Multi-scale modelling and analysis is becoming increasingly important and relevant. Analysis of the emergent properties from the interactions between scales of multi-scale systems is important to aid in solutions. There is no universally adopted theoretical/computational framework or language for the construction of multi-scale models. Most modelling approaches are specific to the problem that they are addressing and use a hybrid combination of modelling languages to model specific scales. This thesis addresses if process algebra can offer a unique opportunity in the definition and analysis of multi-scale models. In this thesis the generic Process Algebra with Layers (PAL) is defined: a language for multi-scale integration modelling. This work highlights the potential of process algebra to model multi-scale systems. PAL was designed based on features and challenges found from modelling a multi-scale system in an existing process algebra. The unique features of PAL are the layers: Population and Organism. The novel language modularises the spatial scales of the system into layers, therefore, modularising the detail of each scale. An Organism can represent a molecule, organelle, cell, tissue, organ or any organism. An Organism is described by internal species. An internal species, dependent on the scale of the Organism, can also represent a molecule, organelle, cell, tissue, organ or any organism. Populations hold specific types of Organism, for example, life stages, cell phases, infectious states and many more. The Population and Organism layers are integrated through mirrored actions. This novel language allows the clear definition of scales and interactions within and between these scales in one model. PAL can be applied to define a variety of multi-scale systems. PAL has been applied to two unrelated multi-scale system case studies to highlight the advantages of the generic novel language. Firstly the effects of ocean acidification on the life stages of the Pacific oyster. Secondly the effects of DNA damage from cancer treatment on the length of a cell cycle and cell population growth.

The feasibility of using freshwater and first marine year scale patterns to identify component stocks of steelhead trout (Salmo gairdneri) in the Skeena River was investigated. Scale samples and sex and size data were attained from adult steelhead originating from five Skeena River tributaries (Zymoetz, Kispiox, Morice-Bulkley, Babine, Sustut) over a series of different years. Adult scale samples were also collected from the 1984 incidental steelhead catch in the Area 4 commercial salmon fishery for potential stock classification purposes. Significant differences in scale pattern growth, age composition, and sizes at age were found between the five Skeena River steelhead stocks. Linear discriminant function analysis indicated that the five stocks could be classified to correct river of origin with between 45% and 62% average classification accuracy (range Zymoetz 29%-60%, Kispiox 35%-60%, Morice-Bulkley 44%-76%, Babine 54%-64%, Sustut 56%-72%) depending upon the classification model used. Juvenile morphometric analysis for three of the stocks (Kispiox, Morice-Bulkley, Zymoetz) indicated the presence of significant between stock differences in standardized body form. These results support the notion that Skeena River steelhead exist as quantifiably discrete stocks. Classifying the 1984 mixed stock commercial fishery catches to probable stock of origin indicated that distinct peaks of stock abundance and run-timing occur through the fishery. In general, Morice-Bulkley and Sustut River steelhead were predicted to be most abundant with run-timings during the earlier portions of the fishery. Kispiox, Babine, and Zymoetz River steelhead were predicted to be less abundant with later run-timings through the fishery. Potential commercial fishery impacts to steelhead are briefly discussed. These observations suggest that the technique of scale patterns is a feasible method for stock separation in Skeena River steelhead. Further study is required to clarify yearly variance in the technique and to better establish stock specific differences. / Science, Faculty of / Zoology, Department of / Graduate

This is a comparative study of the Swedish and Norwegian syllabi for English for the minimum courses required in order to be allowed to apply for university courses in both countries. The study focuses on the assessment of oral production and what guidelines teachers and students are provided with in order to know what is to be assessed. As a reference point while comparing, the Common European Framework of Reference has been used as a framework for this study.  The comparison has been done solely in a text-oriented manner, comparing both of the syllabi with the reference document. In the conclusion, the results drawn from this comparison will be put against each other in order to see any differences between the two syllabi and the ways in which they have interpreted the reference document.  The conclusion was that both of the syllabi were largely inspired by the reference document and so turned out to be very similar in many aspects within oral proficiency assessment, as well as there were some aspects where they were quite different. The most obvious of these were the aspect of descriptors of different grade levels which was an aspect where all three documents differed in some manner, the Norwegian syllabus being the document that was least alike the two other documents.

Climate change will lead to higher temperatures and longer summers in the future, which will likely influence the growing season of fish living in temperate lakes. The warm summer of 2018 in Sweden matches prognoses for normal summers at the end of the century and can thus be used to investigate the effect of temperature related factors on fish growth. In this study I used back-calculation of the growth of roach (Rutilus rutilus) caught in Lake Tåkern, Sweden, to find differences in growth during 2018’s hot summer versus the period 2012-2017. I compared growth during these years with results from a similar study from Lake Tåkern in 1978. For this comparison I used 1977 as a representative year for the 1970’s. I applied sclerochronology to the scales to determine age and growth. The results show that growth in terms of length increment was faster in 2018 than in 2012 – 2016. The results indicate that 2018 had an effect on the whole roach population, since significant differences were found across age groups. Additional comparisons between 1977 and 2018 showed no significant difference. Differences in roach growth rate between 2012-2018 could be caused by the differences in mean temperature during the roaches growing season, since 2018 was abnormally warm, and the difference between 1997 and 2018 could be attributed to 1977’s fish death. This means that if the pattern of climate change continues, roach growth rates will increase in the future regardless of age group.

Introduction: Gout is a painful form of acute inflammatory arthritis associated with elevated uric acid crystal deposition especially in the joints, but also in tendons and the kidney. Between 1 and 2% of Western populations are affected and in severe cases, gout sufferers can be completely incapacitated. Despite the number of gout sufferers, the high number of risk factors and high incidence of adverse drug reactions using the standard treatment regimens, little research involving gout has been done within the highly diverse multiracial and multicultural population of South Africa. Hypothesis: This study was a hypothesis generating observational study to assess whether serum levels of pro-inflammatory cytokines and acute phase protein levels could be used as markers of the gout status of a patient. Method: Thirty gout patients were enrolled onto the study and attended two visits. At the screening visit; medical history, vital signs and demographic details were collected from intercritical gout patients. At both visits, patients completed visual analogue scales; namely: subject’s assessment of pain and subject’s assessment of disease activity. A doctor completed the physician’s assessment of disease activity at both of the visits. At the end visit, patients experiencing an acute gout attack were asked to list various foods and beverages that triggered said attacks. Patients were requested to return for their second visit as soon as they experienced a gout attack, however, those patients that did not experience a gout attack were asked to return to the clinic to complete the follow up visit four months after their baseline visit. Uric acid, IL-1β, TNF-α and CRP were measured for each patient at both visits. Results: Many of the patients displayed risk factors for metabolic syndrome. The mean subject’s assessment of pain score increased from 31mm at the screening visit to 40mm at the end visit (p=0.1947; n=26), while the mean subject’s assessment of disease activity score and the mean physician’s assessment of disease activity increased from 30mm to 37mm (p=0.3196; n=26) and 23mm to 35 mm (p=0.0937; n=26) respectively. Uric acid levels decreased from 1.053mmol/L to 0.871mmol/L between visits (p=0.0926; n=25) while CRP concentrations increased significantly from 10.2mg/L to 26.6mg/L (p=0.0278, n=24). IL-1β concentrations remained similar (12.17pg/ml to 12.54pg/ml) while TNF-α concentrations decreased from 12.63pg/ml to 3.54pg/ml, however neither of these were statistically significant differences. Upon stratifying results into active and non-active patients, both IL-1β and TNF-α concentrations decreased between non-active and active patients, while CRP and urate concentrations increased. However, none of these differences were statistically significant. Conclusion: The visual analogue scales all showed an increase between the screening and final visits, although this was not statistically significant. Uric acid concentrations decreased between visits, however this increase was once again not statistically significant. There appears to be no association between inflammatory markers and the level of gout activity, although this needs to be tested in a larger sample population. Results in South African patients have confirmed results from previous studies where gout patients are at a higher risk of metabolic syndrome than the normal population. Copyright / Dissertation (MSc)--University of Pretoria, 2011. / Pharmacology / unrestricted

The fact that Davis changed his mind radically several times throughout his life appeals to the curiosity. This thesis considers what could be one of the most important and definitive changes: the change from hard bop to modal jazz. This shift, although gradual, is best represented by and culminates in Kind of Blue, the first Davis album based on modal style, marking a clear break from hard bop. This thesis explores the motivations and reasons behind the change, and attempt to explain why it came about. The purpose of the study is to discover the reasons for the change itself as well as the reasons for the direction of the change: Why change and why modal music?

Language is a cultural construct, and the relationship between words is taught. Priming research has long investigated the relationship between related and unrelated words. Similar research has been seen in music relationships, but most of these investigate harmonic relations despite the melodic relationship being the one listeners are mostly likely to describe. Further, these studies typically measure existing relationships and do not attempt to teach a new relationship, nothing that most adults are experienced musical listeners. This study seeks to establish a new melodic relationship (the enigmatic Scale) in addition to a familiar one (the major Scale) while measuring response time to the musical sequences. A baseline was conducted in which participants listened to a musical sequence and selected via response box if the final note is consonant (major Scale) or dissonant (enigmatic Scale). Following baseline a training section occurred in which participants heard sequences ranging from 2-7 notes and were provided feedback for correct and incorrect responses. Following completion of the training participants completed a post-test identical to baseline. Behavioral results are discussed in relation to Palmer's (2009) concept of the repertoire.

This master‘s thesis deals with the business performace assesment of the company using the Balanced Scorecard method. Based on the acquired theoretical knowledge about this method analyse the financial and non-financial customer perspective, perspective of internal processes, perspective of learning and growth. The strategic goals and scales are designed based on the findings obtained during the analysis, which should help the company to improve its overall performace in the upcoming years.

The phenomena of sexual violence have been studied on college campuses for over 50 years. Despite changes in society's attitudes towards women and gains made by women in education and the work force since the 1960s, research reveals that the incidence and prevalence rates of date rape have not changed significantly over the years. Extant literature indicates that endorsement of rape myths has been found to be associated with sexual aggression by males. A review of existing instruments revealed that current assessments of rape supportive attitudes and beliefs appear outdated in their language and may not be geared for today's college population. This study used a newly developed instrument, the Rape Supportive Attitudes and Beliefs Scale (RABS), by Gerald H. Burgess (2007) to survey male and female undergraduate students (N=224) with respect to their attitudes and beliefs regarding rape. The male participants were also asked if they had engaged or would consider engaging in forced sexual behavior under a variety of circumstances. The present study was designed to replicate and extend the findings of Burgess. Burgess studied a sample of undergraduate students in a rural university. Participants in this study, in contrast, were from a large metropolitan university with a much more diverse student body. This study found, similar to Burgess' research, that there are significant gender differences in endorsement of rape myths between men and women, as measured by a series of t-tests. As expected, men scored higher than women on the RABS, meaning greater endorsement of rape myths. In contrast to Burgess' findings, this study did not find that endorsement of rape myths was related to proclivity to sexual violence. Exploratory factor analysis (EFA) additionally revealed a factor structure that differed from the original 5-factor structure proposed by Burgess. The discussion focuses on the meaning of the similarities and differences between the two studies and directions for future research.

DOCTORAL THESIS Nikola Jajcay Spatial and temporal scales of atmospheric dynamics Abstract Earth climate, in general, varies on many temporal and spatial scales. In particular, climate observables exhibit recurring patterns and quasi- oscillatory phenomena with different periods. Although these oscillations might be weak in amplitude, they might have a non-negligible influence on variability on shorter time-scales due to cross-scale interactions, recently observed by Paluš[1]. This thesis supplies an introductory material for inferring the cross-scale information transfer from observational data, where the time series of interest are obtained using wavelet transform, and possible information transfer is studied using the tools from information theory. Finally, cross- scale interactions are studied in two climate phenomena: air temperature variability in Europe, in which we study phase-amplitude coupling from a slower oscillatory mode with an 8-year period on faster variability and its effects, and El Niño/ Southern Oscillation where we observe a causal chain of phase-phase and phase-amplitude couplings among distinct oscillatory modes. [1] M. Paluš. Multiscale atmospheric dynamics: cross-frequency phase-amplitude coupling in the air temperature. Physical Review Letters, 112(7):078702, 2014.