis 2006, Santé Canada exige que les nouvelles molécules et leurs métabolites soient évalués en phase préclinique pour le risque d’allongement de l’intervalle QT. La méthode de référence évalue l’électrophysiologie des cardiomyocytes en culture lors d’une courte exposition au médicament (<30min). Bien que cette méthode soit la plus fiable actuellement, elle permet seulement d’identifier les molécules qui bloquent directement le passage des ions dans le pore du canal (effet aigu). La méthode HERG-BRET vise à identifier les molécules susceptibles d’interagir avec le canal Kv11.1 par le moyen d’une altération du trafic vésiculaire (effet chronique). Ce type d’interaction est considéré comme un biomarqueur de la capacité à bloquer l’activité de ce canal. L’étude présentée tente de déterminer si un test de localisation cellulaire de hERG basé sur le BRET permettra un criblage à haut débit et une meilleure évaluation de l’affinité d’interaction avec hERG, comparativement aux méthodes alternatives actuelles. Dans le modèle HERG-BRET, la protéine hERG fusionnée à la luciférase de renilla (donneur d’énergie) est exprimée dans une lignée cellulaire HEK293. Cette même lignée exprime également une protéine verte fluorescente modifiée (accepteur d’énergie) qui est ancrée à la membrane plasmique. L’échange d’énergie entre le donneur et l’accepteur est un indice de la localisation de hERG à la membrane plasmique. Les fluctuations de ratio BRET suite à une exposition de 16h à un composé pharmaceutique reflètent donc l’effet du composé sur la translocation de Kv11.1. Vingt-cinq composés pharmaceutiques déjà caractérisés dans la littérature scientifique ont été testés : 12 ont été classés comme chaperons pharmacologiques, 4 comme inhibiteurs du trafic, 1 comme inhibiteur ayant les deux effets mentionnés et 8 n’ont pas pu être classés. Le comportement du biosenseur à l’égard des composés testés suggère que la méthode HERG-BRET ne peut pas être utilisée seule pour évaluer le risque cardiotoxique des médicaments. Toutefois, elle peut fournir des informations complémentaires pertinentes quand à la nature de l’interaction entre un composé pharmaceutique et la sous unité hERG du canal Kv11.1. / The Kv11.1 channel is directly involved in cardiotoxic adverse effects since its inhibition is responsible for a prolongation of the QT interval. In 2006, Health Canada established a guideline that constrains drug developers to a preclinical evaluation of QT prolongation risks for new molecules and their metabolites. The gold standard method (patch-clamp) consists in electrophysiology measurements on cultured cardiomyocytes for a brief exposition to the tested compound (<30min). Even though this method is the most reliable, it only allows the identification of molecules that inhibit the channel by preventing ions from traveling through the pore (acute effect). The HERG-BRET method aims to identify molecules that can interact with Kv11.1 and alter its vesicular transport as a proxy for inhibiting the activity of the channel (chronic effects). This study attemps to determine if a BRET-based cellular localization assay will allow a high throughput screening and a better evaluation of the affinity of pharmaceuticals compounds with hERG, in comparison to alternative methods. In the HERG-BRET model, a fusion protein generated with the gene sequence for hERG and the one for the renilla luciferase (energy donor) is stably expressed in a HEK 293 cell line. The same cell line also stably expresses a green fluorescent protein (energy acceptor) that is anchored at the plasma membrane. The energy transfer that occurs between the donor and the acceptor suggests that hERG is located at the membrane. Variations of BRET ratios following a 16 hours inucabtion with a compound reflects the compound’s effects on Kv11.1’s translocation. Twenty-five compounds that have been previously characterized in the literature were tested: 12 were categorized as pharmacological chaperones, 4 as traffic inhibitors, 1 as an inhibitor that undergoes both effects and 8 remain uncategorized. The biosensor’s behavior towards the tested compounds suggests that the HERG-BRET method cannot be used alone to assess cardiotoxic liability, but it can bring interesting facts to our attention regarding the nature of the interaction between the hERG subunits of Kv11.1 and a tested compound.