O objetivo deste estudo foi caracterizar as doenças dos gatos domésticos pertencentes à casuística do Serviço de Patologia Animal do Departamento de Patologia da FMVZ/USP entre janeiro de 1998 e dezembro de 2008. Foram identificados e analisados os dados de 634 exames necroscópicos e 585 exames histopatológicos. Os dados escolhidos para o presente estudo foram: número de registro (exame histopatológico/exame necroscópico), data de entrada, idade, sexo, raça, coloração da pelagem, local da lesão, diagnóstico e no caso do exame necroscópico, causa mortis e moléstia principal. Foram elaborados dois bancos de dados, sendo um para exame histopatológico e outro para exame necroscópico, utilizando-se o programa Excel®. Salienta-se que não foi realizada a revisão de lâminas. As doenças foram classificadas em infecciosas, inflamatórias, neoplásicas e outros processos (hipertrofias, hiperplasias, displasias). Além disso, as doenças foram relacionadas a faixa etária, sexo, raça e coloração de pelagem, nos casos em que havia dados suficientes, foi abordada a relação entre causa mortis e moléstia principal. O presente estudo revelou que a maior causa de mortalidade em gatos domésticos são as complicações cardio-respiratórias, provenientes principalmente de intoxicações exógenas por carbamatos e por peritonite infecciosa felina, afetando principalmente animais até 24 meses em ambos os casos. Os processos inflamatórios no presente estudo apresentam mais características de caráter crônico. A análise das neoplasias revelou que os gatos tendem a apresentar neoplasias de comportamento maligno e de origem epitelial. Além disso, verificou-se que as fêmeas são as mais acometidas por neoplasias, com exceção do linfoma e do fibrossarcoma. A análise das faixas etárias mostrou que estes animais são mais velhos, embora haja animais jovens apresentando processos neoplásicos, o que também ocorreu na análise de dados nos quais havia mais de um tecido do mesmo animal para avaliação histopatológica. Tanto nas neoplasias, nos processos inflamatórios e outros processos houve maior frequência de afecções cutâneas, explicado sobretudo pela facilidade de acesso e de visualização. / The aim of this study was to characterize the diseases of domestic cats of the casuistry of the Veterinary Pathology Service from the Department of Pathology - FMVZ/USP between January of 1998 and December of 2008. It was analyzed data from 634 necroscopic examinations and 585 histopathological submissions. The analysis of the following data was performed: register number (histopathological submissions/necroscopic examination), date of entry, age, gender, breed, color of hair, localization of lesion, diagnosis, and for necropsies, data about causa mortis and necropsy findings. Two databases were organized by utilizing the software Excel®. The glass slides were not reviewed. The diseases were classified as infectious, inflammatory, neoplastic and other diagnosis (hypertrophy, hyperplasia, dysplasia). Moreover, diseases were related to age group, gender, breed, color of hair, and it was established the relationship between causa mortis and necropsy findings. The major cause of death of domestic cats was cardiorrespiratory arrest due to poisoning by carbamate and feline infectious peritonitis, both affecting animals until 24 months in both cases. The most frequent inflammatory processes in this study presented chronic features. The analysis of neoplastic diseases revealed that cats are prone to present neoplasms with epithelial origin and malign features, affecting mainly females, by the exception of lymphoma and fibrosarcoma. The analysis of age group has shown that those animals were older, although there was a low frequency of younger animals presenting neoplastic diseases. Both in inflammatory and neoplastic diseases, lesions in the skin were more frequent, which was explained by the easier visualization and access of this organ.

Submitted by Ubirajara Cruz (ubirajara.cruz@gmail.com) on 2017-05-05T16:19:59Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_Ana_Coelho_Resumo.pdf: 90160 bytes, checksum: 6cf246cb235e638b3225341ae0a27627 (MD5) / Approved for entry into archive by Aline Batista (alinehb.ufpel@gmail.com) on 2017-05-05T17:11:40Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_Ana_Coelho_Resumo.pdf: 90160 bytes, checksum: 6cf246cb235e638b3225341ae0a27627 (MD5) / Made available in DSpace on 2017-05-05T17:11:40Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_Ana_Coelho_Resumo.pdf: 90160 bytes, checksum: 6cf246cb235e638b3225341ae0a27627 (MD5) Previous issue date: 2015-02-27 / Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq / Com o objetivo de determinar as principais enfermidades de suínos que ocorrem na região Sul do Rio Grande do Sul foi realizado um estudo retrospectivo revisando-se os protocolos de necropsia do Laboratório Regional de Diagnóstico da Faculdade de Veterinária da Universidade Federal de Pelotas em um período de 35 anos. O levantamento determinou que os suínos na zona sul do Estado são criados de forma extensiva, com pouca tecnologia e manejo sanitário deficiente e que a média de suínos criados por propriedade varia de 4 a 11. As doenças bacterianas totalizaram 142 casos (28,63%); as doenças virais totalizaram 26 casos (5,24%); as doenças parasitárias foram observadas em 19 oportunidades (3,83%); as doenças carenciais totalizaram 10 casos (2,02%); as intoxicações e micotoxicoses juntas totalizaram, também, 10 casos (2,02%); e, as doenças metabólicas foram observadas apenas em uma oportunidade (0,20%). As condições diversas/doenças de etiologia indeterminada representaram 204 casos (41,13%); e, os diagnósticos inconclusivos totalizaram 84 casos (16,94%). Foi observado que embora este estudo tenha sido conduzido em uma região sem tradição de criação de suínos, com propriedades voltadas a pequenas criações familiares a morbidade, mortalidade e letalidade da maioria das doenças diagnosticadas tiveram percentuais relativamente elevados. As enfermidades mais frequentes foram as que em geral dependem de cuidados higiênico-sanitários como a maioria das doenças bacterianas, destacando-se as enfermidades causadas por Eschericha coli, sendo a doença do edema a mais frequentemente diagnosticada. Foi possível concluir que mesmo em criações de suínos em pequena escala, com pouca tecnificação, estes cuidados higiênico-sanitários são necessários para diminuir prejuízos econômicos, melhorando assim a produtividade e consequentemente a renda familiar dos criadores. / With the purpose to determine swine diseases that occur in the southern Rio Grande do Sul a retrospective study was conducted by reviewing the necropsy protocols of the Laboratório Regional de Diagnóstico of the Faculdade de Veterinária of the Universidade Federal de Pelotas in a period of 35 years. The survey determined that swine in the southern region of the state are created extensively with low technology and poor sanitary management. The average swine per farm ranges 4-11.Bacterial diseases accounted for 142 cases (28.63%); viral diseases accounted for 26 cases (5.24%); parasitic diseases were observed in 19 opportunities (3.83%); deficiency diseases totaled 10 cases (2.02%); poisonings and mycotoxicosis together also totaled 10 cases (2.02%); and metabolic disorders were observed in only one opportunity (0.20%). The various conditions/diseases of unknown etiology accounted for 204 cases (41.13%); and inconclusive diagnoses totaled 84 cases (16.94%).It was noted that although this study was conducted in a region with no tradition of swine breeding with farms with small flocks, the morbidity, mortality and lethality rates of the most diagnosed diseases had relatively high percentages. The most common diseases were those that generally depend on hygiene-sanitary care as most bacterial diseases, especially those caused by Eschericha coli, of which the edema disease was the most often diagnosed. It was concluded that even in swine breeding on a small scale and little technification, these hygienic-sanitary care are needed to reduce economic losses, there by improving productivity and hence household income of creators.

O objetivo deste estudo foi caracterizar as doenças dos gatos domésticos pertencentes à casuística do Serviço de Patologia Animal do Departamento de Patologia da FMVZ/USP entre janeiro de 1998 e dezembro de 2008. Foram identificados e analisados os dados de 634 exames necroscópicos e 585 exames histopatológicos. Os dados escolhidos para o presente estudo foram: número de registro (exame histopatológico/exame necroscópico), data de entrada, idade, sexo, raça, coloração da pelagem, local da lesão, diagnóstico e no caso do exame necroscópico, causa mortis e moléstia principal. Foram elaborados dois bancos de dados, sendo um para exame histopatológico e outro para exame necroscópico, utilizando-se o programa Excel®. Salienta-se que não foi realizada a revisão de lâminas. As doenças foram classificadas em infecciosas, inflamatórias, neoplásicas e outros processos (hipertrofias, hiperplasias, displasias). Além disso, as doenças foram relacionadas a faixa etária, sexo, raça e coloração de pelagem, nos casos em que havia dados suficientes, foi abordada a relação entre causa mortis e moléstia principal. O presente estudo revelou que a maior causa de mortalidade em gatos domésticos são as complicações cardio-respiratórias, provenientes principalmente de intoxicações exógenas por carbamatos e por peritonite infecciosa felina, afetando principalmente animais até 24 meses em ambos os casos. Os processos inflamatórios no presente estudo apresentam mais características de caráter crônico. A análise das neoplasias revelou que os gatos tendem a apresentar neoplasias de comportamento maligno e de origem epitelial. Além disso, verificou-se que as fêmeas são as mais acometidas por neoplasias, com exceção do linfoma e do fibrossarcoma. A análise das faixas etárias mostrou que estes animais são mais velhos, embora haja animais jovens apresentando processos neoplásicos, o que também ocorreu na análise de dados nos quais havia mais de um tecido do mesmo animal para avaliação histopatológica. Tanto nas neoplasias, nos processos inflamatórios e outros processos houve maior frequência de afecções cutâneas, explicado sobretudo pela facilidade de acesso e de visualização. / The aim of this study was to characterize the diseases of domestic cats of the casuistry of the Veterinary Pathology Service from the Department of Pathology - FMVZ/USP between January of 1998 and December of 2008. It was analyzed data from 634 necroscopic examinations and 585 histopathological submissions. The analysis of the following data was performed: register number (histopathological submissions/necroscopic examination), date of entry, age, gender, breed, color of hair, localization of lesion, diagnosis, and for necropsies, data about causa mortis and necropsy findings. Two databases were organized by utilizing the software Excel®. The glass slides were not reviewed. The diseases were classified as infectious, inflammatory, neoplastic and other diagnosis (hypertrophy, hyperplasia, dysplasia). Moreover, diseases were related to age group, gender, breed, color of hair, and it was established the relationship between causa mortis and necropsy findings. The major cause of death of domestic cats was cardiorrespiratory arrest due to poisoning by carbamate and feline infectious peritonitis, both affecting animals until 24 months in both cases. The most frequent inflammatory processes in this study presented chronic features. The analysis of neoplastic diseases revealed that cats are prone to present neoplasms with epithelial origin and malign features, affecting mainly females, by the exception of lymphoma and fibrosarcoma. The analysis of age group has shown that those animals were older, although there was a low frequency of younger animals presenting neoplastic diseases. Both in inflammatory and neoplastic diseases, lesions in the skin were more frequent, which was explained by the easier visualization and access of this organ.

<p>Cilj istraţivanja je bio da ispita efekte opaţenog iskustva disciplinovanja, na uverenja o disciplinovanju dece u mlaĊem odraslom dobu, kao i ulogu uslova i naĉina na koji je roditeljska disciplina sprovoĊena, u relacionom odnosu iskustva i aktuelnih uverenja o disciplinovanju. Iskustva disciplinovanja iz detinjstva su operacionalizovana preko &scaron;irokog spektra roditeljske korektivne discipline, tj. kaţnjavajućih i nekaţnjavajućih postupaka prilikom korigovanja neprimerenih pona&scaron;anja dece. Pored roditeljske disciplinske prakse, okolnosti disciplinovanja su operacionalizovane i preko uslova u okviru kojih je sprovoĊena disciplina (emocionalna klima, partnerski<br />iii<br />konflikti, neefikasnost u disciplinovanju) i naĉina na koji su roditelji korigovali pona&scaron;anja dece (toplina i doslednost, fleksibilnost, taktiĉnost/impulsivnost). Uverenja o disciplinovanju su operacionalizovana preko dimenzija pozitivne discipline, kaţnjavajuće discipline, te disciplinovanja uskraćivanjem ljubavi i agresivno&scaron;ću.<br />U uzorak istraţivanja je ukljuĉeno 276 studenata Univerziteta u Novom Sadu, pri ĉemu je broj studentkinja bio ne&scaron;to veći i iznosi 55%. Od ukupog broja, 79% ispitanika je odraslo sa oba roditelja, a 64% se izjasnilo da potiĉe iz porodice proseĉnog materijalnog statusa. Najveći broj roditelja ima srednji nivo obrazovanja (majke 64%, oĉevi 68%).<br />Prilikom prikupljanja podataka kori&scaron;ćena je testovna baterija, Inventar dimenzija disciplinovanja - forma za odrasle (Dimensions of Discipline Inventory Adult-recall form - DDI A), ĉiji su autori Straus i Fauchier (2007). Pored procene disciplinskih postupaka roditelja, DDI A omogućava procenu uslova i naĉina koji su bili dominantni u tim situacijama, a vezani su za period detinjstva, kada su ispitanici imali 10 godina, tako da su dobijeni podaci retrospektivne prirode. TakoĊe, bateriju saĉinjava i skala kognitivne procene korektivnih postupaka roditelja prema deci (uverenja o disciplinovanju), te skala sociodemografskih podataka. Kako je DDI A inventar kod nas prvi put upotrebljen upravo za potrebe ovog istraţivanja, pored prevoda instrumenta, sprovedena je i provera strukture i psihometrijskih karakteristika. Rezultati faktorske analize ukazuju na manje stabilnu strukturu instrumenta na domaćem uzorku, u odnosu na originalna istraţivanja, &scaron;to se moţe pripisati kulturolo&scaron;kim specifiĉnostima roditeljskog disciplinovanja. Psihometrijske karakteristike svih skala u inventaru su zadovoljavajuće.</p><p>Proverom hipotetskog modela, utvrĊeni su direktni efekti koje demografske karakteristike i iskustvo disciplinovanja ostvaruju na uverenja o disciplinovanju mladih odraslih, a pored toga, utvrĊeni su i moderatorski efekti disciplinskih okolnosti na aktuelna uverenja o kaţnjavajućoj disciplini. Znaĉajne interakcije su utvrĊene za disciplinsko pona&scaron;anje oĉeva (stroga i restriktivna disciplina) i majki (suoĉavanje sa posledicama neprimerenih pona&scaron;anja, fiziĉka i psiholo&scaron;ka agresivnost), u odnosu na specifiĉne uslove (partnerski konflikti) i naĉine (taktiĉnost/impulsivnost) disciplinovanja. Rezultati su diskutovani u svetlu teorije socijalnog uĉenja, u smislu potvrde efekata neposrednog iskustva disciplinovanja na uverenja o disciplinovanju u mlaĊem odraslom dobu, kao i potvrde znaĉaja disciplinskih okolnosti, tj. specifiĉnih uslova i naĉina na koji je disciplinovanje sprovoĊeno. Pored toga, razmatrane su i praktiĉne implikacije rezultata istraţivanja u kontekstu aktuelne izmene zakonske regulative, vezane za mogućnost uvoĊenja zabrane fiziĉkog kaţnjavanja, kao i<br />v<br />znaĉaja kulturolo&scaron;kih karakteristika disciplinovanja u planiranju i sprovoĊenju izmena roditeljske disciplinske prakse.</p> / <p>The aim of the research was to examine the observed effects of early discipline experiences in relation with the parents on beliefs on disciplining of young adults, as well as to examine the role of context in which parental discipline is conducted. The experiences of discipline in childhood were operationalised through a wide spectrum of parental correctional discipline i.e. punitive and non-punitive acts which are used while correcting child&lsquo;s misbehavior.<br />Besides disciplinary behavior practice of a parent, the discipline settings were operationalised through the context under which the discipline is conducted (emotional climate, relationship conflicts, discipline inefficiency) and the modes parents used in order to correct their children&lsquo;s behaviour (affection, consistency, flexibility, tactfulness, impulsiveness). The discipline beliefs were operationalised through positive discipline, punitive discipline as well as disciplining by love withdrawal and aggression.</p><p>The sample consists of 276 students from the University of Novi Sad. The number of female students was slightly higher and amounts to 55% of the total students. 79% of the students grew up in the families with both parents, and 64% claimed to have belonged to middle class families. The majority of their parents had secondary education (64% of mothers, 68% of fathers).<br />In the process of data collecting, the test battery -Dimensions of Discipline Inventory Adult recall form &ndash; DDI A, whose authors are Straus and Fauchier (2007), was used. Besides parent discipline behaviour evaluation, DDI A enables the evaluation of the dominant context and modes, related to childhood period when the interviewees were 10 years old. Therefore, the data gathered is of retrospective nature. Furthermore, the battery contains the scales of cognitive appraisal of different corrective acts of parents towards their children (discipline beliefs), as well as the scale of demographic data.<br />As DDI A inventory is used for the first time in Serbia for the purposes of this research, the<br />ix<br />instrument was translated and the structure with psychometric characteristics was tested. The results of factor analysis show less stable structure of the instrument on domestic sample in comparison to the original research, which can be attributed to the cultural specifications of the parental discipline. Psychometric characteristics of all the scales in the inventory are satisfactory.<br />By testing hypothetic model, direct effects of the demographic characteristics and the experience of disciplining in the childhood were established. Furthermore, the moderator effects of discipline setting based on contemporary beliefs on punitive discipline were also established. Significant interactions for discipline manner of the fathers (strict, restrictive discipline) and the mothers (dealing with consequences of misbehavior, physical and psychological aggression), based on specific context (relationship conflicts) and modes of discipline (tactfulness, impulsiveness) were also established. The results were discussed in accordance with the theory of social studies, which confirms the effects of immediate experience of the discipline on discipline beliefs during early adulthood, and also proves the importance of discipline setting, i.e. specific context and modes used for discipline conduction.<br />Practical implications of the results of this research were also analysed, as they could be taken into consideration during the current<br />x<br />changes in legislation related to possible prohibition of corporal punishment, while the importance of the cultural characteristics of the discipline should be considered during planning and implementation of the changes in discipline practice.</p>

Osteoporosis is a disease characterized by low bone mineral density (BMD), which compromises bone tissue increasing fragility and susceptibility to fracture. It affects nearly 50% of women and 20% of men over the age of 50, and fractures resulting from osteoporosis cause significant morbidity and mortality. Therefore, patients with or at risk for osteoporosis should be identified before rather than after a fracture occurs. The gold standard in diagnosing patients with osteoporosis is dual X-ray absorptiomerty (DXA). The purpose of this study is to evaluate the usefulness of assessing BMD at various parts of the distal radius (ultra-distal, mid-point, one third, and total) compared to the conventional sites (lumbar vertebrae and proximal femur) using DXA to diagnose osteoporosis. This was a retrospective study on 1,641 male patients over the age of 50 who had undergone bone densitometry (DXA scans) of at least one hip, lumbar vertebrae and distal radius. Ordinary regression and correlation analysis was used to assess the association between the lowest of the bone density scores of the hip or lumbar vertebrae and scans at the various sites on the radius. Comparing standardized scores from the radius method with the lowest standardized scores from the hip or lumbar vertebrae, a highly significant correlation was found, R = 0.59, p < 0.001 for the left UD radius, R =0.59, p < 0.001 for left MD radius, R =0.54, p < 0.001 for the left 1/3 radius, and R =0.60, p < 0.001 for the total left radius. The results indicate that the left radius total is the most accurate in diagnosing osteoporosis in our study population. The results of this study can have far-reaching psychosocio-economic implications showing that DXA scans of the distal radius can be used to effectively diagnose osteoporosis by using inexpensive, low-technology, portable scanners. These findings are particularly relevant to the needs of the undeserved rural populations of Central Appalachia.

O objetivo desse estudo foi avaliar as taxas de sobrevida de implantes unitários, instalados na maxila, com diferentes tratamentos de superfícies: oxidação anódica (AO), duplo ataque ácido (DAE), ataque ácido e jateamento (SAE) e ataque ácido e jateamento modificada (SAE modificada). Também avaliou a influência de outras variáveis sobre estas taxas. Foram avaliados pacientes com implantes unitários em maxila, atendidos no Centro Odontológico da Polícia Militar de São Paulo e do Centro de Excelência em Prótese e Implantes da Universidade de São Paulo (Brasil), entre janeiro de 2008 e julho de 2013. Os seguintes dados foram coletados: sexo do paciente, características do implante (forma, diâmetro, comprimento), tratamento de superfície, localização do implante (maxila anterior ou posterior), presença de enxerto ósseo e falhas de implantes. O desfecho primário foi a perda do implante (falha). Estatísticas descritivas foram realizadas para caracterizar a distribuição de frequência de implantes em relação às variáveis. A análise da falha do implante foi feita por curvas de sobrevida de Kaplan-Meier. O teste de Mantel-Cox identificou as variáveis associadas à falha do implante ao longo do tempo. A amostra analisada foi constituída por 1076 implantes em 549 pacientes. As falhas ocorreram em 20 implantes (1,9%), 15 deles (75%) em homens e 5 em mulheres (25%). A frequência de falha foi maior em regiões de enxerto ósseo, e esta diferença ocorreu nos implantes em homens e com superfície DAE. A presença de enxerto aumentou em seis vezes as chances de falha do implante em relação às áreas de osso natural. Nos pacientes com implantes com superfície DAE estimou-se que essa chance de falha do implante em área de enxerto aumentou em nove vezes. / The purpose was evaluate the survival rates of single implants installed in maxilla with different surface treatments: anodic oxidation (AO), dual acid-etching (DAE), sandblasted and acid-etched (SAE) e sandblasted and acid-etched modified (SAE modified). It also evaluated the influence of other variables on these rates. Patients with installed single implants in the maxilla treated at Dental Center of Military Police of São Paulo and the Center for Excellence in Prosthodontics and Implants of the University of São Paulo (Brazil) between January 2008 and July 2013 were evaluated. The following data were collected: patient gender, implant characteristics (shape, diameter, length), surface treatment, location of the implant (anterior or posterior maxilla), presence of bone graft and implant failures. The primary outcome was the loss of the implant (failure). Descriptive statistics were used to characterize the frequency distribution of implants in relation to the variables. The analysis of implant failure was made by survival curves of Kaplan-Meier. The Mantel-Cox test was performed to identify variables associated with implant failure over time. The sample consisted of 1076 implants in 549 patients. Failures occurred in 20 implants (1.9%), while 15 of them (75%) were men and 5 women (25%). The frequency of failure was higher in regions of bone graft, and this difference was related to implants in men and in DAE implants. The presence of graft area increased by 6 times the chances of implant failure in relation to areas of natural bone. In DAE implants was estimated that the chance of failure of the implant graft area increased by 9 times.

Made available in DSpace on 2014-08-20T14:30:10Z (GMT). No. of bitstreams: 1 Dissertacao_aya_qassem_shqair.pdf: 1122970 bytes, checksum: 71dd26c729fef2590a8b79552213c7bd (MD5) Previous issue date: 2012-12-14 / This study aimed at investigating the influence of the radicular maturity level of primary teeth in the sequelae of dental trauma as well as the moment that such sequelae take place. Two longitudinal retrospective studies, which collected data from dental records and radiographies of patients with dental trauma in one or both upper central primary incisors. was conducted. In the first one, sequelae such as crown discoloration, pulp canal obliteration and inflammatory root resorption were evaluated in a follow-up period 12-18 months after the trauma, using the registers from 150 patients. In the second study, only intruded and subluxated teeth were included. Clinical and radiographic sequelae such as crown discoloration, fistula, pulp canal obliteration, inflammatory and internal root resorption were evaluated. The data regarding the sequelae were distributed into eight follow-up intervals: 0-30 days; 31-90 days; 91-180 days; 181-365 days; 1 to 2 years; 2 to 3 years; 3 to 4 years and > 4 years. From 150 patients included at the first study, 118 (78.7%) presented luxations and 32 (21.3%) had dental fractures. Shortly after the injury, 13 teeth (9.2%) presented immature roots, 114 (80.3%) presented closed apexes, and 15 of them (10.6%) had visible root resorption. The results showed an association between the radicular maturity level of traumatized teeth and the occurrence pulp obliteration (P = 0.023) and inflammatory root resorption (P = 0.004) after 12-18 months of follow-up period. There was also an association between the type of injury and the occurrence of crown discoloration (P = 0.036) as well as the type of injury and the development of pulp canal obliteration (P = 0.001). Regarding the second study, the sample comprised 99 subluxation cases and 70 intruded teeth. Crown discoloration was the most prevalent sequelae. Among subluxated teeth, more than 50% of inflammatory root resorption, fistula, crown discoloration and pulp obliteration occurred within 180 days after the traumatic injury, however the diagnosis of sequelae still occurred after longer periods. The majority sequelae of intrusion were diagnosed within the 181-365 days and 1-2 years periods but they were still observed after > 4 years follow up period. It can be concluded that the occurrence of trauma sequelae can be determined by the type of injury, as well as by the radicular maturity level of primary teeth at the moment of trauma. Besides, in intrusion and subluxation cases, the diagnosis of sequelae was performed even after the 3-4 years follow-up period. / Este estudo teve como objetivo investigar a influência do grau de maturidade radicular dos dentes decíduos nas sequelas dos traumatismos alveolodentários, assim como investigar o momento que tais sequelas ocorrem. Para tal, foram conduzidos dois estudos longitudinais retrospectivos, os quais coletaram dados clínicos e radiográficos de registros de pacientes com traumatismo dentário em um ou mais incisivo central superior decíduo. No primeiro, sequelas como discoloração coronária, obliteração pulpar, e reabsorção inflamatória foram avaliadas em um período de 12-18 meses após o traumatismo, usando os registros de 150 pacientes que atenderam aos critérios de inclusão no estudo. No segundo estudo, foram avaliados apenas os casos de intrusão e subluxação. Sequelas clínicas e radiográficas como discoloração coronária, fistula, obliteração pulpar, reabsorção inflamatória e reabsorção interna foram avaliadas. Os dados referentes às sequelas foram distribuídos em oito intervalos de acompanhamento: 0--30 dias; 31-90 dias; 91-180 dias; 181-365 dias; 1 to 2 anos; 2 to 3 anos; 3 to 4 anos e > que 4 anos. Dos 150 pacientes incluídos no primeiro estudo, 118 (78.7%) apresentaram luxações e 32 (21.3%) tiveram fraturas dentárias. Imediatamente após o traumatismo, 13 dentes (9.2%) apresentavam raizes incompletas, 114 (80.3%) apresentavam ápices fechados e 15 (10.6%) tinham reabsorção radicular visível. Os resultados mostraram associação entre o grau de maturidade radicular dos dentes traumatizados e a ocorrência de obliteração pulpar (P = 0.023) assim como de reabsorção radicular inflamatória (P = 0.004). Houve ainda, associação entre o tipo de traumatismo e a ocorrência de discoloração coronária (P = 0.036) assim como do tipo de traumatismo e desenvolvimento de obliteração pulpar (P = 0.001). Com relação ao Segundo estudo, a amostra foi constituída de 99 casos de subluxação e 70 casos de intrusão. Dentre as sequelas, a discoloração coronária foi a mais prevalente. Considerando os dentes com subluxação, mais de 50% das reabsorções radiculares inflamatórias, e dos casos de discoloração coronária, fístula e obliteração pulpar ocorreram até 180 dias após o traumatismo. No entanto, as sequelas surgiram mesmo após períodos mais longos de acompanhamento. A maioria das sequelas de intrusão foram diagnosticadas nos períodos de 181-365 dias e 1-2 anos, mas continuaram surgindo mesmo no período de acompanhamento superior a 4 anos. Pode-se concluir que a ocorrência das sequelas de traumatismo na dentição decídua pode ser determinada pelo tipo de injuria, assim como pelo nível de maturidade radicular no momento do traumatismo. Além disso, nos casos de intrusão e subluxação, mesmo após acompanhamento superior a 3-4 anos, as sequelas continuaram sendo diagnosticadas.

Background. Maintainability of software products continues to be an area of im- portance and interest both for practice and research. The time used for maintenance usually exceeds 70% of the whole period of software development process. At present, there is a large number of metrics that have been suggested to indicate the main- tainability of a software product. However, there is a gap in validation of proposed source code metrics and the external quality of software maintainability. Objectives. In this thesis, we aim to catalog the proposed metrics for software maintainability. From this catalog we will validate a subset of commonly proposed maintainability indicators. Methods. Through a literature review with a systematic search and selection ap- proach, we collated maintainability metrics from secondary studies on software main- tainability. A subset of commonly metrics identified in the literature review were validated in a retrospective study. The retrospective study used a large open source software "Elastic Search" as a case. We collected internal source code metrics and a proxy for maintainability of the system for 911 bug fixes in 14 version (11 experi- mental samples, 3 are verification samples) of the product. Results. Following a systematic search and selection process, we identified 11 sec- ondary studies on software maintainability. From these studies we identified 290 source code metrics that are claimed to be indicators of the maintainability of a soft- ware product. We used mean time to repair (MTTR) as a proxy for maintainability of a product. Our analysis reveals that for the "elasticsearch" software, the values of the four indicators LOC, CC, WMC and RFC have the strongest correlation with MTTR. Conclusions. In this thesis, we validated a subset of commonly proposed source code metrics for predicting maintainability. The empirical validation using a popu- lar large-scale open source system reveals that some metrics have shown a stronger correlation with a proxy for maintainability in use. This study provides important empirical evidence towards a better understanding of source code attributes and maintainability in practice. However, a single case and a retrospective study are insufficient to establish a cause effect relation. Therefore, further replications of our study design with more diverse cases can increase the confidence in the predictive ability and thus the usefulness of the proposed metrics.

The objectives of this research were to (1) characterize the demographics and vocal health history of collegiate-level singers, particularly those with a voice disorder and (2) describe and compare self-reported symptoms of singers across diagnostic categories of vocal fold disorders. Clinical reports of 56 collegiate-level singers (15 male and 41 female) who visited the Voice Diagnostic Clinic at the University of North Texas for voice evaluations between 2010 and 2015 were reviewed. Information was extracted from clinical records including demographic data, vocal health history, self-reported voice-related symptoms, and voice diagnosis confirmed by strobolaryngoscopic examinations and phonatory function testing. Diagnoses of voice disorders were grouped under three categories: normal (i.e., no perceptible pathology), benign lesions and irritation/inflammation. Seven singers were diagnosed as normal, 27 (51.8%) with benign lesions, and 22 (39.3%) with irritation/inflammation. All singers diagnosed as normal were females. Female singers have twice as many benign lesions as irritation/inflammation whereas males presented the opposite pattern. Nodules, polyps, cysts and irritation/inflammation were the most common voice disorders. Singers with allergies and a past history of voice problems demonstrated a higher incidence of voice disorders. The top five self-reported vocal symptoms were worse voice in the morning (50%), pain in throat (46.4%), voice worse with prolonged use (44.6%), vocal fatigue (42.9%), and breathiness (41.1%). Self-reported symptoms are not a reliable screening tool to determine presence or absence of vocal pathology. Voice teachers must be familiar with the singing and speaking voice of each student, so as to perceive early onset of vocal attrition symptoms and encourage the student in seeking medical attention.

In der Literatur finden sich viele Angaben zur Wirkung des Testosterons, zur Symptomatik eines Testosteron-Defizits, zu den Auswirkungen eines zu hohen Spiegels durch Doping und auch internationale Guidelines zur Diagnose und Therapie des Testosteron-Defizits. Zu dessen Ursachen ist vieles bekannt, vor allem zum angeborenen Mangel, weniger zum erworbenen Mangel. Es besteht eine Liste von Ätiologien, aber ohne Angaben zu deren Häufigkeit. Dies ist der Ausgangspunkt der Arbeit. In einer allgemein-internistischen Praxis werden Daten von einer Patientenpopulation von 108 Männern mit Testosteron-Defizit erhoben. Neben den Laborwerten und der Symptomatik werden Untersuchungsbefunde vor Therapiebeginn erfasst. Diese Angaben werden systematisch ergänzt durch eine Anamnese von Krankheiten, die in den Guidelines als Ätiologien des erworbenen Testosteron-Defizits stehen. Daraus können Prävalenzen dieser Krankheiten in der Patientenpopulation errechnet werden. Prävalenzen für die Gesamtbevölkerung sind in der Literatur zu finden. Diese werden statistisch miteinander verglichen. Für die Befunde Hodenvolumen kleiner als15 ml, Hodenhochstand, Infertilität und verminderte Zeugungsfähigkeit und St n. Vasektomie kann in der Patientenpopulation eine höhere Prävalenz nachgewiesen werden. Zwischen Hodenvolumen (gemessen mit Orchidometern nach Prader) und Testosteron-Spiegel besteht eine Korrelation, die mit einer linearen Regression dargestellt werden kann. Eine entsprechende Korrelation zwischen dem Intervall zwischen Vasektomie und Diagnose des Testosteron-Defizits und dem Testosteron-Spiegel ist nicht signifikant. Diese Daten werden anhand der Literatur diskutiert, speziell auch im Hinblick auf Inflammation in den Testes als mögliche gemeinsame Pathogenese. Als Schlussfolgerungen werden Empfehlungen für die Präventivuntersuchung des Mannes bei Hausärzten und Urologen, für Abklärungen beim Fertilitätsspezialisten und die Forschung dargelegt. / There are many indications in the literature about the effects of testosterone, on the symptoms of a testosterone deficit, on the effects of excessive levels of doping, and also international guidelines for the diagnosis and treatment of the testosterone deficit. There are many known causes of this, especially the congenital deficiency, less of the acquired deficiency. There is a list of etiologies, but no information about their frequency. This is the starting point of the work. In a general-internal practice, data are collected from a patient population of 108 men with testosterone deficit. In addition to the laboratory values ​​ and the symptoms, examination findings are recorded before the start of therapy. These data are systematically supplemented by an anamnesis of diseases that are included in the guidelines as etiologies of the acquired testosterone deficit. Prevalence of these diseases in the patient population can be calculated from this. Prevalence for the whole population can be found in the literature. These are compared statistically with each other. A higher prevalence can be detected in the patient population for the findings of testicular volume of less than 15 ml, meldescensus testis, infertility and reduced fertility and status after vasectomy. There is a correlation between testicular volume (as measured by Orchidometers according to Prader) and testosterone level, which can be represented by a linear regression. A corresponding correlation between the interval between vasectomy and diagnosis of the testosterone deficiency and the testosterone level is not significant. These data are discussed with reference to the literature, especially with regard to inflammation in the testes as possible common pathogenesis. Conclusions include recommendations for preventive examinations of the man in general practitioners and urologists, for examinations in fertility specialists and research.