By undertaking a number of different experimental approaches at the genetic, cellular/ molecular and integrative physiology levels, I investigated functional variation in the Hypoxia-Inducible Factor (HIF) transcription pathway in humans. My studies focused on Tibetan natives. Tibetan highlanders are adapted to life in a hypoxic environment and exhibit distinct physiological traits at high altitude. Recent studies identified positive selection at two genetic loci, EPAS1 (HIF2α) and EGLN1 (PHD2), in Tibetan highlanders and demonstrated an association of EGLN1/EPAS1 genotype with haemoglobin concentration. Both are genes of the HIF pathway, which coordinates an organism’s response to hypoxia. Patients living at sea level with genetic diseases of the HIF pathway have characteristic phenotypes at both the integrative physiology and cellular levels. I investigated whether Tibetans living at sea level also possess distinct phenotypic characteristics, and whether these may be related to underlying variation within the HIF pathway. I compared Tibetans living at sea level with Han Chinese, their most closely-related major ethnic group, and found that Tibetans possess a significantly different integrative physiology phenotype. Tibetans had a lower haemoglobin concentration and haematocrit, a higher pulmonary ventilation relative to metabolism, and blunted pulmonary vascular responses to both acute (minutes) and sustained (8 hours) hypoxia. Regarding genotype- phenotype relationships within the Tibetans, I found a significant correlation between both EPAS1 and EGLN1 genotype and the induction of erythropoietin by systemic hypoxia. At an intermediate cellular level, the relative expression and the hypoxic induction of HIF- regulated genes were significantly lower in peripheral blood lymphocytes from Tibetans compared with Han Chinese. I also investigated whether the genetic variation in EPAS1 selected for in Tibetans may be functional at the molecular level by affecting transcription of EPAS1 in cells and whether certain coding variants in <e,>EGLN1 found in Tibetans affect protein (PHD2) activity in cells and in vitro. A small supplementary study was undertaken in patients with idiopathic erythrocytosis, who have elevated or inappropriately normal erythropoietin levels, to investigate if they have genetic alterations in the HIF system.

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Cette thèse est consacrée à l’étude de la question tibétaine et des différents aspects sous lesquels elle est traitée : géographique, économiques, stratégiques et politiques. Nous étudions l’évolution des attitudes et les divergences d’opinion selon une polarisation allant du conservatisme au progressisme. Nous en mesurons les influences dans l’histoire récente et nous projetons les développements probables à court et moyen termes.- Cette thèse s’attache à démontrer que le Tibet reste un enjeu important pour la Chine et qu’à ce titre, la ligne de chemin de fer reliant le Qinghai au Tibet symbolise la politique et la solution chinoise vis-à-vis du Tibet. - Cette thèse s’attache à démontrer que le dalaï-lama est toujours considéré par les tibétains comme la seule instance à même de pouvoir résoudre les problèmes tibétains, et ceci en dépit des nombreuses crises auxquelles le chef spirituel a pu être confronté.- Enfin, cette thèse s’attache à démontrer que la société chinoise est en train d’évoluer vers une attitude plus progressiste. Sur cette question notamment, les intellectuels chinois ont acquis davantage d’influence que par le passé, influence qui pourrait, à l’avenir, se développer davantage. Ce travail, relevant d’un champ d’analyse pluridisciplinaire, couvre l’essentiel du XXème siècle et de l’époque actuelle. Il se focalise particulièrement sur la période postérieure aux années 1980, qui a été le témoin d’une internalisation plus poussée de la question tibétaine. / This thesis focuses on the Tibetan issue in its various aspects: geographic, economic, strategic and political. We examine the evolution of attitudes and differences of opinion according to their polarization ranging from conservatism to progressivism. We assess their influences in recent history and we project the likely developments in the near future.- This thesis aims at showing that Tibet remains an important matter at stake for China. Hence the Qinghai-Tibet rail link embodies the Chinese national policy as well as the Chinese solution vis-à-vis Tibet.- This thesis aims at demonstrating that the Dalai Lama is still regarded by Tibetans as the key to the resolution of Tibetan problems despite the many crises the spiritual leader has had to face.- Finally this thesis aims at pointing out that the Chinese society is evolving towards a more progressive attitude. On this issue Chinese intellectuals have acquired more influence than before and this influence could develop even further in the future. This work belongs to an inter-disciplinary field of study and covers most of the 20th century and present times. It focuses especially on the post 1980’s period when the Tibetan issue became more international.

This diploma thesis aims to create the comprehensive summary of modern Tibetan history before and after Chinese invasion, primarily the period between the years 1933-1959. At the same time the description of discrepancies between respective researchers is emphasized. Although high-quality secondary literature was used, there can be found minor or major contradictions in the statements of reputable scientists. For this reason there are mentioned both statements in these cases. Description of possible reason of the contradiction is also included. Several major discrepancies between the researchers' statements have been found, which were elaborated more precisely. Summary of a part of modern Tibetan history was created as well, because there is a lack of Czech language publications concerning this topic.

This dissertation explores entanglements of body, national identity and nature in contemporary Mongolia. The project is situated within the rising popularity of natural remedies and alternative medicine during a time described as disorganized (zambaraagui) and disorderly. Data was collected from 33 months of fieldwork in Ulaanbaatar and elsewhere, focused on non-biomedical practices and therapeutic landscapes, especially medicinal springs (arshaan) and their sanatoria. This work contributes to studies of post-socialist Mongolia in a few ways. The methodological decision to engage in interview and participant observation of fortunetellers (üzmerch), practitioners of Buddhist and traditional medicine (otoch, ardiin emch), astrologists (zurhaich), energy healers (bio energich), shamans (böö, zairan, udgan), enlightened lamas (huvilgaan) and massage therapists (bariach) was driven by the fluid approach with which patients approach fulfilling the needs of their health and wellbeing. Such fluidity was also echoed in healing practice; as opposed to bounded by strict conceptual distinctions, healers re-purposed personally and culturally-familiar techniques, ranging from biomedical to those of Buddhist medicine (sowa rigpa) to occult practices. Many of the same techniques were practiced by a range of practitioners. The term orthopraxy, commonality of practice across conceptual difference, is used to address this phenomena. Such pairing together of different kinds of therapies – biomedical or otherwise – calls into question a “traditional” vs. modern or neo-spiritual framework within which such practices are often cast. I employ Robbin’s anthropology of discontinuity (2003), suggesting that Soviet influences represented “hard” cultural forms that provided a partial rupture in cultural knowledge between pre-revolutionary society and 1990. Nature (baigal) and natural surroundings (baigal orchin) were concepts often raised when discussing health and wellbeing. “Spiritual” earth and mountain masters (gazariin/uuliin ezed) of estranged homelands (nutag) that cause illness in families relocated to Ulaanbaatar; the water, flora, and mutton from one’s homeland as especially medicinally-suited to the body; shamans empowered to heal by appropriating into their practices the worship of nationally-significant mountains: territorialized national identity represented a prominent trend in healing practices. The revering of a nation through natural landmarks I call national nature, and suggest it be seen both with respect to romantic and utilitarian conceptions of a therapeutic nature that underpinned Soviet medicine, and Soviet indigenization campaigns and the ethnonationalism that was encouraged to flourish in borderland republics. Affective rooting to natural landmarks to maintain or restore wellbeing was also a way to enact Mongol-ness, rendering healing the body at once a practice of national subject-making.

Made available in DSpace on 2016-04-25T19:20:55Z (GMT). No. of bitstreams: 1 Julia Signer e Cruz.pdf: 940902 bytes, checksum: 08ea98e2b16c5857fa67dab7a4a23bab (MD5) Previous issue date: 2008-09-15 / This paper has as purpose to observe the psychological effects of the rigpa´s (clear light) experience among some Tibetan Buddhist practioners. As I didn t find academic researches with this object, this paper came to fullfill this fault. We use as theoretical base the Jung s psychology and the philosophy of Ati and Anutara Yogas of Tibetan Buddhism. Twenty two practioners, ages between 23 and 71 years old of both sexes were interviewed. The results allows us to conclude that rigpa s experience make possible to realize the human existence in a more open way where the Consciousness is fixed in a place deeper than the ego, what may produce a existential experience of union with the universe, a natural feeling of joy, freedom and well being, a body relaxation and a sense of mental openness with a spontaneously sense of natural wisdom / Esta dissertação tem como objetivo observar os efeitos psicológicos da experiência de rigpa (clara luz) entre praticantes do Budismo Tibetano. Como não foram encontradas pesquisas acadêmicas que enfoquem esse objeto, o presente estudo visa suprir essa carência. Como base teórica usamos a psicologia junguiana e a filosofia das yogas Ati e Anutara do Budismo Tibetano. Realizou-se uma pesquisa de campo constituída de entrevistas semi-abertas com 22 praticantes de idades variantes entre 23 e 71 anos, de ambos os sexos. Os resultados revelam que a experiência de rigpa permite conceber a existência humana de maneira mais profunda e sediar a Consciência em um lugar mais profundo do que o eu, o que leva a uma vivência existencial unida a todo o Universo, a um sentimento espontâneo de alegria, liberdade e leveza, a um relaxamento corporal e a uma sensação de abertura mental, com o surgimento espontâneo de uma sabedoria natural

L'objectif de cette thèse est de comprendre la formation, la structuration et les processus de réactivation d'une chaîne de montagne intracontinentale atypique : les Longmen Shan, situés dans la province du Sichuan, en Chine. Localisés à la limite entre le craton du Yangtze où s'est déposé le bassin du Sichuan (au Sud-Est) et le bloc du Songpan Garze appartenant au plateau tibétain (au Nord-Ouest), les Longmen Shan se sont majoritairement structurés lors de l'orogénèse indosinienne, à la fin du Trias et ont ensuite subit plusieurs réactivations.Cette chaîne de montagne est donc un endroit privilégié pour étudier la réactivation et l'héritage structural et thermique d'une structure intracontinentale, en relation étroite avec la formation et l'évolution du plateau tibétain. Tout d'abord, pour contraindre les paramètres crustaux, une imagerie crustale détaillée le long d'une coupe à travers cette chaîne est proposée. Une réseau sismologique de 35 stations a été déployé pendant plus de 2 ans le long d'un profil dense. La technique des fonctions récepteurs a été appliquée et les données gravimétriques ont été utilisées conjointement pour renforcer l'imagerie obtenue. Un saut de Moho abrupt de 20km a été imagé, entre une croûte tibétaine épaisse d'environ 63km et la croûte du craton du Yangtze , épaisse de 45km. Ce résultat traduit la confrontation de deux lithosphères d'épaisseurs et de propriétés physiques contrastées. Les rapports Vp/Vs ainsi que les mesures d'anisotropie crustale et mantellique ont montré l'absence d'une zone à faible vitesse ou d'une zone de fluage important au sein de la croûte, ce qui réfute les modèles de déformation de la croûte tibétaine impliquant un chenal de déformation au sein de la croûte tibétaine. L'imagerie crustale a donc mis en évidence un important contraste à l'échelle lithosphérique. Le second axe de ce travail a consisté à étudier cette région à plus long terme en menant une étude stratigraphique, tectonique et métamorphique afin de déduire l'importance de l'héritage géologique dans sa structuration actuelle. Dès le début du Paléozoïque, la marge passive qui sera ensuite inversée présentait déja probablement une variation abrupte de l'épaisseur crustale. Un premier contraste d'épaisseur lithosphérique au niveau des Longmen Shan se situaient donc à la limite entre deux domaines paléogéographiques différents. A la fin du Trias, lors de la fermeture de la Paléotéthys, l'épais prisme sédimentaire du Songpan Garze a débordé sur la marge passive de la bordure Ouest du craton du Yangtze, dans la région des Longmen Shan. Cependant, il n'y a aucune évidence de subduction dans cette chaîne et le métamorphisme associé à cette phase de déformation correspond à des moyennes températures (jusqu'à plus de 600°C) pour des pressions relativement modestes. Les données métamorphiques ont montré un pic de pression (relativement faible, inférieur à 8kbar) suivi d'un pic de température pouvant conduire à une migmatisation associée à une exhumation variable en fonction de la localisation au sein de la chaîne. Les variations latérales de l'exhumation sont interprétées comme directement associées à la dynamique de la mise en place de la nappe du Songpan Garze sur la marge Ouest du craton du Yangtze. L'apex des Longmen Shan correspond donc au front de la nappe du Songpan Garze et délimite deux domaines structuraux et métamorphiques contrastés.Cette étude met en évidence une phase de réactivation à la fin du Crétacé de la chaîne, probablement associée à la rotation dans le sens horaire du craton du Yangtze. Enfin, la dernière phase de déformation affectant les Longmen Shan est une répercussion de la collision entre l'Inde et l'Eurasie qui fini de structurer cette chaîne.Nous avons donc montré qu'une limite paléogéographique majeure, héritée d'une structure en marge passive transtensive peut subir le débordement de nappes sédimentaires provenant d'un prisme distant de très grande taille. Ce débordement a provoqué une inversion de relief et un surépaississement crustal en conséquence de la superposition de ces épaisses nappes. Une fois cette limite tectonique formée, la région va subir plusieurs réactivations liées à des déformations annexes comme l'orogénèse Yanshanienne ou la collision entre l'Inde et l'Eurasie. Cette chaîne est encore active aujourd'hui comme l'a démontré le séisme du Sichuan du 12 Mai 2008 qui a eu lieu dans les Longmen Shan avec des caractéristiques atypiques. / The aim of this study is to understand formation, evolution and reactivation processes of an atypic intracontinental mountain range : the Longmen Shan (Sichuan, China). The Longmen Shan are located at the boundary between the Yangtze craton and the tibetan crust and were mostly formed during the indosinian orogeny, at the end of the Triassic. After this orogeny, the Longmen Shan were reactivated by several deformation phases. This mountain range is a key area to study reactivation processes and structural and thermal inheritance. Furthermore, the Longmen Shan tectonic history is linked with the formation and the evolution of the Tibetan Plateau.At first, a detailed seismological imagery was performed along a cross-section through the Longmen Shan, passing by the epicenter of the Sichuan earthquake. 35 seismological stations were deployed during more than 2 years with a small interstation distance. Using the receiver function method and gravimetric data, a steep Moho step of about 20km between the 63km-thick Tibetan crust and the 45km-thick Yangtze craton was imaged. This geometry is the result of the confrontation between the thick and soft tibetan lithosphere abutting the resistant Yangtze lithosphere. Vp/Vs ratio and crustal and mantellic anisotropic measurements indicate that there is no extensive zone of partial melting inside the tibetan crust, which is in disagreement with models that proposed the occurence of a channel flow inside the crust. The second part of this word was focused on the long-term study of the deformation in the Longmen Shan using stratigraphic, tectonic and metamorphic data. This part highlights the importance of the geological inheritance in the present-day crustal geometry of the mountain range. Since the beginning of the Paleozoïc, the Western passive margin of the Yangtze crust was probably already associated with a crustal thickness step, as a consequence of the transtensive openning context. The Longmen Shan were located at a paleogeographic boundary. At the end of the Triassic, the closure of the Paleotethys is responsible of the formation of the thick Songpan Garze accretionary wedge which overflowed on the Western part of the Yangtze craton margin, in the Longmen Shan area. There is no evidence of subduction in this belt and the associated metamorphism consists of middle temperatures and relatively low pressures. Metamorphic data indicates that a pressure maximum (lower than 8kbar) was followed by a temperature maximum which could be associated with partial melting, as observed in Danba metamorphic complexe. Lateral variations of the recorded exhumation are interpreted as a consequence of the dynamics of the setting up of the Songpan Garze nappe on the Yangtze craton margin. The Longmen Shan are located at the front of the Songpan Garze nappe and marks a transition zone between two contrasted tectonic and metamorphic provinces.This study highlights a cretaceous reactivation phase probably associated with the clockwise rotation of the Yangtze craton. At the end, the last deformation phase is a consequence of the India/Eurasia collision.The Longmen Shan were a major paleogeographic boundary at the end of the Paleozoïc which were subject to the overflow of the thick Songpan Garze accretionary wedge. This overflow is responsible of a relief inversion and a crustal thickenning as a consequence of superposition of the sedimentary pile. After this episode, the region will be reactivated by the distant Yanshanian and the Himalayan orogenies.

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Esta pesquisa integra aspectos do ensinamento budista tibetano no processo de criação cênica, com o objetivo de proporcionar ao ator e o diretor uma ampliação da percepção de si durante o fazer teatral. Para tanto, utiliza a meditação tibetana como prática principal visando possibilitar aos integrantes, através dos seus corpos, um encontro com uma presença plena e as Cinco Sabedorias apresentadas pelos ensinamentos tibetanos. Promove assim, a passividade criadora ressaltada por Jerzy Grotowski. Esta prática é experimentada primeiramente pela própria atriz/pesquisadora e depois compartilhada com um grupo em processo de criação da peça, Canção de Ninar, de Samuel Beckett. O método fenomenológico foi a abordagem utilizada para compreender, na cotidianidade do trabalho, as impressões e relações estabelecidas pelo grupo na experiência desta proposta. / This research integrate aspects of Tibetan Buddhist teaching in the process of scenic creation, with the objective of provide for the actor and the director a enlargement of the person‟s perception by themselves in the theatrical process. For this, uses meditation tibetan as main practice aiming at enble the leading members, through their bodies, a meeting with a full presence and the Five Wisdoms presented by Tibetan teachings. Thus promote the creative passivity underscored by Jerzy Grotowski. This practice is experienced primarily by the actress / researcher and then shared with a group in the process of creating the play, Canção de Ninar, by Samuel Beckett. The phenomenological method was the approach used to understand, in the everyday work, the impressions and relations, established by the group, through this proposal.

The westernmost spur of the Tibetan Plateau stretches to Eastern Ladakh in India. It is a region which remains poorly explored because of challenging conditions and long periods of political instability. At the same time, it is one of the highest places on earth supporting angiosperm life, which goes beyond 6000 m a.s.l. here. The whole region, due its remoteness, is practically unaffected by plant invasions and direct human activities. Thus, Ladakh represents a kind of "natural experiment", providing very long gradient of elevation suitable for comparative functional ecology as well as for testing various hypotheses concerning limitations of vascular plants. Arid climate and extreme elevations are the common factors. Our team pursued the goal of systematic botanical and ecological exploration of Ladakh, started by late Leoš Klimeš. This thesis provides insight into the main vegetation types, clonality in plants, plant-plant interactions and soil phototroph communities.