Avec la multiplication des systèmes électroniques analogiques et numériques embarqués dans les moyens de transports actuels, l’environnement électromagnétique (EM) devient de plus en plus riche en signaux de toutes sortes et, donc, il devient plus complexe à caractériser. Dans ces travaux de thèse, nous nous intéressons au GSM-R (Global System for Mobile communications - Railways). Il s’agit du nouveau système de communication radio numérique portant la signalisation actuellement en cours de déploiement sur le réseau ferroviaire européen afin d'assurer l'interopérabilité des TGV. Ainsi, tous les pays d’Europe utiliseront le même système, ce qui facilitera la circulation des trains transfrontaliers d’un pays à l’autre. En environnement ferroviaire, le GSM-R doit faire face à différentes sources de bruit EM, notamment aux perturbations EM transitoires provenant du contact glissant entre la caténaire et le pantographe. Ces perturbations couvrent de larges bandes de fréquences dont, potentiellement, celles du GSM-R. Nous proposons une méthode de classification qui permet de prédire l’effet des perturbations EM transitoires sur la qualité des transmissions GSM-R. Cette méthode de classification pourrait être mise en place à bord des trains où elle permettrait d’identifier et localiser les zones critiques pour la qualité des transmissions GSM-R. Du point de vue de la standardisation, ces travaux de recherche pourraient contribuer à l’évolution nécessaire des équipements et des méthodologies définies dans les normes CEM afin de s’adapter aux nouvelles problématiques émanant de la multiplicité des systèmes et protocoles de communication sans fils employés dans le monde des transports. / With the proliferation of analog and digital electronic systems in the current means of transport, the electromagnetic (EM) environment becomes richer and richer in all kinds of signals and, therefore, it becomes more difficult to characterize.In this thesis, we focus on a particular digital system: the GSM-R (Global System for Mobile communications - Railways). It is the new digital radio communication system under deployment on the European rail network in order to ensure the interoperability of high-speed trains in Europe. Then, all countries in Europe will use the same system, which will facilitate the movement of cross-border trains from a country to another one. In the railway environment, the GSM-R is subject to different EM noise sources, including transient EM interferences coming from the sliding contact between the pantograph and the catenary. These disturbances cover wide frequency bands including, potentially, those of the GSM-R system. We propose a classification method for predicting the effect of transient EM disturbances on the quality of GSM-R transmissions.This classification method could be implemented on trains where it could identify and locate critical areas for the quality of GSM-R transmissions along the journey. From the point of view of standardization, these research works could contribute to the necessary evolution of equipment and methods defined in EMC standards in order to cover the new problems arising from the multiplicity of wireless communication systems and protocols employed nowadays in the world of transports.

The Alexander Wallace Spanier cohomology theory associates with an arbitrary topological space an abelian group. In this paper, an arbitrary topological space is associated with an R-module. The construction of the R-module is similar to the Alexander Wallace Spanier construction of the abelian group.

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Unlike RNA viruses, which typically encode their own RNA-dependent RNA polymerases, DNA viruses typically utilize host RNA Polymerase II (RNAPII) to transcribe their genes. Therefore, host factors that interact with RNAPII often maintain important regulatory roles during DNA virus infections. Senataxin (SETX) is a ubiquitously expressed 303 kDa RNA:DNA helicase that associates with RNAPII. It is involved in the resolution of R-loops and plays a role during the DNA damage response. Mutations in SETX are implicated in the neurodegenerative diseases Type 2 Ataxia with Oculomotor Apraxia (AOA2) and juvenile Amyotrophic Lateral Sclerosis (ALS4). Recent work from our group has demonstrated that SETX also acts as an antagonist of the antiviral response during RNA virus infections. Infections, including those caused by Herpes Simplex Virus type I (HSV-1), have been identified as potential environmental triggers of neurodegenerative diseases. Therefore, we elected to study the role of SETX during DNA virus infections since, in addition to regulating host genes, it may also play a role in viral transcription and/or DNA replication. Our data suggests that SETX is involved in the regulation of viral gene expression, and that SETX facilitates DNA replication and contributes to viral biogenesis. SETX attenuates the antiviral response, and in mouse models of infection, is protective against HSV-1 disease pathogenesis. These studies have enhanced our understanding of the role played by SETX during viral infection and may shed light on the mechanism(s) through which SETX dysfunction results in neurodegenerative diseases. / Thesis / Master of Health Sciences (MSc) / DNA viruses utilize host proteins in gene expression, therefore, associated factors play roles during DNA virus infections. Senataxin (SETX) is a RNA:DNA helicase associated with these proteins. SETX mutations are implicated in the neurodegenerative diseases Type 2 Ataxia with Oculomotor Apraxia (AOA2) and juvenile Amyotrophic Lateral Sclerosis (ALS4). Recently, our group demonstrated SETX antagonizes antiviral responses to RNA virus infections. Infections, including those caused by Herpes Simplex Virus type I (HSV-1), are identified as potential triggers of neurodegenerative diseases. We elected to study the role of SETX during DNA virus infections. Our data suggests that SETX is involved in the regulation of viral gene expression, facilitates HSV-1 DNA replication, attenuates the antiviral response, and in mouse models of infection, is protective against HSV-1 disease pathogenesis. These studies enhance understanding of the role of SETX during viral infection and may shed light on the mechanism(s) of SETX role in neurodegenerative disease.

Note: CD misisng

In an interview with Hy Bender, Neil Gaiman states, "We have the right, and the obligation, to tell old stories in our own ways, because they are our stories." While fantasy stands apart from other types of fiction, it still provides a particular kind of commentary on the culture/time it is being created in, often by toying with older themes and conventions. Stories of the quest for kingship tend to fall by the wayside in favor of the "unlikely hero" tale. While the king's story is not always vastly different from that of the hero, there are some key points that need to be taken into consideration. Unlike many heroes, especially in the modern sense, kings (whether recognized at first or not) are born for the duty they must eventually fulfill. A hero may be unaware of the problem at first or later reluctant to engage it; more often than not in tales of kingship there is a deep awareness of the problem and the knowledge of their potential in solving it. There is always a sense of inherent purpose and destiny: they must undertake quests in order to legitimize themselves and their power — their right to rule. These stories bear a similar structure and shared themes that can be found in medieval sources as well as earlier myths. Tales of kingship in modern fiction, specifically in the work of Neil Gaiman (The Sandman) and George R. R. Martin (A Game of Thrones), are similar to the medieval models, as kingship and the requirements of kingship were popular themes in medieval texts, including Beowulf and King Horn. The role of the king in epic tales varies from hero to villain, at times even occupying both roles depending on the story. In the tales explored herein and in much of the medieval source material that inspired the fantasy tradition, the king also takes on the role of healer. The interwoven plots of George R. R. Martin's A Song of Fire and Ice series revolve around the struggle for the rightful rule over seven kingdoms, and while the protagonist in The Sandman is in many ways vastly different from Tolkien's Aragorn, the character still exists with a sense of purpose, responsibility, and duty; a regal bearing that does not necessarily occur in the majority of typical heroes. The influence of Tolkien's work both as a scholar and an author is apparent in Gaiman's use of mythology and Martin's style of world creation; both authors have admitted their creative debt to and continuing admiration of Tolkien's style of fantasy. It is impossible to discuss modern fantasy without acknowledging Tolkien as an influence to these two more recent authors. This paper will discuss The Lord of the Rings as a bridge between modern fantasy and medieval/mythological sources. In each of these modern fantasy tales of kingship, healing and reunion become major themes, tied into the right/duty of a ruler. The patterns established by medieval tales are used by modern authors to create fantasy kings, giving their narratives legitimacy that may have been difficult to establish without these patterns and links back to the medieval tradition. / Master of Arts

This text is especialy intended to those who are interested into fuzzy logic and its application in relational databases. It is mainly focused on concept of fuzzyfied relational database and implementation of such database. This text consists of two parts: theoretical aspects of fuzzyfication and implementation part. Selected extension is based on fuzzy E-R model so the requirements of the real world can be better met. This paper also describes existing solutions on different level of fuzzyfication. Part of the work is design and implementation of a simple software for querying over fuzzyfied relational database. This work shoud also serve as a guide for design and implementation of fuzzy database.

Investments in R&D activities are essential to firms. Decisions to increase or decrease R&D investments may rely according to changes in macroeconomic factors. The purpose of this paper is: to examine how firms in the industries; manufacturing computers, electronics and optics and manufacturing electrical equipment, have increased or decreased their R&D investments, in conjunction with macro factors during the 2000s. The sample is 49 Swedish firms. This paper is based on quantitative firm-level panel data on R&D activity investments and aggregated quantitative macro-level data on macro factors. The firm-level panel data set has been put together completely from scratch, using collected and transformed raw data. Using a logistic regression model, the results show that macro factors do affect R&D investments on a micro-level, to some extent. Further, the results show that change in macro factors does to a greater extent, affect decreases in R&D investments than increases in R&D investments. The process of increase and decrease of R&D investment should be considered as two different dynamic processes. Increase and decrease do not follow the same pattern, thus a decrease of R&D investments is a more explicit decision than a decision to increase R&D investments.