Introdução: O câncer de pulmão é a causa mais comum de morte por câncer no mundo. Objetivo: Descrever os achados clínicos ecomparar as características do câncer de pulmão em relação ao sexo, à idade e à história tabágica. Métodos: Estudo histórico com revisão de prontuários de 460 pacientes com câncer de pulmão. Resultados: A média de idade foi de 61±10 anos, sendo 359 (78%) homens. A história tabágica foi positiva em 93,7% dos pacientes. Dos 28 pacientes não tabagistas, 23 eram mulheres. Doença pulmonar obstrutiva crônica (DPOC) foi observada em 325 pacientes (70,7%) e pneumonia obstrutiva em 31,5% dos pacientes. Os principais sintomas e sinais respiratórios foram tosse, dispneia, dor torácica e hemoptise em respectivamente, 78,3%, 61,5%, 53,9% e 37,4% dos casos. Os sintomas sistêmicos mais comuns foram emagrecimento em 71,1%, anorexia em 54,1% e febre em 25,4% dos pacientes. Os tipos histológicos mais frequentes foram adenocarcinoma, carcinoma escamoso e carcinoma de células pequenas em respectivamente, 44,4%, 35% e 13,9% dos pacientes. O estádio tumoral foi IA/IB em 10% dos pacientes e IIIB/IV em 65,6% dos casos. Em 16,7% dos casos o tratamento foi cirúrgico. Dor torácica e síndrome da veia cava superior foram mais frequentes nos pacientes com menos de 50 anos. Adenocarcinoma predominou nos pacientes não tabagistas (75% vs 42,1%; p<0,01), e nas mulheres (60,4% vs 39,8%; p<0,005). Não houve diferença significativa em relação ao estádio ou tratamento quando comparados pacientes de acordo com sexo, idade e história tabágica. Conclusões: A prevalência de DPOC entre os pacientes com câncer de pulmão foi elevada. Os sintomas mais comuns foram tosse e emagrecimento e a maioria dos casos era de doença avançada. O tipo histológico mais frequente foi o adenocarcinoma, com prevalência aumentada em mulheres e não tabagistas. Sexo, idade e tabagismo não influenciaram no estadiamento e tratamento. / Introduction: Lung cancer is the most common cause of cancer death worldwide. Aim: To describe clinical findings and to compare the characteristics of lung cancer accordingto gender, age and smoking history. Methods: Retrospective chart reviewof 460 patients with lung cancer. Results: The mean age was 61 ± 10 years; 359 of the patients (78%) were men. The smoking history was positive in 93.7% of the patients. Of the 28 non-smoking patients, 23 were women. Chronic obstructive lung disease (DPOC) was found in 325 patients (70.7%) and obstructive pneumonia in 31.5% of the cases. The most frequent respiratory complains were cough, dyspnea, thoracic pain and hemoptysis in 78.3%, 61.5%, 53.9% and 37.4% of the cases, respectively. The common systemic symptoms were weight loss in 71.1%, anorexia in 54.1% and fever in 25.4%. The most frequent histological types were adenocarcinoma, squamous cell carcinoma and small cell carcinoma in 44.4%, 35% and 13.9%, respectively. The cancer staging was IA/IB in 10% and IIIB/IV in 65.6% of the patients. In 16.7% of the cases the lung cancer was treated by surgery. Thoracic pain and superior vena cava syndrome were more frequent in patients £ 50 years old. The frequency of adenocarcinoma was significantly higher in non-smokers (75% vs 42.1%; p<0.01) and in women (60.4% vs 39.8%; p<0.005). There were no differences in relationship to the cancer staging or treatment when patients were compared according to gender, age and smoking history. Conclusions: The prevalence of COPD was high among patients with lung cancer. The commonest symptoms were cough and weight loss and most of the patients had advanced disease. The most frequent histological type was adenocarcinoma, highly prevailing in non-smoking women. Cancer staging and treatment was not related to gender, age and smoking history.

Orientador: Frederico Andrade e Silva / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-07-23T17:55:26Z (GMT). No. of bitstreams: 1 Silveira_ValmirRaimundoda_M.pdf: 3057154 bytes, checksum: 244d3ab3b0663d0c04d0fed87ed33021 (MD5) Previous issue date: 1997 / Resumo: Foram examinados e tratados dez (10) pacientes do sexo feminino, na faixa etária entre 23 e 50 anos de idade, com sinais e sintomas de alterações funcionais do sistema estomatognático, divididos em dois grupos de cinco pessoas cada. Um grupo foi submetido a tratamento com aparelhos de cobertura oclusal plana e, o outro grupo tratado com aparelhos de pistas duplas tipo Planas, 1987. Os sintomas relatados com mais freqüência, foram as dores de cabeça seguidas de sensação de desconforto muscular. Todos os pacientes foram submetidos aos seguintes procedimentos: anamnése, exame clínico, exame físico através da palpação muscular, moldagem e modelos de estudo. Além dos exames e procedimentos preliminares, foram realizadas duas fases laboratoriais: uma para a captação dos potenciais elétricos dos músculos estudados e, a outra fase para o enceramento dos aparelhos em articulador semi-ajustável e respectivas prensagens em resina acrílica incolor termicamente ativada. Os aparelhos foram instalados e neles foram realizados os primeiros ajustes em relação aos dentes antagônicos. A primeira captação dos potenciais elétricos ocorreu antes da instalação dos aparelhos; a segunda aos 30 dias de uso e a terceira, após o refinamento oclusal, por volta de 60 a 120 dias do início do tratamento. A análise dos potenciais elétricos obtidos durante o período de tratamento com aparelhos de cobertura oclusal plana e do tipo Planas, com a mandíbula em posição postural, na mordida incisivo com resistência, na mordida molar com resistência e mordida molar sem resistência, evidenciou que os pares de músculos estudados, funcionalmente, com o decorrer da terapêutica proposta, tenderam a se equivaler. Em relação ao tipo de aparelho utilizado, ambos mostraram-se efetivos, sendo o de melhor manipulação, os de cobertura oclusal plana. O ajuste oclusal por desgaste seletivo, mostrou ser, importante do ponto de vista da manutenção da posição da mandíbula, conseguida com o uso dos aparelhos intra-orais, quando avaliado através da captação dos potenciais elétricos dos músculos estudados e do relato da remissão dos sinais e sintomas clínicos / Abstract: Ten female patients, with age between 23 to 50 years old, were submitted to a clinical examination and were treated with intra oral appliances, since all of them presented symptomatology related to functional alterations of the stomatognathic system. This group of 10 patients were divided into two groups of 05 patients each. The first group started the treatment wearing flat occlusal splints and the second group started the treatment wearing Planas's appliances with functional tracks (1987). The major and the most importants complaints of all patients were headache followed by muscle discomfort sensation. The all patients were also submitted to anamnesis and during the clinical examination a muscle palpation was perfomed by the professional as well as the impression of the jaws followed the execution of the respective stone cast models. Two laboratory procedures were also realized, firstly for determination of the eletrical potential of the masseter and temporalis and after for the waxing, the appliances were fixed in semi-adjustable articulador and were posteriorly cast with an incolor acrylic resin activated thermically. The appliances were installed in the respective patients mouths and the first adjustments were realized based on the antagonists teeth. The determinations of muscle electrical potentials were performance, firstly, before the instalation of the appliances, after 30 days of their usage, and finally in the period between 60 and 120 days after beggining of the treatment associated with the occlusal adjustment. The muscle electrical potential were obtained during the treatment of the 2 groups of patients, with the respective intra oral appliances referred previously, with the mandible at differents positions such as: postural position, incisor bitting with resistance, molar bitting with resistance and molar whithout resistance, showed that the pair of muscles studied had a functional behavior similar to each other independently of the treatment proposed. / Mestrado / Protese Dental / Mestre em Clínica Odontológica

Os sintomas negativos têm sido apontados como grande causa de sobrecarga nos pacientes esquizofrênicos, apesar dos recentes avanços no tratamento. Este estudo teve por objetivo investigar a correlação entre os sintoma s negativos e a qualidade de vida, em pacientes esquizofrênicos refratários e super-refratários. Cento e dois pacientes que preenchiam os critérios DSM-IV para esquizofrenia foram observados durante seis meses. Os pacientes foram divididos de acordo com critérios pré-estabelecidos, em três grupos: não refratários (N=22), refratários (N= 47) e super-refratários (N= 31), A psicopatologia foi avaliada por meio da Escala para Avaliação da Síndrome Positiva e Negativa (PANSS), Entrevista para Síndrome Deficitária (SDS) e Escala de Calgary para Depressão na Esquizofrenia. A qualidade de vida foi medida pela Escala de Qualidade de Vida (QV) . Os super-refratários tiveram os menores escores de QV, quando comparados ao grupo não refratário (p < 0,05). Não houve diferenças significativas nos escores médios de QV entre os refratários e superrefratários. Pacientes não refratários apresentaram menos sintomas negativos e melhores escores de QV. Os sintomas negativos tiveram uma correlação negativa com a qualidade de vida. Pacientes super-refratários, com mais sintomas negativos, tenderam a ter os menores escores de qualidade de vida / Negative symptoms have been reported as a major cause of burden in schizophrenic patients and often do not respond to drug treatment, in spite of recent advances in antipsychotic therapy. The present study aims to investigate the correlation of negative symptoms with quality of life in refractory schizophrenic patients. One hundred two outpatients meeting DSM-IV criteria for schizophrenia, were observed during 6 months. Subjects were divided into 3 groups: non-refractory (N=22), refractory (N= 47) and superrefractory (N= 31), according to pre-established criteria. Psychopatology was assessed with the Positive and Negative Syndrome Scale (PANSS), Schedule for Deficit Syndrome (SDS) and the Calgary Depression Scale for Schizophrenia. Quality of life was measured with the Quality of Life Scale (QoL). The super-refractory group had significantly lower QoL scores compared with the non-refractory group (P< 0,05). Mean QoL scores of superrefractory and refractory patients did not show a significant difference between them. Nonrefractory patients had fewer negative symptoms and better QoL scores. Negative symptoms negatively correlate with quality of life in schizophrenic patients. Superrefractory schizophrenic patients have the highest level of negative symptoms, and therefore the lowest QoL scores

A disfunção temporomandibular (DTM) abrange vários problemas clínicos que envolvem a musculatura da mastigação, a articulação temporomandibular (ATM) e estruturas associadas, cujas características são: dor crônica, fadiga, sensibilidade nos músculos da mastigação, ruídos e limitação de movimento. Este estudo teve por objetivo verificar presença e intensidade de características clínicas como sintomas, mobilidade articular, atividade eletromiográfica e sensibilidade dolorosa nos principais músculos mastigatórios e estabilizadores cervicais, qualidade de vida e curvatura cervical de portadores de DTM miogênica, Helkimo III. Foram selecionadas para esta pesquisa 46 mulheres, divididas em dois grupos. O Grupo I, composto por 28 mulheres com DTM e média de idade de 30,1 (5,8) anos; e o Grupo II, controle, composto por 18 mulheres saudáveis com idade média de 23,4 (5,5) anos. O Grupo com DTM foi subdividido em um grupo com e um sem alteração da curvatura cervical, para verificar a relação entre a curvatura e a DTM. A intensidade dos sintomas foi avaliada por meio de escala analógica visual, a sensibilidade dolorosa com dolorímetro, a amplitude dos movimentos da mandíbula com um paquímetro, a qualidade de vida foi mensurada pelo Questionário de Qualidade de Vida SF-36 e a curvatura cervical avaliada por inspeção de radiografias. Os resultados mostraram que indivíduos com DTM, têm maior intensidade dos sintomas avaliados, sensibilidade dolorosa e atividade eletromiográfica dos músculos masseter, temporal anterior, trapézio superior e esternocleidomastoideo e qualidade de vida, estatisticamente diferentes do grupo controle (p<0,05). Não houve diferenças estatisticamente significantes na abertura da mandíbula e em relação aos sintomas, sensibilidade dolorosa e atividade eletromiográfica, das pacientes com e sem alterações da curvatura cervical (p>0,05). Foi possível concluir que, mulheres com DTM miogênica, têm maior intensidade dos sintomas avaliados, sensibilidade dolorosa e atividade eletromiográfica nos músculos mastigatórios e cervicais, pior qualidade de vida quando comparadas com mulheres saudáveis. Não foi possível estabelecer relação entre intensidade de sintomas, sensibilidade dolorosa e atividade eletromiográfica com a postura cervical destas pacientes / Temporomandibular disfunction (TMD) embraces different clinical problems which include the muscles of mastigation, temporomandibular articulation (TMA) and associated structures. Their characteristics are chronicle pain, fatigue, sensibility in the muscles of mastigation, noise, limited motion. The aim of this study is to examine the presence and intensity of clinical characteristics such as symptoms, articular mobility electromyographic activity and painful sensibility in the main muscles of mastigation and cervical stabilizer, quality of life and cervical curvature in miogenic TMD, HelKimo III carrier. For this research, there were 46 women selected. They were shared in two groups. In group 1, there were 28 women with TMD, 30,1 (5,8) years old. The group 2 control was constituted by 18 healthy women 23,4 (5,5) years old. The TMD group was subdivided in a group with cervical curvature alteration and one without it, in order to confirm the relationship between the TMD and the curvature. The intensity of the symptoms was evaluated by a visual analogic scale, to painful sensibility with a algometer, the largeness of the mandible movements with a caliper, the quality of life was measured by SF-36 Quality of Life Questionary and the cervical curvature evaluated by radiography examination. The results showed that TMD persons present severe intensity of the evaluated symptoms, painful sensibility and electromyographic activity of masseter, anterior temporal, superior trapezoid and sternocleidomastoid muscles and in statistics different quality of life from control group (p<0,05). In statistics there weren`t any signicative differences in the largeness of the mandible considering symptoms, pain sensibility and electromiographic activity in patients with and without cervical curvature alterations. It follows that miogenic TMD women present severe intensity of the evaluated symptoms, painful sensibility and electromiographic activity in the cervical and mastigation muscles, the quality of life is worse than in healthy women. It was not possible to stablish relationship between the intensity of the symptoms, aching sensibility and electromyographic activity with cervical posture in these patients

During the nineteenth century, as today, nausea and vomiting were common signs and symptoms of illness, the interpretation of which contributed to doctors' diagnostic, prognostic and therapeutic choices. At the core of this thesis lies the research question: how did medical understandings and management of nausea and vomiting change in the period 1800-1900? In addition to being signs of bodily disorder, nausea and vomiting constituted an individual, typically non-medicalised experience of sickness. As such, a secondary thesis question is: how were nausea and vomiting experienced, interpreted and responded to by sufferers? These questions are pursued through four key themes: physiology, vomit analysis, morning sickness and sea-sickness. Medical textbooks, journals, hospital case reports, newspapers, letters and diaries are the principal source base. Throughout the nineteenth century physiological explanations for nausea and vomiting followed a generally reductionist path. In the 1830s Marshall Hall's reflex theory encouraged new perceptions of the nervous mechanisms involved in nausea and vomiting, and helped stimulate their redefinition into local, central and peripheral causes. Changing physiological explanations for nausea and vomiting were also contemporaneous to the growth of microscopy. This thesis draws attention to the interest nineteenth-century practitioners showed in using vomited matters as pathological fluids. This is explored primarily through a case study of sarcina ventriculi, a vegetable microorganism discovered in fermenting vomit. Responses to this discovery showed that laboratory techniques were largely inapplicable to everyday occurrences of nausea and vomiting. Consequently, neither the increasing localisation of the causes of vomiting, nor interest in vomited matters as pathological fluids, contributed to specificity in diagnoses or treatments. This research thereby demonstrates the cumulative and overlapping nature of nineteenth-century medical cosmologies - 'bedside', 'hospital' and 'laboratory' - and the continuation of the 'clinical art'. The histories of morning sickness and sea-sickness contextualise medical understandings of nausea and vomiting in relation to these transient conditions. They bring to the fore perceptions of health and sickness and show that medical theory was often secondary to cultural beliefs and practices. Specifically, this thesis questions the medicalisation of pregnancy during the nineteenth century and uses experiences of sea-sickness to reveal new features of Victorian understandings of the mind-body relationship. This thesis shows that 'feeling sick' (nausea) was arguably as significant to contemporaries as actually 'being sick' (vomiting). It also confirms the complexity and fluidity of taken-for-granted terms such as: 'patient', 'sufferer', 'disease', 'illness' 'sign' and 'symptom', and, of course, 'sick'. Furthermore, it demonstrates the importance to historians of studying everyday, self-limiting illnesses and morbidity.

Orientador: Wilkens Aurelio Buarque e Silva / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-27T14:28:46Z (GMT). No. of bitstreams: 1 Corradini_GustavoForjaz_M.pdf: 1092734 bytes, checksum: 59537ced0e1acdef3e19856bb3234b78 (MD5) Previous issue date: 2015 / Resumo: O objetivo neste trabalho foi caracterizar e verificar a prevalência de sinais e sintomas de desordens temporomandibulares em pacientes portadores de desordens crânio cervicais. Foram selecionados aleatoriamente 176 prontuários clínicos de pacientes que foram tratados no Curso de Especialização em Prótese Dental da Faculdade de Odontologia de Piracicaba. Todos os voluntários foram submetidos às avaliações previstas na Ficha Clínica do CETASE (Centro de Estudos e Tratamento das Alterações Funcionais do Sistema Estomatognático da FOP-UNICAMP) com o objetivo de identificar os sinais e sintomas de Desordem Temporomandibular (DTM), por meio de exames anamnésicos, clínicos e físicos; os voluntários foram diagnosticados com Desordem Crânio Cervicais (DCC). Os resultados obtidos foram agrupados em tabelas, a análise percentual foi realizada no programa computacional Excel 2007 e a analise estatística foi feita por meio do Teste Qui-quadrado e Coeficiente de Correlação de Pearson. Os sinais e sintomas da DTM que apresentaram maior prevalência nos pacientes com DCC foram: ausência do espaço de Christensen, dores espontâneas nas costas, apito ou zumbido, dores espontâneas na nuca e/ou pescoço, sensação de surdez, anuviamento visual, dvo baixa, dor a palpação no músculo trapézio e a dor a palpação no músculo masseter. Todos os sinais e sintomas observados foram mais prevalentes no gênero feminino. Houve inter-relação significativa (p?0,05) entre quase todos os sinais e sintomas observados sugerindo alta probabilidade de ocorrerem conjuntamente / Abstract: The aim of this study was to characterize and determine the prevalence of signs and symptoms of Temporomandibular Disorders (TMD) in patients with Cervical Spine Disorders (CSD). Were randomly selected 176 medical records from patients who were treated in the Specialization Course in Dental Prosthesis of Piracicaba Dental School. All volunteers were subjected to the evaluations defined in medical records of Centro de Estudos e Tratamento das Alterações Funcionais do Sistema Estomatognático da FOP-UNICAMP (CETASE) in order to identify the signs and symptoms of TMD, through anamnestic examinations, clinical and physical. All volunteers had diagnosis of CSD. The results were grouped in tables, the percentage analysis was performed using Excel 2007 computer program and the statistical analysis was performed using the Chi-square test and Pearson's correlation coefficient. The signs and symptoms of TMD more prevalent in patients with CSD were: absence of Christensen space (73.29%), spontaneous back pain (59.66%), whistle or hum (44.88%), pain spontaneous neck and/or neck (44.88%), deafness (43.18%), visual numbness (43.18%), low DVO (42.61%), pain on palpation trapezius muscle (38.07 %) and pain on palpation in the masseter muscle (33.52%). All observed signs and symptoms were more prevalent in females. There was a significant inter-relationship (p?0.05) between almost all signs and symptoms observed, suggesting a high probability of occurring together / Mestrado / Protese Dental / Mestre em Clínica Odontológica

We carried out an observational, retrospective and descriptive study in order to identify the clinical and epidemiological characteristics of children with SARS-CoV-2 infection admitted to a Peruvian national referral hospital. We included patients from one month old to fourteen years old hospitalized between March and August 2020. A total of 125 patients with SARS-CoV-2 infection were admitted, 18.4% (n = 23) had critical illness and 16.8% (n = 21) had multisystem inflammatory syndrome (MIS-C). The absence of comorbidities and previous history of epidemiological contact were more frequent in patients with MIS-C. Patients in critical condition and patients with MIS-C had lower lymphocyte and platelet counts, and higher C-reactive protein, ferritin and D-dimer values than patients who did not have said conditions. Six (4.8%) out of 125 children died, as well as 3 (13%) children from the group of patients in critical condition. None of the children with MIS-C died. / Revisión por pares

Konsekvenserna för barn som utsatts för barnmisshandel är allvarliga. Det kan leda till psykisk och fysisk ohälsa, suicidalt beteende, alkohol- och drogmissbruk. Hälso- och sjukvårdspersonal upptäcker inte alltid barnmisshandel och kunskap om detta saknas. Akutsjuksköterskan ska kunna identifiera personer som misstänks ha utsatts för våld eller övergrepp och därmed kunna upptäcka de barn som misstänks ha utsatts för barnmisshandel samt upprätta en orosanmälan till Socialtjänsten så att barnet kan få hjälp. Syftet var att beskriva hur sjuksköterskan kan identifiera tecken, symtom och skador som tyder på fysisk eller psykisk barnmisshandel hos barn som söker akutsjukvård. Som metod valdes en litteraturöversikt utifrån en systematisk struktur. Sökningarna utfördes i databaserna Cinahl och PubMed och resulterade i 15 artiklar publicerade 2010–2020. Alla artiklar kvalitetsgranskades utifrån Sophiahemmet högskolas bedömningsunderlag och en integrerad analys av innehållet i artiklarna gjordes. Resultatet presenterades i två kategorier; Bedömning av tecken, symtom och skador som barnet uppvisar och Fråga vårdnadshavaren om orsak till skadans uppkomst. Blåmärken och brännskador på vissa delar av kroppen eller i form av specifika mönster, multipla frakturer, frakturer som var läkta och specifika typer av frakturer kunde tyda på att barnet utsatts för misshandel. Åldern på barnet som utsatts för misshandel var låg, flertalet var &lt;1 år och medelåldern var i många fall &lt;6 månader. Vårdnadshavarens historia rörande händelseförloppet kring hur barnets skada uppkommit kunde ha stor betydelse för om misstanke om barnmisshandel skulle väckas. Slutsatsen är att det är svårt att identifiera barn som utsatts för fysisk eller psykisk barnmisshandel inom akutsjukvården då de tecken och symtom barnet uppvisar kan vara vaga eller saknas helt. Enskilda tecken, symtom och skador är i sig inte ett bevis för att barnet utsatts för misshandel utan det krävs alltid en samlad bedömning av barnets tecken, symtom och skador samt av vårdnadshavarens förklaring till hur dessa uppkommit. / The consequences for children who have been abused are serious. It can lead to mental and physical illness, suicidal behavior, alcohol- and drug abuse. Healthcare professionals do not always detect child abuse and lack knowledge about it. The emergency nurse must be able to identify persons who are suspected of having been subjected to violence or abuse and thus be able to discover the children who are suspected of having been subjected to child abuse and draw up a report of concern to the Social Services so that the child can receive help. The aim of this study was to describe how the nurse can identify signs, symptoms and injuries that indicate physical or psychological child abuse in children seeking emergency care. A literature review based on a systematic structure was chosen as the method. The searches were performed in the databases Cinahl and PubMed and resulted in 15 articles published in 2010–2020. All articles were quality reviewed on the basis of Sophiahemmet University's assessment and an integrated analysis of the content of the articles was made. The results were presented in two categories; Assessment of signs, symptoms and injuries that the child shows and Ask the caregiver about the cause of the injury. Bruises and burns on certain parts of the body or in the form of specific patterns, multiple fractures, fractures that were healed and specific types of fractures could indicate that the child had been abused. The age of the child who was abused was low, the majority was &lt;1 year and the average age was in many cases &lt;6 months. The caregiver´s history regarding the course of events of how the child's injury arose could have a decisive effect on whether suspicion of child abuse should be raised. The conclusion is that it is difficult to identify children who have been subjected to physical or psychological child abuse in emergency care as the signs and symptoms the child shows may be vague or completely absent. Individual signs, symptoms and injuries are not in themselves proof that the child has been abused, but an overall assessment of the child's signs, symptoms and injuries is always required, as well as the caregiver's explanation of how these arose.

<p>Uprkos rezultatima postignutih imunizacijom, veliki ka&scaron;alj je i danas vodeći uzrok smrti među zaraznim bolestima protiv kojih se sprovodi imunizacija. Postojanje različitih vrsta nadzora, prisutnih nedostataka laboratorijske dijagnostike oboljenja, slabosti u dostupnim definicijama slučaja velikog ka&scaron;lja i neprepoznavanje oboljenja, otežavaju realno sagledavanje opterećenja velikim ka&scaron;ljem i poređenje postignutih rezultata u različitim zemljama. Postojeće definicije slučaja velikog ka&scaron;lja nisu prihvatljive u svim uzrastima. Cilj istraživanja je bio da se na reprezentativnom uzorku Grada Novog Sada utvrdi: stopa incidencije velikog ka&scaron;lja tokom jedne godine savremenog nadzora; senzitivnost i specifičnost definicija slučaja velikog ka&scaron;lja, datih od strane Globalne pertusis inicijative za tri uzrasne grupe. U istraživanje je uključeno 213 ispitanika pacijenata iz sentinelnog nadzora nad velikim ka&scaron;ljem Doma zdravlja Novi Sad i 107 ispitanika pacijenata iz hospitalnog nadzora sa iste teritorije koji su ispunjavali predložene definicije slučaja za tri uzrasne grupe (0-3 meseca; 4 meseca-9 godina života; 10 godina i stariji). Podaci za istraživanje dobijeni su popunjavanjem anketnog upitnika. Laboratorijsko testiranje sumnji na veliki ka&scaron;alj sprovedeno je u Centru za mikrobiologiju Instituta za javno zdravlje Vojvodine. Kod pacijenata sa ka&scaron;ljem u trajanju do 21 dan testiranje je vr&scaron;eno upotrebom PCR metoda, a kod pacijenata sa ka&scaron;ljem u trajanju vi&scaron;e od 21 dan, dokazivanje oboljenja vr&scaron;eno je upotrebom ELISA IgA i IgG serolo&scaron;kih testova. Potvrđenim slučajem velikog ka&scaron;lja smatran je pacijent sa ispunjenom definicijom slučaja oboljenja i laboratorijskom potvrdom oboljenja, PCR ili ELISA testom. Procenjena stopa incidencije velikog ka&scaron;lja u Novom Sadu je 237,7/100.000, a stopa incidencije hospitalizovanih u Novom Sadu je 16,4/100.000. Najvi&scaron;e stope incidencije velikog ka&scaron;lja u sentinelnom nadzoru registruju se u uzrastu 10-14, a u hospitalnom u uzrastu od 7 do 9 godina. Senzitivnost, specifičnost i stepen verovatnoće pozitivnog rezultata testiranog simptoma/znaka iz predloženih definicija slučaja se razlikuju po uzrastima i po pojedinim simptomima/znacima. Predložene definicije slučaja u uzrastima od 4 meseca do 9 godina i u uzrastu od 10 godina i starijih imaju veću verovatnoću otkrivanja obolelih u hospitalnom u odnosu na sentinelni nadzor za pojedine simptome/znakove. Budući da je tokom istraživanja u sentinelnom nadzoru oboljenje potvrđeno kod svakog petog, a u hospitalnom kod svakog drugog testiranog pacijenta, predložene definicije slučaja se mogu koristiti u nadzoru nad velikim ka&scaron;ljem.</p> / <p>Despite all results achieved by immunization, pertussis is still the leading cause of death among vaccine preventable diseases. Different types of surveillance and laboratory confirmation of pertussis, weakness of existing case definitions for pertussis and broad spectrum clinical manifestation of disease, complicate overview of disease and result comparison of surveillance in different countries. The current pertussis case definition is not acceptable for all age groups of patients. The aim of this research was to determine: the pertussis incidence rate in population of Novi Sad during one year of modern surveillance; the sensitivity and specificity of clinical case definition for pertussis, given by the Global Pertussis Initiative for three age groups, with a representative sample of population in the City of Novi Sad. 213 patients from sentinel surveillance of pertussis Novi Sad Health Centre and 107 hospitalized patients from Novi Sad, who fulfilled criteria of case definition proposed for the three age groups (0-3 months, 4 months-9 years; 10 years of age and older), were included in the research. Research data obtained from a questionnaire. Laboratory testing of suspected cases were conducted at the Centre for Microbiology, Institute of Public Health of Vojvodina. For patients with coughing less than 21 days PCR method was used, and for patients with cough lasting more than 21 days, laboratory confirmation of disease was performed using ELISA IgA and IgG serological tests. Confirmed case of pertussis consider to be a patient with symptoms/signs according to proposed case definition and with laboratory confirmation of the pertussis, PCR or ELISA. Estimated incidence rate of pertussis for population in the city of Novi Sad was 237.7/100,000, and the pertussis incidence rate in hospitalized patient in Novi Sad was 16.4/100,000. The highest incidence rate of pertussis in the sentinel surveillance was registered in the age group 10-14 and in the hospital surveillance in the group 7 to 9 years of age. The values of sensitivity, specificity and positive likelihood ratio of symptoms/signs from the proposed case definition were calculated and they different by age and by certain symptoms/signs from proposed case definition. Certain symptoms/signs of the proposed case definition have a higher probability of detection among patients aged 4 months to nine, and at the age of ten year and older, in the hospital versus those in sentinel surveillance for pertussis. During research from the patients who were tested in sentinel surveillance every fifth was laboratory confirmed case and in the hospital surveillance every second patient was confirmed case, so the proposed case definitions can be used in the surveillance of pertussis.</p>

Sua história natural e o real risco à função renal foram pouco estudados. Objetivo: Avaliar o impacto do cálculo ureteral silencioso sobre a função renal antes a após o tratamento, procurando por fatores preditivos de uma melhor evolução. Material e Método: O cálculo ureteral silencioso foi definido como aquele em que o paciente não apresentava nenhum sintoma subjetivo ou objetivo a ele relacionado. Os pacientes com cálculo ureteral silencioso foram prospectivamente incluídos no estudo, sendo avaliados com 99mTc-DMSA, creatinina sérica (Cr), ritmo de filtração glomerular (RFG) e ultrassonografia (USG) no pré-tratamento, três e 12 meses após o mesmo. Pacientes que receberam tratamento fora de nossa instituição e aqueles com avaliação perioperatória incompleta foram excluídos. A análise estatística incluiu os testes de ANOVA, Qui-quadrado/Fisher, e regressão logística/múltipla. O nível de significância foi estabelecido em p<0,05. Resultados: Entre jan/2006 e jan/2014, 26 pacientes com cálculo ureteral silencioso, correspondendo a 2,1% de todos os cálculos ureterais tratados, preencheram os critérios de inclusão do estudo. Treze pacientes eram do sexo feminino, com idade média de 59,3 ± 11,3 anos. O diagnóstico do cálculo foi relacionado a uma causa urológica em 14 (53,8%) casos. O diâmetro e densidade média dos cálculos era de 11,8 ± 2,8 mm e 1201 ± 272 UH, respectivamente. Apenas dois pacientes não apresentavam hidronefrose ao USG inicial e a espessura média do parênquima renal era 10,7 ± 4,1 mm. Os valores médios pré-operatórios de Cr, RFG e 99mTc-DMSA foram 1,24 ± 0.87 mg/dl, 72,5 ± 25.2 mL/min e 33,4 ± 16,7%, respectivamente. Vinte (77%) pacientes apresentavam 99mTc-DMSA < 45% no exame inicial. Regressão múltipla revelou que idade (p=0,041) e espessura do parênquima renal (p=0,001) predizem o valor do 99mTc-DMSA inicial. Quando comparados com os valores pré-operatórios, a Cr (p=0,89), o RFG (p=0,48) e a função renal ao 99mTc-DMSA (p=0,19) permaneceram inalterados com três e 12 meses após o tratamento. A hidronefrose apresentou melhora três meses após o tratamento (p < 0,01), mas manteve-se inalterada no período entre três e 12 meses (p=0,06). Nenhuma variável pré-operatória foi capaz de prever uma variação > 5% do 99mTc-DMSA entre pré e pós-operatório, sendo que o tamanho do cálculo (p=0,12) e tempo para tratamento (p=0,15) tiveram influência marginal. Conclusão: O cálculo ureteral silencioso está associado à diminuição da função renal e algum grau de hidronefrose já ao diagnóstico. Idade, espessura do parênquima renal e grau de hidronefrose predizem o valor inicial do 99mTc-DMSA. Enquanto a hidronefrose regride após a remoção do calculo, a função renal se mantém inalterada. Nenhum fator conseguiu predizer significativamente a evolução da função renal ao 99mTc-DMSA doze meses após o tratamento / Introduction: Ureteral stones may be asymptomatic in 0.3-5.3% of patients. The natural history and the disease influence on renal function have been poorly studied. Objective: to evaluate the impact of silent ureteral stone on renal function before and after treatment, searching for predictive factor of better outcomes. Material and Method: A ureteral stone was defined as silent if the patient had no subjective/objective symptoms related to the calculus. Patients with a silent ureteral stone were prospectively enrolled in the study. Patients were evaluated with 99mTc-DMSA scintigraphy, serum creatinine (Cr), Cr clearance (CrCl) and ultrasound (USG) pre and post-operatively on months three and 12. Patients treated outside our institution or with incomplete perioperative evaluation were excluded. ANOVA, Chi-square/Fisher test, and regression analysis were used. Significance was set at p < 0.05. Results: Between Jan/06-Jan/14, 26 patients with silent ureteral stones met our inclusion criteria, comprising 2.1% of all ureteral stones treated at our institution. Half of patients were female, mean age was 59.3 ± 11.3 years-old. Stone diagnosis was related to a urological cause in 14 (53.8%) cases. Mean stone diameter and density were 11.8 ± 2.8 mm and 1201 ± 272 HU, respectively. Only two patients had no hydronephrosis at initial USG evaluation and mean renal parenchyma thickness was 10.7 ± 4.1mm. Mean preoperative Cr, CrCl and 99mTc-DMSA were 1.24 ± 0.87 mg/dL, 72.5 ± 25.2 mL/min and 33.4 ± 16.7%, respectively. Twenty (77%) patients had 99mTc-DMSA < 45% at initial examination. Multiple regression revealed age (p=0.041) and renal parenchyma thickness (p=0.001) to predict initial 99mTc-DMSA. When compared to preoperative values, Cr (p=0.89), CrCl (p=0.48) and 99mTc-DMSA (p=0.19) remained unaltered three and 12 months postoperatively. Hydronephrosis improved from before to three months after treatment (p < 0.01), but remained unchanged from three to 12 months (p=0.06). No preoperative variable was able to predict a > 5% variation on 99mTc-DMSA from pre to postoperative periods, though stone size (p=0.12) and time to treatment (p=0.15) had a marginal influence. Conclusion: Silent ureteral stones are associated with decreased renal function and hydronephrosis already at diagnosis. Age, renal parenchyma thickness and degree of hydronephrosis predict initial 99mTc-DMSA. Hydronephrosis tends to diminish after stone removal, while renal function remains stable. No preoperative factor significantly predicted renal function progression twelve months postoperatively