I denna uppsats har jag undersökt hur den svenska arbetarförfattaren Ivar Lo-Johansson (1901–1990) beskriver könssjukdomar i romanen Kungsgatan (1935). Lo-Johansson smittades själv av gonorré i början av 1930-talet och kände därför som författare att han hade ett syfte att göra detta ämne lite mindre tabu. Han skulle dock inte berätta om sin sjukdom för någon under denna tid. En stor del av uppsatsen kommer ägnas åt hur romanen mottogs i den samtida pressen. Jag har försökt bevisa – tvärtemot vad som flera litteraturvetare och även författaren själv gjort tidigare – att romanen inte kan klassas som en skandalroman som fick uteslutande negativ kritik på grund av dess två huvudteman prostitution och könssjukdomar.  Den vanligaste åsikten bland litteraturkritiker var att romanen generellt kraftigt borde kortats ner innan utgivning. / In this paper, I have analyzed how the Swedish proletarian writer Ivar Lo-Johansson (1901–1990) describes venereal diseases in his novel Kungsgatan (1935). Lo-Johansson contracted gonorrhea during the early 1930s, and because of this, he felt he had a social purpose as an author to make this subject a little less taboo. He would not, however, reveal his case for anybody during this period. A significant part of this paper will be dedicated to the initial critical reception of Kungsgatan. I have tried to prove – in contrast to previous scholars, even the author himself – that the novel in the beginning wasn’t regarded as scandalous by most literary critics, nor it wasn't criticized because of its main themes: prostitution and venereal diseases. Rather, the most common opinion by critics was that the novel in general should have been shortened down heavily before publication.

This dissertation studies the development of a regulation of prostitution in Stockholm during the period 1812-1880. The development of the regulation system is seen in the light of an analytical framework, developed from Carole Pateman's ideas on the sexual contract, and a feministic critique and elaboration of Jürgen Habermas's ideas on the public sphere. The regulation of prostitution was a common characteristic for many metropolises in Europe during the nineteenth century, where supposedly loose and lecherous women were medically and spatially controlled to impede the spread of venereal diseases. Stockholm, and Sweden as a whole, went from a non-gendered to a gendered control of venereal disease, which eventually developed into a spatial control of public women. This study argues that the practices of a regulation system was at first part of an attempt to import what was seen as part of modernisation. Rather than to prohibit extra-marital sexual relations, these were to be controlled and supervised. Eventually the system was adapted to local circumstances in Stockholm, and a control of women's sexuality in public became part of a metropolitan modernity. In the process of the professionalisation of groups such as the police and the physicians, public women were over time perceived as a group of professional prostitutes. The possibility to live off prostitution as a transitory stage in women's lives disappeared, and prostitution became a medically and spatially controlled trade.

Despite what the title suggests, Saskatchewan had a booming sex trade in its early years. The area attracted hundreds of women sex workers before Saskatchewan had even become a province in 1905. They were drawn to the area by the demands of bachelors who dominated Canada's prairie west. According to Saskatchewan's moral reformers, however, the sex trade was a hindrance to the province's Christian potential. They called for its abolishment and headed white slavery campaigns that characterized prostitution as a form of slavery. Their approach stood in contrast with law enforcement's stance on the trade. The police took a tolerant approach, allowing its operation as long as sex workers and their clients remained circumspect. Law enforcement's approach reflected their own propensity to use the services of sex workers as well as community attitudes toward the trade. Some communities were more welcoming of sex workers, while others demanded that police suppress the trade. Saskatchewan's newspapers also reflected differing attitudes toward the trade. While Regina's Leader purveyed a no tolerance view of the sex trade, Saskatoon's Phoenix and Star held more tolerant views. Saskatchewan's newspapers reveal that as the province's population increased and notions of moral reform gained popularity, police were challenged to take a less tolerant approach. However, reformers' efforts to end the sex trade dwindled with the onset of the First World War and attitudes toward sex workers shifted drastically as responsibility for venereal disease was placed largely on women who sold sex. Using government and police records, moral reform and public health documents, and media sources such as newspapers, as well as intersectional analysis of gender, race, class, and ethnicity, this examination of Saskatchewan’s sex trade investigates the histories and social responses to the buying and selling of sex, revealing the complex and, at times, contradictory place of sex workers and the sex trade in Saskatchewan’s early history.

The canine transmissible venereal tumour (CTVT) is a contagious cancer that is naturally transmitted between dogs by the allogeneic transfer of living cancer cells during coitus. CTVT first arose several thousand years ago and has been reported in dog populations worldwide. The goals of this Thesis were (1) to gain further understanding of CTVT distribution patterns and prevalence around the world, (2) to use genetics to trace the historical spread of CTVT and (3) to map the genetic as well as phenotypic diversity of CTVT tumours around the world. To understand the distribution patterns of CTVT, I obtained information from 645 veterinarians and animal health workers in 109 countries, and generated a snapshot of the locations in which this disease is found. Additionally, as preparation for further genetic analysis, I collected samples from over one thousand CTVT cases from more than 50 countries, optimised methods for high-throughput DNA extraction and quantification and optimised a qPCR-based assay for CTVT diagnosis and host contamination detection. With the goal of tracing the historical spread of CTVT and learning about the genetic diversity of this disease, I sequenced complete mitochondrial genomes of 449 CTVT tumours and their matched hosts. The analysis of the CTVT mitochondrial diversity revealed that CTVT has captured mitochondrial DNA (mtDNA) through horizontal transfer events at least five times during the history of the lineage, delineating five tumour clades. CTVT appears to have spread rapidly around the world within the last 2,000 years, perhaps transported by dogs travelling along historic maritime trade routes. This work indicated that negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and that recombination has caused occasional mtDNA re-assortment. A histology-based screen of CTVT clades did not show any significant phenotypic differences between groups. In order to determine how the five mtDNA clades relate to each other, I analysed data from 539 CTVT exomes. This revealed that a single canine mtDNA haplogroup has recurrently and recently undergone multiple horizontal transfer events. Analysis of this haplotype highlighted a number of candidate genetic variants which may be conferring a selective advantage to this haplotype in CTVT, possibly by influencing mtDNA transcription or replication. Overall, genetic and phenotypic analysis of CTVT tumours from across the globe has broadened our understanding of CTVT diversity, and provided important insights into the biology of a unique transmissible cancer.

Orientador: Konradin Metze / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-10T11:27:03Z (GMT). No. of bitstreams: 1 Valladao_MariaLuizadeCastroRamos_M.pdf: 884922 bytes, checksum: 2e058daa788641932fbfccd1408d3d69 (MD5) Previous issue date: 2007 / Resumo: O Tumor Venéreo Transmissível Canino (TVTC) é uma neoplasia muito comum em caninos com livre acesso as ruas. O TVTC pode provocar metástases que levam o animal à morte. A presente tese realizou estudo exploratório e prospectivo em 100 caninos portadores de TVTC de ocorrência natural. Foram anotados dados clínicos como raça, sexo, idade, peso corporal e escore na Escala de Desempenho Karnofsky Adaptada (EDKA), bem como amostras citológicas. O objetivo do estudo foi elaborar fatores prognósticos relacionados à sobrevida e fatores preditivos da resposta da monoterapia com vincristina. Os resultados demonstraram que o a idade, o peso corporal do cão e o escore na EDKA são fatores independentes prognósticos da sobrevida durante o tratamento. Cães com escore na EDKA abaixo de 50 tiveram um péssimo prognóstico de sobrevida. O tempo de interrupção do tratamento, época do ano em que se iniciou o tratamento, área do núcleo e a "rugosidade" da cromatina em preparações citológicas mostraram ser fatores independentes preditivos do sucesso da terapia. A sobrevida durante a terapia depende do estado clínico do animal, enquanto a resposta terapêutica depende tanto de características da neoplasia como de fatores ambientais externos que modificam o estado clínico do animal / Abstract: The veneral transmissible tumor of dogs (CTVT) is a common neoplasia in free roaming dogs. Since this tumor may metastasize it is a possible tread for the animals. In a prospective exploratory study based on 100 dogs with naturally occuring CTVT we collected data on breed, sex, age, weight, tumor size and the score on a modified Karnofsky Performance Scale, as well cytologic smears. The objective of the investigation was study to elaborate prognostic factors related to survival and predicitive factors related to the response to vincristine monochemotherapy. Age, sex and the Karnofsky score showed to be independent prognostic factors for survival during chemotherapy. A score below 50 indicated poor survival. Time of interruption of the treatment, season of the year, nuclear area and "roughness" of the cromatin in cytologic preparations showed to be independent prognostic factors for the success of therapy. Thus survival during therapy depends on the performance status of the dog, whereas therapy success depends both on tumor characteristics and external factors modificating the animals performance / Mestrado / Biologia Estrutural, Celular, Molecular e do Desenvolvimento / Mestre em Fisiopatologia

Since more and more customers switch to online purchases, the last-mile delivery problemhas created a huge burden on companies and cities. The increasing parcel delivery leads toextra operational costs in logistics and congestion in cities. IKEA, the furniture retailcompany, is going to propose a project – IKEA Urban Multi Hub to solve this problem byallowing customers to carry back orders themselves. This study collaborates with IKEA toinvestigate and formulate a robust hub that customers are willing to visit. The aim of thisresearch is to identify appropriate locations for the hub and possible future mobility that thehub should provide. Moreover, develop concepts and strategies for two cities - Shanghai cityand New York City.Research and customer interview were fundamental parts of this project. The research partincludes literature review and background that helps to preliminary clarify urban conditions,possible future mobility, and travel behavior. The customer interview part investigatescustomers’ preferences in two selected cities which helps to realize their needs and gaininspiration. The results showed that clustering with metro stations and providingautonomous mobility may create a smooth customer self-delivery experience for IKEA UrbanMulti Hub. Besides, cooperating with logistic companies can reduce the operation risk of theHub and strengthen the business model. Further concepts and strategies developed for twoselected cities are described in the thesis.

During the Progressive Era in the United States, social hygiene reformers underwent a fundamental change in their stance toward women accused of prostitution or promiscuous behavior. Rather than viewing such women as unfortunate victims of circumstance who were worthy of compassion, many Progressives deemed them as predatory villains who instead deserved incarceration, forced rehabilitation, and non-consenting medical interference. Texas, due to the many military bases within its borders, became a key battleground in this moral crusade against women as the carriers and proliferators of VD. "Promiscuous" women were seen as not only dangerous to the soldiers but also as a threat to the nation's security, creating an environment that led Texas Progressives to suppress women's civil liberties in the name of protecting soldiers. The catalyst for this change in attitude was World War I. The Great War brought to the forefront an unpleasant reality facing a significant percentage of America's fighting men: venereal disease. While combating sexually transmitted diseases was a serious medical and manpower concern for the military in the era before penicillin, the sole focus on women as the carriers and proliferators of VD led to a nationwide campaign against the "social evil" that demonized women and led to the suspension of thousands of women's habeas corpus rights. This dissertation examines how the twin crusades of Progressivism and the War to End All Wars created conditions in Texas that for many women meant appalling repression rather than progress toward the enjoyment of greater equality.