Master thesis deals with general basic design od autoclaves. It deals with the design of an optimal design solution autoclave to set parameters with the design requirement of hermetic doors for loading the workpiece. This solution is analyzed regard to stable pressure vessels. The whole design is processed in parametric SolidWorks software with which they are executed and initial stress analysis of individual designs. Final strength FEM analysis is performed using Ansys. Some proposals are technical-economic evaluation.

This master's thesis deals with design and development of a system for measuring altitude (height above ground level) of flying objects. It describes theoretical background related to altitude measurements in avionics as well as various techniques of altitude measuring. The measurement is conducted by HMD (Height measuring device) - embedded system which uses barometric pressure sensor to measure altitude. The main part of this thesis is dedicated to ground unit - a server running custom set of applications. Using this server and radio link, it is possible to send control commands to HMD, receive data, and propagate data into web application. Furthermore server acts as a data storage and is able to process and analyse data. The thesis also discusses the precision of the measurement and the data output. System was tested and used during several glider aerobatics competitions.

Anorexigenic neuropeptides have the potential to decrease food intake and ameliorate obesity and its complications such as high blood glucose or high blood pressure. However, they are not able to cross the blood-brain barrier after peripheral application. Recently, we have designed and synthesized lipidized analogs of prolactin-releasing peptide (PrRP), which resulted in stabilization of the molecule and allowed us to apply the peptide to the periphery to achieve its central biological effect, as it was demonstrated by increased neuronal activity shown by c-Fos in particular hypothalamus nuclei. The aim of this study was to choose the effective dose in acute food intake experiments and then to characterize the subchronic effect of palmitoylated PrRP analogs in mouse and rat models of obesity and diabetes. Several animal models were used: diet-induced obese (DIO) mice (C57Bl/6J), DIO Sprague-Dawley rats, and two rat models with leptin receptor-deficiency: Zucker diabetic (ZDF) rats and spontaneously hypertensive (SHROB) rats. Consumption of a high-fat diet in DIO mice and rats increased their body weight and blood pressure. Two-week intraperitoneal treatment with palmitoylated PrRP31 lowered the food intake, body weight, and returned the blood pressure to normal levels. This treatment also improved...

v anglickém jazyce The possible assessments of unprofessional exposures of low frequency noise Introduction: Along with technical development, the number of sources of low frequency noise increases in the human environment and the number of complaints from people exposed to noise from these sources increases as well. The statutory limit for non-professional exposure to low frequency noise has not yet been established (due to the limited amount of data on low frequency noise exposure risks) in the EU countries (USA) and no WHO recommendations have been issued in this area. For these reasons, the hygienic limit for municipal/non-professional exposure to low frequency noise was not specified in the Czech Republic. Objecticve: The present dissertation thesis was to investigate whether the short-term experimental exposure to low frequency noise with the tonic component induces significant changes in the circadian rhythm of cortisol and alpha-amylase in saliva in the experimental set of volunteers. Saliva is a biological material that allows low-invasiveness collection. The work was supposed to assess whether possible changes could be used as objective indicators of the presence of the stress response to the noise exposure. Material and metods: An experimental study was conducted on a set of 100...

This thesis is focusing on objectifying the postural function of diaphragm with a biofeedback sensor in patients with low back pain (LBP). The theoretical part provides an overview of known facts about the postural function of the abdominal muscles and diaphragm and the connection between their activation and the change in intra-abdominal pressure and the origin of LBP. The thesis gives specifics of LBP, its etiology and possible methods of classification of non-specific LBP, as well as the methods of evaluating subjective disability. Other methods of objectifying postural functions other than the one used in this thesis are mentioned briefly. Methodology: In the experimental part, we used a capacitive force sensor to test 31 patients with non-specific chronic LBP (aver. age 25.25, SD ± 4.66, aver. height 176.77 cm, SD ± 9.97, aver. weight 77.93 kg, SD ±18.40) in 3 posturally different seated scenarios - resting breathing, with added external load when the subjects held a dumbbell of 20 % of their body weight) and with maximum voluntary increase in intra-abdominal pressure (the diaphragm test). The sensor position was on lumbar triangle and in the groin area. Oswestry Questionaire v2.1a was used to evaluate subjective disability. Results: An independent t-test analysis showes increase in the...

The thesis examines the relationship between the level of intra-abdominal pressure and abdominal wall expansion. The theoretical part brings an overview of knowledge about the function of intra-abdominal pressure and about the possibilities of objectification of postural functions. There are described studies which dealt with the influence of intra-abdominal pressure on the stability of spine. Theoretical part also includes detailed description of individual invasive and non-invasive methods of measurement of intra-abdominal pressure and activation of abdominal muscles. Work methodology: In the practical part the intra-abdominal pressure was measured using anorectal manometry and abdominal wall expansion by utilizing DNS brace device. 31 healthy examinees with average age of 26.77 (SD 3.01) were measured in five different standing postural situations: during resting breathing, Valsalva Maneuver, Müller's maneuver, diaphragm test and in the situation with added external load in the form of static holding of dumbbell. Results of the thesis: Among the values of the pressure gathered from the DNS brace device and from anorectal manometry was proven statistically important correlation (p < 0.001) in all five tested situations. In all situations the Pearson Correlation Coefficient was higher than 0.6...

Epiphytic lichens are under considerable grazing pressure due to invertebrate lichenivores, mostly gastropods. Preferences of tree-climbing gastropods affect vertical distribution of lichens, their habitat preferences and whole area of distribution. Higher grazing pressure is expected on sites with basic subsoil and sufficient sources of calcium, where the abundance of gastropods is higher. Most of researches about the topic of grazing pressure were therefore conducted on such sites, although this hypothesis has never been formally tested. Epiphytic communities are also affected by pH and other properties specific to its photophyte. Nevertheless, it is not known, if the same applies for grazing gastropods and how is the grazing pressure affected by tree species. I have addressed these questions in my thesis. I set an 80-days-long field transplantation experiment in the mixed forest of Moravský kras (South Moravia, Czech Republic). Glass fiber meshes with lichen thalli were placed on sixty trunks of three tree species (Carpinus betulus - hornbeam, Abies alba - fir, Fagus sylvatica - common beech) on both calcareous (limestone) and acidic (granodiorite) sites. Abundance and diversity of gastropods were measured. Determined grazing pressure was higher than pressure detected by other authors and was...

Moisture in a sandstone body plays a notable role in hydrological, weathering, biological and other processes. Knowledge about presence and movement of moisture within porous medium of natural sandstone exposures is, however, rather limited. Aim of the doctoral thesis was thus to quantify selected moisture characteristics of several natural sandstone exposures in Český ráj (Czech Republic). According to long-term logging, mean annual temperature at studied areas was between 8.5 řC to 11.5 řC, mean annual relative humidity was between 73 % to 85 %. Deforested area was found warmer and drier and amplitude of the values was higher there than at the forested areas. Values of water content (more than 400 measurements) and suction (more than 150 measurements) of the exposures including their spatial-temporal changes were obtained. Mean volumetric water content in zone from the sandstone's surface to 12 cm depth was from 3 % to 10 % and mean suction in depth 2-12 cm was from 2 kPa to more than 130 kPa. Using uranine powder coloring, spatial distribution of moisture near the sandstone's surface was visualized repeatedly for the first time. The coloring divided the surficial area of the sandstone into capillary (wet) and diffusion (dry) zone. The sharp transition between the two zones was represented by...

This thesis deals with the description of the pressure sewerage systems. Primarily focuses on the assessment of operation of the pressure sewerage system of the municipality Štěpánovice, where he was evaluated on the network pressure, flow of waste water, waste water quality and system silure rate.

The dissertation thesis deals with optimization of the selected areas of the hydraulic system for small and medium transport aircrafts. Newly developed small aircraft EV-55 is a representative in the category of the small aircrafts . The selected areas of the hydraulic systems , important and useful for domestic producers of the hydraulic devices and whole hydraulic systems for the airplane EV-55 , are subjected to optimization efforts in the dissertation thesis. Design parameters of the hydraulic system (type of hydraulic source, level of pressure, weight of connecting tube), hydraulic devices ( tribology, machining process), simulation of the servomechanism and areas of diagnostic of technical status of the hydraulic system are optimized in the dissertation thesis.