Abstract Chronic, non-healing wounds constitute a massive financial burden on health care system. The healing processes of these wounds and their underlying pathology are only partly understood. In this study, important biological functions performed by Retinoic acid with its regulatory protein cellular retinoic acid binding protein 2 (CRABP2) were discussed. Possibly, these biological func-tions might be linked with chronic wound therapeutic by inducing antiproliferative activity of cells which leads to reduction in migration and growth rate of fibroblast during skin regeneration pro-cess in chronic wound healing. The aim of this study was to comparatively analyze the expression pattern of CRABP2 and P16 cyclic dependent kinase inhibitor in dermal fibroblasts at mRNA levels along with their morphological pattern, migration and growth rate. Fibroblasts were cultured and their morphology were observed by phase-contrast imaging. Difference in viability, migratory capacity was examined by Cell titer blue and scratch assay respectively and expression were meas-ured by polymerase chain reaction. Interestingly, the date revealed that morphology was altered and growth rate and migration velocity was significantly lower in chronic wound fibroblasts and senescent fibroblasts when compared with their control. Expression pattern revealed that CRABP2 was highly up-regulated only by senescent cells but not in chronic wound fibroblasts which point novel function for this protein in term of replicative senescence. However, P16 was not signifi-cantly altered among all fibroblasts which demands supplementary studies to conform the role of CRABP2 in fibroblast dysfunction and cellular senescence in chronic wounds.

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Syfte: Uppsatsen syftar till att undersöka utvecklingen av sinnesmarknadsföring genom att ta reda på hur det används av företag inom dagligvarubranschen.   Metod: Studien har en kvalitativ forskningsstrategi. Fem intervjuer och tio observationer utfördes som metod i undersökningen. Intervjuerna utfördes på fem anställda på olika dagligvarubutiker i Solna, och samma butiker observerades under två tillfällen. Urvalet valdes utifrån ett bekvämlighetsurval.   Slutsatser: Sinnesmarknadsföring är ett relativt okänt begrepp. Synen är människans största sinne och därför riktas marknadsföringen främst mot visuella uttryck. I den här undersökningen har det visat sig att lukten är ett lika viktigt sinne, eftersom att dofter har förmågan att väcka minnen och även stimulera de övriga sinnena. ICA Maxi var den enda butik av samtliga undersökta, som skapade en multisensorisk varumärkesupplevelse där alla sinnen samarbetade. / Purpose: The purpose of this study is to examine Sensory marketing by finding out how it is used by companies in the retail industry. Method: The study has a qualitative research strategy. Five interviews and ten observations were carried out as method for the research. The interviews were conducted with five employee at various grocery stores in Solna, the stores were also observed during two occasions. They were selected based on a convenience sample. Conclusion: Sensory marketing is a relatively unknown term. The sight is our biggest sense, therefore are marketers primarily targeting visual expressions. This study has shown that the smell is an important sense, because its ability to evoke memories and stimulate the other senses as well. ICA Maxi was the only store of all investigated who had created a multisensory brand experience where all senses cooperated.