Sammanfattning Detta examensarbete är baserat på ett uppdrag från AB Mälarplast, en plasttillverkare i Eskilstuna, med syftet att designa en serie med tre olika glastyper. Ett vin-, champagne- och grogglas skulle ges förslag på, som alla innehöll en gemensam nämnare som kopplade de alla glastyperna. Uppdragsgivaren hade redan före arbetet skapa kontakt med en kund som importerade en glasserie från Nya Zeeland. På grund av att den långa transportvägen innebär en hög kostnad försöker Mälarplast ta över den utländska leverantörens plats, och därigenom kunna erbjuda ett bättre pris. Examensarbetet är ett stöd för tillverkningen som kommer starta innan årets slut. Arbetet kom att baseras på en bakgrundsundersökning av vinkultur, materiallära och produktionsteknik för att sedan genom olika verktyg och modeller komma fram till en konkurrenskraftig lösning för AB Mälarplasts situation. De nämnda verktygen behandlar följande områden: marknad, kvalitet och design för att nå fram till ett koncept som uppfyller kraven från uppdragsgivaren och lämpar sig bäst enligt egna observationer. Materialalternativen och ekonomiska faktorer beskrivs i arbetet men behandlas inte djupgående eftersom de av AB Mälarplast redan fastsällts och därmed mer eller mindre lämnats låsta för mig. Dessutom var begränsningar nödvändiga och dessa delar fick stå utanför. Större fokus lades istället på det som uppdragsgivaren bad om hjälp med dvs. designen och basera detta på en vetenskaplig grund genom olika designrelaterade verktyg som lärts ut på Mälardalens högskola. Det har varit viktigt att inte lägga fram ogrundade förslag när man som designer kontra VD haft olika syn på vad som bör prioriteras: försäljning genom design eller högre intäkter genom ekonomistyrning. Uppdragsgivaren granskade det slutgiltiga förslaget i form av en fysisk modell av typen vinglas, då denna är huvudprodukten. Därefter resulterade den slutliga designen i en CAD-fil.  Detta är grunden till framtida produktion av glasserien.

The newspaper industry changes with the society. New trends and developments affect how layout and design are perceived. Therefore it is important for the survival of a news­paper to catch up with trends and retain contemporaneity. This demands that a daily paper frequently updates its appearance and sometimes even redesign the whole newspaper. Folkbladet, a newspaper in Norrköping, is currently in need of a new layout. The employees often deviate from the graphic guidelines that exist at the company today, due to that it doesn’t feel contemporary, but also because they don’t appreciate the appearance as it is today. This thesis is based on a study of the layout of Folkbladet and analyse: which tools can be used to create a distinct identity regarding layout, which tools you can use to create a clear structure and readability in a newspaper, and how Folkbladet can make use of these tools. To find out about the company’s situation today and their identity, interviews have been made with employees. An analysis of how the content are presented in the newspaper has also been made, with the purpose to investigate how it is perceived today, and to se which improvements that are needed. The interviews and the analysis constitute the foundation of the new design concept and the new guidelines. The result became a newspaper with a more distinct sectioning, with a new colour palette, and new and limited amount of typefaces, that better reflects Folkbladet’s vision. The new layout is also designed to make an airy feeling. Together these aspects contribute to a livelier and more distinguishing paper, “the newspaper shall dance”. You can create a clear and distinct identity with a consistent use of different design element, like colour, typefaces, and reoccurring shapes. It is important to be aware of your concept and what the brand stands for, so that the graphic layout will convey the same feeling. By focusing on the vision of Folkbladet, to be more sharp and cocky, this will contribute to a more distinct identity. This could be enhanced by typeface, colour and shape. A clear layout with good readability can be achieved through a logical sectioning, which are designed in a uniformed way. Readability can be improved with well-selected typefaces, adjusted length of lines and sizes. Together, all these aspects contribute to the new layout for Folkbladet. / Tidningsbranschen förändras i takt med samhället. Nya trender och teknikutvecklingar påverkar hur utseendet och layouten på en tidning uppfattas. För en tidnings överlevnad är det således viktigt att följa med i utvecklingen och behålla aktualiteten. Detta kräver att tidningar med jämna mellanrum uppdaterar sin layout och genomgår en redesign.Folkbladet, en dagstidning i Norrköping, är idag behov av en ny layout. De grafiska riktlinjer som finns, används knappt eftersom de upplevs som omoderna av personalen. Tidningen anser därför att en förändring är nödvändig.Denna rapport grundar sig på en studie av Folkbladets layout och undersöker: vilka verktyg som finns för att skapa en tydlig identitet med hjälp av layout, vilka verktyg som finns för att skapa tydlig struktur och läsbarhet i en dagstidning samt hur Folkbladet kan använda dessa verktyg vid en redesign.Genom semistrukturerade intervjuer med Folkbladets personal har nuläget och tidningens identitet fastställts. En innehållsanalys genomfördes på en av Folkbladets tidningar med syftet att undersöka hur tidningen upplevs idag samt se vilka förbättringar som kan genomföras. Intervjuerna och analysen utgör tillsammans grunden för ett nytt designförslag samt nya riktlinjer för Folkbladet, som återspeglar deras vision bättre. Resultatet blev en tidning med tydligare sektionsindelning, bland annat med hjälp av färg, nya och begränsat antal teckensnitt. Det nya layoutförslaget har också fokuserat på att skapa en luftigare layout. Tillsammans ska alla dessa delar bidra till en mer levande och särskiljande tidning, “tidningen ska dansa”. En tydlig identitet kan skapas med hjälp av konsekvent användade av olika designelement såsom färg, teckensnitt och återkommande former. Att ha ett klart utformat koncept där det finns en medvetenhet om vad varumärket står för, gör att den grafiska utformningen kan anpassas utifrån detta och på så sätt medverka till en tydligare identitet. Genom att fokusera på Folkbladets vision om att vara en vass och kaxig tidning, bidrar detta till en mer distinkt identitet. Med hjälp av teckensnitt, färg och form har denna identitet kunnat förstärkats.En tydlig struktur med god läsbarhet kan uppnås genom logiskt sektionsindelning utformat på ett enhetligt sätt. Läsbarheten kan förbättras med väl valda teckensnitt, anpassade radlängder och storlek. Detta ligger sammantaget som grund för en ny layout för Folkbladet.

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This thesis has been written at Linköping University for the company Instrument Control Sweden AB (ICS). ICS is a small company located in Linköping that develops software and hardware for Unmanned Aerial Vehicles, UAV. At present, ICS has a fully functional autopilot called EasyPilot but they want to reduce the autopilot’s size to make it more attractive. The purpose of this thesis was to investigate if it was possible to reduce the size of the autopilot and how, in that case, it would be done. It was also necessary to examine whether the old processors should be replaced by new ones and how hard it would be to convert the old software to these new processors. To succeed with the goals many of the old components had to be changed for new, smaller ones. Some less necessary parts were also completely removed. The results showed that the size could be reduced quite a bit, exactly how much is hard to say since no PCB-layout were done. By doing some programming tests on the new components it could be shown that some parts of the old code could be reused on the new design. It was mainly algorithms and other calculations. However, a lot of new code still had to be written in order to successfully convert the old software to the new hardware.

This report is a product of Bachelor Degree Project at Mechanical Engineering department inLinnaeus University, Växjö, Sweden. The project is about a design improvement of industrialcompact mixers.This project is accomplished with Xylem, one of the main suppliers of compact mixers in theindustry, located at Emmaboda, Sweden. The company has a problem with the existing designof the two part, oil housing and entrance cover, in 4610/20 compact mixers. The 4610/20compact mixers has suffered from quality problems which affect the production and the endcustomer because of the existing design of these part. The aim of this study is to improve thequality of the product by redesigning of oil housing and entrance cover. In addition to theredesigning of these parts, another important purpose of the project is to produce these partsfrom different material than existing one.The computer aided design programs are widely used, Solid Works, during the project. Forselection of a new material a wide literature research has been accomplished.

A reading machine from LVI which can scan and read a text for visual impaired people needed a redesign to stay competitive. This redesign is done by two students. The students made a specialized method to execute the redesign. They found out that the focus of the redesign should lay on: easy to use, reliable result and appealing for the user. With this taken in consideration the students achieved to design a more competitive reading machine. Prototypes where made for a new camera arm (which goes high enough to scan A3 format) and a new control panel. The students gave a recommendation how to continue with the project from now on.

The objective to this bachelor degree project was to redesign a structure of the doors and add windows of a convertible car. This was carried out in collaboration with the company Hurtan Desarrollos S.L. To establish the requirements for the design, initial studies were performed: a literature review, a benchmark of related products and a study of standard car door designs. After this the final requirements were defined and the concept generation design phase was begun. In this phase a number of design methods were applied. The design concepts were systematically evaluated in respect to if, and to what degree, the concepts met the defined demands and needs of the design. The final concepts were completed with the demands of the company to obtain the results. In order to define, create and communicate ideas and solutions, the design was modelled in Solidworks software and exported to Creo Parametric 2.0 to create the final renders. Once the overall design was defined, materials and accessories were specified. The final result is presented in detail in photorealistic renderings and a physical design made by Hurtan Desarrollos S.L.

Active site mutations that disrupt drug binding are an important mechanism of drug resistance. Such resistance causing mutations impair drug binding, thus reducing drug efficacy. Knowledge of potential resistance mutations, before they are clinically observed, would be useful in a number of ways. During the lead prioritization phase of drug development, this knowledge may direct the research team away from candidate drugs that are most likely to experience resistance. In the clinical setting, knowledge of potential resistance mutations could allow the development of treatment regimens, with drug cocktails likely to maximize efficacy. In this thesis I present a structure-based approach to predict resistance and its evolution. This method utilizes a two-pass search, which is based on a novel protein design algorithm, to identify mutations that impair drug binding while maintaining affinity for the native substrate. The approach is general and can be applied to any drug-target system where a structure of the target protein, its native substrate and the drug is available. Furthermore, it requires no training data for predictions and instead predicts resistance using structural principles. Finally, I use approximate force-field calculations from MMPBSA and simple assumptions about the relationship between binding energy and fitness to build fitness landscapes for a target protein under selective pressure from either a single drug or a drug cocktail. I use a Markov-chain based model to simulate evolution on this fitness landscape and to predict the likely evolutionary trajectories for resistance starting from a wild-type. The structure-based method was used to probe resistance in four drug-target systems: isoniazid-enoyl-ACP reductase (tuberculosis), ritonavir-HIV protease (HIV), methotrexate-dihydrofolate reductase (breast cancer and leukemia), and gleevec-ABL kinase (leukemia). This method was validated using clinically known resistance mutations for all four test systems. In all cases, it correctly predicts the majority of known resistance mutations. Furthermore, exploiting the relationship between binding energy, drug resistance and fitness of a mutant, evolution was simulated on the HIV-protease fitness landscape. This hybrid evolutionary model further improves the resistance prediction. Finally, good agreement between these evolutionary simulations and observed evolution of drug resistance in patients was found.

This folio explores the theory and practice of managing organisational redesign within a public sector agency— the 'Out of School Services‘ provided by an education jurisdiction, Fraser Cooloola district, within Education Queensland, Australia. The objective of the project and research was to develop and implement an approach to organisational redesign that derived from Limerick et al.‘s (1998) Fourth Blueprint theory (particularly their concept of metastrategy), and to measure the impact of the redesign process on selected organisational operations within the education jurisdiction. In the context of this study, Limerick et al.‘s metastrategic management cycle (1998) is defined as an approach to strategic management that is constituted of four elements— (a) founding vision (b) identity (c) configuration design and (d) systems of action (Limerick et al. 1998, p 152).The concept of metastrategy is revealed by the research as having clear potential for application in public sector settings. That is, the study captured its successful application to the task of leading a process of organisational redesign within an education system and uncovered complex subtleties of that application. The study also revealed that organisational redesign to bring about sustained cultural change in a public sector setting is difficult, complex and subject to threat by political decisions. In leading and managing the process of organisational design in an educational setting, eleven key leadership skills across three distinct domains - individual leadership capacity and action; conceptual development and organisational implementation - were found to be significant: The leadership skill areas are: (1) developing clarity regarding professional values, the nature of the design task and how a leader might undertake the task; (2) developing a set of options informed by a synthesis of local priorities, the broader organisational direction and relevant, organisational theory; (3) undertaking engaged and purposeful communication aimed at creating greater knowledge of the design or adding value to the intended design and the quality of its implementation; (4) creating a common language as a platform for engaging stakeholders; (5) leading in a manner that encourages creative difference and distinctiveness; (6) displaying a capacity for reflective appraisal; (7) acknowledging pertinent ethical considerations; (8) Identifying, engaging, managing and leading key stakeholders; (9) assessing important leverage points; (10) identifying relevant networks and (11) setting and implementing governance arrangements. These eleven skill areas complement and extend Limerick‘s metastrategic management cycle with its four basic elements of: - founding vision; - identity - configuration design; and - systems of action Each of the above four elements generally align with two of the three domains developed to capture the nature of critical leadership skills required to lead organisational redesign in an educational setting—inner circle or domain-individual leadership capacity and action and middle circle or domain. The leadership skills captured in the outer domain entitled 'organisational implementation‘ extends on the metastrategic cycle by giving focus to the processes that need to be considered when applying the metastrategic management cycle.

Successful implementation of organizational redesign depends on the support of employees at all levels of the organization. This study looked at some of the factors that are related to employee support for organizational redesign. Subjects (82 support staff members of a small manufacturing plant undergoing organizational change) were administered a survey which measured employee perceptions about the change management process and the disruption the change caused to their daily routine. Eleven variables were assessed as independent variables in terms of their relationship to the dependent variable which was employee support of the organizational change. All eleven variables were significantly related to the dependent variable. The implications of these results and issues for further research was discussed.