Background: Patients diagnosed with melanoma frequently search the internet for treatment information, including novel and complex immunotherapy. However, health literacy is limited among half of the German population, and no assessment of websites on melanoma treatment has been performed so far. Objective: The aim of this study was to identify and assess the most visible websites in German language on melanoma immunotherapy. Methods: In accordance with the common Web-based information-seeking behavior of patients with cancer, the first 20 hits on Google, Yahoo, and Bing were searched for combinations of German synonyms for “melanoma” and “immunotherapy” in July 2017. Websites that met our predefined eligibility criteria were considered for assessment. Three reviewers independently assessed their quality by using the established DISCERN tool and by checking the presence of quality certification. Usability and reliability were evaluated by the LIDA tool and understandability by the Patient Education Materials Assessment Tool (PEMAT). The Flesch Reading Ease Score (FRES) was calculated to estimate the readability. The ALEXA and SISTRIX tools were used to investigate the websites’ popularity and visibility. The interrater agreement was determined by calculating Cronbach alpha. Subgroup differences were identified by t test, U test, or one-way analysis of variance. Results: Of 480 hits, 45 single websites from 30 domains were assessed. Only 2 website domains displayed a German quality certification. The average assessment scores, mean (SD), were as follows: DISCERN, 48 (7.6); LIDA (usability), 40 (2.0); LIDA (reliability), 10 (1.6); PEMAT, 69% (16%); and FRES, 17 (14), indicating mediocre quality, good usability, and understandability but low reliability and an even very low readability of the included individual websites. SISTRIX scores ranged from 0 to 6872 and ALEXA scores ranged from 17 to 192,675, indicating heterogeneity of the visibility and popularity of German website domains providing information on melanoma immunotherapy. Conclusions: Optimization of the most accessible German websites on melanoma immunotherapy is desirable. Especially, simplification of the readability of information and further adaption to reliability criteria are required to support the education of patients with melanoma and laypersons, and to enhance transparency.

Structure, composition, and optical properties of colloidal mercaptoacetate-stabilized Cu2ZnSnS4 (CZTS) nanocrystal inks produced by a “green” method directly in aqueous solutions were characterized. A size-selective precipitation procedure using 2-propanol as a non-solvent allows separating a series of fractions of CZTS nanocrystals with an average size (bandgap) varying from 3 nm (1.72 eV) to 2 nm (2.04 eV). The size-selected CZTS nanocrystals revealed also phonon confinement, with the main phonon mode frequency varying by about 4 cm−1 between 2 nm and 3 nm NCs.

Cancer cells use the interaction between immune-checkpoint receptor programmed cell death protein 1 (PD-1) on activated T cells and programmed cell death ligand 1 (PD-L1) on tumor cells and various cell types of the tumor microenvironment to evade immune surveillance. Blocking the interaction between PD-1 and PD-L1 with checkpoint inhibitors can improve T-cell reactions and mediate efficient antitumor activity in a variety of solid tumors including melanoma. However, clinical data from patients with myeloid diseases that are treated with these agents are limited to clinical trials in advanced disease. Pembrolizumab (PEM) is a humanized monoclonal antibody of the immunoglobulin G4/κ isotype designed to block PD-1/PD-L1 interactions and is approved for various solid tumors including advanced melanoma.

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Der Coronavirus SARS-CoV-2 hat die TU Dresden im Sommersemester 2020 gezwungen, innerhalb von ca. einem Monat fast die gesamte Lehre in den virtuellen Raum zu verlegen. Diese spezielle Situation an der TU Dresden wurde wissenschaftlich durch das Zentrum für Qualitätsanalyse begleitet. Um den Veränderungsprozess auch über einen gewissen Zeitraum begleiten zu können, wurden alle Lehrenden und Studierenden insgesamt drei Mal im Sommersemester 2020 befragt. Die erste Befragung fand nach zwei Wochen Lehrveranstaltungsbetrieb, die zweite ca. in der 10. Woche des Lehrveranstaltungsbetriebs und die dritte kurz nach Beginn der Prüfungszeit statt. Im vorliegenden Bericht werden die Ergebnisse der ersten Befragung vorgestellt. Die Forschungsstudie wurde konzipiert und durchgeführt in enger Zusammenarbeit mit dem Prorektorat für Bildung und Internationales (Dr. Rainer Schaffer) und dem Zentrum für interdisziplinäres Lernen und Lehren (Henriette Greulich). Wir danken für die Unterstützung durch die Mitarbeiterinnen des Forschungsprojektes „tech4comp - Personalisierte Kompetenzentwicklung durch skalierbare Mentoringprozesse“, gefördert vom Bundesministerium für Bildung und Forschung (BMBF) – FKZ: 16DHB2103.:Verzeichnis der Tabellen Verzeichnis der Abbildungen 1. Ziel der Studie und erste zentrale Erkenntnisse 2. Aktuelle Pandemiesituation und Stand der Umstellung auf virtuelle Lehre 3. Von den Lehrenden verwendete Tools und den Studierenden angebotene Formate 4. Arbeits- und Studiensituation im Notbetrieb/Homeoffice 5. Kompetenzen im Bereich digitaler Lehre und Unterstützung durch die TU Dresden 6. Gesamteinschätzung der Umstellung zur digitalen Lehre Anhang Anhang 1: Zielgruppe und methodischer Zugang Anhang 2: Startseite und Datenschutzerklärung Anhang 3: Fragebogen Lehrende Anhang 4: Fragebogen Studierende

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