The East African Community (EAC) suffers from a critical lack of cross-border railway networks that, if remedied, could improve regional connectivity and boost intraregional trade. The region would also become more investor friendly. Cross-border railway connectivity is particularly important owing to the challenging geographical location and small, uncompetitive and inefficient Partner States. The EAC Partner States have embarked on an ambitious programme to jointly revamp the region’s railways to address the transport deficits. Joint implementation of transport infrastructure projects offers economies of scale. However, joint efforts are constrained by inefficiencies of the region’s legal and institutional frameworks. The region is characterised by inefficient legal and institutional frameworks. This research argues that it is critical to first address the legal and institutional bottlenecks which will in turn constitute the backbone to support EAC’s efforts towards development and sustainable management of cross-border railways in the EAC. The research reviews effectiveness of the existing legal and institutional frameworks, identifies gaps and, using Southern African Development Community (SADC) as a benchmark proposes solutions for improvement. / Dissertation (LLM)--University of Pretoria, 2014. / gm2015 / Centre for Human Rights / LLM / Unrestricted

The main objectives of the study was to determine the exclusivity of the objectives of the regional groupings within the SADC region and to assess the impact that membership overlaps has on the realization of specific regional grouping objectives.A qualitative research approach was adopted. Semi-structured in-depth expert interviews were used to determine the issues arising from regional membership overlaps in the SADC region.Due to limited literature around the subject of regional integration in the SADC region, work done by my supervisor Dr Jannie Rossouw were cited in some instances.Recent developments in the Western economies that have resulted in the refocusing of the SADC region have resulted in polarization amongst the regional groupings in Africa. Furthermore, existing regional groupings within the Southern Africa, have endenvoured on an ambitious regional integration agenda which has resulted in membership overlaps within the existing regional bodies. The study found that these regional overlaps are costing the affected member states in the form of monetary subscription and through the deployment of the rare human skilled resources to regional secretariats. The advent of the European Partnership Agreements has caused polarization within the SADC region through the signing of various bi-lateral and multi-lateral agreements. Most importantly, this study found that structural overlaps exist within SADC itself. A lack of sufficient political will amongst SADC member states was also noted as an impediment to regional integration.However, the study also noted some positive performances of existing regional grouping despite membership overlaps. The Common Monetary Area was highlighted as a grouping that was performing in line with prescribed regional integration convergence indicators. / Dissertation (MBA)--University of Pretoria, 2012. / Gordon Institute of Business Science (GIBS) / Unrestricted

Citrus black spot (CBS) caused by Guignardia citricarpa is responsible for economic losses in Southern African countries such as South Africa, Mozambique, Swaziland, Zimbabwe and Namibia. Black spot is considered to be a phytosanitary disease for the European Union and the United States of America markets. Exporters to these countries incur losses throughout the supply chain due to phytosanitary restrictions. For these reasons, the occurrence and management practices of CBS and its impact on growers in Southern Africa were investigated through a survey using a questionnaire. In the study, it was found that when CBS was present it was primarily managed by using chemicals and general orchard sanitation. In addition, growers in some of the surveyed countries or production regions follow spraying programs that are based on disease forecasting models and this practice has proven very effective in managing the disease. Furthermore, furfural, a sugarcane waste product was assessed for its efficacy in controlling G. citricarpa. The efficacy of the product as a contact or a fumigant was demonstrated in vitro and in vivo on fresh leaves, leaf litter and fruit lesions as well as in soil. A molecular study, using a Polymerase Chain Reaction protocol was conducted to assess the survival of the pathogen in the soil after exposure to furfural. The product however only proved efficient under natural conditions. The non-target effect of furfural on the soil micro-flora was also assessed. The product proved suitable for soil applications as it is not phytotoxic and has minimal non-target effects on bacterial populations. Furfural proved to control G. citricarpa, by breaking the life cycle, thus reducing the disease incidence. The application of furfural on a larger scale (irrigation or spraying) will therefore improve the control of CBS in developing countries. / Dissertation (MInstAgrar)--University of Pretoria, 2008. / Microbiology and Plant Pathology / unrestricted

Fifteen countries which are members of the Southern African Development Community (SADC) have embarked on a regional integration initiative. In 1996, a trade protocol that aimed to increase trade among members by removing trade barriers was signed. In the year 2000, this protocol was implemented, leading to a Free Trade Area (FTA) in 2008. More than 85 % of SADC trade was free of customs duties from 2008 onwards. However, while custom tariffs were reduced, the share of SADC trade did not show any improvement over the tenyear period after implementing the trade protocol. Accordingly, the objective of this study is to examine the factors which contributed to lack of improvement in SADC trade, particularly the role of Non-Tariff Measures (NTMs). One of the main challenges in analysing NTMs in SADC is the unavailability of relevant information. An SADC NTM database was built as a repository of official NTMs. In order to quantify NTMs, a database was classified, similarly to the international database. Agricultural products at HS 4-digit level for ten SADC countries were included in this repository, and groupedinto six main categories; namely animal products, cereals, horticultural products, oilseeds, industrial and processed products. The trade data challenges within SADC countries inadvertently prescribed the econometric methods to apply for the set objectives of the study. The two main challenges of SADC trade data are missing data for some years and high percentage of zero trade flows. A latent threshold gravity model was employed with hierarchical specification to control for country effects. The hierarchical model captures individual country effects, such as the impact of NTMs on trade volumes, and thus intra-SADC trade. Such impact was then assessed when an additional NTM is introduced or increases trade volumes. The two effect models were examining the attributes of changes in regional trade, as well as those attributes of change in NTMs. The effects NTMs were incorporated into the model by weighting the number of NTMs by share of trade in the region, as well as ranks of country NTMs within product groups. Types of NTMs which were estimated are Sanitary and Phyto-Sanitary measures (SPS), Technical Barriers to Trade (TBT) and an aggregation of all other NTMs which do not belong to the two groups. Results show that there is evidence NTMs were increasing at the same period when tariffs were being reduced. Using the inventory methods of evaluating presence and prevalence of NTMs, it was also evident that NTMs are used across most agricultural products. The percentage of products affected by NTMs in 2010 was much higher than in 2000. The econometric model results show that all gravity model variables, GDP, border and language were consistent with the theoretical expectations.Distance does nothave significant influence on SADC trade. The reason for this has to do with the trading pattern of SADC countries, which is very high between contiguous members, compared to non-contiguous members. The estimation of zero observed trade, using a threshold model, provided additional understanding of the role and reasons for such trade. The estimated effects of the observed zero trade showed that if this threshold is high, implying that trade costs (NTMs) are restricting trade, then zero trade was observed. When high percentage of zero trade is observed, then intra-SADC trade remains small or declines. However, if the threshold is low, intra-SADC trade increases, as was observed in the case of industrial products. The overall results confirm that NTMs do have an impact on intra-SADC trade. Industrial and cereal products are more responsive to NTMs than the other five product groups. A unit change in NTMs by regional trade members has more effects on intra- regional trade than a unit change in trade value. That is the case because the SADC is already exchanging a large share of its total trade with non-SADC members. Therefore, attention should be given to addressing the way NTMs are introduced. One of the important findings from the study is that the intra-SADC trade is affected more by the effect of an additional NTM, than an additional unit of trade in value. The effect of addressing NTMs is one and half more than those of additional trade value. So, in order to improve intra-SADC trade performance, focus must on addressing the NTMs and growing trade. In addressing NTMs, it does not necessarily require removing or even reducing them. It is about making it easy to comply with them. SADC trade can be improved substantially by aiming to harmonise NTMs and overall policies. / Thesis (PhD)--University of Pretoria, 2014. / lk2014 / Agricultural Economics, Extension and Rural Development / PhD / unrestricted

The aim of the thesis is to examine the relationship between inflation and economic growth using the Southern African Development Community (SADC) as a case study. The motivation emanates not only because of the lack of studies analysing this relationship in the SADC region, but also due to the fact that this relationship may differ from the one that exists in developed countries due to the level of economic development and prudent macroeconomic policies being practised in the latter (Sarel, 1996). The relationship may differ because the vast majority of developed countries have established independent central banks with a clear mandate to keep inflation levels within a specific range (adopted an inflation targeting framework). However, in most developing countries, central banks do not have a clear inflation targeting monetary policy framework, for instance, in the SADC region, only South Africa has adopted an inflation targeting monetary policy framework. High inflation episodes are known to contribute to macroeconomic instability, therefore policy makers find it important to understand the kind of the relationship that exists between inflation and economic growth in order to develop and implement sound macroeconomic policies. Therefore, inflation is viewed to be one of the basic indicators of macroeconomic stability; hence it is an indicator of the ability of the government to manage the economy. High levels of inflation may be indicative of a lack of sound governance by the monetary authority of a country. In addition, it is a sign of government that has lost control of its finances (Fischer,1993). The thesis addresses issues of nonlinearities in the inflation-growth nexus by endogenously estimating the threshold level of inflation below which inflation may have no, or positive, impact on economic growth, or above which inflation may be detrimental to economic growth. It also assesses the effects of a shock to inflation in South Africa, being the largest economy in the region, on inflation and economic growth of the rest of the region. First, different panel data methodologies; Fixed Effects (FE), Difference Generalised Method of Moments (DIF-GMM), System Generalised Method of Moments (SYSGMM), and Seemingly Unrelated Regression (SUR) estimators are used in order to examine the relationship between inflation and economic growth in the region. Second, Panel Smooth Transition Regression (PSTR) methodology is utilised to examine the nonlinearities in the inflation-growth nexus. In particular, the threshold level of inflation is endogenously estimated and the smoothness of the transition from a low to a high inflation regime in the region is also estimated1. Thirdly, the effects of South African inflation on the inflation and economic growth in the rest of the region are assessed using impulse-response functions derived from estimating a Panel Vector Autoregression (PVAR) model. Overall, the study deals with problems which are normally encountered when using cross-country data such as endogeneity, heterogeneity and cross-sectional dependence. The main findings of the study are that inflation and economic growth in the region are negatively related, as is also the case in other regions of the world as depicted by the empirical literature (Fischer, 1993 and De Gregorio, 1993). Therefore, in terms of the inflation-growth link, the SADC region is not different from all the other regions around the globe. Secondly, the threshold level of inflation in the region is estimated at 18.9 per cent, which is in line with the findings of authors like Drukker et al. (2005), Mignon and Villavicencio (2011), and Ibarra and Trupkin (2011), who found a threshold level of 19.2 per cent, 19.6 per cent, and 19.1 per cent for developing countries. However, this threshold level marginally exceeds that of Khan and Senhadji (2001), Schiavo and Vaona (2007), Moshiri and Sepehri (2009) and Espinoza et al. (2010), which studies report threshold values between 10 and 12 per cent for developing countries. The empirical results also reveal that shocks to South African inflation have significant economic impact on inflation, openness, investment and economic growth in the rest of the SADC region. In particular, more interestingly, South African inflation is found to have a negative and statistically significant impact on economic growth in the region for up to about 12 years after the shock, after which, it becomes insignificant. The contribution of the thesis to the literature is that, firstly, this looks into the inflation-growth relationship in the context of Africa, in particular the SADC region; as such an investigation or research has not been conducted before. Secondly, the research takes advantage of panel data methodologies so as to provide more robust estimates and confront the potential bias emanating from problems such as endogeneity, heterogeneity and cross-country dependence that may have affected previous empirical work on inflation-growth nexus. This is believed to provide more informative estimates on the inflation-growth link, and therefore deepens our knowledge of the region. / Thesis (PhD)--University of Pretoria, 2012. / Economics / unrestricted

>Magister Scientiae - MSc / Wetlands are unique ecosystems that are acknowledged among the world’s most productive and valuable ecosystems. They are recognized as being essential to sustainable development and human welfare due to their unique environmental and socio-economic value. These highly productive ecosystems provide functions such as recycling of nutrients, watershed protection and flood control as well as grazing resources. Wetlands provide the basis for human livelihoods in Africa through ecosystem services. However, these ecosystems are affected by internal and external factors within and outside their catchments, hence the importance of monitoring those changes around these wetlands.

A Research Report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfilment of the requirements for the Degree of Master of Science in Medicine (Pharmaceutical Affairs) Johannesburg, 2016 / Background The World Health Organization (WHO) defines medicines regulation as the “promotion and protection of public health by ensuring the safety, efficacy and quality of drugs, and the appropriateness and accuracy of product information” (1). Medicines regulation is a key function in the realisation of the right to essential medicines. However, a satisfactory level of harmonization of regulatory activities has not been achieved in the Southern African Development Community (SADC) region as yet. Objectives The study evaluated the current status of medicines regulatory harmonization within the SADC region, as well as explored perceived barriers to regulatory harmonization and potential strategies to address these. Methods A cross-sectional exploratory study design with qualitative techniques, as well as an inductive approach was used. In-depth, semi-structured, face-to-face interviews with interviewees from the SADC Secretariat, the African Medicines Harmonization (AMRH) Initiative and the Southern Africa Regional Programme on Access to Medicines and Diagnostics (SARPAM) was used, involving secondary formal qualitative approaches to identify the emergent themes, was utilised initially. A questionnaire was formulated and adapted using secondary data collected from the face-to-face interviews, then piloted. Questionnaires were sent to senior members of all 15 regulatory authorities belonging to SADC, including registrars and deputy registrars. Theoretical and analytical codes were identified from repeated ideas, concepts or elements. Codes were grouped into concepts, and then into categories. Trend analysis was conducted, involving an in-depth analysis of patterns. Results Barriers to regulatory harmonization in the SADC region perceived by participants included i) deficiencies in governance and leadership within the SADC Secretariat, ii) human resource and technical capacity constraints, iii) limited financial resources, iv) lack of political will within SADC governments, v) lack of intra-SADC relationships, vi) risk-benefit analysis differences in assessment of applications and bias according to local population needs, as well as vii) different guidance documents and legal frameworks among member countries. Strategies identified to address these included i) using other harmonization initiatives as models, ii) application format harmonization and African Union (AU) Model Law adoption, iii) redirecting focus of harmonization to information sharing and technical matter rather than complex legislative frameworks, iv) regulator initiatives of harmonization instead of SADC secretariat reliance, v) World Bank Agreement adoption, vi) human resource capacity development and vii) convergence of guidelines instead of complete harmonization of all regulatory requirements. Conclusions The findings in this study suggest that it may be necessary to redirect the focus of harmonization to more readily achievable activities and aim for convergence of guidelines. Regulatory harmonization is possible if barriers to it are addressed. / MT2016

Globalisation and trade integration have positioned Foreign Direct Investment (FDI) as a development imperative for many developing countries, including Southern African Development Community (SADC) economies. Despite concerted efforts both at individual country level and at regional level, FDI flows to the SADC region have declined compared to other regions in the world. The main reasons posited for SADC's inability to attract and retain FDI include negative risk perceptions; a weak ease of doing business environment, and endemic corruption. Hence, the study seeks to investigate the relationship between FDI inflows and corruption and ease of doing business in SADC. The research applies Generalised Method of Moments (GMM) analysis to all 16 SADC countries over a period of 2010 to 2019. The results show that although both corruption and ease of doing business are significantly and positively relate to FDI inflows in SADC, ease of doing business affects FDI to a greater extent compared to corruption. In addition, the inclusion of the interaction between corruption and ease of doing business shows that FDI inflows are more closely attracted by ease of doing business than by corruption.

The majority of the world’s most widespread and problematic pathogens evade host immune responses by inducing strain-specific immunity. The host immune system seems to induce a vigorous immune response towards hypervariable epitopes, seemingly attracting less attention to more highly conserved vital regions. The South African Territory (SAT)-2 foot-and-mouth disease virus (FMDV) is the most prevalent and antigenic diverse of the SAT serotypes with the occurrence of multiple antigenic and genetic subtypes. Identification of the fine antigenic structure of the capsid of these viruses remains essential in the design and engineering of a vaccine seed strain that confers cross-protection against intra-typic viruses. Towards refocusing the antigenicity of SAT2/ZIM/07/83 virus, two strategies were utilised, (1) replacement of predicted antigenic determinants to corresponding sites of the antigenic distant SAT2/EGY/09/12 virus and (2) charge-dampening of previously identified epitope regions with alanine residues. The antigenic distance of refocused mutants was evaluated by (1) virus neutralisation assays using parental and heterologous convalescent bovine sera and (2) through antigenic profiling with non-neutralising SAT2-specific murine monoclonal antibodies (mAbs). One antigenic site on VP1 (Site 3) was identified using bovine polyclonal antibodies, whereas an additional three epitope regions were elucidated using the murine mAbs. Furthermore, the cell culture-adapted vSAT2 was shown to utilise a third FMDV alternate receptor to infect integrin- and heparin sulphate-deficient cell lines. Comprehensive knowledge on the antigenic structure of these viruses will assist in the fundamental design of engineered vaccines by incorporating critical antigenic sites that confer increased antigenicity and cross-protective immune response against myriad SAT2 field strains. Furthermore, this information will not only improve design of vaccine seed viruses, but will also contribute towards novel vaccine constructs or even empty nanoparticles as a vaccine strategy in the future. / Thesis (PhD)--University of Pretoria, 2020. / Agricultural Research Council / National Research Foundation / Red Meat Industry Trust / Poliomyelitis Research Foundation / Microbiology and Plant Pathology / PhD / Unrestricted

This thesis examines regional integration in Southern Africa and the evolution of SADC. Regional developments are evaluated with the yardsticks of integration theory, against the background of international regionalisation, and in terms of the region's practical record, its rhetoric and future agenda. The extent to which economic integration is progressing, is determined, after which the thesis focuses on political integration within SADC - both de Jure and de facto. Finally, developments within the region are evaluated in light of normative prerequisites for increased political integration. The thesis finds that the integration process in SADC does not fit into traditional integration theory, and concludes that successful economic integration in the region is not necessarily a prerequisite to political integration, but would facilitate it. The research finally concludes that there is evidence of embryonic political integration within SADC, which will wane or grow depending primarily on the political will of its constituents / Political Science / M.A. (Politics)