Vilsono liga (VL) ir HFE-hemochromatozė – monogeninės, pagal Mendelio dėsnius paveldimos retos ligos. Šių ligų priežastis yra ATP7B arba HFE genų mutacijos, sukeliančios gyvybei pavojingas lėtines ligas. Šio darbo metu buvo tirti ligonių, sergančių metabolinėmis kepenų ligomis – VL ir HFE–hemochromatoze genų mutacijos, jų dažnis, ligų fenotipinės charakteristikos bei HFE geno dažniausių mutavusių alelių dažnis Lietuvos savanorių kraujo donorų populiacijoje. Buvo nustatyta, kad Rytų ir Centrinės Europos šalių populiacijoms būdinga c.3207C>A (p.His1069Gln) mutacija ATP7B gene taip pat dažniausia ir Lietuvoje. Patvirtinta, kad VL jautriausias metodas - molekulinis genetinis diagnostikos metodas. Kitiems klinikiniams laboratoriniams tyrimo metodams buvo būdingas mažesnis jautrumas. Ištyrus Lietuvos savanorius kraujo donorus nustatyta, kad HFE–hemochromatozės geno c.845G>A (p.Cys282Tyr) ir c.187C>G (p.His63Asp) mutacijų dažnis yra artimiausias Lenkijai ir kitoms Rytų ir Centrinės Europos šalims. HFE-hemochromatozės išsivystymo rizika yra 1,3 proc. Lietuvos savanoriams kraujo donorams, kurių genotipas c.[845G>A]; [845G>A] (0,1 proc. tiriamųjų) arba genotipas c.[845G>A];[187C>G], (1,2 proc. tiriamųjų). Tiriant HFE geno mutacijų paplitimą tarp skirtinguose Lietuvos etnokultūriniuose regionuose gyvenančių savanorių kraujo donorų nustatyta, kad c.845G>A mutacijos dažnis statistiškai patikimai buvo dažnesnis Žemaitijoje. / Wilson’s disease (WD) and HFE-hemochromatosis are monogenic rare diseases inherited following Mendel’s laws. These diseases are caused by ATP7B or HFE gene mutations, which cause life-threatening chronic diseases. This study analyzed gene mutations in patients with metabolic liver diseases – WD and HFE–hemochromatosis, the frequency of such mutations, the phenotypic characteristics of these diseases, and the frequency of the most common mutations in the alleles of the HFE gene in the population of Lithuanian volunteer blood donors. The study showed that the ATP7B gene mutation c.3207C>A (p.His1069Gln), which is characteristic of the populations of Central and Eastern Europe, was also most common in Lithuania. The study confirmed that molecular genetic diagnostics was the most sensitive technique in detecting WD. Other clinical laboratory diagnostic techniques demonstrated lower sensitivity. The examination of Lithuanian volunteer blood donors showed that the frequency of HFE–hemochromatosis mutations c.845G>A (p.Cys282Tyr) and c.187C>G (p.His63Asp) was closest to that in Poland and other Eastern and Central European countries. The risk of developing HFE-hemochromatosis among Lithuanian volunteer blood donors with genotype c.[845G>A]; [845G>A] (0.1% of the subjects) or c.[845G>A];[187C>G] (1.2% of the subjects) was 1.3%. The analysis of the prevalence of HFE gene mutations among Lithuanian volunteer blood donors from different ethno-cultural regions of Lithuania showed that... [to full text]

Die vorliegende medizinische Dissertation beschäftigt sich mit der Evaluation nicht-invasiver Diagnostikverfahren zur Detektion einer Leberfibrose bei Patienten mit Morbus Wilson. Untersucht wurden die Transiente Elastographie (TE), die Acoustic Radiation Force Impulse (ARFI)-Elastographie sowie verschiedene laborbasierte Fibrose-Indices bezüglich der Anwendbarkeit und ihres diagnostischen Nutzens. Der Morbus Wilson ist eine seltene hereditäre Kupferspeicherkrankheit, die über Kupferakkumulation im Leberparenchym zur Ausbildung einer Zirrhose führen kann. Die Kenntnis des Leberfibrosegrades ist unabdingbar für therapeutische Entscheidungen und prognostische Einschätzungen. Dafür sind regelmäßige Kontrollen der Leber im Krankheitsverlauf notwendig, wobei die Leberbiopsie den diagnostischen Goldstandard darstellt. Die Invasivität sowie das Komplikationspotential limitieren jedoch deren wiederholte Anwendbarkeit. TE sowie ARFI bieten hierzu eine moderne Alternative, deren Nutzen anhand großer Studien bei Patienten mit verschiedenen chronischen Lebererkrankungen bereits aufgezeigt werden konnte. Die Verfahren beurteilen die Parenchymsteifigkeit als Surrogatparameter der Leberfibrose, wobei mit steigendem Fibrosegrad die Gewebesteifigkeit zunimmt. Die Grenzwerte zur Definition des Fibrosegrades sowie die Anwendbarkeit beider Verfahren variieren in Abhängigkeit von der Grunderkrankung. Ziel dieser Studie war es, Grenzwerte und diagnostischen Nutzen der Elastographieverfahren bei M. Wilson zu definieren. Beide Verfahren können eine Leberbeteiligung des M. Wilson nachweisen und das Vorliegen einer Leberzirrhose detektieren. Die potentiell bessere diagnostische Treffsicherheit der TE wird durch Einschränkungen in der Anwendbarkeit limitiert.

The scope of this thesis falls under the title, “Woodrow Wilson, World War I and the Rise of Poland”. The author’s intention in selecting this topic is to examine the national and political re-emergence of Poland in the early twentieth century from a predominantly American perspective, as no other Western nation had played as great a hand in this “rebirth”. Covering the better part of a decade and more that begins by tracing Woodrow Wilson’s ascension to the United States presidency, the examination centres upon the extent of and reasoning behind this Wilson-led influence as wielded through the channels of foreign diplomacy with and regarding Poland. Underlining America’s first substantial foray into internal European diplomatic affairs, the study analyses, in turn, American involvement and interest in the Poles’ burgeoning drive towards self-determination and national sovereignty leading into and throughout the First World War; Poland’s weighty part in the American government’s documented preparations for peace in Europe; and Wilson’s significant personal response to the ultimately successful course of the Polish independence movement, among other European developments leading up to the war’s close. Research conducted in this exercise comprises an analysis of primarily American foreign diplomatic and domestic political sources (including considerable emphasis upon the personal papers and documents of Woodrow Wilson himself), as well as of similar Polish sources where they pertain to American interest. Furthermore, scrutiny of the diplomatic records of other nations necessarily involved in this arena of “Great Power” politics, such as Russia, Germany, Austria-Hungary and the Western Powers, adds to the inspection. The author believes that such investigation exposes the unlikely dimensions of America’s, and especially Wilson’s, critical involvement within this particular East European historical setting. In this light, Wilson’s triumphant crusading on behalf of the rights of small nations – and equally his ensuing reversal of fortunes over the Versailles Treaty and the League of Nations Charter – can be seen to be embodied within the momentous revival of Poland’s independence and the subsequently rocky path of the “new” nation’s fledgling statehood.

Diss. Stockholm : Stockholms universitet, 2005.

Thesis (Ph.D.) -- University of Western Sydney, 2005. / Includes bibliography.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1971. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 675-687).

Thesis (Ph.D.)--Ohio University, June, 2003. / Title from PDF t.p. Includes bibliographical references (leaves 205-239)

abstract: Historians often characterize first ladies in the Progressive Era as representatives of the last vestiges of Victorian womanhood in an increasingly modern society. This dissertation argues that first ladies negotiated an image of themselves that fulfilled both traditional and modern notions of womanhood. In crafting these images, first ladies constructed images of their celebrity selves that were uniquely modern. Thus, images of first ladies in the Progressive Era show them as modest and feminine but also autonomous, intelligent, and capable. Using the historian Charles Ponce de Leon's research on modern human-interest journalism, I contend that first ladies in the Progressive Era worked with the modern press in a symbiotic relationship. This relationship allowed the press exclusive access to what was, ostensibly, the first lady's private, and therefore authentic, self. By purporting to reveal parts of their private lives in the press, first ladies showed themselves as down-to-earth despite their success and fulfilled by their domestic pursuits despite their compelling public lives. By offering the press exclusive access to their lives, first ladies secured the opportunity to shape specific images of themselves to appeal, as broadly as possible, to their husbands and parties' constituents and the American public. First ladies in the Progressive Era thus acted as political figures by using both public and private, or what historian Catherine Allgor terms, "unofficial spaces" to support and reflect their husbands and parties' political agendas. In examining representations of first ladies in popular magazines and newspapers from 1901 to 1921 in tandem with letters, memoirs, and other personal papers from these women, a clear pattern emerges. Despite personal differences, first ladies in the Progressive Era represented themselves according to a specific formula in the modern press. The images, constructed by first ladies in this time period, reflect shifts in economic, social, and political life in Progressive Era America, which called for women to be independent and intelligent yet still maintain their femininity and domesticity. / Dissertation/Thesis / Ph.D. History 2011

The energy-momentum tensor (EMT) is the Noether current associated with translations. It is of interest because, first of all, it has physical meaning as it contains the energy density and the momentum density. Moreover, its trace can be related to the beta function so that the scaling behaviour of the theory at hand can be studied. We are particularly interested in the scaling behaviour of strongly coupled theories. To explore the strong coupling regime it is necessary to compute the EMT non-perturbatively, i.e. on the lattice. This complicates matters greatly. On the lattice translation invariance is broken which leads to additional terms in the translation Ward identity from which the EMT is derived. This results in turn in the need to renormalise the EMT on the lattice. In this thesis we extend recent studies on the renormalisation of the EMT in four-dimensional gauge theory to the case of a three-dimensional scalar theory to investigate its divergence structure and the numerical feasibility of the suggested procedure on a more basic level. Furthermore, scalar φ4-theory in three dimensions exhibits an infrared fixed point and can thus serve as a toy model to examine mechanisms for building theories beyond the standard model. Our strategy to renormalise the EMT on the lattice is to identify all possible terms that can mix with both sides of the translation Ward identity. The renormalised EMT is a combination of operators of the same or lower dimension obeying the symmetries of the theory. The mixing is determined by requiring that the renormalised EMT satisfies the correct Ward identities. Using different probes in the translation Ward identity one can compute the coefficients of the EMT by solving a linear system of equations. However, contact terms can arise. One solution is the recently introduced Wilson flow. Its renormalisation properties allow for expectation values free of contact terms. That way the Wilson flow provides for a meaningful theoretical formulation of the EMT on the lattice that can be used in practice. In this thesis we review the renormalisation properties and the phase diagram of scalar φ4-theory in three dimensions, the translation Ward identity and the EMT in the continuum, as well as the gradient flow for scalar theory. A large part is dedicated to the perturbative renormalisation of the EMT on the lattice. Finally, our strategy to compute the renormalisation constants of the EMT in scalar theory non-perturbatively is discussed in detail, and our results for the renormalisation constants are presented.

Sir Henry Wilson remains one of the most controversial British Army generals of the Great War. A colourful character in life, he attracted admirers and detractors in equal measure; in death, his reputation was ruined by a biography based on his personal diaries. The Wilson of the historiography is, at best, a politician rather than a soldier, at worst an ambitious Francophile intriguer. This thesis looks beyond this accepted characterisation, reassessing his role in the formation of British and Allied strategy in the final months of the war. Wilson attained influence, and subsequently power, when Lloyd George consulted him after failing to persuade Britain’s leading generals to change their strategic focus. The thesis re-examines Wilson’s policy critique, which led to the creation of the Supreme War Council, and negated plans for a major Allied offensive on the Western Front in 1918. This thesis aims to shine new light on Wilson’s work on the Council, with an analysis of its policy recommendations. The research will also explore the manpower crisis, the key issue for the entente in this period, and Wilson’s contribution to the establishment of Allied unity of command. The diplomatic skills Wilson deployed to defuse serious strains between the entente powers will be examined, with particular reference to his time as Chief of the Imperial General Staff. His contribution to the debate on Britain’s post-war imperial grand strategy will also be evaluated. The thesis will refute the long-established onedimensional view of Wilson and suggest that he played a more influential role in British strategic development than has hitherto been acknowledged.