Herausgegeben im Auftrag des Kanzlers:1. Vorwort 1 2. Abkürzungen und Definitionen 2 3. Allgemeines 3.1 Geschichte der TU Dresden 3 3.2 Struktur der TU Dresden 2002 5 3.3 Leitung, Gremien und Kuratorium an der TU Dresden 2002 6 3.4 Studiengänge an der TU Dresden im WS 2002/03 (Angebote) 7 4. Studenten 4.1 Studierende im WS 2002/03 (Kopfzahlen) 9 4.2 Studierende im WS 2002/03 (Kopfzahlen mit Anteilen weiblich, Ausländer und Beurlaubte) 10 4.3 Studienanfänger im SS 2002 (Kopfzahlen) 11 4.4 Studienanfänger im WS 2002/03 (Kopfzahlen) 12 4.5 Studierende im WS 2002/03 (Fallzahlen) 13 4.6 Studienanfänger im SS 2002 (Fallzahlen) 14 4.7 Studienanfänger im WS 2002/03 (Fallzahlen) 15 4.8 Studierende (Gesamtstudenten) in den Wintersemestern 1996/97-2002/03 nach Studienarten 16 4.9 Studierende in den Wintersemestern 1997/98-2002/03 (Kopfzahlen) 17 4.10 Studienanfänger pro Studienjahr 1995/96-2002/03 (Kopfzahlen) 18 4.11 Studierende und Studienanfänger 1995/96-2002/03 (Diagramm) 19 4.12 Studierende nach Wissenschaftsgebieten 1997-2002 (Diagramm) 20 4.13 Studienanfänger pro Studienjahr nach Wissenschaftsgebieten 1997/98-2002/03 (Diagramm) 21 4.14 Studierende in den WG Naturwissenschaften und Medizin 1997-2002 (Diagramm) 22 4.15 Studierende im WG Geistes- und Sozialwissenschaften 1997-2002 (Diagramm) 23 4.16 Studierende im WG Ingenieurwissenschaften 1997-2002 (Teil 1) (Diagramm) 24 4.17 Studierende im WG Ingenieurwissenschaften 1997-2002 (Teil 2) (Diagramm) 25 4.18 Studierende im WS 2002/03 nach Fakultätsbelegung und Geschlecht (Kopfzahlen) 26 4.19 Ausländische Studierende in den Wintersemestern 1997/98-2002/03 27 4.20 Ausländische Studienanfänger (1. FS) pro Studienjahr 1997/98-2002/03 (Kopfzahlen) 28 4.21 Ausländische Studierende nach Wissenschaftsgebieten 1997/98-2002/03 (Diagramm) 29 4.22 Betreuungsverhältnisse Studenten/ Personal 1997-2002 30 4.23 Betreuungsverhältnisse Studenten/ Professoren 1997-2002 in den WG Naturwiss. und Medizin (Diagr.) 31 4.24 Betreuungsverhältnisse Studenten/ Professoren 1997-2002 im WG Geistes- u. Sozialwiss. (Diagr.) 32 4.25 Betreuungsverhältnisse Studenten/ Professoren 1997-2002 im WG Ingenieurwiss. (Teil 1) (Diagr.) 33 4.26 Betreuungsverhältnisse Studenten/ Professoren 1997-2002 im WG Ingenieurwiss. (Teil 2) (Diagr.) 34 4.27 Gasthörer an der TU Dresden 1992-2002 35 4.28 Auslastung der Lehreinheiten pro Studienjahr 1999/00-2002/03 (ohne Medizin) 36 4.29 Auslastung der Lehreinheiten pro Studienjahr 1999/00-2002/03 (ohne Medizin; Diagramm) 37 5. Herkunft der Studierenden 5.1 Herkunft der Studierenden im WS 2002/03 (mit Diagrammen) 38 5.2 Herkunft der Studierenden im WS 2002/03 nach Wissenschaftsgebieten 39 5.3 Herkunft der Studienanfänger im WS 2002/03 (mit Diagramm) 40 5.4 Herkunft der Studierenden WS 1997/08 bis WS 2002/03 (mit Diagramm) 41 6. Prüfungen/ Graduierungen 6.1 Bestandene Hochschulabschlussprüfungen im Studienjahr 2001/02 42 6.2 Bestandene Hochschulabschlussprüfungen 1996/97-2001/02 (Diagramme) 43 6.3 Promotionen an der TU Dresden 2002 44 6.4 Promotionen an der TU Dresden 1997-2002 (mit Diagramm) 45 6.5 Habilitationen an der TU Dresden 2002 46 6.6 Habilitationen an der TU Dresden 1997-2002 (mit Diagramm) 47 6.7 Regelstudienzeit und durchschnittliche Studiendauer 2000/01 und 2001/02 48 6.8 Regelstudienzeit und durchschnittliche Studiendauer 1996/97-2001/02 (Diagramme) 49 6.9 Absolventenquoten an der TU Dresden 2000/01-2001/02 50 7. Forschung und Kooperation 7.1 Sonderforschungsbereiche an der TU Dresden 2002 51 7.2 Graduiertenkollegs und Innovationskollegs an der TU Dresden 2002 52 7.3 Forschergruppen und große, übergreifende Forschungsprojekte an der TU Dresden 2002 (Auswahl) 53 7.4 Stiftungsprofessuren an der TU Dresden 2002 56 7.5 Gemeinsame Berufungen an der TU Dresden 2002 57 7.6 Schutzrechtsanmeldungen 1997-2002 an der TU Dresden (mit Diagramm) 59 7.7 An-Institute der TU Dresden 2002 60 7.8 Forschungs- und Kooperationsverträge der TU Dresden 2002 (Auswahl) 61 8. Personal und Haushalt 8.1 Stellenverteilung an der TU Dresden 2002 (Haushaltsfinanzierung/ mit Diagrammen) 62 8.2 Personalbestand der TU Dresden 1996-2002 (Beschäftigungsfälle in Personen) 63 8.3 Personalbestand der TU Dresden 1997-2002 (Beschäftigungsfälle in Personen/ ohne Medizin) (Diagr.) 64 8.4 Haushaltspersonal (Planstellen) nach Wissenschaftsgebieten 1997-2002 (Diagramm) 65 8.5 Drittmittelpersonal (VZÄ) nach Wissenschaftsgebieten 1997-2002 (Diagramm) 65 8.6 Drittmittelpersonal der TU Dresden 2001-02 (mit Diagramm 1996-2002) 66 8.7 Haushalt der TU Dresden 1997-2002 67 8.8 Investitionen (Ist-Ausgaben) der TU Dresden bei HBFG-Großgeräten 1999-2002 68 8.9 Drittmittelvolumen der TU Dresden nach Fakultäten 1997-2002 69 8.10 Drittmittelvolumen der TU Dresden nach Wissenschaftsgebieten 1997-2002 (Diagramm) 70 8.11 Drittmittelprojekte der TU Dresden/ Anzahl der Projekte 1997-2002 (Diagramm) 71 9. Gebäude 9.1 Baufinanzen der TU Dresden/ Verausgabte Mittel 1999-2002 (1991-2002) 72 9.2 Hauptnutzflächen (HNF) der TU Dresden nach Fakultäten 1997-2002 (mit Diagramm) 73 9.3 Hauptnutzflächen (HNF) nach Wissenschaftsgebieten 1997-2002 (Diagramm) 74 9.4 Anzahl der Räume nach Wissenschaftsgebieten 1997-2002 (ohne Medizin) (Diagramm) 74 9.5 Flächenbestand der TU Dresden 2002 nach Altersstruktur (ohne Medizin/ mit Diagramm) 75 9.6 Laufende Große Baumaßnahmen (GBM) an der TU Dresden und am UKD 2002 76 10. Literaturhinweise 77 11. Gebäude und Lagepläne 2002 der TU Dresden 78 Übersichtsplan Dresden (mit Lage der Teilpläne der TU Dresden) Lageplan des Campus der TU Dresden (Südvorstadt) Teilplan 1 - Weberplatz und Johannstadt Teilplan 2 - Blasewitz (Medizin) Teilplan 3 - Tharandt

Mit der Ausgabe 2016/2017 (2019) wurde das Erscheinen eingestellt.

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of the transcription factors OCT4, SOX2, KLF4, and c-Myc holds great promise for the development of personalized cell replacement therapies. In an attempt to minimize the risk of chromosomal disruption and to simplify reprogramming, several studies demonstrated that a reduced set of reprogramming factors is sufficient to generate iPSC. We recently showed that a reduction of reprogramming factors in murine cells not only reduces reprogramming efficiency but also may worsen subsequent differentiation. To prove whether this is also true for human cells, we compared the efficiency of neuronal differentiation of iPSC generated from fetal human neural stem cells with either one (OCT4; hiPSC1F-NSC) or two (OCT4, KLF4; hiPSC2F-NSC) reprogramming factors with iPSC produced from human fibroblasts using three (hiPSC3F-FIB) or four reprogramming factors (hiPSC4F-FIB). After four weeks of coculture with PA6 stromal cells, neuronal differentiation of hiPSC1F-NSC and hiPSC2F-NSC was as efficient as iPSC3F-FIB or iPSC4F-FIB. We conclude that a reduction of reprogramming factors in human cells does reduce reprogramming efficiency but does not alter subsequent differentiation into neural lineages. This is of importance for the development of future application of iPSC in cell replacement therapies.

Vocal tract morphology is an important factor in voice production. Its analysis has potential implications for educational matters as well as medical issues like voice therapy. The knowledge of the complex adjustments in the spatial geometry of the vocal tract during phonation is still limited. For a major part, this is due to difficulties in acquiring geometry data of the vocal tract in the process of voice production. In this study, a centerline-based segmentation method using active contours was introduced to extract the geometry data of the vocal tract obtained with MRI during sustained vowel phonation. The applied semiautomatic algorithm was found to be time- and interaction-efficient and allowed performing various three-dimensional measurements on the resulting model. The method is suitable for an improved detailed analysis of the vocal tract morphology during speech or singing which might give some insights into the underlying mechanical processes.

Dresdner Universitätsjournal vom 14. Juli 2015

Amniotic membrane is applied to the diseased ocular surface to stimulate wound healing and tissue repair, because it releases supportive growth factors and cytokines. These effects fade within about a week after application, necessitating repeated application. Generally, amniotic membrane is fixed with sutures to the ocular surface, but surgical intervention at the inflamed or diseased site can be detrimental. Therefore, we have developed a system for the mounting of amniotic membrane between two rings for application to a diseased ocular surface without surgical intervention (sutureless amniotic membrane transplantation). With this system, AmnioClip, amniotic membrane can be applied like a large contact lens. First prototypes were tested in an experiment on oneself for wearing comfort. The final system was tested on 7 patients in a pilot study. A possible influence of the ring system on the biological effects of amniotic membrane was analyzed by histochemistry and by analyzing the expression of vascular endothelial growth factor-A (VEGF-A), hepatocyte growth factor (HGF), fibroblast growth factor 2 (FGF 2) and pigment epithelium-derived factor (PEDF) from amniotic membranes before and after therapeutic application. The final product, AmnioClip, showed good tolerance and did not impair the biological effects of amniotic membrane. VEGF-A and PEDF mRNA was expressed in amniotic membrane after storage and mounting before transplantation, but was undetectable after a 7-day application period. Consequently, transplantation of amniotic membranes with AmnioClip provides a sutureless and hence improved therapeutic strategy for corneal surface disorders.

The dual role of glycolytic enzymes in cytosol-located metabolic processes and in cell surface-mediated functions with an influence on virulence is described for various micro-organisms. Cell wall-less bacteria of the class Mollicutes including the common human pathogen Mycoplasma pneumoniae possess a reduced genome limiting the repertoire of virulence factors and metabolic pathways. After the initial contact of bacteria with cells of the respiratory epithelium via a specialized complex of adhesins and release of cell-damaging factors, surface-displayed glycolytic enzymes may facilitate the further interac-tion between host and microbe. In this study, we described detection of the four subunits of pyruvate dehydrogenase complex (PDHA-D) among the cytosolic and membrane-associated proteins of M.pneumoniae. Subunits of PDH were cloned, expressed and purified to produce specific polyclonal guinea pig antisera. Using colony blotting, fractionation of total proteins and immunofluorescence experiments, the surface localization of PDHA-C was demonstrated. All pecombinant PDH subunits are able to bind to HeLa cells and human plasminogen. These interactions can be specifically blocked by the corresponding polyclon-al antisera. In addition, an influence of ionic interactions on PDHC-binding to plasminogen as well as of lysine residues on the association of PDHA-D with plasminogen was confirmed. The PDHB subunit was shown to activate plasminogen and the PDHB-plasminogen complex induces degradation of human fibrinogen. Hence, our data indicate that the surface-associated PDH subunits might play a role in the pathogenesis of M.pneumoniae infections by interaction with human plasminogen.

Digitized by Kansas Correctional Industries

This thesis examines the rise of modern Chinese libraries between the1840s and the 1930s in the context of educational reform, intellectual development, national regeneration and state building. It focuses on how educational reform and other factors influenced the way in which modern libraries came into being in China. It argues that the establishment of modern libraries in China was a complicated and long process, as China followed neither the “industrialisation and democracy” model of the United States nor the “modernisation” model of Meiji Japan. Modern libraries were introduced into China in the closing years of the Qing Dynasty (1644–1911) to facilitate educational reform and national regeneration. The Nationalist government, established in 1928, further stimulated the expansion of Chinese libraries as part of the government’s state building efforts. This thesis examines the Chinese case in the emergence of modern libraries: the case of “underdevelopment” with distinctive Chinese characteristics. To explore the factors that contributed to the underdevelopment of modern Chinese libraries as they emerged, this thesis employs a case study of the Metropolitan Library of Beijing—the predecessor of the National Library of China—between 1909 and 1937 in terms of its formation, early development, and problems. This analysis reveals that both the macro and micro factors conducive to library development were not present in China before the 1920s. Even when the conditions improved during the 1920s and the 1930s, especially during the Nanjing Decade, the development of modern Chinese libraries was far from satisfactory for various reasons, with low library consciousness being an important one. The Conclusion of this thesis outlines the continuing impediment of low library consciousness in China today. / Doctor of Philosophy (PhD)

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